TDR Targets

Basic information

Technical information

TDR Targets ID: 669106
Name: (5Z)-3-(2-methylpropyl)-5-[[5-(2-nitrophenyl) furan-2-yl]methylidene]-1,3-thiazolidine-2,4- dione
MW: 372.395 | Formula: C18H16N2O5S
H donors: 0 H acceptors: 4 LogP: 4.3 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CC(CN1C(=O)SC(=Cc2ccc(o2)c2ccccc2[N+](=O)[O-])C1=O)C
InChi: 1S/C18H16N2O5S/c1-11(2)10-19-17(21)16(26-18(19)22)9-12-7-8-15(25-12)13-5-3-4-6-14(13)20(23)24/h3-9,11H,10H2,1-2H3/b16-9-
InChiKey: YZNCMBQCCLPQHF-SXGWCWSVSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(5Z)-3-isobutyl-5-[[5-(2-nitrophenyl)-2-furyl]methylene]thiazolidine-2,4-dione
(5Z)-3-isobutyl-5-[[5-(2-nitrophenyl)-2-furyl]methylene]thiazolidine-2,4-quinone
ZINC01182710

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.3044	0.3799
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0263	0.0322
Trichomonas vaginalis	rotamase, putative	0.0034	0.2548	0.3178
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0013	0.0824	0.1023
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0824	0.1023
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0263	0.0322
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0033	0.2481	0.3095
Trypanosoma brucei	DNA damage repair protein, putative	0.0012	0.0745	0.0924
Plasmodium falciparum	thioredoxin reductase	0.0013	0.0824	0.2803
Loa Loa (eye worm)	glutathione reductase	0.0038	0.2924	0.3648
Trypanosoma brucei	chrX additional, unordered contigs	0.0012	0.0745	0.0924
Leishmania major	DNA polymerase eta, putative	0.0039	0.3044	0.3799
Trypanosoma cruzi	hypothetical protein, conserved	0.0012	0.0745	0.0924
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.215	0.2681
Trichomonas vaginalis	CAMK family protein kinase	0.0049	0.3816	0.4764
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0263	0.0322
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0034	0.2548	0.3178
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.3044	0.3799
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0013	0.0824	0.1023
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0013	0.0824	0.1023
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0039	0.3044	0.3799
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0039	0.3044	0.3799
Trypanosoma brucei	hypothetical protein, conserved	0.0012	0.0745	0.0924
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0465	0.0574
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0039	0.3044	0.3799
Brugia malayi	Thioredoxin reductase	0.0038	0.2924	0.3648
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.0033	0.2481	0.3095
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0013	0.0824	0.0824
Schistosoma mansoni	glutamate synthase	0.0003	0.0006	0.0006
Echinococcus granulosus	dna polymerase eta	0.0039	0.3044	0.3799
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.3044	0.3799
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0034	0.2548	0.3178
Trypanosoma brucei	DNA polymerase IV, putative	0.0039	0.3044	0.3799
Trypanosoma brucei	DNA polymerase IV, putative	0.0039	0.3044	0.3799
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0007	0.0001
Echinococcus multilocularis	expressed protein	0.0034	0.2548	0.3178
Plasmodium vivax	thioredoxin reductase, putative	0.0038	0.2924	1
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0039	0.3044	0.3799
Loa Loa (eye worm)	thioredoxin reductase	0.0038	0.2924	0.3648
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0263	0.0322
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.8003	1
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.8003	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.3044	0.3799
Schistosoma mansoni	DNA polymerase eta	0.0039	0.3044	0.3044
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0263	0.0322
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0013	0.0824	0.1023
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0824	0.1023
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0013	0.0824	0.2692
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0087	0.704	0.8958
Leishmania major	trypanothione reductase	0.0038	0.2924	0.3648
Schistosoma mansoni	serine/threonine protein kinase	0.0098	0.8003	0.8003
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0824	0.1023
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.001	0.0573	0.0709
Toxoplasma gondii	BRCA1 C Terminus (BRCT) domain-containing protein	0.0012	0.0745	0.1708
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0087	0.704	0.8958
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0087	0.704	0.8958
Schistosoma mansoni	sulfide quinone reductase	0.0003	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0745	0.0924
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0317	0.0388
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0263	0.0322
Echinococcus granulosus	dna polymerase kappa	0.0039	0.3044	0.3799
Trypanosoma brucei	unspecified product	0.0027	0.201	0.2505
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0013	0.0824	0.1042
Schistosoma mansoni	sulfide quinone reductase	0.0003	0.0006	0.0006
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0263	0.0322
Brugia malayi	ImpB/MucB/SamB family protein	0.0039	0.3044	0.3799
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0013	0.0824	0.2803
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0263	0.0322
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0098	0.8003	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0013	0.0824	1
Trichomonas vaginalis	rotamase, putative	0.0033	0.2481	0.3095
Mycobacterium tuberculosis	Probable oxidoreductase	0.0096	0.7858	1
Trypanosoma brucei	unspecified product	0.0027	0.201	0.2505
Brugia malayi	glutathione reductase	0.0038	0.2924	0.3648
Trypanosoma cruzi	DNA polymerase eta, putative	0.0039	0.3044	0.3799
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0098	0.8003	1
Plasmodium falciparum	DNA repair protein REV1, putative	0.0012	0.0745	0.2533
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0039	0.3044	0.3869
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0263	0.0322
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0039	0.3044	0.3799
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.3044	0.3799
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0096	0.7858	1
Trypanosoma brucei	polo-like protein kinase	0.0098	0.8003	1
Trichomonas vaginalis	DNA polymerase eta, putative	0.0039	0.3044	0.3799
Brugia malayi	polk-prov protein	0.0012	0.0745	0.0924
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0039	0.3044	0.3799
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0317	0.0317
Toxoplasma gondii	thioredoxin reductase	0.0038	0.2924	0.6744
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0013	0.0824	0.1023
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0317	0.0388
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0263	0.0322
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.8003	1
Mycobacterium ulcerans	DNA polymerase IV	0.0039	0.3044	1
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0013	0.0824	0.1023
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.8003	1
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0012	0.0745	0.1708
Schistosoma mansoni	rotamase	0.0034	0.2548	0.2548
Leishmania major	DNA polymerase eta, putative	0.0012	0.0745	0.0924
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0013	0.0824	0.1023
Trichomonas vaginalis	helicase, putative	0.0007	0.0263	0.0322
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0039	0.3044	0.3044
Echinococcus multilocularis	dna polymerase kappa	0.0039	0.3044	0.3799
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0013	0.0824	0.1891
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.3044	0.3799
Trypanosoma brucei	trypanothione reductase	0.0038	0.2924	0.3648
Trypanosoma cruzi	DNA damage repair protein, putative	0.0012	0.0745	0.0924
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0263	0.0322
Trypanosoma cruzi	polo-like protein kinase, putative	0.0098	0.8003	1
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.001	0.0573	0.0709
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0096	0.7858	1
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0013	0.0824	0.1023
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0061	0.4885	0.4885
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0013	0.0824	0.2803
Leishmania major	DNA damage repair protein, putative	0.0012	0.0745	0.0924
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0039	0.3044	0.3799
Schistosoma mansoni	disulfide oxidoreductase	0.0003	0.0006	0.0006
Trypanosoma brucei	DNA polymerase kappa, putative	0.0027	0.201	0.2505
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0033	0.2481	0.3095
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0263	0.0322
Echinococcus multilocularis	cpg binding protein	0.0031	0.2289	0.2855
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0013	0.0824	0.2803
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0013	0.0824	0.1023
Trypanosoma brucei	DNA polymerase kappa, putative	0.0027	0.201	0.2505
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0033	0.2481	0.3095
Giardia lamblia	DINP protein human, muc B family	0.0039	0.3044	0.3799
Schistosoma mansoni	glutamate synthase	0.0003	0.0006	0.0006
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0012	0.0745	0.1708
Leishmania major	DNA polymerase kappa, putative	0.0039	0.3044	0.3799
Schistosoma mansoni	hypothetical protein	0.0003	0.0006	0.0006
Trypanosoma cruzi	polo-like protein kinase, putative	0.0098	0.8003	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0317	0.0388
Schistosoma mansoni	cpg binding protein	0.0029	0.215	0.215
Trichomonas vaginalis	mercuric reductase, putative	0.0013	0.0824	0.1023
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.8003	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.0087	0.704	0.8958
Mycobacterium ulcerans	hypothetical protein	0.0012	0.0745	0.2433
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.2548	0.3178
Plasmodium vivax	DNA repair protein REV1, putative	0.0012	0.0745	0.2533
Echinococcus multilocularis	dna polymerase eta	0.0039	0.3044	0.3799
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0004	0.0061	0.0061
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0038	0.2924	0.3716
Trichomonas vaginalis	CAMK family protein kinase	0.0049	0.3816	0.4764
Schistosoma mansoni	DNA polymerase IV / kappa	0.0012	0.0745	0.0745
Brugia malayi	CXXC zinc finger family protein	0.0029	0.215	0.2681
Trypanosoma brucei	DNA polymerase kappa, putative	0.0012	0.0745	0.0924
Onchocerca volvulus		0.0029	0.215	0.2681
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0824	0.1023
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0456	0.0562
Schistosoma mansoni	glutamate synthase	0.0003	0.0006	0.0006
Schistosoma mansoni	cpg binding protein	0.0031	0.2289	0.2289
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.3044	0.3799
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0039	0.2967	0.3702
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0317	0.0388
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0039	0.3044	0.3799
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0013	0.0824	0.1023
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0013	0.0824	1
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0013	0.0824	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0263	0.0322
Mycobacterium ulcerans	DNA polymerase IV	0.0039	0.3044	1
Echinococcus granulosus	cpg binding protein	0.0031	0.2289	0.2855
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0263	0.0322
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0263	0.0322
Trypanosoma brucei	unspecified product	0.0039	0.3044	0.3799
Giardia lamblia	Kinase, PLK	0.0098	0.8003	1
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0098	0.8003	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0465	0.0574
Trichomonas vaginalis	glutathione reductase, putative	0.0013	0.0824	0.1023
Echinococcus granulosus	thioredoxin glutathione reductase	0.0039	0.2967	0.3702
Schistosoma mansoni	kinase	0.005	0.3925	0.3925
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0098	0.8003	1
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0013	0.0824	0.1023
Plasmodium falciparum	glutathione reductase	0.0013	0.0824	0.2803
Toxoplasma gondii	NADPH-glutathione reductase	0.0013	0.0824	0.1891
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0013	0.0824	0.2692
Trypanosoma brucei	DNA polymerase kappa, putative	0.0027	0.201	0.2505
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0087	0.704	0.8958
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.3044	0.3799
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.3044	0.3799
Plasmodium vivax	glutathione reductase, putative	0.0038	0.2924	1
Trypanosoma brucei	DNA polymerase eta, putative	0.0039	0.3044	0.3799
Treponema pallidum	NADH oxidase	0.0013	0.0824	1
Brugia malayi	serine/threonine-protein kinase plk-2	0.0098	0.8003	1
Trypanosoma brucei	DNA damage repair protein, putative	0.0012	0.0745	0.0924
Trypanosoma cruzi	hypothetical protein, conserved	0.0012	0.0745	0.0924
Leishmania major	DNA polymerase kappa, putative	0.0012	0.0745	0.0924
Trypanosoma cruzi	DNA damage repair protein, putative	0.0012	0.0745	0.0924
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0039	0.3044	0.3799
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.001	0.0573	0.0709
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0039	0.3044	0.3869
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.8003	1
Trypanosoma brucei	hypothetical protein, conserved	0.0012	0.0745	0.0924
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0013	0.0824	0.2692
Giardia lamblia	DNA damage repair protein	0.0012	0.0745	0.0924
Trypanosoma brucei	DNA polymerase IV, putative	0.0039	0.3044	0.3799
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0824	0.1023
Trypanosoma cruzi	DNA polymerase eta, putative	0.0012	0.0745	0.0924
Toxoplasma gondii	peptidylprolyl isomerase	0.0033	0.2481	0.5721
Trypanosoma cruzi	trypanothione reductase, putative	0.0038	0.2924	0.3648
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0039	0.3044	0.3799
Mycobacterium tuberculosis	Probable reductase	0.0087	0.704	0.8958
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.8003	1
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0013	0.0824	0.1023
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.0033	0.2481	0.3095
Loa Loa (eye worm)	hypothetical protein	0.0039	0.3044	0.3799
Wolbachia endosymbiont of Brugia malayi	parvulin-like peptidyl-prolyl isomerase, PPID	0.001	0.0573	0.6933
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0087	0.704	0.8958
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0465	0.0574
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0096	0.7858	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0013	0.0824	0.1023
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0004	0.0007	0.0001
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0263	0.0322
Brugia malayi	ImpB/MucB/SamB family protein	0.0039	0.3044	0.3799
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0039	0.3044	0.3044
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0263	0.0322
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.3044	0.3799
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0098	0.8003	1
Plasmodium falciparum	thioredoxin reductase	0.0038	0.2924	1
Trichomonas vaginalis	hypothetical protein	0.0004	0.0007	0.0001
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0824	0.1023
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.001	0.0529	0.0653
Leishmania major	peptidyl-prolyl cis-trans isomerase, putative	0.001	0.0573	0.0709
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0013	0.0824	0.1023
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0098	0.8003	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0012	0.0745	0.0924
Echinococcus granulosus	expressed protein	0.0034	0.2548	0.3178
Plasmodium falciparum	glutathione reductase	0.0038	0.2924	1
Schistosoma mansoni	cpg binding protein	0.0031	0.2289	0.2289
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.4332	1
Toxoplasma gondii	PPIC-type PPIASE domain-containing protein	0.001	0.0573	0.1311
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0013	0.0824	0.2803
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0013	0.0824	0.1023
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.001	0.0529	0.0653

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 669106