Detailed information for compound 669129

Basic information

Technical information
  • TDR Targets ID: 669129
  • Name: (5Z)-3-ethyl-5-[[5-(2-nitrophenyl)furan-2-yl] methylidene]-1,3-thiazolidine-2,4-dione
  • MW: 344.342 | Formula: C16H12N2O5S
  • H donors: 0 H acceptors: 4 LogP: 3.34 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN1C(=O)SC(=Cc2ccc(o2)c2ccccc2[N+](=O)[O-])C1=O
  • InChi: 1S/C16H12N2O5S/c1-2-17-15(19)14(24-16(17)20)9-10-7-8-13(23-10)11-5-3-4-6-12(11)18(21)22/h3-9H,2H2,1H3/b14-9-
  • InChiKey: LGLFDVSNBUEAJW-ZROIWOOFSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (5Z)-3-ethyl-5-[[5-(2-nitrophenyl)-2-furyl]methylene]thiazolidine-2,4-dione
  • (5Z)-3-ethyl-5-[[5-(2-nitrophenyl)-2-furyl]methylene]thiazolidine-2,4-quinone
  • AN-698/40704427
  • ZINC01007614

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus chromobox protein 1 0.0073 0.3412 0.4745
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.2899 0.5126
Echinococcus granulosus tar DNA binding protein 0.0067 0.2899 0.3405
Plasmodium vivax thioredoxin reductase, putative 0.005 0.1594 0.5
Echinococcus granulosus chromobox protein 1 0.0073 0.3412 0.4745
Trichomonas vaginalis CAMK family protein kinase 0.01 0.5425 1
Toxoplasma gondii thioredoxin reductase 0.005 0.1594 0.5
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0126 0.7491 1
Trichomonas vaginalis CAMK family protein kinase 0.01 0.5425 1
Trichomonas vaginalis chromobox protein, putative 0.0073 0.3412 0.629
Echinococcus multilocularis chromobox protein 1 0.0073 0.3412 0.4745
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.1552 0.286
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.2899 0.4384
Loa Loa (eye worm) heterochromatin protein 1 0.0073 0.3412 0.6117
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0114 0.6513 0.8342
Loa Loa (eye worm) thioredoxin reductase 0.005 0.1594 0.2611
Trichomonas vaginalis chromobox protein, putative 0.0044 0.1167 0.2151
Brugia malayi TAR-binding protein 0.0067 0.2899 0.4384
Trichomonas vaginalis chromobox protein, putative 0.0044 0.1167 0.2151
Brugia malayi serine/threonine-protein kinase plk-2 0.01 0.5425 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0926 0.1322
Schistosoma mansoni tar DNA-binding protein 0.0067 0.2899 0.1492
Schistosoma mansoni chromobox protein 0.0073 0.3412 0.2108
Mycobacterium tuberculosis Probable dehydrogenase 0.0114 0.6513 0.8342
Mycobacterium tuberculosis Probable oxidoreductase 0.0126 0.7491 1
Schistosoma mansoni tar DNA-binding protein 0.0067 0.2899 0.1492
Entamoeba histolytica serine/threonine protein kinase, putative 0.01 0.5425 0.5
Echinococcus granulosus serine:threonine protein kinase PLK1 0.01 0.5425 1
Loa Loa (eye worm) RNA binding protein 0.0067 0.2899 0.5126
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.01 0.5425 1
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0926 0.1707
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0126 0.7491 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0114 0.6513 0.8342
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0926 0.1707
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0926 0.1322
Brugia malayi Thioredoxin reductase 0.005 0.1594 0.1485
Echinococcus multilocularis chromobox protein 1 0.0073 0.3412 0.4745
Brugia malayi glutathione reductase 0.005 0.1594 0.1485
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.01 0.5425 1
Trypanosoma cruzi polo-like protein kinase, putative 0.01 0.5425 1
Brugia malayi Heterochromatin protein 1 0.0073 0.3412 0.5526
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0114 0.6513 0.8342
Trichomonas vaginalis CAMK family protein kinase 0.01 0.5425 1
Loa Loa (eye worm) TAR-binding protein 0.0067 0.2899 0.5126
Schistosoma mansoni chromobox protein 0.0073 0.3412 0.2108
Trichomonas vaginalis CAMK family protein kinase 0.01 0.5425 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.01 0.5425 1
Schistosoma mansoni tar DNA-binding protein 0.0067 0.2899 0.1492
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.1552 0.286
Echinococcus multilocularis tar DNA binding protein 0.0067 0.2899 0.3405
Plasmodium falciparum thioredoxin reductase 0.005 0.1594 0.5
Trichomonas vaginalis CAMK family protein kinase 0.01 0.5425 1
Schistosoma mansoni tar DNA-binding protein 0.0067 0.2899 0.1492
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.1167 0.1786
Trichomonas vaginalis chromobox protein, putative 0.0073 0.3412 0.629
Trichomonas vaginalis CAMK family protein kinase 0.01 0.5425 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.01 0.5425 1
Giardia lamblia Kinase, PLK 0.01 0.5425 0.5
Trichomonas vaginalis CAMK family protein kinase 0.01 0.5425 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0114 0.6513 0.8342
Plasmodium vivax glutathione reductase, putative 0.005 0.1594 0.5
Trypanosoma cruzi polo-like protein kinase, putative 0.01 0.5425 1
Trypanosoma brucei polo-like protein kinase 0.01 0.5425 1
Brugia malayi RNA binding protein 0.0067 0.2899 0.4384
Plasmodium falciparum glutathione reductase 0.005 0.1594 0.5
Mycobacterium tuberculosis Probable reductase 0.0114 0.6513 0.8342
Schistosoma mansoni tar DNA-binding protein 0.0067 0.2899 0.1492
Schistosoma mansoni serine/threonine protein kinase 0.01 0.5425 0.4519
Loa Loa (eye worm) glutathione reductase 0.005 0.1594 0.2611
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0126 0.7491 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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