Detailed information for compound 667703

Basic information

Technical information
  • TDR Targets ID: 667703
  • Name: N-(5-chloro-2-methoxyphenyl)-2-cyclohexylacet amide
  • MW: 281.778 | Formula: C15H20ClNO2
  • H donors: 1 H acceptors: 1 LogP: 4.37 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1NC(=O)CC1CCCCC1)Cl
  • InChi: 1S/C15H20ClNO2/c1-19-14-8-7-12(16)10-13(14)17-15(18)9-11-5-3-2-4-6-11/h7-8,10-11H,2-6,9H2,1H3,(H,17,18)
  • InChiKey: KGMYHJVZXBQRJH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(5-chloro-2-methoxy-phenyl)-2-cyclohexyl-acetamide
  • N-(5-chloro-2-methoxy-phenyl)-2-cyclohexyl-ethanamide
  • Oprea1_084645
  • STK161574

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.3576 0.3576
Loa Loa (eye worm) acetyltransferase 0.0153 1 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.3576 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.3576 0.3688
Schistosoma mansoni tar DNA-binding protein 0.0065 0.3775 0.3775
Echinococcus granulosus lamin 0.0027 0.1149 0.1185
Echinococcus multilocularis musashi 0.0027 0.1149 0.1149
Echinococcus multilocularis tar DNA binding protein 0.0065 0.3775 0.3775
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.2118 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.2336 0.2336
Schistosoma mansoni tar DNA-binding protein 0.0065 0.3775 0.3775
Onchocerca volvulus 0.0027 0.1149 0.5
Brugia malayi Cytochrome P450 family protein 0.002 0.0652 0.0652
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.2118 0.5
Echinococcus granulosus lamin dm0 0.0027 0.1149 0.1185
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.3576 1
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.3576 0.3576
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.3576 1
Loa Loa (eye worm) CYP4Cod1 0.002 0.0652 0.0652
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.2383 0.6663
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0652 0.0652
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.2336 0.2409
Schistosoma mansoni tar DNA-binding protein 0.0065 0.3775 0.3775
Trypanosoma brucei cytochrome P450, putative 0.002 0.0652 1
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.3775 0.3775
Schistosoma mansoni lamin 0.0027 0.1149 0.1149
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0153 1 1
Echinococcus multilocularis lamin 0.0027 0.1149 0.1149
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.3775 0.3775
Schistosoma mansoni intermediate filament proteins 0.0027 0.1149 0.1149
Mycobacterium leprae putative cytochrome p450 0.0011 0 0.5
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0248 0.0248
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.2336 0.2336
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.1149 0.1149
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.3576 0.3576
Loa Loa (eye worm) hypothetical protein 0.0027 0.1149 0.1149
Loa Loa (eye worm) hypothetical protein 0.0013 0.011 0.011
Schistosoma mansoni tar DNA-binding protein 0.0065 0.3775 0.3775
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0652 0.0652
Mycobacterium leprae Conserved hypothetical protein 0.0011 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0013 0.0145 0.0145
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0652 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.1149 0.1149
Brugia malayi TAR-binding protein 0.0065 0.3775 0.3775
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.2841 0.2841
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.002 0.0652 0.1824
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.2336 0.2336
Schistosoma mansoni lamin 0.0027 0.1149 0.1149
Loa Loa (eye worm) intermediate filament protein 0.0027 0.1149 0.1149
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.2383 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.2336 0.2336
Brugia malayi Cytochrome P450 family protein 0.0051 0.2841 0.2841
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0248 0.0248
Schistosoma mansoni tar DNA-binding protein 0.0065 0.3775 0.3775
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0153 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.2336 0.2409
Brugia malayi intermediate filament protein 0.0027 0.1149 0.1149
Loa Loa (eye worm) RNA binding protein 0.0065 0.3775 0.3775
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.2383 0.5
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.2383 0.6663
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.2118 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.2336 0.2336
Brugia malayi RNA binding protein 0.0065 0.3775 0.3775
Onchocerca volvulus 0.0027 0.1149 0.5
Echinococcus multilocularis lamin dm0 0.0027 0.1149 0.1149
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.3576 1
Brugia malayi Cytochrome P450 family protein 0.002 0.0652 0.0652
Echinococcus granulosus histone acetyltransferase KAT2B 0.0148 0.9697 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.2336 0.2336
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0145 0.0145
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.2383 0.2457
Loa Loa (eye worm) hypothetical protein 0.0013 0.011 0.011
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.3576 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.2383 0.5
Loa Loa (eye worm) hypothetical protein 0.0027 0.1113 0.1113
Loa Loa (eye worm) TAR-binding protein 0.0065 0.3775 0.3775
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0145 0.015
Echinococcus granulosus intermediate filament protein 0.0027 0.1149 0.1185
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.2336 0.2336
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.3576 1
Echinococcus granulosus tar DNA binding protein 0.0065 0.3775 0.3892
Leishmania major cytochrome p450-like protein 0.002 0.0652 0.1824
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0652 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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