Detailed information for compound 667993

Basic information

Technical information
  • TDR Targets ID: 667993
  • Name: ZINC01144117
  • MW: 459.356 | Formula: C21H19BrN2O3S
  • H donors: 1 H acceptors: 3 LogP: 4.52 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)S(=O)(=O)N(c1ccc(cc1)C(=O)Nc1cccc(c1)Br)C
  • InChi: 1S/C21H19BrN2O3S/c1-15-6-12-20(13-7-15)28(26,27)24(2)19-10-8-16(9-11-19)21(25)23-18-5-3-4-17(22)14-18/h3-14H,1-2H3,(H,23,25)
  • InChiKey: CIQGRXIHXBZWIU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0063 0.363 0.6285
Echinococcus granulosus discoidin domain containing receptor 2 0.0011 0.0266 0.0463
Loa Loa (eye worm) hypothetical protein 0.001 0.0197 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.028 0.0025
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.2241 0.377
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0697 0.0804
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.007 0.4079 0.7255
Loa Loa (eye worm) hypothetical protein 0.0011 0.0266 0.0269
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.0161 1 1
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0385 0.0674
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0402 0.0402
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.2564 0.4292
Trichomonas vaginalis chromobox protein, putative 0.0069 0.4012 0.6998
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0197 0.0086
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0786 0.0682
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0161 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.1511 0.2531
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0011 0.028 0.0014
Brugia malayi M-phase phosphoprotein, mpp8 0.0011 0.028 0.017
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0197 0.0086
Loa Loa (eye worm) hypothetical protein 0.0011 0.028 0.0293
Echinococcus multilocularis discoidin domain containing receptor 2 0.0011 0.0266 0.0463
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0197 0.019
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0197 0.0339
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0197 0.019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0197 0.0142
Loa Loa (eye worm) hypothetical protein 0.001 0.0197 0.0142
Onchocerca volvulus 0.0011 0.028 0.0153
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0385 0.0674
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.5619 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0063 0.363 0.6457
Echinococcus multilocularis chromobox protein 1 0.0069 0.4012 0.7137
Schistosoma mansoni DNA polymerase eta 0.0019 0.0786 0.078
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0063 0.363 0.6457
Brugia malayi CXXC zinc finger family protein 0.0028 0.1389 0.1292
Leishmania major DNA polymerase eta, putative 0.0019 0.0786 0.0786
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0786 0.078
Loa Loa (eye worm) hypothetical protein 0.0011 0.028 0.0293
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0197 0.0339
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.028 0.0025
Schistosoma mansoni chromobox protein 0.0069 0.4012 0.4008
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0786 0.0786
Brugia malayi Valyl-tRNA synthetase 0.0011 0.028 0.017
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.028 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0786 0.0786
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0697 0.0804
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0786 0.0786
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0786 0.097
Schistosoma mansoni chromobox protein 0.0011 0.028 0.0274
Schistosoma mansoni discoidin domain receptor 0.0011 0.0266 0.026
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0197 0.0339
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.5619 0.5619
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0197 0.0339
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.2051 0.3334
Trypanosoma brucei unspecified product 0.0019 0.0786 0.0786
Schistosoma mansoni hypothetical protein 0.0011 0.028 0.0274
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.5619 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0063 0.363 0.6285
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0697 0.0804
Brugia malayi Heterochromatin protein 1 0.0069 0.4012 0.3944
Echinococcus multilocularis Chromo domain 0.0011 0.028 0.0487
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0786 0.1388
Trichomonas vaginalis chromobox protein, putative 0.0011 0.028 0.0025
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0385 0.0484
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0197 0.019
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0786 0.0786
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.5619 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0504 0.0443
Schistosoma mansoni cpg binding protein 0.003 0.1494 0.1488
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.0161 1 1
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0197 0.019
Onchocerca volvulus 0.0011 0.0266 0.0128
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.028 0.0274
Loa Loa (eye worm) hypothetical protein 0.0039 0.2051 0.3513
Plasmodium vivax heterochromatin protein 1, putative 0.0011 0.028 0.0014
Loa Loa (eye worm) helicase 0.0011 0.028 0.0293
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.5619 0.5616
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0786 0.0786
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0011 0.0266 0.0463
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0786 0.0682
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.028 0.0014
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0786 0.0786
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0786 0.0786
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0063 0.363 0.6285
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0.028 0.0014
Brugia malayi SET domain containing protein 0.0012 0.032 0.0211
Loa Loa (eye worm) hypothetical protein 0.001 0.0197 0.0142
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0197 0.0086
Plasmodium vivax hypothetical protein, conserved 0.0011 0.028 0.0014
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0786 0.0786
Trypanosoma brucei polo-like protein kinase 0.0093 0.5619 0.5619
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.028 0.0274
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0197 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0197 0.0086
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.028 0.0025
Brugia malayi hypothetical protein 0.0011 0.028 0.017
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0197 0.0339
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0197 0.0339
Loa Loa (eye worm) hypothetical protein 0.001 0.0197 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.1321 0.197
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0197 0.0086
Trichomonas vaginalis chromobox protein, putative 0.0069 0.4012 0.6998
Schistosoma mansoni coup transcription factor 0.001 0.0197 0.019
Leishmania major dihydroorotate dehydrogenase 0.0161 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.028 0.0293
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0786 0.0786
Schistosoma mansoni septate junction protein 0.0011 0.0266 0.026
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0011 0.028 0.0014
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0063 0.363 0.6285
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0786 0.0786
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0161 1 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.5619 0.557
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0197 0.019
Echinococcus granulosus dna polymerase eta 0.0019 0.0786 0.1388
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.3034 0.2844
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0697 0.0804
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0786 0.0786
Plasmodium falciparum heterochromatin protein 1 0.0011 0.028 0.0014
Leishmania major DNA polymerase kappa, putative 0.0019 0.0786 0.0786
Loa Loa (eye worm) hypothetical protein 0.0019 0.0786 0.1213
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0161 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0786 0.0786
Echinococcus multilocularis discoidin domain containing receptor 2 0.0011 0.0266 0.0463
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0385 0.0379
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.028 0.0025
Trichomonas vaginalis Heterochromatin protein, putative 0.0011 0.028 0.0025
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.028 0.0025
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0697 0.0804
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0786 0.0786
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.0161 1 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0786 0.097
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0786 0.0786
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.5619 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0197 0.0339
Loa Loa (eye worm) hypothetical protein 0.0011 0.0266 0.0269
Plasmodium falciparum dihydroorotate dehydrogenase 0.0161 1 1
Onchocerca volvulus 0.0011 0.028 0.0153
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.5619 1
Trypanosoma brucei unspecified product 0.0013 0.0402 0.0402
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.028 0.0487
Trichomonas vaginalis chromobox protein, putative 0.0011 0.028 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.028 0.0025
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.4012 0.7078
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0197 0.0142
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0197 0.0086
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0786 0.0786
Schistosoma mansoni hypothetical protein 0.0011 0.0266 0.026
Brugia malayi steroid hormone receptor 0.001 0.0197 0.0086
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0063 0.363 0.6285
Schistosoma mansoni discoidin domain receptor 0.0011 0.0266 0.026
Brugia malayi chromobox protein homolog 3 0.0039 0.2051 0.1961
Echinococcus multilocularis discoidin domain receptor 0.0011 0.0266 0.0463
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.2051 0.3334
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.028 0.0487
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.5619 0.5619
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.5619 1
Onchocerca volvulus 0.003 0.1511 0.2423
Echinococcus multilocularis chromobox protein 2 0.0011 0.028 0.0487
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.0161 1 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.032 0.0314
Schistosoma mansoni dihydroorotate dehydrogenase 0.0161 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0786 0.0786
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0197 0.019
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0063 0.363 0.363
Trypanosoma brucei unspecified product 0.0013 0.0402 0.0402
Schistosoma mansoni btb and poz domain-containing protein 0.0011 0.0266 0.026
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0197 0.0339
Echinococcus multilocularis dna polymerase eta 0.0019 0.0786 0.1388
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0197 0.019
Echinococcus granulosus Chromobox protein 3 0.0011 0.028 0.0487
Loa Loa (eye worm) hypothetical protein 0.001 0.0197 0.0142
Brugia malayi Protein kinase domain containing protein 0.0011 0.0266 0.0157
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0786 0.0786
Schistosoma mansoni kinase 0.0048 0.2644 0.2639
Echinococcus multilocularis discoidin domain containing receptor 2 0.0011 0.0266 0.0463
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0697 0.0804
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0197 0.0086
Echinococcus granulosus dna polymerase kappa 0.0019 0.0786 0.1388
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.5619 1
Onchocerca volvulus 0.0028 0.1389 0.2199
Schistosoma mansoni thyroid hormone receptor 0.001 0.0197 0.019
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.028 0.0025
Trichomonas vaginalis chromobox protein, putative 0.0041 0.2241 0.3689
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0786 0.1213
Echinococcus granulosus chromobox protein 1 0.0069 0.4012 0.7137
Echinococcus granulosus chromobox protein 2 0.0011 0.028 0.0487
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0473 0.0386
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0786 0.1388
Echinococcus granulosus chromobox protein 1 0.0069 0.4012 0.7137
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0197 0.0142
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0197 0.0086
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0197 0.0339
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0197 0.0142
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0197 0.0339
Plasmodium vivax hypothetical protein, conserved 0.0011 0.028 0.0014
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.0161 1 0.5
Onchocerca volvulus 0.0011 0.0266 0.0128
Brugia malayi CHD4 protein 0.0013 0.0385 0.0276
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0197 0.019
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0197 0.019
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.2564 0.4292
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0786 0.0786
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.5619 1
Echinococcus granulosus discoidin domain receptor 0.0011 0.0266 0.0463
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.0161 1 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0786 0.078
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0197 0.0086
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.5619 1
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.007 0.4079 0.7255
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0197 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0197 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.028 0.0025
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.1389 0.231
Schistosoma mansoni nuclear hormone receptor 0.001 0.0197 0.019
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0063 0.363 0.6285
Loa Loa (eye worm) hypothetical protein 0.0011 0.028 0.0293
Brugia malayi nuclear receptor NHR-88 0.001 0.0197 0.0086
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0197 0.0339
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0197 0.0339
Loa Loa (eye worm) hypothetical protein 0.001 0.0197 0.0142
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.5619 0.5619
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0786 0.0786
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.2051 0.3419
Trichomonas vaginalis chromobox protein, putative 0.0041 0.2241 0.3689
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0063 0.363 0.6275
Echinococcus multilocularis cpg binding protein 0.003 0.1494 0.265
Echinococcus granulosus FTZ F1 alpha 0.001 0.0197 0.0339
Schistosoma mansoni cpg binding protein 0.0028 0.1389 0.1383
Schistosoma mansoni cpg binding protein 0.003 0.1494 0.1488
Brugia malayi Protein cec-1. 0.0011 0.028 0.017
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.5619 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0697 0.0804
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0197 0.0142
Echinococcus granulosus discoidin domain containing receptor 2 0.0011 0.0266 0.0463
Loa Loa (eye worm) hypothetical protein 0.0011 0.028 0.0293
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0197 0.0142
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0197 0.0339
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0119 0.02
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0197 0.0142
Schistosoma mansoni dock 0.007 0.4079 0.4075
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.3451 0.3447
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0697 0.0804
Echinococcus granulosus cpg binding protein 0.003 0.1494 0.265
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.028 0.0274
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0161 1 1
Brugia malayi Zinc finger, C2H2 type family protein 0.0063 0.363 0.3558
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.028 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0786 0.0786
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0786 0.0786
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0197 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0197 0.0086
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0197 0.0339
Brugia malayi nuclear hormone receptor 0.001 0.0197 0.0086
Loa Loa (eye worm) hypothetical protein 0.001 0.0197 0.0142
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0402 0.0402
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0786 0.0786
Trichomonas vaginalis hypothetical protein 0.0011 0.028 0.0025
Echinococcus granulosus discoidin domain containing receptor 2 0.0011 0.0266 0.0463
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.5619 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0197 0.0142
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0197 0.0086
Schistosoma mansoni chromobox protein 0.0069 0.4012 0.4008
Echinococcus multilocularis Chromobox protein 3 0.0011 0.028 0.0487
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0786 0.0947
Loa Loa (eye worm) hypothetical protein 0.0011 0.028 0.0293
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.028 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0504 0.0443
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0119 0.02
Trichomonas vaginalis chromobox protein, putative 0.0011 0.028 0.0025
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0063 0.363 0.6457
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0786 0.0786
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0197 0.0339
Schistosoma mansoni thyroid hormone receptor 0.001 0.0197 0.019
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0197 0.0339
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.0161 1 1
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0786 0.1388
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.5619 1
Brugia malayi ecdysteroid receptor 0.001 0.0197 0.0086
Schistosoma mansoni chromobox protein 0.0011 0.028 0.0274
Loa Loa (eye worm) hypothetical protein 0.0011 0.028 0.0293
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0197 0.0339
Echinococcus multilocularis dedicator of cytokinesis protein 0.0059 0.3362 0.5978
Loa Loa (eye worm) hypothetical protein 0.0011 0.0266 0.0269
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.1321 0.197
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0402 0.0402
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0197 0.0142
Echinococcus granulosus Chromo domain 0.0011 0.028 0.0487
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0786 0.0786
Onchocerca volvulus 0.0012 0.032 0.0227
Echinococcus multilocularis chromobox protein 1 0.0069 0.4012 0.7137
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.028 0.017
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0197 0.0086
Giardia lamblia Kinase, PLK 0.0093 0.5619 1
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.028 0.0014
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0063 0.363 0.6457
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.028 0.017
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.0011 0.0266 0.0266

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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