Detailed information for compound 667635

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 299.795 | Formula: C18H18ClNO
  • H donors: 1 H acceptors: 1 LogP: 4.84 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)C(=CC=Nc1ccccc1C(C)C)O
  • InChi: 1S/C18H18ClNO/c1-13(2)16-5-3-4-6-17(16)20-12-11-18(21)14-7-9-15(19)10-8-14/h3-13,21H,1-2H3
  • InChiKey: AUQGENOBUBZYPD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.019 0.1381 0.2951
Onchocerca volvulus 0.0014 0.0001 0.0005
Trichomonas vaginalis penicillin-binding protein, putative 0.0145 0.1023 0.6455
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0048 0.0047
Echinococcus granulosus expressed protein 0.0017 0.0023 0.0022
Brugia malayi PHD-finger family protein 0.0026 0.0096 0.0271
Loa Loa (eye worm) PHD-finger family protein 0.0026 0.0096 0.0204
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0017 0.0046
Echinococcus granulosus geminin 0.0352 0.2656 0.2655
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.0001 0.0012
Plasmodium falciparum phd finger protein, putative 0.0026 0.0096 0.2841
Loa Loa (eye worm) CXXC zinc finger family protein 0.009 0.0599 0.1279
Brugia malayi hypothetical protein 0.0137 0.0961 0.2727
Schistosoma mansoni tar DNA-binding protein 0.0463 0.3523 0.3522
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0195 0.1227
Loa Loa (eye worm) jmjC domain-containing protein 0.0054 0.0316 0.0675
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0017 0.0023 0.0031
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0271 0.2639
Echinococcus multilocularis lysine specific demethylase 5A 0.0032 0.0139 0.0138
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0116 0.0115
Mycobacterium ulcerans bacterioferritin BfrA 0.0017 0.0023 0.0217
Schistosoma mansoni DNA polymerase eta 0.0038 0.0185 0.0184
Brugia malayi ecdysteroid receptor 0.002 0.0048 0.0136
Schistosoma mansoni ferritin 0.0017 0.0023 0.0022
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0188 0.1184
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0023 0.0073 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0048 0.0136
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0048 0.0103
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0048 0.0047
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0188 0.1834
Echinococcus multilocularis geminin 0.0352 0.2656 0.2655
Trichomonas vaginalis conserved hypothetical protein 0.002 0.005 0.0312
Echinococcus granulosus jumonji domain containing protein 0.0037 0.0177 0.0176
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0048 0.0047
Schistosoma mansoni tar DNA-binding protein 0.0463 0.3523 0.3522
Echinococcus granulosus mixed lineage leukemia protein mll 0.0023 0.0073 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.002 0.005 0.0312
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0145 0.1023 0.1022
Brugia malayi hypothetical protein 0.0148 0.1049 0.2977
Schistosoma mansoni apoferritin-2 0.0017 0.0023 0.0022
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0103
Echinococcus multilocularis beta LACTamase domain containing family member 0.0145 0.1023 0.1022
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0195 0.0194
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0188 0.1184
Entamoeba histolytica acyl-coA synthetase, putative 0.0049 0.0271 0.2579
Echinococcus multilocularis dnaJ subfamily B 0.1288 1 1
Loa Loa (eye worm) hypothetical protein 0.0145 0.1023 0.2187
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0188 0.1507
Trypanosoma cruzi hypothetical protein, conserved 0.0145 0.1023 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0188 0.1184
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0001 0.0005
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.005 0.0312
Onchocerca volvulus 0.0014 0.0001 0.0005
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0001 0.0002
Echinococcus granulosus ferritin 0.0017 0.0023 0.0022
Schistosoma mansoni thyroid hormone receptor 0.002 0.0048 0.0047
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0016 0.0017 0.0022
Trypanosoma brucei DNA polymerase IV, putative 0.0016 0.0017 0.0159
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0001 0.0007
Schistosoma mansoni alpha-glucosidase 0.0148 0.1049 0.1048
Schistosoma mansoni alpha-glucosidase 0.0148 0.1049 0.1048
Leishmania major GTP-binding protein, putative 0.0042 0.0219 0.2139
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0017 0.0159
Echinococcus multilocularis importin subunit beta 1 0.0057 0.0338 0.0337
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0017 0.0159
Trichomonas vaginalis esterase, putative 0.0145 0.1023 0.6455
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0026 0.0096 0.0095
Trypanosoma brucei DNA polymerase IV, putative 0.0016 0.0017 0.0159
Schistosoma mansoni cpg binding protein 0.0096 0.064 0.0638
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0174 0.0243
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0017 0.0159
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0016 0.0017 0.0016
Brugia malayi hypothetical protein 0.0027 0.0098 0.0277
Mycobacterium ulcerans lipase LipD 0.0145 0.1023 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.005 0.0312
Brugia malayi jmjC domain containing protein 0.0086 0.0567 0.1607
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0188 0.1184
Trypanosoma cruzi hypothetical protein, conserved 0.0145 0.1023 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0103
Onchocerca volvulus 0.0049 0.0271 0.1707
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0103
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0188 0.1184
Onchocerca volvulus 0.0145 0.1023 0.6455
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0042 0.0219 0.0218
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0048 0.0136
Trypanosoma brucei DNA polymerase IV, putative 0.0016 0.0017 0.0159
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0017 0.0159
Echinococcus granulosus PHD finger protein rhinoceros 0.0026 0.0096 0.0095
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0271 0.0378
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0195 0.0552
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0098 0.0959
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0145 0.1023 1
Echinococcus multilocularis snurportin 1 0.061 0.4679 0.4678
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0048 0.0047
Loa Loa (eye worm) hypothetical protein 0.0049 0.0271 0.0578
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0271 0.0768
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0048 0.0047
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0195 0.1227
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0103
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0016 0.0017 0.0035
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.0001 0.0007
Trichomonas vaginalis ferritin, putative 0.0017 0.0023 0.0145
Loa Loa (eye worm) histone methyltransferase 0.0029 0.0117 0.0248
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0098 0.0955
Brugia malayi TAR-binding protein 0.0463 0.3523 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0172 0.1237 0.1236
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0145 0.1023 0.1433
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0145 0.1023 0.2904
Echinococcus multilocularis lysosomal alpha glucosidase 0.0172 0.1237 0.1236
Trichomonas vaginalis D-aminoacylase, putative 0.0145 0.1023 0.6455
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0188 0.1834
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0048 0.0047
Schistosoma mansoni nuclear hormone receptor 0.002 0.0048 0.0047
Loa Loa (eye worm) hypothetical protein 0.0036 0.0174 0.0372
Schistosoma mansoni alpha glucosidase 0.0038 0.0188 0.0187
Brugia malayi steroid hormone receptor 0.002 0.0048 0.0136
Onchocerca volvulus 0.0145 0.1023 0.6455
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0148 0.1049 0.1048
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0017 0.0159
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0048 0.0047
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0271 0.2644
Loa Loa (eye worm) hypothetical protein 0.0036 0.0174 0.0372
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0096 0.0938
Trichomonas vaginalis D-aminoacylase, putative 0.0145 0.1023 0.6455
Echinococcus multilocularis ferritin 0.0017 0.0023 0.0022
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0172 0.1237 0.2642
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0209
Brugia malayi RNA recognition motif domain containing protein 0.0463 0.3523 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0027 0.0097 0.0946
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0042 0.0219 0.0621
Loa Loa (eye worm) hypothetical protein 0.0145 0.1023 0.2187
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0116 0.0115
Trichomonas vaginalis DNA polymerase eta, putative 0.0016 0.0017 0.0103
Mycobacterium ulcerans hypothetical protein 0.0049 0.0271 0.2639
Plasmodium vivax importin-beta 2, putative 0.0057 0.0338 0.33
Echinococcus granulosus snurportin 1 0.061 0.4679 0.4678
Echinococcus multilocularis tar DNA binding protein 0.0463 0.3523 0.3522
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0271 0.2644
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0195 0.0194
Loa Loa (eye worm) RNA binding protein 0.0463 0.3523 0.753
Toxoplasma gondii histone lysine methyltransferase SET1 0.0172 0.1242 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0188 0.1184
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0023 0.0073 0.0072
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0048 0.0047
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0103
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0188 0.0187
Mycobacterium ulcerans DNA polymerase IV 0.0016 0.0017 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.002 0.005 0.0312
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0195 0.1901
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0195 0.1901
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.1391 0.139
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0159 0.0221
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0048 0.0136
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.0001 0.0036
Loa Loa (eye worm) hypothetical protein 0.0045 0.0244 0.052
Plasmodium vivax SET domain protein, putative 0.0029 0.0116 0.1137
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0117 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.002 0.005 0.0312
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0271 0.2639
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0023 0.0073 0.0072
Schistosoma mansoni thyroid hormone receptor 0.002 0.0048 0.0047
Mycobacterium tuberculosis Conserved protein 0.0145 0.1023 0.1433
Treponema pallidum bacterioferrin (TpF1) 0.0017 0.0023 0.5
Loa Loa (eye worm) hypothetical protein 0.0036 0.0174 0.0372
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0188 0.1184
Entamoeba histolytica hypothetical protein 0.0148 0.1049 1
Schistosoma mansoni hypothetical protein 0.0352 0.2656 0.2655
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.0195 0.0194
Echinococcus granulosus dna polymerase kappa 0.0016 0.0017 0.0016
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.018 0.0179
Mycobacterium ulcerans esterase/lipase LipP 0.0145 0.1023 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0048 0.0047
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0048 0.0047
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0086 0.0567 0.0565
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0048 0.0103
Leishmania major DNA polymerase eta, putative 0.0038 0.0185 0.1806
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0048 0.0047
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0048 0.0047
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.1391 0.139
Schistosoma mansoni transcription factor LCR-F1 0.0148 0.1049 0.1048
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0188 0.1834
Schistosoma mansoni cpg binding protein 0.009 0.0599 0.0598
Mycobacterium ulcerans bacterioferritin BfrB 0.0017 0.0023 0.0217
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0103
Onchocerca volvulus 0.0099 0.0669 0.4215
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0103
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0116 0.0115
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0048 0.0303
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0001 0.0007
Trypanosoma brucei DNA polymerase eta, putative 0.0038 0.0185 0.1806
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0048 0.0103
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0049 0.0271 0.2639
Schistosoma mansoni ran 0.0042 0.0219 0.0218
Brugia malayi Pre-SET motif family protein 0.019 0.1381 0.392
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.0271 0.2639
Loa Loa (eye worm) hypothetical protein 0.0057 0.0338 0.0721
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0174 0.1694
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0048 0.0047
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0017 0.0159
Onchocerca volvulus 0.0014 0.0001 0.0005
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0188 0.0187
Loa Loa (eye worm) hypothetical protein 0.0145 0.1023 0.2187
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0048 0.0103
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.005 0.0312
Echinococcus multilocularis jumonji domain containing protein 0.0037 0.0177 0.0176
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0048 0.0103
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0195 0.1901
Echinococcus multilocularis cpg binding protein 0.0096 0.064 0.0638
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.0271 0.2639
Echinococcus granulosus peregrin 0.0026 0.0096 0.0095
Brugia malayi nuclear hormone receptor 0.002 0.0048 0.0136
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0048 0.0136
Onchocerca volvulus 0.0014 0.0001 0.0005
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0048 0.0136
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0048 0.0136
Trichomonas vaginalis penicillin-binding protein, putative 0.0145 0.1023 0.6455
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0145 0.1023 0.1433
Onchocerca volvulus 0.0145 0.1023 0.6455
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.018 0.0179
Onchocerca volvulus Alhambra homolog 0.0026 0.0096 0.0602
Echinococcus granulosus FTZ F1 alpha 0.002 0.0048 0.0047
Echinococcus granulosus beta LACTamase domain containing family member 0.0145 0.1023 0.1022
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0017 0.0023 0.0217
Echinococcus granulosus dna polymerase eta 0.0038 0.0185 0.0184
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0042 0.0219 1
Mycobacterium leprae conserved hypothetical protein 0.0145 0.1023 1
Schistosoma mansoni tar DNA-binding protein 0.0463 0.3523 0.3522
Leishmania major hypothetical protein, conserved 0.0145 0.1023 1
Brugia malayi nuclear receptor NHR-88 0.002 0.0048 0.0136
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0174 0.5
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0017 0.0023 0.0031
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0271 0.2639
Entamoeba histolytica hypothetical protein 0.0148 0.1049 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0185 0.0395
Trichomonas vaginalis conserved hypothetical protein 0.002 0.005 0.0312
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0116 0.0115
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0048 0.0047
Onchocerca volvulus 0.009 0.0599 0.3777
Brugia malayi RNA, U transporter 1 0.0163 0.1165 0.3306
Echinococcus multilocularis dna polymerase eta 0.0038 0.0185 0.0184
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0048 0.0136
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0253 0.1593
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0098 0.0955
Trichomonas vaginalis set domain proteins, putative 0.0216 0.1585 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.005 0.0312
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0048 0.0136
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0188 0.1184
Trichomonas vaginalis importin beta-1, putative 0.0046 0.0253 0.1593
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0017 0.0023 0.5
Trypanosoma brucei hypothetical protein, conserved 0.0145 0.1023 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0027 0.0097 0.0774
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0017 0.0159
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0271 0.2639
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0001 0.0002
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.005 0.0312
Brugia malayi jmjC domain containing protein 0.0037 0.018 0.0509
Trichomonas vaginalis conserved hypothetical protein 0.002 0.005 0.0312
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0001 0.0002
Mycobacterium tuberculosis Probable lipase LipE 0.0145 0.1023 0.1433
Loa Loa (eye worm) TAR-binding protein 0.0463 0.3523 0.753
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0219 0.2139
Loa Loa (eye worm) hypothetical protein 0.0049 0.0271 0.0578
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0048 0.0136
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0188 0.1184
Entamoeba histolytica hypothetical protein 0.0148 0.1049 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0049 0.0271 0.2639
Trypanosoma cruzi importin beta-1 subunit, putative 0.0046 0.0253 0.2468
Loa Loa (eye worm) hypothetical protein 0.0026 0.0096 0.0204
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0117 0.0115
Schistosoma mansoni hypothetical protein 0.0148 0.1049 0.1048
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0001 0.0007
Echinococcus granulosus tar DNA binding protein 0.0463 0.3523 0.3522
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0001 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0017 0.0159
Schistosoma mansoni hypothetical protein 0.061 0.4679 0.4678
Schistosoma mansoni coup transcription factor 0.002 0.0048 0.0047
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0271 0.2579
Schistosoma mansoni ferritin light chain 0.0017 0.0023 0.0022
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0048 0.0047
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0145 0.1023 0.2187
Mycobacterium ulcerans hypothetical protein 0.0145 0.1023 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0017 0.0159
Loa Loa (eye worm) hypothetical protein 0.0039 0.0195 0.0416
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0159 0.0221
Brugia malayi Glycosyl hydrolases family 31 protein 0.0172 0.1237 0.3509
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0271 0.2579
Loa Loa (eye worm) hypothetical protein 0.0036 0.0174 0.0372
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0048 0.0047
Echinococcus multilocularis peregrin 0.0026 0.0096 0.0095
Mycobacterium tuberculosis Probable hydrolase 0.0145 0.1023 0.1433
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.1391 0.139
Schistosoma mansoni apoferritin-2 0.0017 0.0023 0.0022
Trypanosoma brucei glucosidase, putative 0.0038 0.0188 0.1834
Entamoeba histolytica hypothetical protein 0.0046 0.0253 0.2407
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0001 0.0007
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0098 0.2907
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0048 0.0047
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0032 0.0141 0.014
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0048 0.0047
Brugia malayi beta-lactamase 0.0145 0.1023 0.2904
Leishmania major DNA polymerase kappa, putative 0.0016 0.0017 0.0159
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0001 0.0007
Schistosoma mansoni ran 0.0042 0.0219 0.0218
Trichomonas vaginalis ran, putative 0.0042 0.0219 0.1381
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0271 0.0768
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0048 0.0047
Plasmodium vivax hypothetical protein, conserved 0.0145 0.1023 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0016 0.0017 0.0103
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0116 0.0115
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0048 0.0047
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0048 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0048 0.0136
Schistosoma mansoni jumonji domain containing protein 0.0069 0.0427 0.0426
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0191 0.1391 0.3949
Schistosoma mansoni ferritin light chain 0.0017 0.0023 0.0022
Leishmania major DNA polymerase eta, putative 0.0027 0.0097 0.0946
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0001 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0048 0.0136
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0148 0.1049 0.1048
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0017 0.0159
Schistosoma mansoni ferritin 0.0017 0.0023 0.0022
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0188 0.1789
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0857 0.6615 0.6615
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.018 0.0179
Mycobacterium tuberculosis Conserved protein 0.0145 0.1023 0.1433
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0048 0.0303
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0048 0.0047
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0116 0.0115
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0145 0.1023 0.1433
Mycobacterium ulcerans beta-lactamase 0.0145 0.1023 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0116 0.0928
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.005 0.0312
Echinococcus multilocularis lysosomal alpha glucosidase 0.0172 0.1237 0.1236
Brugia malayi beta-lactamase family protein 0.0145 0.1023 0.2904
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0001 0.0002
Echinococcus multilocularis expressed protein 0.0017 0.0023 0.0022
Mycobacterium tuberculosis Conserved protein 0.0145 0.1023 0.1433
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0017 0.0159
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0145 0.1023 0.2187
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0042 0.0219 0.0468
Trichomonas vaginalis helicase, putative 0.002 0.005 0.0312
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0042 0.0219 0.6493
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0048 0.0047
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0219 0.2139
Brugia malayi Importin beta-1 subunit 0.0057 0.0338 0.0957
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0923 0.7136 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.0195 0.0194
Echinococcus granulosus GTP binding nuclear protein Ran 0.0042 0.0219 0.0218
Toxoplasma gondii PHD-finger domain-containing protein 0.0026 0.0096 0.0764
Leishmania major importin beta-1 subunit, putative 0.0046 0.0253 0.2468
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.005 0.0312
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0042 0.0219 0.2143
Plasmodium falciparum importin beta, putative 0.0057 0.0338 1
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0098 0.0781
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0145 0.1023 0.1022
Onchocerca volvulus 0.0029 0.0116 0.0732
Loa Loa (eye worm) hypothetical protein 0.0145 0.1023 0.2187
Mycobacterium leprae Probable lipase LipE 0.0145 0.1023 1
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0048 0.0047
Toxoplasma gondii PHD-finger domain-containing protein 0.0026 0.0096 0.0764
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0191 0.1391 0.139
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0338 0.3297
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0086 0.0567 0.0565
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0191 0.1391 0.139
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0191 0.1391 0.139
Toxoplasma gondii HEAT repeat-containing protein 0.0057 0.0338 0.2713
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0188 0.0401
Loa Loa (eye worm) MH2 domain-containing protein 0.0134 0.094 0.2008
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.018 0.0384
Brugia malayi hypothetical protein 0.0017 0.0024 0.0067
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0048 0.0136
Loa Loa (eye worm) hypothetical protein 0.0145 0.1023 0.2187
Leishmania major hypothetical protein, conserved 0.0027 0.0098 0.0955
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.005 0.0312
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0253 0.1593
Schistosoma mansoni terminal deoxycytidyl transferase 0.0016 0.0017 0.0016
Loa Loa (eye worm) hypothetical protein 0.0049 0.0271 0.0578
Loa Loa (eye worm) hypothetical protein 0.0029 0.0116 0.0248
Mycobacterium tuberculosis Probable lipase LipD 0.0145 0.1023 0.1433
Brugia malayi MH2 domain containing protein 0.0134 0.094 0.2667
Mycobacterium tuberculosis Probable esterase LipL 0.0145 0.1023 0.1433
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0048 0.0136
Mycobacterium tuberculosis Conserved hypothetical protein 0.0016 0.0017 0.0022
Loa Loa (eye worm) oxidoreductase 0.0014 0.0001 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0017 0.0159
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0098 0.2907
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0463 0.3523 0.753
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0048 0.0103
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0195 0.1227
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.005 0.0312
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0048 0.0303
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0188 0.0533
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.061 0.4679 1
Trichomonas vaginalis D-aminoacylase, putative 0.0145 0.1023 0.6455
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0039 0.0195 0.8799
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0049 0.0271 0.0378
Entamoeba histolytica hypothetical protein 0.0148 0.1049 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0195 0.0194
Schistosoma mansoni hypothetical protein 0.0352 0.2656 0.2655
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0185 0.1806
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0271 0.0768
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0016 0.0017 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.002 0.005 0.0312
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0001 0.0002
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0271 0.2639
Brugia malayi beta-lactamase family protein 0.0145 0.1023 0.2904
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0195 0.1855
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0193 0.1403 0.1402
Schistosoma mansoni tar DNA-binding protein 0.0463 0.3523 0.3522
Entamoeba histolytica deoxycytidyl transferase, putative 0.0016 0.0017 0.0155
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0048 0.0047
Loa Loa (eye worm) hypothetical protein 0.0036 0.0174 0.0372
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0195 0.1901
Echinococcus granulosus cpg binding protein 0.0096 0.064 0.0638
Schistosoma mansoni hypothetical protein 0.1288 1 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0159 0.0221
Schistosoma mansoni ferritin 0.0017 0.0023 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.002 0.005 0.0312
Schistosoma mansoni tar DNA-binding protein 0.0463 0.3523 0.3522
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0048 0.0103
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0174 0.5164
Loa Loa (eye worm) hypothetical protein 0.0137 0.0961 0.2054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0048 0.0103
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.0195 0.0194
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0026 0.0093 0.0092
Schistosoma mansoni importin beta-1 0.0057 0.0338 0.0337
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0271 0.2644
Giardia lamblia PHD finger protein 15 0.0026 0.0096 0.391
Echinococcus multilocularis dna polymerase kappa 0.0016 0.0017 0.0016
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0174 0.1704
Brugia malayi F/Y-rich N-terminus family protein 0.0037 0.0181 0.0513
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0188 0.1789
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0098 0.0955
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0103
Brugia malayi CXXC zinc finger family protein 0.009 0.0599 0.1699
Onchocerca volvulus 0.0137 0.0961 0.6062
Echinococcus granulosus importin subunit beta 1 0.0057 0.0338 0.0337
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0191 0.1391 0.2973
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0001 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0017 0.0159
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0016 0.0017 0.0159
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0048 0.0136
Schistosoma mansoni ferritin 0.0017 0.0023 0.0022
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0001 0.0007
Schistosoma mansoni hypothetical protein 0.0026 0.0096 0.0095
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.0195 0.0194
Brugia malayi RNA binding protein 0.0463 0.3523 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0338 0.3297
Brugia malayi Bromodomain containing protein 0.0026 0.0096 0.0271
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0048 0.0047
Loa Loa (eye worm) beta-lactamase 0.0145 0.1023 0.2187
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0048 0.0136
Toxoplasma gondii ABC1 family protein 0.0145 0.1023 0.824
Loa Loa (eye worm) transcription factor SMAD2 0.0134 0.094 0.2008
Trypanosoma brucei unspecified product 0.0016 0.0017 0.0159
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0159 0.0221
Mycobacterium ulcerans DNA polymerase IV 0.0016 0.0017 0.0152
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0017 0.0159
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0042 0.0219 0.1758
Echinococcus multilocularis PHD finger protein rhinoceros 0.0026 0.0096 0.0095
Schistosoma mansoni cpg binding protein 0.0096 0.064 0.0638
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0191 0.1391 0.139
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0001 0.0002
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0042 0.0219 0.2139
Onchocerca volvulus 0.002 0.0048 0.0303
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0185 0.0525
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0116 0.0115
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0016 0.0017 0.0016
Entamoeba histolytica Ran family GTPase 0.0042 0.0219 0.2087
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0001 0.0005
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0001 0.0002
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0195 0.0194
Onchocerca volvulus 0.0216 0.1585 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0048 0.0136
Brugia malayi Pre-SET motif family protein 0.0029 0.0116 0.0329

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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