Detailed information for compound 668928

Basic information

Technical information
  • TDR Targets ID: 668928
  • Name: (E)-3-(1,3-benzodioxol-5-yl)-N-[5-(methoxymet hyl)-1,3,4-thiadiazol-2-yl]prop-2-enamide
  • MW: 319.336 | Formula: C14H13N3O4S
  • H donors: 1 H acceptors: 3 LogP: 1.46 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCc1nnc(s1)NC(=O)C=Cc1ccc2c(c1)OCO2
  • InChi: 1S/C14H13N3O4S/c1-19-7-13-16-17-14(22-13)15-12(18)5-3-9-2-4-10-11(6-9)21-8-20-10/h2-6H,7-8H2,1H3,(H,15,17,18)/b5-3+
  • InChiKey: MPAWDOYSECXKLT-HWKANZROSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(1,3-benzodioxol-5-yl)-N-[5-(methoxymethyl)-1,3,4-thiadiazol-2-yl]prop-2-enamide
  • (E)-3-(1,3-benzodioxol-5-yl)-N-[5-(methoxymethyl)-1,3,4-thiadiazol-2-yl]acrylamide
  • 3-(1,3-benzodioxol-5-yl)-N-[5-(methoxymethyl)-1,3,4-thiadiazol-2-yl]acrylamide
  • IDI1_022616
  • STK118353
  • ZINC00475589
  • ChemDiv3_004706

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0003 0.001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0052
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.1755 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.0449 0.1561
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0027 0.0156
Brugia malayi hypothetical protein 0.0018 0.0015 0.0052
Brugia malayi Protein kinase domain containing protein 0.0245 0.1418 0.4934
Brugia malayi metabotropic glutamate receptor type 2 0.002 0.0027 0.0093
Echinococcus multilocularis protein patched 0.0126 0.0682 0.0681
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0027 0.0156
Trichomonas vaginalis replication factor C large subunit, putative 0.002 0.0027 0.0156
Onchocerca volvulus Huntingtin homolog 0.012 0.0649 0.8252
Loa Loa (eye worm) hypothetical protein 0.0154 0.0857 0.2982
Brugia malayi Niemann-Pick C1 protein precursor 0.0293 0.1716 0.5969
Brugia malayi fructose-1,6-bisphosphatase 0.0481 0.2874 1
Schistosoma mansoni hypothetical protein 0.0031 0.0097 0.0227
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.0682 0.3888
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0052
Schistosoma mansoni hypothetical protein 0.0029 0.0083 0.0195
Loa Loa (eye worm) hypothetical protein 0.0067 0.0319 0.1111
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.1755 1
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.006 0.4052
Brugia malayi Patched related family protein 4 0.0018 0.0015 0.0052
Schistosoma mansoni hypothetical protein 0.0121 0.0654 0.1531
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0097 0.0223
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.1755 1
Mycobacterium ulcerans hypothetical protein 0.0048 0.0199 0.2199
Echinococcus multilocularis sterol regulatory element binding protein 0.0126 0.0682 0.0681
Entamoeba histolytica hypothetical protein 0.0107 0.0569 0.3135
Brugia malayi Patched family protein 0.0018 0.0015 0.0052
Brugia malayi topoisomerase 0.002 0.0027 0.0095
Loa Loa (eye worm) hypothetical protein 0.0036 0.0125 0.0434
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0199 0.2462
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0051 0.0222 0.0773
Schistosoma mansoni tyrosine kinase 0.0143 0.0788 0.1845
Echinococcus granulosus replication factor c subunit 1 0.002 0.0027 0.006
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0199 0.2199
Loa Loa (eye worm) hypothetical protein 0.002 0.0027 0.0095
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0179 0.1009 0.3512
Brugia malayi Patched family protein 0.0018 0.0015 0.0052
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0199 0.0693
Echinococcus multilocularis aryl hydrocarbon receptor 0.0051 0.0222 0.0221
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.006 0.0207
Brugia malayi hypothetical protein 0.0475 0.2837 0.9868
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0183 0.0424
Onchocerca volvulus Huntingtin homolog 0.012 0.0649 0.8252
Entamoeba histolytica protein kinase, putative 0.0088 0.0452 0.2456
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0199 0.0995
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0036 0.0126 0.0438
Brugia malayi hypothetical protein 0.002 0.0027 0.0095
Echinococcus granulosus Protein patched homolog 1 0.0126 0.0682 0.1594
Plasmodium vivax replication factor C subunit 1, putative 0.002 0.0027 0.1115
Echinococcus granulosus epidermal growth factor receptor 0.0239 0.1382 0.3232
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0481 0.2874 1
Echinococcus multilocularis epidermal growth factor receptor 0.0444 0.2644 0.2642
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0052
Brugia malayi hypothetical protein 0.0036 0.0128 0.0444
Echinococcus granulosus metabotropic glutamate receptor 5 0.005 0.0212 0.0493
Loa Loa (eye worm) TK/ALK protein kinase 0.0245 0.1418 0.4932
Loa Loa (eye worm) hypothetical protein 0.002 0.0027 0.0095
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0199 0.2199
Brugia malayi CHE-14 protein 0.0126 0.0682 0.2374
Brugia malayi hypothetical protein 0.0025 0.006 0.0207
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0052
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0199 0.0693
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0179 0.1009 0.3478
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0125 0.0172
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0183 0.0181
Schistosoma mansoni fructose-16-bisphosphatase-related 0.0481 0.2874 0.6728
Loa Loa (eye worm) TK/INSR protein kinase 0.0143 0.0788 0.2742
Brugia malayi Patched family protein 0.0018 0.0015 0.0052
Onchocerca volvulus 0.0048 0.0199 0.2398
Brugia malayi protein C24B5.3 0.0018 0.0015 0.0052
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.002 0.0027 0.0095
Echinococcus multilocularis geminin 0.0342 0.2015 0.2013
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0097 0.0337
Schistosoma mansoni tyrosine kinase 0.0239 0.1382 0.3235
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0052
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0097 0.0503 0.175
Loa Loa (eye worm) hypothetical protein 0.0293 0.1716 0.5969
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.0027 0.0156
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0052
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0036 0.0128 0.0299
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0511 0.1778
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.002 0.0027 0.0000020034
Brugia malayi Patched related family protein 12 0.0018 0.0015 0.0052
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0199 0.0693
Entamoeba histolytica protein kinase domain containing protein 0.0088 0.0452 0.2456
Toxoplasma gondii fructose-bisphospatase I 0.0179 0.1009 0.3478
Brugia malayi hypothetical protein 0.002 0.0027 0.0095
Echinococcus granulosus insulin receptor 0.0143 0.0788 0.1842
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0052
Echinococcus multilocularis nibrin 0.002 0.0027 0.0026
Echinococcus granulosus GPCR family 2 0.0031 0.0097 0.0223
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0183 0.0428
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0183 0.0428
Schistosoma mansoni hypothetical protein 0.0342 0.2015 0.4716
Schistosoma mansoni topbp1 0.002 0.0027 0.0064
Schistosoma mansoni survival motor neuron protein 0.0097 0.0503 0.1178
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0199 0.0693
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.1755 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0183 0.0424
Schistosoma mansoni transcription factor LCR-F1 0.0107 0.0569 0.1331
Loa Loa (eye worm) patched family protein 0.0018 0.0015 0.0052
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.0027 0.0095
Entamoeba histolytica protein kinase, putative 0.0088 0.0452 0.2456
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0319 0.1111
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.006 0.0156
Loa Loa (eye worm) hypothetical protein 0.002 0.0027 0.0095
Loa Loa (eye worm) hypothetical protein 0.002 0.0027 0.0095
Onchocerca volvulus 0.0097 0.0503 0.6357
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0125 1
Schistosoma mansoni microtubule-associated protein tau 0.0707 0.4272 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0052
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.006 0.0207
Loa Loa (eye worm) TK/EGFR protein kinase 0.0444 0.2644 0.9197
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.006 0.4052
Brugia malayi Patched family protein 0.0018 0.0015 0.0052
Entamoeba histolytica hypothetical protein 0.0107 0.0569 0.3135
Entamoeba histolytica heat shock transcription factor, putative 0.0096 0.05 0.2734
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.1755 1
Echinococcus multilocularis dual specificity 0.0088 0.0452 0.045
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0052
Schistosoma mansoni tyrosine kinase 0.0444 0.2644 0.6188
Loa Loa (eye worm) hypothetical protein 0.0036 0.0126 0.0438
Echinococcus granulosus metabotropic glutamate receptor 2 0.0034 0.0114 0.0264
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.006 0.0113
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0052
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.0027 0.0156
Schistosoma mansoni hypothetical protein 0.0121 0.0654 0.1531
Loa Loa (eye worm) hypothetical protein 0.0098 0.0511 0.1778
Brugia malayi hypothetical protein 0.012 0.0649 0.2257
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0156
Loa Loa (eye worm) hypothetical protein 0.002 0.0027 0.0095
Echinococcus multilocularis metabotropic glutamate receptor 5 0.005 0.0212 0.0211
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0199 0.2462
Echinococcus granulosus Niemann Pick C1 protein 0.0419 0.2493 0.5834
Loa Loa (eye worm) hypothetical protein 0.0031 0.0097 0.0337
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0199 0.2199
Brugia malayi Protein kinase domain containing protein 0.0143 0.0788 0.2742
Loa Loa (eye worm) hypothetical protein 0.0036 0.0126 0.0438
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0199 0.0995
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.0481 0.2874 0.2873
Echinococcus granulosus geminin 0.0342 0.2015 0.4714
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0052
Loa Loa (eye worm) hypothetical protein 0.0475 0.2837 0.9868
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0052
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0037 0.0131 0.0456
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0125 1
Schistosoma mansoni hypothetical protein 0.0067 0.0319 0.0748
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0097 0.0337
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0143 0.0788 0.0787
Trypanosoma brucei fructose-1,6-bisphosphatase 0.0481 0.2874 1
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0036 0.0128 0.0444
Schistosoma mansoni tyrosine kinase 0.0239 0.1382 0.3235
Brugia malayi Metabotropic glutamate receptor precursor. 0.004 0.0155 0.0538
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0183 0.0636
Loa Loa (eye worm) hypothetical protein 0.0048 0.0199 0.0693
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0156
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0183 0.0428
Schistosoma mansoni hypothetical protein 0.0121 0.0654 0.1531
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0199 0.0693
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0146 0.0809 1
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0046 0.0189 0.0442
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0088 0.0452 0.1571
Echinococcus multilocularis microtubule associated protein 2 0.0707 0.4272 0.4271
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0199 0.2199
Loa Loa (eye worm) patched family protein 0.0018 0.0015 0.0052
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.1755 1
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0088 0.0452 0.149
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.03 0.1755 1
Echinococcus granulosus MAM 0.0029 0.0083 0.0191
Brugia malayi hypothetical protein 0.0107 0.0569 0.1979
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0097 0.0223
Onchocerca volvulus Tyrosine kinase homolog 0.0142 0.0783 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0052
Loa Loa (eye worm) patched family protein 0.0018 0.0015 0.0052
Brugia malayi DKFZp564C0469 protein 0.002 0.0027 0.0095
Brugia malayi Pax transcription activation domain interacting protein 0.002 0.0027 0.0095
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0088 0.0452 0.1571
Onchocerca volvulus 0.0135 0.0741 0.9458
Schistosoma mansoni topbp1 0.002 0.0027 0.0064
Echinococcus multilocularis 0.0137 0.0749 0.0748
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0179 0.1009 0.345
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.1755 1
Brugia malayi Patched protein homolog 1 0.0018 0.0015 0.0052
Loa Loa (eye worm) patched family protein 0.0018 0.0015 0.0052
Entamoeba histolytica heat shock transcription factor, putative 0.0096 0.05 0.2734
Brugia malayi Protein kinase domain containing protein 0.0088 0.0452 0.1571
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.0481 0.2874 1
Brugia malayi Patched family protein 0.0018 0.0015 0.0052
Schistosoma mansoni hypothetical protein 0.0121 0.0654 0.1531
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0052
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0199 0.0693
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0199 0.2199
Onchocerca volvulus Protein cycle homolog 0.0036 0.0128 0.1465
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0052
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0052
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0183 0.0181
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.002 0.0027 0.5
Loa Loa (eye worm) hypothetical protein 0.0036 0.0125 0.0434
Trypanosoma cruzi FHA domain containing protein, putative 0.002 0.0027 0.0095
Brugia malayi hypothetical protein 0.0051 0.0221 0.0768
Schistosoma mansoni tyrosine kinase 0.0143 0.0788 0.1845
Loa Loa (eye worm) hypothetical protein 0.012 0.0649 0.2257
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0003 0.001
Leishmania major protein kinase, putative 0.0016 0.0003 0.001
Brugia malayi Immunoglobulin I-set domain containing protein 0.0152 0.0843 0.2934
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0097 0.0337
Echinococcus granulosus Niemann Pick C1 protein 0.0293 0.1716 0.4014
Loa Loa (eye worm) hypothetical protein 0.0025 0.006 0.0207
Echinococcus multilocularis MAM 0.0029 0.0083 0.0082
Toxoplasma gondii ATPase, AAA family protein 0.002 0.0027 0.0043
Onchocerca volvulus 0.002 0.0027 0.0159
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0293 0.1716 0.9775
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0481 0.2874 1
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.0452 0.1057
Chlamydia trachomatis DNA ligase 0.002 0.0027 0.2187
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0143 0.0788 0.1842
Echinococcus multilocularis epidermal growth factor receptor 0.0239 0.1382 0.1381
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0199 0.124
Schistosoma mansoni tyrosine kinase 0.0235 0.1355 0.3171
Onchocerca volvulus Heat shock factor protein 2 homolog 0.0096 0.05 0.6311
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0107 0.0569 0.1328
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0034 0.0114 0.0113
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0088 0.0452 0.1571
Echinococcus multilocularis GPCR, family 2 0.0031 0.0097 0.0095
Entamoeba histolytica hypothetical protein 0.0107 0.0569 0.3135
Brugia malayi Patched family protein 0.0018 0.0015 0.0052
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.0511 0.1778
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0156
Schistosoma mansoni chromosome transmission fidelity factor 0.002 0.0027 0.0064
Loa Loa (eye worm) glutamate receptor 0.0016 0.0003 0.0012
Loa Loa (eye worm) hypothetical protein 0.0126 0.0682 0.2374
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0152 0.0843 0.2934
Echinococcus granulosus expressed conserved protein 0.0276 0.1606 0.3757
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0125 0.1248
Loa Loa (eye worm) hypothetical protein 0.0051 0.0221 0.0768
Loa Loa (eye worm) glutamate receptor 0.004 0.0155 0.0538
Onchocerca volvulus 0.0029 0.0083 0.0887
Echinococcus multilocularis survival motor neuron protein 1 0.0475 0.2837 0.2835
Leishmania major protein kinase, putative 0.0016 0.0003 0.001
Brugia malayi protein C24B5.3 0.0018 0.0015 0.0052
Echinococcus multilocularis insulin receptor 0.0143 0.0788 0.0787
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0052
Brugia malayi hypothetical protein 0.0016 0.0005 0.0017
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0003 0.001
Schistosoma mansoni hypothetical protein 0.0031 0.0097 0.0227
Echinococcus granulosus microtubule associated protein 2 0.0707 0.4272 1
Schistosoma mansoni tyrosine kinase 0.0235 0.1355 0.3171
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0036 0.0128 0.0444
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0126 0.0682 0.2374
Entamoeba histolytica heat shock transcription factor, putative 0.0096 0.05 0.2734
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0027 0.0095
Brugia malayi Furin-like cysteine rich region family protein 0.0444 0.2644 0.9197
Schistosoma mansoni hypothetical protein 0.0107 0.0569 0.1331
Entamoeba histolytica hypothetical protein 0.0088 0.0452 0.2456
Loa Loa (eye worm) hypothetical protein 0.0036 0.0125 0.0434
Echinococcus granulosus fructose 16 bisphosphatase 1 0.0481 0.2874 0.6727
Treponema pallidum fructose-bisphosphate aldolase 0.03 0.1755 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0052
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0146 0.0809 1
Brugia malayi hypothetical protein 0.0018 0.0015 0.0052
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0052
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0052
Brugia malayi hypothetical protein 0.0029 0.0083 0.0289
Brugia malayi Patched family protein 0.0018 0.0015 0.0052
Echinococcus multilocularis Niemann Pick C1 protein 0.0419 0.2493 0.2492
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0052
Schistosoma mansoni hypothetical protein 0.0031 0.0097 0.0227
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.002 0.0027 0.0338
Loa Loa (eye worm) hypothetical protein 0.002 0.0027 0.0095
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0199 0.2199
Schistosoma mansoni metabotropic glutamate receptor 0.0034 0.0114 0.0267
Brugia malayi Patched family protein 0.0018 0.0015 0.0052
Brugia malayi Patched family protein 0.0018 0.0015 0.0052
Onchocerca volvulus 0.0029 0.0083 0.0887
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0052
Loa Loa (eye worm) hypothetical protein 0.0036 0.0126 0.0438
Onchocerca volvulus 0.0051 0.0221 0.2678
Schistosoma mansoni hypothetical protein 0.0097 0.0503 0.1178
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.006 0.4052
Echinococcus granulosus dual specificity 0.0088 0.0452 0.1054
Loa Loa (eye worm) hypothetical protein 0.0088 0.0449 0.1561
Loa Loa (eye worm) hypothetical protein 0.0036 0.0126 0.0438
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0179 0.1009 0.3512
Brugia malayi Myosin head containing protein 0.0018 0.0015 0.0052
Echinococcus granulosus sterol regulatory element binding protein 0.0126 0.0682 0.1594
Loa Loa (eye worm) patched family protein 0.0018 0.0015 0.0052
Echinococcus multilocularis protein dispatched 1 0.0144 0.0792 0.0791
Schistosoma mansoni hypothetical protein 0.0029 0.0083 0.0195
Loa Loa (eye worm) hypothetical protein 0.012 0.0649 0.2257
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0027 0.0095
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0052
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0052
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0052
Loa Loa (eye worm) hypothetical protein 0.0029 0.0083 0.0289
Echinococcus multilocularis expressed conserved protein 0.0276 0.1606 0.1605
Loa Loa (eye worm) hypothetical protein 0.0096 0.05 0.1738
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0052
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0511 0.1778
Brugia malayi HSF-type DNA-binding domain containing protein 0.0096 0.05 0.1738
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0052
Brugia malayi Patched family protein 0.0018 0.0015 0.0052
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0003 0.001
Loa Loa (eye worm) hypothetical protein 0.0029 0.0083 0.0289
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.03 0.1755 1
Brugia malayi hypothetical protein 0.0018 0.0015 0.0052
Schistosoma mansoni hypothetical protein 0.0031 0.0097 0.0227
Giardia lamblia Fructose-bisphosphate aldolase 0.03 0.1755 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0183 0.0636
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0199 0.124
Brugia malayi Patched family protein 0.0018 0.0015 0.0052
Plasmodium falciparum replication factor C subunit 1, putative 0.002 0.0027 0.1115
Echinococcus granulosus nibrin 0.002 0.0027 0.006
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0052
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0199 0.2199
Echinococcus multilocularis replication factor c subunit 1 0.002 0.0027 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0156
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0052
Loa Loa (eye worm) hypothetical protein 0.0036 0.0125 0.0434
Loa Loa (eye worm) hypothetical protein 0.0036 0.0125 0.0434
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.1755 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0125 1
Schistosoma mansoni hypothetical protein 0.0342 0.2015 0.4716
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0052
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0107 0.0569 0.0567
Loa Loa (eye worm) hypothetical protein 0.0029 0.0083 0.0289
Brugia malayi Patched family protein 0.0018 0.0015 0.0052
Loa Loa (eye worm) hypothetical protein 0.005 0.0212 0.0738
Brugia malayi Patched family protein 0.0018 0.0015 0.0052
Brugia malayi Patched related family protein 10 0.0018 0.0015 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0156
Schistosoma mansoni patched 1 0.0126 0.0682 0.1597
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0052
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0239 0.1382 0.3232
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0097 0.0095
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0298 0.1744 0.4082
Schistosoma mansoni metabotropic glutamate receptor 0.002 0.0027 0.0063
Schistosoma mansoni DNA ligase IV 0.002 0.0027 0.0064
Loa Loa (eye worm) hypothetical protein 0.0048 0.0199 0.0693
Echinococcus granulosus survival motor neuron protein 1 0.0475 0.2837 0.6638
Schistosoma mansoni tyrosine kinase 0.0235 0.1355 0.3171
Schistosoma mansoni aryl hydrocarbon receptor 0.0016 0.0002 0.0004
Entamoeba histolytica hypothetical protein 0.0107 0.0569 0.3135
Brugia malayi Patched family protein 0.0018 0.0015 0.0052
Leishmania major hypothetical protein, conserved 0.0025 0.006 0.0207
Loa Loa (eye worm) hypothetical protein 0.0048 0.0199 0.0693
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0146 0.0809 1
Toxoplasma gondii fructose-bisphospatase II 0.0481 0.2874 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0293 0.1716 0.1715
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0199 0.0995
Brugia malayi hypothetical protein 0.0036 0.0126 0.0438
Leishmania major 0.0481 0.2874 1
Echinococcus granulosus epidermal growth factor receptor 0.0444 0.2644 0.6187
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0036 0.0128 0.0444
Brugia malayi Patched family protein 0.0018 0.0015 0.0052
Brugia malayi hypothetical protein 0.0018 0.0015 0.0052
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0097 0.0095
Loa Loa (eye worm) hypothetical protein 0.0212 0.1213 0.4218
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.002 0.0027 0.0043
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0088 0.0452 0.1571
Echinococcus granulosus aryl hydrocarbon receptor 0.0051 0.0222 0.0517

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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