Detailed information for compound 66858

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 391.243 | Formula: C17H20Cl2O6
  • H donors: 1 H acceptors: 2 LogP: 2.76 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCOCOc1cc(Cl)cc(c1/C=C\[C@@H]1C[C@@H](O)CC(=O)O1)Cl
  • InChi: 1S/C17H20Cl2O6/c1-22-4-5-23-10-24-16-7-11(18)6-15(19)14(16)3-2-13-8-12(20)9-17(21)25-13/h2-3,6-7,12-13,20H,4-5,8-10H2,1H3/b3-2+/t12-,13?/m1/s1
  • InChiKey: FNRPSMYZZQFSQR-OOMRMTIXSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni two-pore calcium channel 0.0083 0.0523 0.1062
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0078 0.0326 0.6238
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0083 0.0523 0.0523
Echinococcus multilocularis potassium large conductance calcium activated 0.0083 0.0523 0.0769
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0083 0.0523 0.1062
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0083 0.0523 0.0523
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0083 0.0523 0.0523
Brugia malayi Transient-receptor-potential like protein 0.0083 0.0523 0.0523
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0083 0.0523 0.1062
Loa Loa (eye worm) hypothetical protein 0.0086 0.0631 0.0631
Echinococcus granulosus integrin alpha 3 0.0134 0.2279 0.335
Echinococcus granulosus voltage dependent calcium channel 0.0083 0.0523 0.0769
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0083 0.0523 0.0769
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0083 0.0523 0.0769
Loa Loa (eye worm) integrin beta-2 0.0359 1 1
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0083 0.0523 0.0769
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0078 0.0326 0.6238
Echinococcus multilocularis integrin alpha 3 0.0134 0.2279 0.335
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0523 0.1062
Loa Loa (eye worm) phenylalanyl-tRNA synthetase 0.0071 0.0116 0.0116
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0083 0.0523 0.0769
Echinococcus granulosus potassium voltage gated channel protein 0.0083 0.0523 0.0769
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0083 0.0523 0.1062
Loa Loa (eye worm) hypothetical protein 0.0083 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0083 0.0523 0.0523
Echinococcus multilocularis hyperpolarization activated cyclic 0.0083 0.0523 0.0769
Schistosoma mansoni calcium-activated potassium channel 0.0083 0.0523 0.1062
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0523 0.1062
Schistosoma mansoni phenylalanyl-tRNA synthetase mitochondrial 0.0071 0.0116 0.0235
Loa Loa (eye worm) hypothetical protein 0.0083 0.0523 0.0523
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0083 0.0523 0.0769
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0083 0.0523 1
Loa Loa (eye worm) voltage-dependent calcium channel 0.0083 0.0523 0.0523
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0083 0.0523 0.0769
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0083 0.0523 0.1062
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0083 0.0523 1
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0083 0.0523 0.0523
Echinococcus granulosus integrin alpha ps 0.0079 0.0361 0.0531
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0083 0.0523 0.0769
Echinococcus multilocularis short transient receptor potential channel 6 0.0086 0.0631 0.0928
Brugia malayi cation channel family protein 0.0083 0.0523 0.0523
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0083 0.0523 0.1062
Echinococcus granulosus phenylalanyl tRNA synthetase 0.0071 0.0116 0.017
Schistosoma mansoni voltage-gated ion channel 0.0083 0.0523 0.1062
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0523 0.1062
Loa Loa (eye worm) hypothetical protein 0.0083 0.0523 0.0523
Echinococcus granulosus calcium activated potassium channel 0.0083 0.0523 0.0769
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0083 0.0523 1
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0083 0.0523 0.0769
Loa Loa (eye worm) hypothetical protein 0.0083 0.0523 0.0523
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0083 0.0523 0.0769
Echinococcus granulosus ryanodine receptor 44f 0.0083 0.0523 0.0769
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0523 0.1062
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0083 0.0523 0.0523
Echinococcus multilocularis sodium channel protein 0.0083 0.0523 0.0769
Loa Loa (eye worm) hypothetical protein 0.0083 0.0523 0.0523
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0083 0.0523 0.0769
Echinococcus multilocularis transient receptor potential cation channel 0.0083 0.0523 0.0769
Echinococcus multilocularis sodium leak channel non selective protein 0.0083 0.0523 0.0769
Echinococcus granulosus short transient receptor potential channel 6 0.0083 0.0523 0.0769
Echinococcus multilocularis transient receptor potential cation channel 0.0086 0.0631 0.0928
Schistosoma mansoni ryanodine receptor related 0.0083 0.0523 0.1062
Echinococcus multilocularis calcium activated potassium channel 0.0083 0.0523 0.0769
Schistosoma mansoni transient receptor potential channel 0.0083 0.0523 0.1062
Schistosoma mansoni vesicular amine transporter 0.0083 0.0523 0.1062
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0083 0.0523 0.0523
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0165 0.3343 0.4915
Loa Loa (eye worm) hypothetical protein 0.0083 0.0523 0.0523
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0083 0.0523 0.0769
Echinococcus multilocularis voltage gated potassium channel 0.0083 0.0523 0.0769
Loa Loa (eye worm) hypothetical protein 0.0083 0.0523 0.0523
Schistosoma mansoni integrin beta subunit 0.0211 0.4927 1
Loa Loa (eye worm) hypothetical protein 0.0138 0.239 0.239
Loa Loa (eye worm) hypothetical protein 0.0083 0.0523 0.0523
Echinococcus multilocularis integrin alpha ps 0.0079 0.0361 0.0531
Echinococcus granulosus transient receptor potential cation channel 0.0083 0.0523 0.0769
Loa Loa (eye worm) hypothetical protein 0.0083 0.0523 0.0523
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0083 0.0523 0.1062
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0083 0.0523 0.0769
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0083 0.0523 0.1062
Echinococcus granulosus transient receptor potential gamma protein 0.0083 0.0523 0.0769
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0083 0.0523 0.0769
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0083 0.0523 0.0769
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0083 0.0523 0.0523
Echinococcus multilocularis phenylalanyl tRNA synthetase 0.0071 0.0116 0.017
Loa Loa (eye worm) hypothetical protein 0.0083 0.0523 0.0523
Toxoplasma gondii hypothetical protein 0.0083 0.0523 1
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0083 0.0523 0.0523
Echinococcus granulosus integrin beta 2 0.0266 0.6802 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0083 0.0523 0.1062
Toxoplasma gondii transporter, cation channel family protein 0.0083 0.0523 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0523 0.0523
Echinococcus granulosus hyperpolarization activated cyclic 0.0083 0.0523 0.0769
Loa Loa (eye worm) hypothetical protein 0.0083 0.0523 0.0523
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0083 0.0523 0.0523
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0083 0.0523 0.0523
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0083 0.0523 0.0523
Brugia malayi ion channel NompC 0.0083 0.0523 0.0523
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0165 0.3343 1
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0165 0.3343 1
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0523 0.1062
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0083 0.0523 0.0769
Echinococcus granulosus voltage dependent calcium channel 0.0083 0.0523 0.0769
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0083 0.0523 0.1062
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0523 0.1062
Echinococcus multilocularis potassium voltage gated channel protein 0.0083 0.0523 0.0769
Schistosoma mansoni integrin alpha 0.0175 0.3685 0.748
Echinococcus granulosus transient receptor potential cation channel 0.0083 0.0523 0.0769
Echinococcus granulosus transient receptor potential cation channel 0.0083 0.0523 0.0769
Echinococcus granulosus hypothetical protein 0.0083 0.0523 0.0769
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0083 0.0523 0.0769
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0083 0.0523 0.1062
Loa Loa (eye worm) hypothetical protein 0.0097 0.0984 0.0984
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0523 0.1062
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0083 0.0523 0.0523
Echinococcus granulosus two pore calcium channel protein 1 0.0083 0.0523 0.0769
Echinococcus granulosus transient receptor potential cation channel 0.0086 0.0631 0.0928
Echinococcus multilocularis potassium voltage gated channel protein 0.0083 0.0523 0.0769
Echinococcus granulosus potassium voltage gated channel protein 0.0083 0.0523 0.0769
Echinococcus multilocularis voltage gated potassium channel 0.0083 0.0523 0.0769
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0083 0.0523 0.0523
Echinococcus multilocularis integrin alpha ps 0.0079 0.0361 0.0531
Loa Loa (eye worm) hypothetical protein 0.0165 0.3343 0.3343
Echinococcus multilocularis transient receptor potential cation channel 0.0086 0.0631 0.0928
Echinococcus granulosus potassium large conductance calcium activated 0.0083 0.0523 0.0769
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0083 0.0523 0.0523
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0083 0.0523 0.1062
Echinococcus granulosus transient receptor potential cation channel 0.0083 0.0523 0.0769
Loa Loa (eye worm) hypothetical protein 0.0083 0.0523 0.0523
Echinococcus multilocularis transient receptor potential gamma protein 0.0083 0.0523 0.0769
Loa Loa (eye worm) voltage-gated potassium channel 0.0083 0.0523 0.0523
Echinococcus multilocularis potassium voltage gated channel protein 0.0083 0.0523 0.0769
Brugia malayi hypothetical protein 0.0083 0.0523 0.0523
Echinococcus multilocularis hyperpolarization activated cyclic 0.0083 0.0523 0.0769
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0083 0.0523 0.0523
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0083 0.0523 0.0769
Toxoplasma gondii hypothetical protein 0.0083 0.0523 1
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0083 0.0523 0.0769
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0083 0.0523 1
Echinococcus multilocularis potassium voltage gated channel protein 0.0083 0.0523 0.0769
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0083 0.0523 0.0769
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0523 0.1062
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0083 0.0523 0.1062
Schistosoma mansoni hypothetical protein 0.0083 0.0523 0.1062
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0083 0.0523 0.1062
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0083 0.0523 0.0769
Echinococcus multilocularis short transient receptor potential channel 6 0.0083 0.0523 0.0769
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0523 0.1062
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0083 0.0523 0.0769
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0083 0.0523 0.0769
Echinococcus granulosus TRP transient receptor potential channel 0.0083 0.0523 0.0769
Echinococcus granulosus sodium leak channel non selective protein 0.0083 0.0523 0.0769
Toxoplasma gondii transporter, cation channel family protein 0.0083 0.0523 1
Echinococcus granulosus voltage gated hydrogen channel 1 0.0083 0.0523 0.0769
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0523 0.1062
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0083 0.0523 0.0769
Loa Loa (eye worm) hypothetical protein 0.0083 0.0523 0.0523
Brugia malayi phenylalanyl-tRNA synthetase, mitochondrial precursor, putative 0.0071 0.0116 0.0116
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0083 0.0523 0.5
Echinococcus multilocularis conserved hypothetical protein 0.0083 0.0523 0.0769
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0523 0.1062
Loa Loa (eye worm) voltage-gated calcium channel 0.0083 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0083 0.0523 0.0523
Echinococcus multilocularis integrin beta 2 0.0266 0.6802 1
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0523 0.1062
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0165 0.3343 0.5
Onchocerca volvulus 0.0083 0.0523 0.5
Schistosoma mansoni integrin alpha-ps 0.0079 0.0361 0.0734
Echinococcus multilocularis transient receptor potential cation channel 0.0083 0.0523 0.0769
Echinococcus multilocularis transfer RNA-Gly 0.0083 0.0523 0.0769
Echinococcus multilocularis two pore calcium channel protein 1 0.0083 0.0523 0.0769
Loa Loa (eye worm) hypothetical protein 0.0083 0.0523 0.0523
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0083 0.0523 0.1062
Loa Loa (eye worm) hypothetical protein 0.0083 0.0523 0.0523
Plasmodium falciparum phenylalanine--tRNA ligase 0.0071 0.0116 0.5
Echinococcus multilocularis transient receptor potential cation channel 0.0083 0.0523 0.0769
Echinococcus granulosus potassium voltage gated channel protein 0.0083 0.0523 0.0769
Toxoplasma gondii transporter, cation channel family protein 0.0083 0.0523 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0523 0.0523
Brugia malayi Cyclic-nucleotide gated cation channel 0.0083 0.0523 0.0523
Echinococcus granulosus shaker cognate 0.0083 0.0523 0.0769
Schistosoma mansoni 60S ribosomal protein L21 0.0083 0.0523 0.1062
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0165 0.3343 0.3343
Echinococcus multilocularis voltage dependent calcium channel 0.0083 0.0523 0.0769
Brugia malayi olfactory channel protein osm-9 0.0086 0.0631 0.0631
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0083 0.0523 0.1062
Schistosoma mansoni voltage-gated cation channel 0.0083 0.0523 0.1062
Echinococcus multilocularis voltage dependent calcium channel 0.0083 0.0523 0.0769
Echinococcus granulosus potassium voltage gated channel protein 0.0083 0.0523 0.0769
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0083 0.0523 0.0769
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0083 0.0523 0.0769
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0523 0.1062
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0523 0.1062
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0523 0.1062
Echinococcus multilocularis shaker cognate 0.0083 0.0523 0.0769
Loa Loa (eye worm) hypothetical protein 0.0083 0.0523 0.0523
Echinococcus granulosus hyperpolarization activated cyclic 0.0083 0.0523 0.0769
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0083 0.0523 0.0769
Brugia malayi cation channel family protein 0.0083 0.0523 0.0523
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0083 0.0523 0.0769
Schistosoma mansoni transient receptor potential channel 0.0086 0.0631 0.1282
Echinococcus granulosus short transient receptor potential channel 6 0.0086 0.0631 0.0928
Echinococcus granulosus voltage gated potassium channel 0.0083 0.0523 0.0769
Loa Loa (eye worm) ryanodine receptor 0.0083 0.0523 0.0523
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0083 0.0523 0.0769
Loa Loa (eye worm) voltage-gated potassium channel 0.0083 0.0523 0.0523
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0083 0.0523 0.1062
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0165 0.3343 0.6785
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0083 0.0523 0.5
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0083 0.0523 0.0769
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0083 0.0523 0.0769
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0133 0.2218 0.2218
Plasmodium vivax phenylalanine--tRNA ligase, putative 0.0071 0.0116 0.5
Loa Loa (eye worm) ion channel NompC 0.0083 0.0523 0.0523
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0083 0.0523 0.1062
Echinococcus granulosus two pore calcium channel protein 2 0.0083 0.0523 0.0769
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0165 0.3343 1
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0523 0.1062
Loa Loa (eye worm) integrin alpha pat-2 0.027 0.6947 0.6947
Echinococcus granulosus voltage gated potassium channel 0.0083 0.0523 0.0769
Schistosoma mansoni transient receptor potential channel 4 0.0083 0.0523 0.1062
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0083 0.0523 0.0769
Schistosoma mansoni transient receptor potential channel 0.0083 0.0523 0.1062
Loa Loa (eye worm) hypothetical protein 0.0083 0.0523 0.0523
Echinococcus granulosus potassium voltage gated channel protein 0.0083 0.0523 0.0769
Echinococcus multilocularis two pore calcium channel protein 2 0.0083 0.0523 0.0769
Brugia malayi voltage-dependent calcium channel 0.0083 0.0523 0.0523
Echinococcus granulosus sodium channel protein 0.0083 0.0523 0.0769
Brugia malayi Integrin alpha pat-2 precursor 0.0175 0.3685 0.3685
Loa Loa (eye worm) hypothetical protein 0.0133 0.2218 0.2218
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0078 0.0326 0.5
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0165 0.3343 0.4915
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0083 0.0523 0.0523
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0083 0.0523 0.0769
Echinococcus multilocularis ryanodine receptor 44f 0.0083 0.0523 0.0769
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0083 0.0523 0.0769
Loa Loa (eye worm) calcium channel 0.0083 0.0523 0.0523
Schistosoma mansoni voltage-dependent calcium channel 0.0083 0.0523 0.1062
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0083 0.0523 0.0523
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0078 0.0326 0.6238
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0083 0.0523 0.0769
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0523 0.1062
Echinococcus granulosus transient receptor potential cation channel 0.0083 0.0523 0.0769
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0165 0.3343 1
Echinococcus multilocularis transient receptor potential cation channel 0.0083 0.0523 0.0769
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0083 0.0523 0.0523
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0523 0.1062

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 11 uM Inhibition of solubilized, partially purified rat liver HMG-CoA reductase ChEMBL. 3950901
Relative potency (binding) = 0.4 Relative potency to inhibit solubilized, partially purified rat liver HMG-CoA reductase compared with that of compactin. ChEMBL. 3950901

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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