Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0073 | 0.3873 | 0.3617 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 0.5334 | 0.6118 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0044 | 0.1992 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.3873 | 0.4305 |
Onchocerca volvulus | 0.0036 | 0.1484 | 0.5 | |
Treponema pallidum | NADH oxidase | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.004 | 0.1747 | 0.8769 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.5334 | 0.5929 |
Toxoplasma gondii | thioredoxin reductase | 0.004 | 0.1747 | 0.8769 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.004 | 0.1749 | 0.5 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0092 | 0.5171 | 0.8837 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.5334 | 0.5929 |
Trypanosoma cruzi | cytochrome P450, putative | 0.002 | 0.04 | 0.2293 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.3873 | 0.4305 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0092 | 0.5171 | 0.8837 |
Plasmodium vivax | thioredoxin reductase, putative | 0.004 | 0.1747 | 0.8769 |
Loa Loa (eye worm) | glutathione reductase | 0.004 | 0.1747 | 0.1402 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.015 | 0.8997 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0146 | 0.8719 | 1 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.015 | 0.8997 | 0.8997 |
Loa Loa (eye worm) | acetyltransferase | 0.015 | 0.8997 | 0.8955 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0103 | 0.5851 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 0.5334 | 0.5929 |
Brugia malayi | TAR-binding protein | 0.0073 | 0.3873 | 0.3873 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0036 | 0.1484 | 0.165 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0044 | 0.1992 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0103 | 0.5851 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.004 | 0.1747 | 1 |
Brugia malayi | glutathione reductase | 0.004 | 0.1747 | 0.1747 |
Mycobacterium ulcerans | putative regulatory protein | 0.0036 | 0.1484 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.002 | 0.04 | 0.04 |
Trypanosoma cruzi | cytochrome P450, putative | 0.002 | 0.04 | 0.2293 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.3873 | 0.4305 |
Plasmodium falciparum | glutathione reductase | 0.004 | 0.1747 | 0.9988 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0092 | 0.5171 | 0.8837 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0073 | 0.3873 | 0.3873 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0095 | 0.5334 | 0.5334 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.004 | 0.1749 | 1 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0044 | 0.1992 | 1 |
Brugia malayi | bHLH-PAS transcription factor | 0.0036 | 0.1484 | 0.1484 |
Echinococcus granulosus | single minded 2 | 0.0036 | 0.1484 | 0.1702 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0092 | 0.5171 | 0.8837 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0014 | 0 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.004 | 0.1747 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0073 | 0.3873 | 0.3617 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0044 | 0.1992 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.002 | 0.04 | 0.2698 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.004 | 0.1747 | 0.2985 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0095 | 0.5334 | 0.5139 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.3873 | 0.4305 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0044 | 0.1992 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0092 | 0.5171 | 0.8837 |
Echinococcus granulosus | tar DNA binding protein | 0.0073 | 0.3873 | 0.4442 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 0.5334 | 0.6118 |
Loa Loa (eye worm) | TAR-binding protein | 0.0073 | 0.3873 | 0.3617 |
Trypanosoma brucei | cytochrome P450, putative | 0.002 | 0.04 | 0.2293 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0044 | 0.1992 | 0.2285 |
Brugia malayi | Cytochrome P450 family protein | 0.0051 | 0.2413 | 0.2413 |
Brugia malayi | hypoxia-induced factor 1 | 0.0153 | 0.9154 | 0.9154 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0041 | 0.1782 | 0.2044 |
Schistosoma mansoni | single-minded | 0.0049 | 0.2331 | 0.259 |
Leishmania major | trypanothione reductase | 0.004 | 0.1747 | 1 |
Brugia malayi | RNA binding protein | 0.0073 | 0.3873 | 0.3873 |
Loa Loa (eye worm) | thioredoxin reductase | 0.004 | 0.1747 | 0.1402 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0041 | 0.1782 | 0.1981 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0051 | 0.2413 | 0.2097 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0014 | 0 | 0.5 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.004 | 0.1749 | 1 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.015 | 0.8997 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0014 | 0 | 0.5 |
Brugia malayi | PAS domain containing protein | 0.0049 | 0.2331 | 0.2331 |
Plasmodium falciparum | thioredoxin reductase | 0.004 | 0.1747 | 0.9988 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0049 | 0.2331 | 0.259 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.3873 | 0.4305 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0103 | 0.5851 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0073 | 0.3873 | 0.4305 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0153 | 0.9154 | 0.9118 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0103 | 0.5851 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.002 | 0.04 | 0.04 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0092 | 0.5171 | 0.8837 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.5334 | 0.5929 |
Brugia malayi | Thioredoxin reductase | 0.004 | 0.1747 | 0.1747 |
Leishmania major | cytochrome p450-like protein | 0.002 | 0.04 | 0.2293 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 0.5334 | 0.5929 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.