Detailed information for compound 668486

Basic information

Technical information
  • TDR Targets ID: 668486
  • Name: methyl 4-(methyl-phenylcarbamoyl)oxybenzoate
  • MW: 285.295 | Formula: C16H15NO4
  • H donors: 0 H acceptors: 2 LogP: 3.1 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1ccc(cc1)OC(=O)N(c1ccccc1)C
  • InChi: 1S/C16H15NO4/c1-17(13-6-4-3-5-7-13)16(19)21-14-10-8-12(9-11-14)15(18)20-2/h3-11H,1-2H3
  • InChiKey: PQWYVZPXJUVVOO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl 4-(methyl-phenyl-carbamoyl)oxybenzoate
  • 4-[(methyl-phenylamino)-oxomethoxy]benzoic acid methyl ester
  • 4-(methyl-phenyl-carbamoyl)oxybenzoic acid methyl ester
  • ZINC00464698
  • STK140483
  • AP-124/41669660
  • methyl 4-{[(methylanilino)carbonyl]oxy}benzoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis GPCR, family 2 0.0179 0.1236 0.2519
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0171 0.0128
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0164 0.0293
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0441 0.0899
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0036
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.0385 0.0364
Brugia malayi PHD-finger family protein 0.0052 0.029 0.0285
Schistosoma mansoni hypothetical protein 0.0094 0.0604 0.1193
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0171 0.0348
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0018 0.0036 0.0031
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0171 0.0706
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0043 0.0089
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0207
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0043 0.0104
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0047 0.0053
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0068 0.0139
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0027 0.0105 0.0171
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0171 1
Loa Loa (eye worm) thyroglobulin type-1 repeat family protein 0.01 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0121 0.08 0.08
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0047 0.0097
Loa Loa (eye worm) hypothetical protein 0.0166 0.1139 0.1139
Giardia lamblia DINP protein human, muc B family 0.0019 0.0047 0.0004
Echinococcus granulosus survival motor neuron protein 1 0.0461 0.3335 0.6798
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0207
Echinococcus granulosus dna polymerase eta 0.0019 0.0047 0.0097
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0171 0.0348
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0047 0.0122
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0566 0.1115
Echinococcus multilocularis Niemann Pick C1 protein 0.0095 0.0613 0.125
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0018 0.0037 0.0031
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0047 0.0038
Echinococcus granulosus expressed conserved protein 0.009 0.057 0.1163
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0171 0.0705
Echinococcus granulosus tumor protein p63 0.0328 0.2341 0.4771
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0207
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0102 0.0102
Echinococcus granulosus neuropeptide receptor A26 0.0448 0.3232 0.6588
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0209 0.0426
Loa Loa (eye worm) hypothetical protein 0.0049 0.027 0.027
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0043 0.0089
Schistosoma mansoni inositol monophosphatase 0.0036 0.0171 0.0305
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0566 0.4111 0.4111
Echinococcus multilocularis cpg binding protein 0.0037 0.0181 0.037
Echinococcus granulosus cpg binding protein 0.0037 0.0181 0.037
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0047 0.0122
Onchocerca volvulus 0.0027 0.0102 0.0258
Trypanosoma brucei ISWI complex protein 0.0031 0.0133 0.061
Echinococcus multilocularis protein dispatched 1 0.0047 0.0252 0.0513
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0143 0.1145
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0179 0.1236 0.1236
Loa Loa (eye worm) inositol-1 0.0036 0.0171 0.0171
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0047 0.0097
Onchocerca volvulus Huntingtin homolog 0.0121 0.08 0.3005
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.001 0.001
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0159 0.0282
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0047 0.0244
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0047 0.0207
Leishmania major hypothetical protein, conserved 0.0049 0.027 0.0248
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0043 0.0104
Leishmania major DNA polymerase kappa, putative 0.0019 0.0047 0.0026
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0171 0.0306
Brugia malayi secreted modular calcium-binding protein 1 0.01 0.0646 0.0642
Echinococcus granulosus tar DNA binding protein 0.0592 0.4307 0.878
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0171 0.0128
Loa Loa (eye worm) hypothetical protein 0.0172 0.1181 0.1181
Loa Loa (eye worm) bromodomain containing protein 0.0035 0.0169 0.0169
Echinococcus multilocularis musashi 0.0027 0.0102 0.0208
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.027 0.0248
Loa Loa (eye worm) latrophilin receptor protein 2 0.0179 0.1236 0.1236
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0043 0.5
Loa Loa (eye worm) hypothetical protein 0.01 0.0646 0.0646
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0219 0.0932
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0102 0.0097
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0645 0.4702 0.4702
Schistosoma mansoni intermediate filament proteins 0.0027 0.0102 0.0165
Echinococcus granulosus neuropeptide s receptor 0.0448 0.3232 0.6588
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0022 0.0022
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0566 0.1154
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0346 0.2915
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0179 0.1236 0.2519
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0027 0.0105 0.0084
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0171 0.0306
Echinococcus multilocularis regulator of G protein signaling 7 0.0018 0.0036 0.0074
Schistosoma mansoni DNA polymerase eta 0.0019 0.0047 0.0053
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0047 0.0122
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0171 0.0128
Brugia malayi latrophilin 2 splice variant baaae 0.0387 0.278 0.2777
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.027 0.1173
Entamoeba histolytica hypothetical protein 0.0036 0.0171 0.0128
Echinococcus multilocularis geminin 0.0673 0.4906 1
Loa Loa (eye worm) macrophage migration inhibitory factor 0.1358 1 1
Schistosoma mansoni tar DNA-binding protein 0.0592 0.4307 0.8775
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0027 0.0105 0.0171
Schistosoma mansoni hypothetical protein 0.0039 0.0198 0.0361
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0346 0.0325
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0027 0.0105 0.0062
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0047 0.0097
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0209 0.0209
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0207
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0171 0.0348
Leishmania major DNA polymerase eta, putative 0.0019 0.0047 0.0026
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.027 0.0248
Brugia malayi hypothetical protein 0.0049 0.027 0.0265
Schistosoma mansoni ap endonuclease 0.0019 0.0043 0.0045
Plasmodium falciparum macrophage migration inhibitory factor 0.1358 1 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0771 0.0771
Brugia malayi N-terminal motif family protein 0.036 0.2579 0.2575
Leishmania major macrophage migration inhibitory factor-like protein 0.1358 1 1
Brugia malayi intermediate filament protein 0.0027 0.0102 0.0097
Toxoplasma gondii t-complex protein beta subunit 0.0027 0.0105 0.0084
Brugia malayi DIX domain containing protein 0.0018 0.0036 0.0031
Schistosoma mansoni hypothetical protein 0.0036 0.0171 0.0305
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0164 0.0335
Echinococcus granulosus segment polarity protein dishevelled 0.0018 0.0036 0.0074
Loa Loa (eye worm) DIX domain-containing protein 0.0018 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0179 0.1236 0.2486
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0171 0.0149
Schistosoma mansoni hypothetical protein 0.0387 0.278 0.5648
Brugia malayi Bromodomain containing protein 0.0152 0.1038 0.1033
Loa Loa (eye worm) hypothetical protein 0.01 0.0646 0.0646
Schistosoma mansoni hypothetical protein 0.0041 0.0213 0.0392
Brugia malayi Latrophilin receptor protein 2 0.0179 0.1236 0.1231
Leishmania major mitochondrial DNA polymerase beta 0.03 0.2136 0.2119
Trichomonas vaginalis chaperonin, putative 0.0027 0.0105 0.0062
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.0961 0.0941
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0089 0.0566 0.0566
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0047 0.0042
Onchocerca volvulus Huntingtin homolog 0.0121 0.08 0.3005
Loa Loa (eye worm) T-complex protein 1 0.0027 0.0105 0.0105
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0139 0.0139
Brugia malayi Niemann-Pick C1 protein precursor 0.0095 0.0613 0.0609
Brugia malayi Inositol-1 0.0036 0.0171 0.0166
Onchocerca volvulus 0.01 0.0646 0.2398
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0047 0.0244
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0346 0.0704
Onchocerca volvulus 0.01 0.0646 0.2398
Echinococcus multilocularis regulator of G protein signaling 7 0.0018 0.0036 0.0074
Entamoeba histolytica hypothetical protein 0.0036 0.0171 0.0128
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0566 0.1154
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0142 0.0961 0.449
Schistosoma mansoni ap endonuclease 0.0019 0.0043 0.0045
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0043 0.0207
Loa Loa (eye worm) TAR-binding protein 0.0592 0.4307 0.4307
Echinococcus granulosus regulator of G protein signaling 7 0.0018 0.0036 0.0074
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0171 0.0348
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0171 0.0128
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0346 0.0663
Schistosoma mansoni hypothetical protein 0.0039 0.0198 0.0361
Brugia malayi regulator of G-protein signaling egl-10 0.0018 0.0036 0.0031
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0179 0.1236 0.2519
Loa Loa (eye worm) hypothetical protein 0.036 0.2579 0.2579
Loa Loa (eye worm) hypothetical protein 0.0121 0.08 0.08
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0171 0.0128
Giardia lamblia Macrophage migration inhibitory factor 0.1358 1 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0179 0.1236 0.1231
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0171 0.0348
Echinococcus granulosus Pleckstrin G protein interacting region 0.0018 0.0036 0.0074
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0022 0.0044
Echinococcus granulosus segment polarity protein dishevelled 0.0018 0.0036 0.0074
Schistosoma mansoni hypothetical protein 0.0022 0.0068 0.0096
Loa Loa (eye worm) hypothetical protein 0.0026 0.0098 0.0098
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0207
Trichomonas vaginalis conserved hypothetical protein 0.0167 0.1146 0.1107
Echinococcus multilocularis neuropeptide s receptor 0.0448 0.3232 0.6588
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0402 0.078
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0171 0.1227
Echinococcus granulosus geminin 0.0673 0.4906 1
Onchocerca volvulus 0.01 0.0646 0.2398
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0089 0.0566 0.0561
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0027 0.0105 0.0062
Schistosoma mansoni tar DNA-binding protein 0.0592 0.4307 0.8775
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0043 0.0022
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0171 0.0128
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.001 0.0005
Schistosoma mansoni inositol monophosphatase 0.0036 0.0171 0.0305
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0047 0.0207
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.027 0.1173
Echinococcus granulosus lamin dm0 0.0027 0.0102 0.0208
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0143 0.5
Echinococcus multilocularis tar DNA binding protein 0.0592 0.4307 0.878
Brugia malayi isocitrate dehydrogenase 0.0016 0.0022 0.0017
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0171 0.0705
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0047 0.0004
Echinococcus multilocularis segment polarity protein dishevelled 0.0018 0.0036 0.0074
Toxoplasma gondii exonuclease III APE 0.0019 0.0043 0.0022
Brugia malayi hypothetical protein 0.0166 0.1139 0.1134
Brugia malayi hypothetical protein 0.0018 0.0036 0.0031
Echinococcus multilocularis segment polarity protein dishevelled 0.0018 0.0036 0.0074
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0179 0.1236 0.2519
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0102 0.0102
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0441 0.0899
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0047 0.0038
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0219 0.0932
Schistosoma mansoni cpg binding protein 0.0032 0.0139 0.0241
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0095 0.0613 0.0572
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0209 0.0426
Loa Loa (eye worm) hypothetical protein 0.0461 0.3335 0.3335
Onchocerca volvulus 0.0094 0.0604 0.2234
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0209 0.0426
Brugia malayi hypothetical protein 0.0018 0.0036 0.0031
Brugia malayi RNA recognition motif domain containing protein 0.0592 0.4307 0.4304
Trypanosoma cruzi ISWI complex protein 0.0031 0.0133 0.0528
Schistosoma mansoni patched 1 0.0041 0.0209 0.0384
Echinococcus granulosus lamin 0.0027 0.0102 0.0208
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0171 0.015
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0047 0.0122
Loa Loa (eye worm) hypothetical protein 0.0035 0.0164 0.0164
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0047 0.0207
Schistosoma mansoni tar DNA-binding protein 0.0592 0.4307 0.8775
Schistosoma mansoni dep domain containing protein 0.0018 0.0036 0.0031
Trichomonas vaginalis macrophage migration inhibitory factor, mif, putative 0.1358 1 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0171 0.0348
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0094 0.0604 0.06
Brugia malayi hypothetical protein 0.0032 0.014 0.0135
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0207
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0164 0.0335
Echinococcus granulosus methyl CpG binding domain protein 2 0.0034 0.0159 0.0325
Plasmodium falciparum T-complex protein 1 subunit beta 0.0027 0.0105 0.0084
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0346 0.0663
Loa Loa (eye worm) hypothetical protein 0.0077 0.0477 0.0477
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0027 0.0105 0.0395
Loa Loa (eye worm) hypothetical protein 0.0041 0.0209 0.0209
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0207
Brugia malayi Thyroglobulin type-1 repeat family protein 0.01 0.0646 0.0642
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0027 0.0102 0.0102
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0171 0.0348
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0171 0.0348
Schistosoma mansoni tar DNA-binding protein 0.0592 0.4307 0.8775
Schistosoma mansoni cpg binding protein 0.0037 0.0181 0.0327
Schistosoma mansoni lamin 0.0027 0.0102 0.0165
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0022 0.0086
Loa Loa (eye worm) hypothetical protein 0.0566 0.4111 0.4111
Brugia malayi Bromodomain containing protein 0.0077 0.0476 0.0472
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0624 0.1234
Echinococcus multilocularis expressed conserved protein 0.009 0.057 0.1163
Schistosoma mansoni hypothetical protein 0.0031 0.0133 0.0229
Loa Loa (eye worm) hypothetical protein 0.005 0.0277 0.0277
Onchocerca volvulus 0.0048 0.0261 0.0885
Schistosoma mansoni lamin 0.0027 0.0102 0.0165
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0207
Brugia malayi MH2 domain containing protein 0.0116 0.0771 0.0766
Echinococcus granulosus Niemann Pick C1 protein 0.0095 0.0613 0.125
Loa Loa (eye worm) thyroglobulin type-1 repeat family protein 0.01 0.0646 0.0646
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0171 0.0128
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.2136 1
Schistosoma mansoni cpg binding protein 0.0037 0.0181 0.0327
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0346 0.2915
Plasmodium vivax macrophage migration inhibitory factor, putative 0.1358 1 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0171 0.0785
Onchocerca volvulus 0.0166 0.1139 0.4336
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0207
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0022 0.0044
Schistosoma mansoni hypothetical protein 0.0039 0.0198 0.0361
Schistosoma mansoni hypothetical protein 0.0673 0.4906 1
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0047 0.0207
Schistosoma mansoni hypothetical protein 0.0673 0.4906 1
Loa Loa (eye worm) RNA binding protein 0.0592 0.4307 0.4307
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0171 0.0348
Mycobacterium tuberculosis Conserved hypothetical protein 0.0158 0.108 1
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0261 0.0491
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0022 0.0086
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.027 0.0248
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0171 0.0305
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0592 0.4307 0.4307
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0209 0.0166
Entamoeba histolytica macrophage migration inhibitory factor-like protein 0.1358 1 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.0513 0.0513
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0043 0.0189
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0219 0.0932
Schistosoma mansoni dishevelled 0.0018 0.0036 0.0031
Brugia malayi CHE-14 protein 0.0041 0.0209 0.0204
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0172 0.1181 0.1177
Loa Loa (eye worm) hypothetical protein 0.01 0.0646 0.0646
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0022 0.0044
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0022 0.0017
Echinococcus granulosus zinc finger protein 0.0041 0.021 0.0429
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0047 0.0255 0.0519
Echinococcus multilocularis zinc finger protein 0.0041 0.021 0.0429
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0027 0.0105 0.0478
Schistosoma mansoni hypothetical protein 0.0039 0.0198 0.0361
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0566 0.1115
Loa Loa (eye worm) hypothetical protein 0.0087 0.0555 0.0555
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0068 0.0139
Brugia malayi RNA binding protein 0.0592 0.4307 0.4304
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0047 0.0004
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.0917 0.187
Schistosoma mansoni hypothetical protein 0.0179 0.1236 0.2486
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.0917 0.187
Onchocerca volvulus 0.0027 0.0102 0.0258
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0566 0.1115
Leishmania major T-complex protein 1, beta subunit, putative 0.0027 0.0105 0.0084
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0047 0.0053
Brugia malayi T-complex protein 1, beta subunit 0.0027 0.0105 0.01
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0043 0.0038
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.0961 0.4442
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0171 0.0706
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0171 0.0166
Loa Loa (eye worm) hypothetical protein 0.0095 0.0613 0.0613
Brugia malayi Calcitonin receptor-like protein seb-1 0.0566 0.4111 0.4108
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0566 0.1154
Echinococcus multilocularis survival motor neuron protein 1 0.0461 0.3335 0.6798
Trypanosoma cruzi ISWI complex protein 0.0031 0.0133 0.0528
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.2136 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0207
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0027 0.0105 0.0171
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0566 0.4111 0.4108
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0566 0.1154
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0022 0.0044
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0043 0.0022
Echinococcus granulosus regulator of G protein signaling 7 0.0018 0.0036 0.0074
Brugia malayi hypothetical protein 0.0121 0.08 0.0796
Echinococcus multilocularis dna polymerase eta 0.0019 0.0047 0.0097
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0036
Brugia malayi hypothetical protein 0.0036 0.0171 0.0166
Leishmania major macrophage migration inhibitory factor-like protein 0.1358 1 1
Entamoeba histolytica hypothetical protein 0.0036 0.0171 0.0128
Schistosoma mansoni hypothetical protein 0.0179 0.1236 0.2486
Loa Loa (eye worm) hypothetical protein 0.0387 0.278 0.278
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0018 0.0036 0.0031
Brugia malayi T-complex protein 1, beta subunit 0.0027 0.0105 0.01
Onchocerca volvulus 0.01 0.0646 0.2398
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0122 0.0809 0.165
Leishmania major hypothetical protein, conserved 0.0031 0.0133 0.0112
Brugia malayi CXXC zinc finger family protein 0.0032 0.0139 0.0134
Loa Loa (eye worm) hypothetical protein 0.0036 0.0171 0.0171
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0122 0.0809 0.165
Brugia malayi Thyroglobulin type-1 repeat family protein 0.01 0.0646 0.0642
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0047 0.0026
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.027 0.1249
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0171 0.0149
Brugia malayi hypothetical protein 0.0461 0.3335 0.3331
Brugia malayi Thyroglobulin type-1 repeat family protein 0.01 0.0646 0.0642
Echinococcus multilocularis lamin 0.0027 0.0102 0.0208
Schistosoma mansoni regulator of G protein signaling 0.0018 0.0036 0.0031
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0034 0.0159 0.0325
Echinococcus multilocularis neuropeptide receptor A26 0.0448 0.3232 0.6588
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0346 0.2915
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0219 0.101
Echinococcus granulosus GPCR family 2 0.0179 0.1236 0.2519
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0047 0.0122
Onchocerca volvulus 0.0032 0.0139 0.0405
Giardia lamblia TCP-1 chaperonin subunit beta 0.0027 0.0105 0.0062
Toxoplasma gondii hypothetical protein 0.0018 0.0036 0.0015
Toxoplasma gondii hypothetical protein 0.0048 0.0265 0.0244
Loa Loa (eye worm) hypothetical protein 0.0142 0.096 0.096
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0036
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0346 0.0325
Echinococcus multilocularis protein patched 0.0041 0.0209 0.0426
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0027 0.0105 0.0214
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0771 0.0771
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0047 0.0255 0.0477
Entamoeba histolytica hypothetical protein 0.0036 0.0171 0.0128
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0022 0.0044
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0346 0.3061
Loa Loa (eye worm) hypothetical protein 0.01 0.0646 0.0646
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0645 0.4702 0.4702
Loa Loa (eye worm) PHD-finger family protein 0.0041 0.0213 0.0213
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0018 0.0036 0.0074
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0164 0.0293
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0346 0.0704
Schistosoma mansoni dishevelled 0.0018 0.0036 0.0031
Echinococcus multilocularis lamin dm0 0.0027 0.0102 0.0208
Loa Loa (eye worm) hypothetical protein 0.0048 0.0261 0.0261
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0287 0.1256
Echinococcus multilocularis tumor protein p63 0.0328 0.2341 0.4771
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0171 0.0128
Trypanosoma brucei unspecified product 0.0019 0.0047 0.0207
Schistosoma mansoni z-protein (S1r protein) 0.0018 0.0036 0.0031
Toxoplasma gondii macrophage migration inhibitory factor, putative 0.1358 1 1
Schistosoma mansoni tar DNA-binding protein 0.0592 0.4307 0.8775
Schistosoma mansoni hypothetical protein 0.0179 0.1236 0.2486
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0027 0.0105 0.0214
Trichomonas vaginalis conserved hypothetical protein 0.1358 1 1
Mycobacterium ulcerans hypothetical protein 0.0158 0.108 1
Schistosoma mansoni zinc finger protein 0.0041 0.021 0.0387
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0171 0.0128
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0179 0.1236 0.2519
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0018 0.0036 0.0036
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.027 0.0248
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0022 0.0044
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0159 0.0282
Echinococcus granulosus dna polymerase kappa 0.0019 0.0047 0.0097
Schistosoma mansoni bromodomain containing protein 0.0129 0.0863 0.1722
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0171 0.0348
Schistosoma mansoni survival motor neuron protein 0.0094 0.0604 0.1193
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.036 0.2579 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0047 0.0004
Schistosoma mansoni zinc finger protein 0.0031 0.0133 0.0229
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0047 0.0042
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0171 0.0787
Trypanosoma brucei mitochondrial DNA polymerase beta 0.03 0.2136 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Brugia malayi TAR-binding protein 0.0592 0.4307 0.4304
Echinococcus granulosus intermediate filament protein 0.0027 0.0102 0.0208
Echinococcus granulosus fetal alzheimer antigen falz 0.0047 0.0255 0.0519
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0043 0.0022

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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