Detailed information for compound 668273

Basic information

Technical information
  • TDR Targets ID: 668273
  • Name: 2-[5-(4-bromophenyl)-4-oxothieno[2,3-d]pyrimi din-3-yl]-N-phenylacetamide
  • MW: 440.313 | Formula: C20H14BrN3O2S
  • H donors: 1 H acceptors: 2 LogP: 4.12 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cn1cnc2c(c1=O)c(cs2)c1ccc(cc1)Br)Nc1ccccc1
  • InChi: 1S/C20H14BrN3O2S/c21-14-8-6-13(7-9-14)16-11-27-19-18(16)20(26)24(12-22-19)10-17(25)23-15-4-2-1-3-5-15/h1-9,11-12H,10H2,(H,23,25)
  • InChiKey: OPLOTRDTSJFVSR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[5-(4-bromophenyl)-4-oxo-thieno[2,3-d]pyrimidin-3-yl]-N-phenyl-acetamide
  • 2-[5-(4-bromophenyl)-4-oxo-3-thieno[2,3-d]pyrimidinyl]-N-phenylacetamide
  • 2-[5-(4-bromophenyl)-4-keto-thieno[2,3-d]pyrimidin-3-yl]-N-phenyl-acetamide
  • 2-[5-(4-bromophenyl)-4-oxo-thieno[2,3-d]pyrimidin-3-yl]-N-phenyl-ethanamide
  • ST5195498
  • ZINC00952360

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.012 0.027
Brugia malayi SET domain containing protein 0.0025 0.0329 0.0377
Brugia malayi M-phase phosphoprotein, mpp8 0.0023 0.0271 0.031
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0366 0.0231
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.012 0.0301
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0298 0.0749
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.013 0.013
Trypanosoma cruzi polo-like protein kinase, putative 0.0188 0.443 1
Schistosoma mansoni chromobox protein 0.0138 0.3183 0.3183
Plasmodium vivax glutathione reductase, putative 0.0048 0.091 0.229
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0366 0.0826
Plasmodium falciparum thioredoxin reductase 0.0048 0.091 0.229
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.012 0.0137
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.012 0.027
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0271 0.0436
Leishmania major dihydroorotate dehydrogenase 0.017 0.3972 0.8967
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0023 0.0271 0.019
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.2749 0.2749
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.087 0.0795
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.012 0.027
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0665 0.1502
Brugia malayi Bromodomain containing protein 0.0078 0.167 0.1911
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.012 0.027
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0665 0.1502
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0023 0.0271 0.031
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0271 0.0436
Trypanosoma cruzi ISWI complex protein 0.0015 0.0086 0.0194
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0366 0.0287
Brugia malayi chromobox protein homolog 3 0.0078 0.1653 0.1891
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0665 0.0761
Trypanosoma brucei polo-like protein kinase 0.0188 0.443 1
Treponema pallidum NADH oxidase 0.0017 0.012 0.5
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0147 1
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.091 0.1041
Echinococcus granulosus Chromobox protein 3 0.0023 0.0271 0.019
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0035 0.0593 0.1005
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.1653 0.2872
Plasmodium falciparum heterochromatin protein 1 0.0023 0.0271 0.0681
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.012 0.027
Loa Loa (eye worm) hypothetical protein 0.0078 0.1653 0.1891
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.017 0.3972 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.012 0.027
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0066 0.1369 0.3089
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.013 0.013
Schistosoma mansoni kinase 0.0096 0.2108 0.2108
Mycobacterium tuberculosis Probable dehydrogenase 0.011 0.2459 0.6071
Brugia malayi Heterochromatin protein 1 0.0138 0.3183 0.3642
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0298 0.0749
Loa Loa (eye worm) helicase 0.0023 0.0271 0.031
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0271 0.0436
Brugia malayi Associated with TFs and helicases family protein 0.0023 0.0271 0.031
Mycobacterium tuberculosis Probable oxidoreductase 0.0122 0.2766 0.687
Loa Loa (eye worm) CHromoDomain protein family member 0.0028 0.04 0.0458
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0665 0.1502
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0349 0.027
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.012 0.027
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0271 0.0436
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0035 0.0593 0.1005
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0023 0.0271 0.0271
Echinococcus multilocularis dedicator of cytokinesis protein 0.0058 0.1167 0.1094
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0038 0.0665 0.0665
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.017 0.3972 0.8967
Schistosoma mansoni terminal deoxycytidyl transferase 0.0038 0.0665 0.0665
Trypanosoma cruzi ISWI complex protein 0.0015 0.0086 0.0194
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0271 0.0681
Loa Loa (eye worm) hypothetical protein 0.0018 0.0147 0.0168
Trichomonas vaginalis CAMK family protein kinase 0.0188 0.443 0.7767
Schistosoma mansoni flap endonuclease-1 0.0024 0.0303 0.0303
Toxoplasma gondii histone lysine methyltransferase SET1 0.0111 0.2486 0.6259
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0605 0.0528
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.087 0.0996
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0071 0.148 0.2567
Loa Loa (eye worm) hypothetical protein 0.0023 0.0271 0.031
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0271 0.0681
Schistosoma mansoni cpg binding protein 0.0062 0.1254 0.1254
Trichomonas vaginalis CAMK family protein kinase 0.0188 0.443 0.7767
Echinococcus granulosus dna polymerase kappa 0.0038 0.0665 0.0588
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0349 0.0349
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0038 0.0665 0.1502
Plasmodium falciparum glutathione reductase 0.0048 0.091 0.229
Echinococcus granulosus flap endonuclease 1 0.0026 0.0366 0.0287
Echinococcus granulosus chromobox protein 2 0.0023 0.0271 0.019
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0298 0.0341
Brugia malayi hypothetical protein 0.0023 0.0271 0.031
Schistosoma mansoni hypothetical protein 0.0409 1 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0856 0.0979
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0147 0.0369
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0271 0.0436
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0366 0.0827
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0271 0.0436
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0145 0.0166
Echinococcus multilocularis chromobox protein 1 0.0138 0.3183 0.3126
Loa Loa (eye worm) hypothetical protein 0.0023 0.0271 0.031
Brugia malayi Protein cec-1. 0.0023 0.0271 0.031
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.017 0.3972 1
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0665 0.1675
Loa Loa (eye worm) hypothetical protein 0.0071 0.1481 0.1695
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.012 0.0301
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0665 0.1502
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0366 0.0605
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0271 0.0681
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.087 0.087
Loa Loa (eye worm) hypothetical protein 0.0024 0.0298 0.0341
Brugia malayi glutathione reductase 0.0048 0.091 0.1041
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0035 0.0593 0.1005
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0271 0.0271
Brugia malayi Pre-SET motif family protein 0.0031 0.0483 0.0553
Trichomonas vaginalis CAMK family protein kinase 0.0188 0.443 0.7767
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0147 0.007
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.012 0.027
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0366 0.0826
Plasmodium falciparum glutathione reductase 0.0017 0.012 0.0301
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.012 0.0301
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.091 0.2054
Loa Loa (eye worm) hypothetical protein 0.0023 0.0271 0.031
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0069 0.1443 0.1372
Brugia malayi serine/threonine-protein kinase plk-2 0.0188 0.443 0.5069
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.011 0.2459 0.5881
Giardia lamblia DINP protein human, muc B family 0.0038 0.0665 0.1502
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0298 0.0672
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0071 0.148 0.1409
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0298 0.0065
Echinococcus multilocularis cpg binding protein 0.0062 0.1254 0.1182
Trypanosoma brucei DNA polymerase eta, putative 0.0038 0.0665 0.1502
Schistosoma mansoni chromobox protein 0.0023 0.0271 0.0271
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0665 0.1502
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.1285 0.1213
Mycobacterium tuberculosis Probable reductase 0.011 0.2459 0.6071
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0298 0.0672
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.1083 0.1867
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.012 0.0301
Echinococcus multilocularis chromobox protein 1 0.0138 0.3183 0.3126
Loa Loa (eye worm) hypothetical protein 0.0041 0.0726 0.0831
Echinococcus granulosus Chromo domain 0.0023 0.0271 0.019
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0366 0.0827
Loa Loa (eye worm) hypothetical protein 0.0023 0.0271 0.031
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0122 0.0007
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0188 0.443 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0078 0.1653 0.2547
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0665 0.1502
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0211 0.0242
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.012 0.027
Trichomonas vaginalis set domain proteins, putative 0.0238 0.5696 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0038 0.0665 0.0588
Schistosoma mansoni hypothetical protein 0.0023 0.0271 0.0271
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.012 0.0301
Trichomonas vaginalis chromobox protein, putative 0.0083 0.1801 0.3133
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0665 0.0761
Trichomonas vaginalis chromobox protein, putative 0.0083 0.1801 0.3133
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.017 0.3972 0.4545
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0665 0.1502
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0188 0.443 0.5069
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.012 0.0301
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.1285 0.1213
Trypanosoma brucei unspecified product 0.0038 0.0665 0.1502
Echinococcus multilocularis Chromobox protein 3 0.0023 0.0271 0.019
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0122 0.2766 0.687
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0366 0.0827
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0271 0.0436
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.012 0.0301
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0023 0.0271 0.019
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.017 0.3972 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0298 0.0749
Plasmodium falciparum flap endonuclease 1 0.0026 0.0366 0.0923
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0271 0.0436
Leishmania major DNA polymerase kappa, putative 0.0038 0.0665 0.1502
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0071 0.148 0.2907
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0169 0.0193
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.012 0.0038
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0665 0.1502
Echinococcus multilocularis Chromo domain 0.0023 0.0271 0.019
Schistosoma mansoni chromobox protein 0.0138 0.3183 0.3183
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0122 0.0007
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0271 0.0436
Loa Loa (eye worm) hypothetical protein 0.0024 0.0298 0.0341
Entamoeba histolytica serine/threonine protein kinase, putative 0.0188 0.443 1
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.017 0.3972 0.4545
Trichomonas vaginalis CAMK family protein kinase 0.0188 0.443 0.7767
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0271 0.0271
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0028 0.04 0.032
Schistosoma mansoni hypothetical protein 0.0015 0.0086 0.0086
Schistosoma mansoni dock 0.0069 0.1443 0.1443
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0359 0.8739 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0349 0.027
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.011 0.2459 0.6071
Onchocerca volvulus 0.0061 0.1231 0.177
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0359 0.8739 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.012 0.0301
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.087 0.087
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0298 0.0749
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.042 0.0699
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0298 0.0065
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0298 0.0672
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0271 0.0436
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0023 0.0271 0.0681
Mycobacterium ulcerans hypothetical protein 0.0024 0.0298 0.0749
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0038 0.0665 0.0588
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.013 0.0048
Schistosoma mansoni bromodomain containing protein 0.0067 0.1375 0.1375
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.087 0.087
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.017 0.3972 0.8967
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0271 0.0436
Schistosoma mansoni chromobox protein 0.0023 0.0271 0.0271
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.0913 0.0838
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.017 0.3972 0.8967
Plasmodium vivax SET domain protein, putative 0.0031 0.0483 0.1217
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0359 0.8739 0.8739
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0665 0.1502
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0054 0.1053 0.1053
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0665 0.1502
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0483 0.1217
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.022 0.0252
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0366 0.0923
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0169 0.0088
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0071 0.148 0.1409
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0366 0.0827
Trichomonas vaginalis Heterochromatin protein, putative 0.0023 0.0271 0.0436
Trichomonas vaginalis chromobox protein, putative 0.0138 0.3183 0.5569
Loa Loa (eye worm) hypothetical protein 0.0023 0.0271 0.031
Echinococcus granulosus zinc finger protein 0.0023 0.0275 0.0194
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0038 0.0665 0.1131
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0665 0.1502
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0023 0.0271 0.0681
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0298 0.0462
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0082 0.0082
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.012 0.027
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.017 0.3972 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0066 0.1369 0.2371
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0038 0.0665 0.0761
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0035 0.0593 0.1005
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0023 0.0271 0.0681
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.012 0.027
Loa Loa (eye worm) hypothetical protein 0.0024 0.0298 0.0341
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0122 0.2766 0.6718
Echinococcus granulosus dna polymerase eta 0.0038 0.0665 0.0588
Loa Loa (eye worm) hypothetical protein 0.0023 0.0271 0.031
Trichomonas vaginalis DNA polymerase eta, putative 0.0038 0.0665 0.1131
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0271 0.0436
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0147 0.0369
Trypanosoma brucei ISWI complex protein 0.0015 0.0086 0.0194
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0366 0.0826
Schistosoma mansoni zinc finger protein 0.0015 0.0086 0.0086
Onchocerca volvulus 0.0057 0.1125 0.1574
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0122 0.0007
Onchocerca volvulus 0.0054 0.1053 0.1443
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.1083 0.1867
Schistosoma mansoni DNA polymerase eta 0.0038 0.0665 0.0665
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0913 0.0913
Loa Loa (eye worm) hypothetical protein 0.0038 0.0665 0.0761
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0271 0.0436
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.4972 0.569
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.012 0.027
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0298 0.0749
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0028 0.04 0.04
Trypanosoma brucei unspecified product 0.0026 0.0366 0.0826
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0038 0.0665 0.1416
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0444 0.0741
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.2046 0.3565
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0008 0.001
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.013 0.0048
Trypanosoma cruzi polo-like protein kinase, putative 0.0188 0.443 1
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.012 0.017
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0665 0.1502
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0483 0.0405
Brugia malayi PHD-finger family protein 0.0028 0.0409 0.0468
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0483 0.0483
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0035 0.0593 0.1005
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0188 0.443 0.4384
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.012 0.027
Onchocerca volvulus Serine\/threonine kinase homolog 0.0188 0.443 0.7666
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0122 0.0007
Echinococcus multilocularis dnaJ subfamily B 0.0409 1 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.1231 0.1408
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0069 0.1443 0.1372
Onchocerca volvulus 0.0023 0.0271 0.000000058028
Trichomonas vaginalis CAMK family protein kinase 0.0188 0.443 0.7767
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0665 0.1502
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0425 0.0345
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.087 0.0795
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0366 0.0419
Loa Loa (eye worm) hypothetical protein 0.0048 0.0913 0.1045
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.003 0.0444 0.0741
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0066 0.1369 0.2371
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0066 0.1369 0.2371
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.012 0.0301
Brugia malayi Bromodomain containing protein 0.0038 0.0665 0.0761
Leishmania major hypothetical protein, conserved 0.0015 0.0086 0.0194
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.091 0.0834
Brugia malayi Zinc finger, C2H2 type family protein 0.0066 0.1369 0.1566
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0035 0.0593 0.1005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0913 0.0913
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0359 0.8739 0.8729
Onchocerca volvulus 0.0238 0.5696 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0188 0.443 0.4384
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0147 0.0369
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0298 0.0341
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0071 0.148 0.1409
Loa Loa (eye worm) hypothetical protein 0.0018 0.0147 0.0168
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.011 0.2459 0.6071
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.0913 0.0838
Trichomonas vaginalis hypothetical protein 0.0023 0.0271 0.0436
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0122 0.2766 0.687
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.1125 0.1287
Loa Loa (eye worm) hypothetical protein 0.0018 0.0147 0.0168
Echinococcus granulosus chromobox protein 1 0.0138 0.3183 0.3126
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.017 0.3972 1
Trypanosoma brucei trypanothione reductase 0.0048 0.091 0.2054
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0071 0.148 0.2567
Schistosoma mansoni hypothetical protein 0.0021 0.022 0.022
Echinococcus granulosus cpg binding protein 0.0062 0.1254 0.1182
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.091 0.229
Trichomonas vaginalis CAMK family protein kinase 0.0188 0.443 0.7767
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0271 0.0436
Loa Loa (eye worm) heterochromatin protein 1 0.0138 0.3183 0.3642
Brugia malayi Valyl-tRNA synthetase 0.0023 0.0271 0.031
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.012 0.027
Loa Loa (eye worm) hypothetical protein 0.0023 0.0271 0.031
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.012 0.027
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.087 0.0795
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0035 0.0593 0.1005
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0298 0.0065
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.012 0.0038
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.012 0.012
Echinococcus multilocularis zinc finger protein 0.0023 0.0275 0.0194
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0298 0.0462
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0359 0.8739 0.8729
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.012 0.027
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0083 0.1801 0.282
Echinococcus multilocularis dna polymerase kappa 0.0038 0.0665 0.0588
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0665 0.1502
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0665 0.1502
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0366 0.0923
Echinococcus multilocularis dna polymerase eta 0.0038 0.0665 0.0588
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0271 0.0681
Schistosoma mansoni dihydroorotate dehydrogenase 0.017 0.3972 0.3972
Plasmodium vivax heterochromatin protein 1, putative 0.0023 0.0271 0.0681
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.091 0.2051
Toxoplasma gondii thioredoxin reductase 0.0048 0.091 0.229
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.017 0.3972 0.8967
Loa Loa (eye worm) hypothetical protein 0.0038 0.0667 0.0763
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0605 0.0528
Brugia malayi Pre-SET motif family protein 0.021 0.4972 0.569
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0665 0.1502
Loa Loa (eye worm) hypothetical protein 0.0018 0.0147 0.0168
Schistosoma mansoni zinc finger protein 0.0023 0.0275 0.0275
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.012 0.027
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.011 0.2459 0.6071
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.012 0.027
Echinococcus granulosus chromobox protein 1 0.0138 0.3183 0.3126
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0035 0.0593 0.1005
Mycobacterium tuberculosis Putative ferredoxin reductase 0.011 0.2459 0.6071
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0665 0.1675
Echinococcus multilocularis chromobox protein 2 0.0023 0.0271 0.019
Schistosoma mansoni cpg binding protein 0.0062 0.1254 0.1254
Giardia lamblia Kinase, PLK 0.0188 0.443 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.087 0.0996
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.1653 0.2872
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0665 0.1502
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.091 0.0834
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.0665 0.1416
Plasmodium falciparum thioredoxin reductase 0.0017 0.012 0.0301
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0298 0.0341
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.087 0.0795
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0665 0.1502
Loa Loa (eye worm) glutathione reductase 0.0048 0.091 0.1041
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.2046 0.3565
Schistosoma mansoni serine/threonine protein kinase 0.0188 0.443 0.443
Trichomonas vaginalis chromobox protein, putative 0.0138 0.3183 0.5569
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.017 0.3972 1
Leishmania major trypanothione reductase 0.0048 0.091 0.2054
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0298 0.0749
Trichomonas vaginalis CAMK family protein kinase 0.0188 0.443 0.7767
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0298 0.0749
Brugia malayi Flap endonuclease-1 0.0026 0.0366 0.0419
Loa Loa (eye worm) hypothetical protein 0.0018 0.0147 0.0168
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0008 0.001
Trypanosoma brucei unspecified product 0.0026 0.0366 0.0826
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0071 0.148 0.1409
Brugia malayi CXXC zinc finger family protein 0.0057 0.1125 0.1287
Brugia malayi Thioredoxin reductase 0.0048 0.091 0.1041
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0169 0.0088
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.012 0.017
Schistosoma mansoni cpg binding protein 0.0057 0.1125 0.1125
Leishmania major DNA polymerase eta, putative 0.0038 0.0665 0.1502
Onchocerca volvulus 0.0024 0.0298 0.005
Entamoeba histolytica deoxycytidyl transferase, putative 0.0038 0.0665 0.0949
Plasmodium falciparum dihydroorotate dehydrogenase 0.017 0.3972 1
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0066 0.1369 0.2371
Brugia malayi CHD4 protein 0.0028 0.04 0.0458
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0028 0.04 0.032

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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