TDR Targets

Basic information

Technical information

TDR Targets ID: 669368
Name: (2-ethylpiperidin-1-yl)-(5-methylfuran-2-yl)m ethanone
MW: 221.295 | Formula: C13H19NO2
H donors: 0 H acceptors: 1 LogP: 2.99 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CCC1CCCCN1C(=O)c1ccc(o1)C
InChi: 1S/C13H19NO2/c1-3-11-6-4-5-9-14(11)13(15)12-8-7-10(2)16-12/h7-8,11H,3-6,9H2,1-2H3
InChiKey: HYKHBSRNBBCIDT-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

(2-ethyl-1-piperidyl)-(5-methyl-2-furyl)methanone
(2-ethyl-1-piperidinyl)-(5-methyl-2-furyl)methanone
IVK/8145920

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0479	0.0416
Echinococcus granulosus	expressed conserved protein	0.0091	0.2248	0.5102
Schistosoma mansoni	tar DNA-binding protein	0.0123	0.3658	0.3658
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0218	0.0153
Brugia malayi	Ets-domain containing protein	0.0071	0.1349	0.1291
Trichomonas vaginalis	glutaminase, putative	0.0267	1	1
Echinococcus multilocularis	GA binding protein alpha chain	0.0071	0.1349	0.2998
Schistosoma mansoni	tar DNA-binding protein	0.0123	0.3658	0.3658
Schistosoma mansoni	tar DNA-binding protein	0.0123	0.3658	0.3658
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0098	0.2574	0.2574
Loa Loa (eye worm)	hypothetical protein	0.0097	0.2508	0.2458
Echinococcus granulosus	Niemann Pick C1 protein	0.0097	0.2508	0.5709
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0218	0.0218
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0218	0.0355
Echinococcus multilocularis	protein dispatched 1	0.0047	0.0326	0.0606
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0218	0.0355
Schistosoma mansoni	tar DNA-binding protein	0.0123	0.3658	0.3658
Brugia malayi	Ets-domain containing protein	0.0071	0.1349	0.1291
Loa Loa (eye worm)	RNA binding protein	0.0123	0.3658	0.3616
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0123	0.3658	0.3616
Loa Loa (eye worm)	glutaminase 2	0.0267	1	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.0896	0.0836
Schistosoma mansoni	glutaminase	0.0267	1	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.0139	0.4343	1
Echinococcus granulosus	GA binding protein alpha chain	0.0071	0.1349	0.2998
Brugia malayi	RNA recognition motif domain containing protein	0.0123	0.3658	0.3616
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0218	0.0355
Echinococcus multilocularis	Niemann Pick C1 protein	0.0097	0.2508	0.5709
Brugia malayi	TAR-binding protein	0.0123	0.3658	0.3616
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0097	0.2508	0.5
Loa Loa (eye worm)	TAR-binding protein	0.0123	0.3658	0.3616
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0218	0.0153
Brugia malayi	Niemann-Pick C1 protein precursor	0.0097	0.2508	0.2458
Schistosoma mansoni	ets-related	0.0215	0.7696	0.7696
Echinococcus multilocularis	tar DNA binding protein	0.0123	0.3658	0.8399
Loa Loa (eye worm)	glutaminase	0.0267	1	1
Brugia malayi	RNA binding protein	0.0123	0.3658	0.3616
Schistosoma mansoni	gabp alpha	0.0071	0.1349	0.1349
Mycobacterium ulcerans	glutaminase	0.0267	1	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0218	0.0218
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0218	0.0218
Brugia malayi	Fli-1 protein	0.0215	0.7696	0.7681
Echinococcus granulosus	Niemann Pick C1 protein	0.0139	0.4343	1
Echinococcus multilocularis	expressed conserved protein	0.0091	0.2248	0.5102
Loa Loa (eye worm)	fli-1 protein	0.0215	0.7696	0.7681
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0218	0.0355
Schistosoma mansoni	patched 1	0.0042	0.0066	0.0066
Echinococcus granulosus	tar DNA binding protein	0.0123	0.3658	0.8399
Schistosoma mansoni	tar DNA-binding protein	0.0123	0.3658	0.3658
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0071	0.1349	0.1291

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 669368