Detailed information for compound 669926

Basic information

Technical information
  • TDR Targets ID: 669926
  • Name: ZINC01126729
  • MW: 397.424 | Formula: C21H23N3O5
  • H donors: 1 H acceptors: 4 LogP: 2.45 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)CNC(=O)C1CCN(CC1)C(=O)c1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C21H23N3O5/c1-29-19-8-2-15(3-9-19)14-22-20(25)16-10-12-23(13-11-16)21(26)17-4-6-18(7-5-17)24(27)28/h2-9,16H,10-14H2,1H3,(H,22,25)
  • InChiKey: PGELLJGJMFIZFB-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0226 0.0374
Toxoplasma gondii Erv1 / Alr family protein 0.0033 0.0192 0.0355
Brugia malayi Augmenter of liver regeneration 0.0033 0.0192 0.0318
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0156 0.0258
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0033 0.0192 0.1667
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.1151 1
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0226 0.0821
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0033 0.0192 0.0355
Brugia malayi Glycosyl hydrolases family 31 protein 0.0484 0.6037 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0226 0.0374
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0352 0.0352
Loa Loa (eye worm) hypothetical protein 0.0066 0.0618 0.1023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0015 0.0025
Echinococcus granulosus geminin 0.0165 0.1898 0.3144
Mycobacterium tuberculosis Conserved protein 0.0036 0.0226 0.0821
Onchocerca volvulus 0.023 0.275 0.8104
Trypanosoma brucei glycosyl hydrolase-like protein 0.004 0.0277 0.2403
Brugia malayi nuclear hormone receptor 0.002 0.0015 0.0025
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0015 0.0028
Entamoeba histolytica hypothetical protein 0.0284 0.3445 0.6373
Loa Loa (eye worm) beta-lactamase 0.0036 0.0226 0.0374
Loa Loa (eye worm) hypothetical protein 0.004 0.0277 0.0458
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0015 0.0025
Loa Loa (eye worm) hypothetical protein 0.0036 0.0226 0.0374
Trichomonas vaginalis sucrase-isomaltase, putative 0.0107 0.1151 0.2129
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.054 0.3142
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0025
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.054 0.3142
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0352 0.0583
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0352 0.0651
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.004 0.0277 0.2403
Toxoplasma gondii ABC1 family protein 0.0036 0.0226 0.0417
Onchocerca volvulus 0.0036 0.0226 0.0624
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0025
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0226 0.0417
Schistosoma mansoni hypothetical protein 0.0031 0.0156 0.0288
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.1016 0.1682
Entamoeba histolytica hypothetical protein 0.0284 0.3445 0.6373
Trichomonas vaginalis deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.0435 0.5406 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0226 0.196
Entamoeba histolytica hypothetical protein 0.0435 0.5406 1
Brugia malayi ecdysteroid receptor 0.002 0.0015 0.0025
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.1151 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0015 0.0015
Loa Loa (eye worm) dUTP diphosphatase 0.0435 0.5406 0.8955
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0226 0.0417
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0156 0.0258
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.1592 0.2946
Loa Loa (eye worm) hypothetical protein 0.0029 0.0135 0.0223
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0435 0.5406 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0156 0.0156
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0226 0.0417
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0015 0.0025
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0277 0.0512
Echinococcus granulosus GPCR family 2 0.0031 0.0156 0.0258
Loa Loa (eye worm) hypothetical protein 0.0036 0.0226 0.0374
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0435 0.5406 1
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0015 0.0028
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0015 0.0028
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0277 0.0512
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0015 0.0025
Brugia malayi Pre-SET motif family protein 0.0029 0.0135 0.0223
Echinococcus multilocularis lysosomal alpha glucosidase 0.0484 0.6037 0.6037
Schistosoma mansoni hypothetical protein 0.0031 0.0156 0.0288
Toxoplasma gondii deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.0435 0.5406 1
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0277 0.0512
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.004 0.0277 0.0775
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0226 0.0821
Mycobacterium tuberculosis Possible penicillin-binding protein 0.023 0.2747 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0015 0.0028
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0015 0.0015
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0226 0.0821
Leishmania major glycosyl hydrolase-like protein 0.004 0.0277 0.2403
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0015 0.0028
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0107 0.1151 0.2129
Echinococcus multilocularis neutral alpha glucosidase AB 0.0107 0.1151 0.1151
Loa Loa (eye worm) hypothetical protein 0.0036 0.0226 0.0374
Leishmania major hypothetical protein, conserved 0.0033 0.0192 0.1667
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0015 0.0025
Schistosoma mansoni alpha-glucosidase 0.0416 0.5162 0.955
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0156 0.0258
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0025
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.2386 0.3953
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0033 0.0192 0.1667
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0277 0.0512
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0226 0.0821
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.054 0.0999
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0015 0.0025
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0033 0.0192 0.0355
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.1016 0.1682
Plasmodium falciparum deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0435 0.5406 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0107 0.1151 0.2129
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0121 0.02
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0025
Schistosoma mansoni alpha-glucosidase 0.0416 0.5162 0.955
Brugia malayi beta-lactamase family protein 0.0036 0.0226 0.0374
Brugia malayi steroid hormone receptor 0.002 0.0015 0.0025
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, putative 0.0151 0.1719 0.3179
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0277 0.0512
Onchocerca volvulus 0.0029 0.0135 0.0355
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.1541 0.2553
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0015 0.0025
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative 0.0435 0.5406 1
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0033 0.0192 0.0318
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0352 0.0583
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0226 0.0821
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0226 0.0226
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0015 0.0028
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0352 0.0352
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0015 0.0025
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0226 0.0417
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0135 0.0249
Echinococcus granulosus dUTP pyrophosphatase 0.0435 0.5406 0.8955
Entamoeba histolytica hypothetical protein 0.0435 0.5406 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0015 0.0025
Trichomonas vaginalis alpha-glucosidase, putative 0.0107 0.1151 0.2129
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.1592 0.2638
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0226 0.0374
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0226 0.0821
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0135 0.0249
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0352 0.0651
Brugia malayi Pre-SET motif family protein 0.0202 0.2386 0.3953
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0015 0.0025
Mycobacterium ulcerans beta-lactamase 0.0036 0.0226 0.1313
Mycobacterium tuberculosis Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase) 0.0151 0.1719 0.6256
Echinococcus granulosus FTZ F1 alpha 0.002 0.0015 0.0025
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0135 0.0249
Schistosoma mansoni coup transcription factor 0.002 0.0015 0.0028
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0226 0.0417
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.054 0.4692
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0297 0.055
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0226 0.1313
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.1016 0.1682
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0033 0.0192 0.0192
Trichomonas vaginalis maltase-glucoamylase, putative 0.0107 0.1151 0.2129
Toxoplasma gondii Erv1 / Alr family protein 0.0033 0.0192 0.0355
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0226 0.0374
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0015 0.0025
Loa Loa (eye worm) acetyltransferase 0.0141 0.1592 0.2638
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0252 0.0467
Onchocerca volvulus 0.028 0.3389 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0015 0.0025
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0352 0.0583
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0015 0.0025
Mycobacterium leprae PROBABLE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE DCD (DCTP DEAMINASE) 0.0151 0.1719 1
Schistosoma mansoni alpha glucosidase 0.0107 0.1151 0.2129
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0015 0.0025
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.054 0.054
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0015 0.0025
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0484 0.6037 1
Schistosoma mansoni thyroid hormone receptor 0.002 0.0015 0.0028
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.054 0.1966
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0435 0.5406 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0015 0.0025
Brugia malayi beta-lactamase 0.0036 0.0226 0.0374
Mycobacterium ulcerans deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0151 0.1719 1
Mycobacterium tuberculosis Conserved protein 0.0036 0.0226 0.0821
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0015 0.0025
Brugia malayi Glycosyl hydrolases family 31 protein 0.0107 0.1151 0.1907
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0297 0.0492
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0107 0.1151 0.2129
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0015 0.0015
Treponema pallidum deoxyuridine 5'-triphosphate nucleotidohydrolase (dut) 0.0435 0.5406 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0484 0.6037 1
Echinococcus multilocularis dUTP pyrophosphatase 0.0435 0.5406 0.5406
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0156 0.0258
Leishmania major hypothetical protein, conserved 0.0036 0.0226 0.196
Wolbachia endosymbiont of Brugia malayi deoxycytidine triphosphate deaminase 0.0151 0.1719 0.3179
Plasmodium vivax SET domain protein, putative 0.0029 0.0135 0.0249
Mycobacterium ulcerans lipase LipD 0.0036 0.0226 0.1313
Loa Loa (eye worm) hypothetical protein 0.0036 0.0226 0.0374
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0107 0.1151 0.2129
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0025
Brugia malayi beta-lactamase family protein 0.0036 0.0226 0.0374
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0015 0.0025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0015 0.0025
Schistosoma mansoni thyroid hormone receptor 0.002 0.0015 0.0028
Trichomonas vaginalis set domain proteins, putative 0.023 0.275 0.5086
Schistosoma mansoni hypothetical protein 0.0031 0.0156 0.0288
Schistosoma mansoni hypothetical protein 0.0031 0.0156 0.0288
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0297 0.055
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0015 0.0028
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0156 0.0258
Wolbachia endosymbiont of Brugia malayi dUTPase 0.0435 0.5406 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0015 0.0025
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.054 0.0999
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0015 0.0025
Echinococcus granulosus neutral alpha glucosidase AB 0.0107 0.1151 0.1907
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0226 0.0821
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.004 0.0277 0.2403
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.1592 0.1592
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0015 0.0025
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0277 0.0512
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0015 0.0025
Echinococcus multilocularis geminin 0.0165 0.1898 0.1898
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0252 0.0467
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0015 0.0015
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0226 0.196
Schistosoma mansoni hypothetical protein 0.0165 0.1898 0.3511
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0033 0.0192 0.1667
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0025
Loa Loa (eye worm) hypothetical protein 0.0031 0.0156 0.0258
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0277 0.0458
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0226 0.1313
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0015 0.0025
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0135 0.0135
Trichomonas vaginalis alpha-glucosidase, putative 0.0107 0.1151 0.2129
Trichomonas vaginalis esterase, putative 0.0036 0.0226 0.0417
Onchocerca volvulus 0.0036 0.0226 0.0624
Schistosoma mansoni nuclear hormone receptor 0.002 0.0015 0.0028
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0297 0.055
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0015 0.0028
Leishmania major alpha glucosidase II subunit, putative 0.0107 0.1151 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.054 0.3142
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0135 0.0135
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0435 0.5406 1
Onchocerca volvulus 0.0036 0.0226 0.0624
Plasmodium vivax deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.0435 0.5406 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0277 0.0512
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0277 0.0512
Schistosoma mansoni hypothetical protein 0.0165 0.1898 0.3511
Trypanosoma brucei glucosidase, putative 0.0107 0.1151 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0015 0.0025
Brugia malayi dUTP diphosphatase 0.0435 0.5406 0.8955
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0025
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0226 0.196
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0025
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0015 0.0025
Entamoeba histolytica hypothetical protein 0.0151 0.1719 0.3179
Trichomonas vaginalis alpha-glucosidase, putative 0.0107 0.1151 0.2129
Echinococcus multilocularis GPCR, family 2 0.0031 0.0156 0.0156
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0226 0.0417
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0135 0.0223
Schistosoma mansoni hypothetical protein 0.0066 0.0618 0.1142
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0015 0.0025
Chlamydia trachomatis deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0435 0.5406 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0135 0.0249
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.054 0.0895
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0107 0.1151 0.2129
Echinococcus multilocularis lysosomal alpha glucosidase 0.0484 0.6037 0.6037
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0036 0.0226 0.0374
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0618 0.1023
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0107 0.1151 0.2129
Trichomonas vaginalis alpha-glucosidase, putative 0.0107 0.1151 0.2129
Loa Loa (eye worm) hepatopoietin HPO2 0.0033 0.0192 0.0318
Mycobacterium ulcerans hypothetical protein 0.0036 0.0226 0.1313
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0297 0.055
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0015 0.0015
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0252 1
Brugia malayi nuclear receptor NHR-88 0.002 0.0015 0.0025
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0297 0.055
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0015 0.0025
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.054 0.0999
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0277 0.0512
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0015 0.0025
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0135 0.0249
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0352 0.0651
Schistosoma mansoni deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0435 0.5406 1
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0226 0.0417
Mycobacterium tuberculosis Conserved protein 0.0036 0.0226 0.0821
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0226 0.0417
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0156 0.0156
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0033 0.0192 0.1667
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0015 0.0028
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0015 0.0015
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0352 0.0583
Loa Loa (eye worm) hypothetical protein 0.0097 0.1016 0.1682
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0107 0.1151 0.1907
Entamoeba histolytica deoxycytidine triphosphate deaminase, putative 0.0151 0.1719 0.3179
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0015 0.0025
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative 0.0435 0.5406 1
Mycobacterium ulcerans deoxycytidine triphosphate deaminase 0.0151 0.1719 1
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0015 0.0025
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0015 0.0025

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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