Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | geminin | 0.0178 | 0.3596 | 0.5354 |
Echinococcus multilocularis | dUTP pyrophosphatase | 0.0176 | 0.3555 | 0.5291 |
Trypanosoma brucei | GTP-binding nuclear protein rtb2, putative | 0.0022 | 0.0253 | 0.1167 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0025 | 0.0302 | 0.0343 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0022 | 0.0253 | 0.1167 |
Leishmania major | hypothetical protein, conserved | 0.0074 | 0.1375 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0186 | 0.0277 |
Schistosoma mansoni | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.0176 | 0.3555 | 0.5291 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0074 | 0.1375 | 0.2046 |
Entamoeba histolytica | hypothetical protein | 0.0115 | 0.2242 | 0.6104 |
Onchocerca volvulus | 0.0074 | 0.1375 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0178 | 0.3596 | 0.5354 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.0105 | 0.0156 |
Echinococcus granulosus | snurportin 1 | 0.0323 | 0.6718 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0074 | 0.1375 | 0.3681 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative | 0.0176 | 0.3555 | 1 |
Trichomonas vaginalis | importin beta-1, putative | 0.0025 | 0.0302 | 0.0343 |
Mycobacterium ulcerans | beta-lactamase | 0.0074 | 0.1375 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0096 | 0.1828 | 0.2721 |
Brugia malayi | hypothetical protein | 0.0246 | 0.5059 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1375 | 0.2046 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0096 | 0.1828 | 0.2721 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0074 | 0.1375 | 0.3529 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0015 | 0.0105 | 0.0156 |
Treponema pallidum | deoxyuridine 5'-triphosphate nucleotidohydrolase (dut) | 0.0176 | 0.3555 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0074 | 0.1375 | 0.1284 |
Entamoeba histolytica | Ran family GTPase | 0.0022 | 0.0253 | 0.0199 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.0105 | 0.0156 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0186 | 0.0236 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0096 | 0.1828 | 0.2721 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0074 | 0.1375 | 0.2717 |
Loa Loa (eye worm) | beta-lactamase | 0.0074 | 0.1375 | 0.2046 |
Mycobacterium tuberculosis | Conserved protein | 0.0074 | 0.1375 | 0.1284 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0074 | 0.1375 | 0.3529 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0074 | 0.1375 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0074 | 0.1375 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0176 | 0.3555 | 1 |
Plasmodium vivax | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative | 0.0176 | 0.3555 | 1 |
Brugia malayi | beta-lactamase | 0.0074 | 0.1375 | 0.2717 |
Leishmania major | importin beta-1 subunit, putative | 0.0025 | 0.0302 | 0.1551 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0074 | 0.1375 | 0.2046 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0096 | 0.1828 | 0.2721 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0176 | 0.3555 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0074 | 0.1375 | 0.2046 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0015 | 0.0105 | 0.0156 |
Brugia malayi | isocitrate dehydrogenase | 0.0015 | 0.0105 | 0.0207 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0074 | 0.1375 | 0.2046 |
Mycobacterium ulcerans | hypothetical protein | 0.0074 | 0.1375 | 1 |
Echinococcus granulosus | geminin | 0.0178 | 0.3596 | 0.5354 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0074 | 0.1375 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.0186 | 0.0641 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.005 | 0.0852 | 0.1684 |
Onchocerca volvulus | 0.0074 | 0.1375 | 1 | |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0074 | 0.1375 | 0.1284 |
Schistosoma mansoni | ran | 0.0022 | 0.0253 | 0.0376 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0022 | 0.0253 | 0.1167 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.003 | 0.0425 | 0.2519 |
Loa Loa (eye worm) | dUTP diphosphatase | 0.0176 | 0.3555 | 0.5291 |
Wolbachia endosymbiont of Brugia malayi | deoxycytidine triphosphate deaminase | 0.0061 | 0.1087 | 0.2674 |
Echinococcus granulosus | importin subunit beta 1 | 0.003 | 0.0425 | 0.0632 |
Mycobacterium tuberculosis | Conserved protein | 0.0074 | 0.1375 | 0.1284 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0323 | 0.6718 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0246 | 0.5059 | 0.7531 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0246 | 0.5059 | 0.7531 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 0.3596 | 0.5354 |
Chlamydia trachomatis | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.0176 | 0.3555 | 1 |
Plasmodium falciparum | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.0176 | 0.3555 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0186 | 0.0641 |
Mycobacterium tuberculosis | Conserved protein | 0.0074 | 0.1375 | 0.1284 |
Schistosoma mansoni | importin beta-1 | 0.003 | 0.0425 | 0.0632 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.0105 | 0.0156 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0074 | 0.1375 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0186 | 0.0368 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.0105 | 0.0156 |
Onchocerca volvulus | 0.0074 | 0.1375 | 1 | |
Brugia malayi | Importin beta-1 subunit | 0.003 | 0.0425 | 0.0839 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0176 | 0.3555 | 1 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0022 | 0.0253 | 0.043 |
Trichomonas vaginalis | ran, putative | 0.0022 | 0.0253 | 0.0199 |
Brugia malayi | dUTP diphosphatase | 0.0176 | 0.3555 | 0.7027 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0096 | 0.1828 | 0.2721 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0176 | 0.3555 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0074 | 0.1375 | 0.1284 |
Schistosoma mansoni | ran | 0.0022 | 0.0253 | 0.0376 |
Brugia malayi | beta-lactamase family protein | 0.0074 | 0.1375 | 0.2717 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0096 | 0.1828 | 0.3613 |
Schistosoma mansoni | survival motor neuron protein | 0.005 | 0.0852 | 0.1268 |
Brugia malayi | RNA, U transporter 1 | 0.0086 | 0.1624 | 0.321 |
Onchocerca volvulus | 0.005 | 0.0852 | 0.6198 | |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0425 | 0.0632 |
Toxoplasma gondii | ABC1 family protein | 0.0074 | 0.1375 | 0.3681 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0074 | 0.1375 | 0.1284 |
Mycobacterium ulcerans | deoxycytidine triphosphate deaminase | 0.0061 | 0.1087 | 0.7577 |
Echinococcus multilocularis | snurportin 1 | 0.0323 | 0.6718 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1375 | 0.2046 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0074 | 0.1375 | 1 |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0022 | 0.0253 | 0.043 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.003 | 0.0425 | 0.2519 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0176 | 0.3555 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0186 | 0.0641 |
Entamoeba histolytica | hypothetical protein | 0.0115 | 0.2242 | 0.6104 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.0186 | 0.0236 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0074 | 0.1375 | 0.3529 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0186 | 0.0277 |
Wolbachia endosymbiont of Brugia malayi | dUTPase | 0.0176 | 0.3555 | 1 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0022 | 0.0253 | 0.0376 |
Mycobacterium ulcerans | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.0061 | 0.1087 | 0.7577 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0022 | 0.0253 | 0.043 |
Trichomonas vaginalis | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative | 0.0176 | 0.3555 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1375 | 0.2046 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0074 | 0.1375 | 0.3529 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0096 | 0.1828 | 0.2721 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0022 | 0.0253 | 0.0376 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0015 | 0.0105 | 0.0156 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0025 | 0.0302 | 0.0343 |
Mycobacterium leprae | conserved hypothetical protein | 0.0074 | 0.1375 | 1 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0022 | 0.0253 | 0.0376 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0186 | 0.0277 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1375 | 0.2046 |
Echinococcus granulosus | dUTP pyrophosphatase | 0.0176 | 0.3555 | 0.5291 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.0186 | 0.0641 |
Plasmodium vivax | importin-beta 2, putative | 0.003 | 0.0425 | 0.0928 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative | 0.0176 | 0.3555 | 1 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.003 | 0.0425 | 0.0928 |
Brugia malayi | beta-lactamase family protein | 0.0074 | 0.1375 | 0.2717 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0186 | 0.0277 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1375 | 0.2046 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0074 | 0.1375 | 0.3529 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.0186 | 0.0082 |
Entamoeba histolytica | deoxycytidine triphosphate deaminase, putative | 0.0061 | 0.1087 | 0.2674 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1375 | 0.2046 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0096 | 0.1828 | 0.2721 |
Brugia malayi | Isocitrate dehydrogenase | 0.0015 | 0.0105 | 0.0207 |
Trichomonas vaginalis | esterase, putative | 0.0074 | 0.1375 | 0.3529 |
Leishmania major | GTP-binding protein, putative | 0.0022 | 0.0253 | 0.1167 |
Entamoeba histolytica | hypothetical protein | 0.0025 | 0.0302 | 0.0343 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.5059 | 0.7531 |
Echinococcus multilocularis | importin subunit beta 1 | 0.003 | 0.0425 | 0.0632 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0015 | 0.0105 | 0.0156 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0186 | 0.0236 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0025 | 0.0302 | 0.1551 |
Entamoeba histolytica | hypothetical protein | 0.0061 | 0.1087 | 0.2674 |
Plasmodium falciparum | importin beta, putative | 0.003 | 0.0425 | 0.0928 |
Mycobacterium leprae | Probable lipase LipE | 0.0074 | 0.1375 | 1 |
Mycobacterium tuberculosis | Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase) | 0.0061 | 0.1087 | 0.0992 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase, putative | 0.0061 | 0.1087 | 0.2674 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0852 | 0.1268 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0074 | 0.1375 | 0.1284 |
Entamoeba histolytica | hypothetical protein | 0.0176 | 0.3555 | 1 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0074 | 0.1375 | 0.1284 |
Toxoplasma gondii | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative | 0.0176 | 0.3555 | 1 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0022 | 0.0253 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0074 | 0.1375 | 0.2046 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0096 | 0.1828 | 0.2721 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0186 | 0.0277 |
Mycobacterium ulcerans | lipase LipD | 0.0074 | 0.1375 | 1 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0074 | 0.1375 | 0.1284 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0022 | 0.0253 | 0.05 |
Schistosoma mansoni | hypothetical protein | 0.0323 | 0.6718 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.