Detailed information for compound 668189

Basic information

Technical information
  • TDR Targets ID: 668189
  • Name: N-(5-chloro-2-methoxyphenyl)-4-methyl-6-(2-me thylphenyl)-2-oxo-3,6-dihydro-1H-pyrimidine-5 -carboxamide
  • MW: 385.844 | Formula: C20H20ClN3O3
  • H donors: 3 H acceptors: 2 LogP: 2.96 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1NC(=O)C1=C(C)NC(=O)NC1c1ccccc1C)Cl
  • InChi: 1S/C20H20ClN3O3/c1-11-6-4-5-7-14(11)18-17(12(2)22-20(26)24-18)19(25)23-15-10-13(21)8-9-16(15)27-3/h4-10,18H,1-3H3,(H,23,25)(H2,22,24,26)
  • InChiKey: NLYYPPNYCILTMX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(5-chloro-2-methoxy-phenyl)-4-methyl-6-(2-methylphenyl)-2-oxo-3,6-dihydro-1H-pyrimidine-5-carboxamide
  • N-(5-chloro-2-methoxy-phenyl)-2-keto-4-methyl-6-(2-methylphenyl)-3,6-dihydro-1H-pyrimidine-5-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0492 0.1033
Echinococcus granulosus geminin 0.0165 0.713 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0276 0.0094
Plasmodium falciparum glutathione reductase 0.0046 0.1832 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.1069 0.1499
Onchocerca volvulus 0.0147 0.63 0.5857
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1783 0.2272
Brugia malayi Pre-SET motif family protein 0.0202 0.876 0.8805
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0492 0.0406
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0492 0.1033
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0492 0.0406
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0696 0.2991
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1783 0.2272
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0884 0.4155
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0492 0.1033
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1783 0.2501
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0884 0.3661
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0492 0.1033
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0492 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.1069 0.1499
Brugia malayi Pre-SET motif family protein 0.0029 0.1069 0.0884
Schistosoma mansoni DNA helicase recq1 0.001 0.0211 0.0296
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.1783 0.162
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0492 0.5
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0492 0.1033
Leishmania major trypanothione reductase 0.0046 0.1832 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0492 0.0689
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0884 0.3661
Plasmodium falciparum thioredoxin reductase 0.0016 0.0492 0.1733
Schistosoma mansoni hypothetical protein 0.0011 0.0276 0.0387
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0492 0.1033
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0603 0.0846
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0492 0.1033
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.4981 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0492 0.1033
Treponema pallidum NADH oxidase 0.0016 0.0492 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.1783 0.162
Loa Loa (eye worm) hypothetical protein 0.0025 0.0884 0.0694
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0492 0.1033
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.4981 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.1069 0.1499
Brugia malayi follicle stimulating hormone receptor 0.0228 0.9919 1
Plasmodium vivax SET domain protein, putative 0.0029 0.1069 0.4335
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0492 0.1733
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.1069 0.124
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.4459 0.8837
Schistosoma mansoni hypothetical protein 0.0165 0.713 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.1832 0.2343
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0884 0.3661
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0822 0.0502
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0822 0.0884
Echinococcus multilocularis geminin 0.0165 0.713 1
Mycobacterium tuberculosis Probable reductase 0.0105 0.4459 0.8837
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0303 0.0095
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0492 0.5
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0492 0.1033
Loa Loa (eye worm) hypothetical protein 0.0118 0.5022 0.4956
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.1069 0.124
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1783 0.2272
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0492 0.0289
Plasmodium falciparum thioredoxin reductase 0.0046 0.1832 1
Loa Loa (eye worm) glutathione reductase 0.0046 0.1832 0.167
Brugia malayi hypothetical protein 0.0025 0.0884 0.0694
Leishmania major hypothetical protein, conserved 0.0025 0.0884 0.3661
Loa Loa (eye worm) RecQ helicase 0.0023 0.0822 0.063
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0492 0.005
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0492 0.2684
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0492 0.1033
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.1832 1
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0822 0.063
Plasmodium falciparum glutathione reductase 0.0016 0.0492 0.1733
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0492 0.1033
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.1832 0.167
Trichomonas vaginalis set domain proteins, putative 0.023 1 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0276 0.0094
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0477 0.2602
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.4459 0.8837
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.1832 0.2343
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0492 0.1733
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.1069 0.124
Brugia malayi hypothetical protein 0.0016 0.0493 0.0291
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0492 0.2684
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0337 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0492 0.5
Brugia malayi Thioredoxin reductase 0.0046 0.1832 0.167
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1783 0.2501
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.4459 0.8837
Plasmodium vivax glutathione reductase, putative 0.0046 0.1832 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0492 0.1033
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0492 0.1033
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0492 0.005
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.4981 1
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0492 0.016
Schistosoma mansoni hypothetical protein 0.0165 0.713 1
Echinococcus granulosus bloom syndrome protein 0.0023 0.0822 0.0884
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.1069 0.5834
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.1069 0.1499
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.4459 0.8837
Brugia malayi glutathione reductase 0.0046 0.1832 0.167
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0492 0.1033
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0822 0.0502
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.1832 0.2985
Loa Loa (eye worm) hypothetical protein 0.0147 0.63 0.6272
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0492 0.1033
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0492 0.1033
Loa Loa (eye worm) hypothetical protein 0.0029 0.1069 0.0884
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0884 0.4828
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0884 0.2965
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0228 0.9919 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1783 0.2272
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.4981 1
Schistosoma mansoni DNA helicase recq5 0.001 0.0211 0.0296
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.1021 0.1172
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0492 0.5
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0884 0.4155
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0492 0.016
Toxoplasma gondii thioredoxin reductase 0.0046 0.1832 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0303 0.0095
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0211 0.115
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.4459 0.8837
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.876 0.8805
Trypanosoma brucei trypanothione reductase 0.0046 0.1832 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1783 0.2501
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.1832 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0211 0.115
Brugia malayi hypothetical protein 0.0147 0.63 0.6272
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0492 0.5
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0492 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.