Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | HMG-CoA reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.0165 | 0.6494 | 0.6015 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0165 | 0.6494 | 0.645 |
Echinococcus granulosus | sodium channel protein | 0.0094 | 0.1255 | 0.0472 |
Schistosoma mansoni | voltage-gated potassium channel | 0.018 | 0.7555 | 0.7743 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0112 | 0.2568 | 0.2007 |
Loa Loa (eye worm) | voltage-gated potassium channel | 0.0112 | 0.2568 | 0.1553 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0112 | 0.2568 | 0.2007 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 0.6494 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 1 | 1 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0165 | 0.6494 | 0.5 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0165 | 0.6494 | 0.6596 |
Echinococcus granulosus | shaker cognate | 0.0112 | 0.2568 | 0.2007 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0165 | 0.6494 | 0.6596 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.6494 | 0.6015 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 0.6494 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0112 | 0.2568 | 0.1665 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0094 | 0.1255 | 0.0472 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0201 | 0.911 | 0.9654 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0205 | 0.9406 | 1 |
Brugia malayi | Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog | 0.0112 | 0.2568 | 0.1553 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0201 | 0.911 | 0.9639 |
Echinococcus multilocularis | shaker cognate | 0.0112 | 0.2568 | 0.2007 |
Brugia malayi | Voltage-gated potassium channel, Shal-family (KCND, Kv4-like) alpha-subunit. C. elegans shl-1 ortholog | 0.018 | 0.7555 | 0.7221 |
Echinococcus multilocularis | potassium voltage gated channel subfamily A | 0.0186 | 0.804 | 0.8403 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 0.6494 | 0.5 |
Echinococcus multilocularis | sodium channel protein | 0.0094 | 0.1255 | 0.0472 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0205 | 0.9406 | 1 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0201 | 0.911 | 0.9654 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0078 | 0 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0205 | 0.9406 | 1 |
Brugia malayi | Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit | 0.0205 | 0.9406 | 0.9325 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.9406 | 0.9325 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0205 | 0.9406 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0 | 0.5 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 0.6494 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily A | 0.0205 | 0.9406 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.33 uM | Inhibition of solubilized, partially purified rat liver HMG-CoA reductase | ChEMBL. | 3950901 |
IC50 (binding) | = 0.33 uM | Inhibition of solubilized, partially purified rat liver HMG-CoA reductase | ChEMBL. | 3950901 |
Relative potency (binding) | = 4.5 | Relative potency to inhibit solubilized, partially purified rat liver HMG-CoA reductase compared with that of compactin. | ChEMBL. | 3950901 |
Relative potency (binding) | = 4.5 | Relative potency to inhibit solubilized, partially purified rat liver HMG-CoA reductase compared with that of compactin. | ChEMBL. | 3950901 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.