Detailed information for compound 669943

Basic information

Technical information
  • TDR Targets ID: 669943
  • Name: methyl 2-(6-chloro-4-ethyl-2-oxochromen-7-yl) oxy-2-phenylacetate
  • MW: 372.799 | Formula: C20H17ClO5
  • H donors: 0 H acceptors: 2 LogP: 4.47 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)C(c1ccccc1)Oc1cc2oc(=O)cc(c2cc1Cl)CC
  • InChi: 1S/C20H17ClO5/c1-3-12-9-18(22)25-16-11-17(15(21)10-14(12)16)26-19(20(23)24-2)13-7-5-4-6-8-13/h4-11,19H,3H2,1-2H3
  • InChiKey: UNKRSKZDPIIBDI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl 2-(6-chloro-4-ethyl-2-oxo-chromen-7-yl)oxy-2-phenyl-acetate
  • 2-[(6-chloro-4-ethyl-2-oxo-7-chromenyl)oxy]-2-phenylacetic acid methyl ester
  • 2-(6-chloro-4-ethyl-2-keto-chromen-7-yl)oxy-2-phenyl-acetic acid methyl ester
  • methyl 2-(6-chloro-4-ethyl-2-oxo-chromen-7-yl)oxy-2-phenyl-ethanoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi jmjC domain containing protein 0.0103 0.0914 0.0907
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0037 0.0037
Trichomonas vaginalis glutaminase, putative 0.0266 0.2643 0.2615
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0037 0.0097
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0934 0.0901
Loa Loa (eye worm) hypothetical protein 0.0021 0.0034 0.0001
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.1767 0.1737
Trypanosoma brucei DNA polymerase eta, putative 0.0279 0.2782 0.2756
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0577 0.0569
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0033 0.0169 0.0135
Trypanosoma brucei DNA polymerase kappa, putative 0.0192 0.1861 0.183
Schistosoma mansoni hypothetical protein 0.0032 0.0149 0.0115
Echinococcus granulosus dna polymerase kappa 0.0279 0.2782 0.2758
Loa Loa (eye worm) hypothetical protein 0.0072 0.0577 0.0545
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.0069 0.0035
Onchocerca volvulus 0.0179 0.1717 0.1689
Echinococcus granulosus serine protein kinase ATM 0.0024 0.0069 0.0035
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1045 0.1015
Trichomonas vaginalis glucosylceramidase, putative 0.028 0.2792 0.2765
Plasmodium falciparum thioredoxin reductase 0.0044 0.0279 0.2407
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0044 0.0279 0.2407
Trypanosoma cruzi DNA polymerase kappa, putative 0.0279 0.2782 0.2782
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0037 0.0003
Trichomonas vaginalis CAMK family protein kinase 0.0957 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0037 0.0029
Echinococcus granulosus expressed protein 0.0036 0.0194 0.016
Echinococcus multilocularis mixed lineage leukemia protein mll 0.003 0.0129 0.0095
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0934 0.0901
Brugia malayi latrophilin 2 splice variant baaae 0.0106 0.0942 0.0934
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0577 0.1965
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0577 0.1693
Plasmodium falciparum phd finger protein, putative 0.0032 0.0149 0.1286
Brugia malayi EGF-like domain containing protein 0.0024 0.007 0.0062
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0037 0.0029
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0044 0.0279 0.088
Echinococcus granulosus integrin alpha 3 0.0045 0.0291 0.0257
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0037 0.0097
Brugia malayi TAR-binding protein 0.0062 0.047 0.0462
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0034 0.0001
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0036 0.0194 0.0186
Loa Loa (eye worm) hypothetical protein 0.0024 0.007 0.0037
Echinococcus granulosus integrin alpha ps 0.0094 0.0809 0.0778
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0036 0.0194 0.0161
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.0934 0.0904
Echinococcus granulosus fibrillin 1 0.0024 0.007 0.0036
Onchocerca volvulus Glucosylceramidase homolog 0.0184 0.1767 0.1739
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0783 0.8154 0.8148
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0035 0.0185 0.0148
Brugia malayi RNA binding protein 0.0062 0.047 0.0462
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0279 0.2782 0.2756
Leishmania major hypothetical protein, conserved 0.0033 0.0169 0.0169
Toxoplasma gondii Erv1 / Alr family protein 0.0033 0.0169 0.0604
Echinococcus multilocularis adam 0.0024 0.007 0.0036
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.022 0.0186
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0034 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0069 0.0032
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0116 0.0079
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0044 0.0279 0.0279
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0101 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.0279 0.2782 0.2756
Brugia malayi 6-phosphofructokinase 0.0105 0.0934 0.0927
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0957 1 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0037 0.0037
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.0279 0.0279
Brugia malayi ImpB/MucB/SamB family protein 0.0279 0.2782 0.2776
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0288 0.288 0.8936
Mycobacterium ulcerans DNA polymerase IV 0.0279 0.2782 1
Echinococcus multilocularis integrin alpha 3 0.0045 0.0291 0.0257
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.0279 0.0279
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0957 1 1
Toxoplasma gondii cathepsin CPC1 0.0114 0.103 0.4544
Echinococcus granulosus geminin 0.0349 0.3527 0.3504
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0034 0.0001
Schistosoma mansoni integrin alpha-ps 0.0094 0.0809 0.0778
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0034 0.0026
Brugia malayi hypothetical protein 0.0028 0.0116 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0101 0.0064
Loa Loa (eye worm) hypothetical protein 0.0054 0.039 0.0357
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0044 0.0279 0.0245
Schistosoma mansoni integrin alpha-ps 0.0049 0.0332 0.0298
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.1767 0.1737
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0037 0.0097
Schistosoma mansoni hypothetical protein 0.0349 0.3527 0.3504
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0044 0.0279 0.5
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0098 0.0098
Schistosoma mansoni hypothetical protein 0.0045 0.0291 0.0257
Echinococcus multilocularis tar DNA binding protein 0.0062 0.047 0.0437
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0101 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.0279 0.2782 0.2756
Echinococcus granulosus fibrillin 2 0.0024 0.007 0.0036
Trichomonas vaginalis DNA polymerase eta, putative 0.0279 0.2782 0.2756
Schistosoma mansoni hypothetical protein 0.0049 0.0335 0.0302
Loa Loa (eye worm) hypothetical protein 0.0045 0.0291 0.0258
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0116 0.0079
Schistosoma mansoni tar DNA-binding protein 0.0062 0.047 0.0437
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0136 0.1264 0.1233
Trypanosoma brucei unspecified product 0.0192 0.1861 0.183
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0105 0.0934 0.2817
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.0069 0.0035
Trypanosoma cruzi DNA polymerase eta, putative 0.0279 0.2782 0.2782
Onchocerca volvulus 0.0021 0.0037 0.0003
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0934 0.0901
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0033 0.0033
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0116 0.0116
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0044 0.0279 0.2407
Leishmania major DNA polymerase eta, putative 0.0087 0.0735 0.0735
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0149 0.0513
Schistosoma mansoni jumonji/arid domain-containing protein 0.0045 0.0293 0.0259
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0934 0.0901
Schistosoma mansoni serine/threonine protein kinase 0.0957 1 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0957 1 1
Onchocerca volvulus 0.0021 0.0037 0.0003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.1264 0.1233
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0149 0.0115
Schistosoma mansoni cpg binding protein 0.0126 0.1157 0.1126
Onchocerca volvulus Serine\/threonine kinase homolog 0.0957 1 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.032 0.3222 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0034 0.0001
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0037 0.0206 0.0173
Echinococcus granulosus dna polymerase eta 0.0279 0.2782 0.2758
Trypanosoma cruzi DNA polymerase eta, putative 0.0087 0.0735 0.0735
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0034 0.0026
Brugia malayi glutathione reductase 0.0126 0.1157 0.115
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0033 0.0169 0.0169
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0034 0.0026
Brugia malayi glutaminase DH11.1 0.0266 0.2643 0.2636
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0098 0.0065
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0335 0.0302
Giardia lamblia DNA damage repair protein 0.0087 0.0735 0.0669
Trichomonas vaginalis rotamase, putative 0.0036 0.0194 0.0157
Schistosoma mansoni terminal deoxycytidyl transferase 0.0279 0.2782 0.2758
Plasmodium vivax DNA repair protein REV1, putative 0.0087 0.0735 0.6346
Schistosoma mansoni tar DNA-binding protein 0.0062 0.047 0.0437
Loa Loa (eye worm) jmjC domain-containing protein 0.0045 0.0293 0.026
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0034 0.0026
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.008 0.066 0.0628
Mycobacterium ulcerans hypothetical protein 0.0087 0.0735 0.2541
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0069 0.0061
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0044 0.0279 0.0271
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0034 0.0026
Brugia malayi ImpB/MucB/SamB family protein 0.0279 0.2782 0.2776
Onchocerca volvulus 0.0021 0.0037 0.0003
Trichomonas vaginalis glutathione reductase, putative 0.0044 0.0279 0.0243
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0098 0.028
Giardia lamblia DINP protein human, muc B family 0.0279 0.2782 0.2731
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0352 0.1077
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0577 0.0569
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0185 0.0185
Loa Loa (eye worm) hypothetical protein 0.01 0.0876 0.0846
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0098 0.0846
Echinococcus granulosus tar DNA binding protein 0.0062 0.047 0.0437
Leishmania major DNA polymerase eta, putative 0.0279 0.2782 0.2782
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0098 0.0061
Brugia malayi phosphofructokinase 0.0105 0.0934 0.0927
Trypanosoma brucei DNA polymerase kappa, putative 0.0279 0.2782 0.2756
Echinococcus granulosus thioredoxin glutathione reductase 0.0128 0.1175 0.1145
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0279 0.2782 0.2758
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0044 0.0279 0.1106
Mycobacterium tuberculosis Probable oxidoreductase 0.032 0.3222 1
Entamoeba histolytica hypothetical protein 0.008 0.066 0.0625
Echinococcus multilocularis dna polymerase eta 0.0279 0.2782 0.2758
Trypanosoma brucei DNA polymerase kappa, putative 0.0279 0.2782 0.2756
Schistosoma mansoni jumonji domain containing protein 0.0082 0.0688 0.0656
Plasmodium vivax acyl-CoA synthetase, putative 0.0054 0.0384 0.3311
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0279 0.2782 0.2758
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0034 0.0026
Trypanosoma brucei hypothetical protein, conserved 0.0087 0.0735 0.07
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.0934 0.0934
Toxoplasma gondii peptidylprolyl isomerase 0.0035 0.0185 0.0676
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0033 0.0169 0.1459
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0352 0.1077
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0194 0.0157
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.1767 0.1737
Brugia malayi ecdysteroid receptor 0.0021 0.0034 0.0026
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0044 0.0279 0.609
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0335 0.0303
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0087 0.0735 0.3193
Loa Loa (eye worm) hypothetical protein 0.0021 0.0037 0.0004
Brugia malayi PHD-finger family protein 0.0032 0.0149 0.0141
Echinococcus granulosus adam 0.0024 0.007 0.0036
Brugia malayi Integrin beta pat-3 precursor 0.0556 0.573 0.5727
Echinococcus granulosus lysine specific demethylase 5A 0.0045 0.0293 0.0259
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0116 0.0079
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0105 0.0934 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0288 0.288 0.8936
Trypanosoma brucei DNA polymerase kappa, putative 0.0192 0.1861 0.183
Schistosoma mansoni transcription factor LCR-F1 0.008 0.066 0.0628
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0103 0.0914 0.0883
Loa Loa (eye worm) hypothetical protein 0.0021 0.0034 0.0001
Plasmodium vivax thioredoxin reductase, putative 0.0126 0.1157 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0037 0.0097
Echinococcus multilocularis GPCR, family 2 0.0049 0.0335 0.0302
Trypanosoma brucei DNA polymerase kappa, putative 0.0279 0.2782 0.2756
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0069 0.0069
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0279 0.2782 0.2758
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0034 0.0026
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0114 0.103 0.8898
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.0934 0.0904
Brugia malayi nuclear receptor NHR-88 0.0021 0.0034 0.0026
Giardia lamblia NADH oxidase lateral transfer candidate 0.0044 0.0279 0.021
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0032 0.0155 0.0147
Trypanosoma cruzi polo-like protein kinase, putative 0.0957 1 1
Mycobacterium ulcerans hypothetical protein 0.0072 0.0577 0.1965
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0577 0.1965
Echinococcus multilocularis cpg binding protein 0.0126 0.1157 0.1126
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0136 0.1264 0.1233
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0288 0.288 0.8936
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0934 0.0901
Mycobacterium tuberculosis Possible toxin MazF1 0.0154 0.1449 0.4487
Giardia lamblia Kinase, PLK 0.0957 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0116 0.0116
Trypanosoma brucei DNA polymerase IV, putative 0.0279 0.2782 0.2756
Trypanosoma cruzi trypanothione reductase, putative 0.0044 0.0279 0.0279
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0101 0.0064
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0149 0.0513
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0072 0.0577 0.1965
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0185 0.0185
Mycobacterium ulcerans DNA polymerase IV 0.0279 0.2782 1
Leishmania major ATP-dependent phosphofructokinase 0.0105 0.0934 0.0934
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0507 0.0475
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0028 0.0116 0.0361
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0149 0.0116
Schistosoma mansoni kinase 0.0486 0.499 0.4973
Loa Loa (eye worm) glutaminase 2 0.0266 0.2643 0.2618
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.1767 0.1737
Brugia malayi F/Y-rich N-terminus family protein 0.0047 0.0311 0.0303
Trypanosoma cruzi DNA damage repair protein, putative 0.0087 0.0735 0.0735
Loa Loa (eye worm) hypothetical protein 0.0087 0.0735 0.0704
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0577 0.0577
Mycobacterium tuberculosis Possible toxin MazF7 0.0154 0.1449 0.4487
Loa Loa (eye worm) hypothetical protein 0.0072 0.0577 0.0545
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0114 0.103 0.8898
Loa Loa (eye worm) hypothetical protein 0.0054 0.0384 0.0351
Leishmania major DNA damage repair protein, putative 0.0087 0.0735 0.0735
Loa Loa (eye worm) hypothetical protein 0.0054 0.0384 0.0351
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0037 0.0037
Echinococcus multilocularis expressed protein 0.0036 0.0194 0.016
Trypanosoma brucei unspecified product 0.0192 0.1861 0.183
Brugia malayi 6-phosphofructokinase 0.0105 0.0934 0.0927
Trichomonas vaginalis CAMK family protein kinase 0.0957 1 1
Trypanosoma brucei DNA damage repair protein, putative 0.0087 0.0735 0.07
Loa Loa (eye worm) hypothetical protein 0.0049 0.0332 0.0299
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0037 0.0097
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0044 0.0279 0.0243
Trypanosoma brucei DNA damage repair protein, putative 0.0087 0.0735 0.07
Loa Loa (eye worm) integrin beta-2 0.0556 0.573 0.5716
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0028 0.0116 0.0079
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0098 0.0061
Toxoplasma gondii preprocathepsin c precursor, putative 0.0114 0.103 0.4544
Schistosoma mansoni hypothetical protein 0.008 0.066 0.0628
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.01 0.0876 0.0845
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1045 0.1015
Schistosoma mansoni integrin beta subunit 0.0442 0.4516 0.4498
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0028 0.0116 0.0046
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0037 0.0318
Trypanosoma brucei DNA polymerase kappa, putative 0.0192 0.1861 0.183
Giardia lamblia PHD finger protein 15 0.0032 0.0149 0.0079
Loa Loa (eye worm) hypothetical protein 0.0021 0.0034 0.0001
Toxoplasma gondii histone lysine methyltransferase SET1 0.0226 0.2222 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0279 0.2782 0.2782
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0044 0.0279 0.0243
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0044 0.0279 0.0279
Mycobacterium tuberculosis Toxin MazF3 0.0154 0.1449 0.4487
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0034 0.0026
Trichomonas vaginalis rotamase, putative 0.0035 0.0185 0.0148
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.01 0.0876 0.0845
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0037 0.0097
Echinococcus multilocularis dna polymerase kappa 0.0279 0.2782 0.2758
Trypanosoma brucei DNA polymerase kappa, putative 0.0279 0.2782 0.2756
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0577 0.0577
Trypanosoma brucei DNA polymerase kappa, putative 0.0279 0.2782 0.2756
Brugia malayi hypothetical protein 0.0179 0.1717 0.171
Echinococcus granulosus jumonji domain containing protein 0.0044 0.0281 0.0247
Loa Loa (eye worm) hypothetical protein 0.0024 0.007 0.0037
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0114 0.103 0.8898
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0577 0.0541
Trypanosoma cruzi polo-like protein kinase, putative 0.0957 1 1
Brugia malayi CXXC zinc finger family protein 0.0119 0.1085 0.1077
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0335 0.0327
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0101 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0101 0.0064
Schistosoma mansoni cpg binding protein 0.0119 0.1085 0.1054
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0101 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.0279 0.2782 0.2756
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0037 0.0206 0.0173
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0034 0.0001
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.003 0.0129 0.0095
Trichomonas vaginalis CAMK family protein kinase 0.0957 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.0279 0.2782 0.2756
Leishmania major trypanothione reductase 0.0126 0.1157 0.1157
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0098 0.0028
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0101 0.0064
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0632 0.6543 0.654
Brugia malayi Thioredoxin reductase 0.0126 0.1157 0.115
Trichomonas vaginalis glucosylceramidase, putative 0.028 0.2792 0.2765
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0105 0.0934 0.2887
Trypanosoma brucei DNA polymerase kappa, putative 0.0279 0.2782 0.2756
Trypanosoma brucei polo-like protein kinase 0.0957 1 1
Brugia malayi hypothetical protein 0.0114 0.1027 0.1019
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0957 1 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0149 0.0116
Mycobacterium tuberculosis Conserved hypothetical protein 0.0279 0.2782 0.8634
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0126 0.1157 0.358
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0149 0.1286
Loa Loa (eye worm) hypothetical protein 0.0279 0.2782 0.2758
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0352 0.1077
Mycobacterium tuberculosis Conserved protein 0.0154 0.1449 0.4487
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0044 0.0279 0.2407
Onchocerca volvulus 0.0021 0.0037 0.0003
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0044 0.0279 0.0245
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0034 0.0026
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0033 0.0169 0.0132
Trypanosoma cruzi hypothetical protein, conserved 0.0087 0.0735 0.0735
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0033 0.0169 0.0135
Brugia malayi Augmenter of liver regeneration 0.0033 0.0169 0.0161
Trichomonas vaginalis glucosylceramidase, putative 0.028 0.2792 0.2765
Brugia malayi EGF-like domain containing protein 0.0024 0.007 0.0062
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0116 0.0999
Loa Loa (eye worm) hypothetical protein 0.0024 0.007 0.0037
Echinococcus multilocularis integrin alpha ps 0.0094 0.0809 0.0778
Trypanosoma brucei chrX additional, unordered contigs 0.0087 0.0735 0.07
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.0279 0.0279
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0288 0.288 0.8925
Brugia malayi Trypsin family protein 0.01 0.0876 0.0868
Trypanosoma brucei unspecified product 0.0279 0.2782 0.2756
Schistosoma mansoni DNA polymerase eta 0.0279 0.2782 0.2758
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0288 0.288 0.8936
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0072 0.0577 0.1965
Entamoeba histolytica hypothetical protein 0.008 0.066 0.0625
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0116 0.0999
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0054 0.0384 0.1174
Echinococcus multilocularis protein jagged 2 0.0024 0.007 0.0036
Loa Loa (eye worm) hypothetical protein 0.0049 0.0332 0.0299
Loa Loa (eye worm) glutathione reductase 0.0126 0.1157 0.1128
Plasmodium vivax glutathione reductase, putative 0.0126 0.1157 1
Trichomonas vaginalis hypothetical protein 0.0024 0.007 0.0033
Echinococcus granulosus integrin alpha ps 0.0045 0.0291 0.0257
Trichomonas vaginalis CAMK family protein kinase 0.0957 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.0279 0.2782 0.2756
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.1264 0.1233
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0033 0.0169 0.0169
Loa Loa (eye worm) TAR-binding protein 0.0062 0.047 0.0438
Loa Loa (eye worm) hypothetical protein 0.0114 0.1027 0.0997
Plasmodium falciparum flap endonuclease 1 0.0027 0.0098 0.0846
Loa Loa (eye worm) hypothetical protein 0.0632 0.6543 0.6531
Brugia malayi Integrin alpha pat-2 precursor 0.0094 0.0809 0.0802
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0044 0.0279 0.0243
Schistosoma mansoni hypothetical protein 0.0049 0.0335 0.0302
Echinococcus multilocularis 6 phosphofructokinase 0.0105 0.0934 0.0903
Echinococcus granulosus GPCR family 2 0.0049 0.0335 0.0302
Trypanosoma cruzi hypothetical protein, conserved 0.0087 0.0735 0.0735
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0072 0.0577 0.1965
Toxoplasma gondii thioredoxin reductase 0.0126 0.1157 0.5128
Mycobacterium ulcerans hypothetical protein 0.0154 0.1449 0.5142
Toxoplasma gondii Erv1 / Alr family protein 0.0033 0.0169 0.0604
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0957 1 1
Loa Loa (eye worm) glutaminase 0.0266 0.2643 0.2618
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0037 0.0097
Brugia malayi nuclear hormone receptor 0.0021 0.0034 0.0026
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0577 0.1693
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.003 0.0129 0.0095
Toxoplasma gondii 6-phosphofructokinase 0.0028 0.0116 0.0361
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.047 0.0438
Loa Loa (eye worm) hypothetical protein 0.0021 0.0034 0.0001
Schistosoma mansoni hypothetical protein 0.0049 0.0335 0.0302
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0116 0.0996
Echinococcus multilocularis geminin 0.0349 0.3527 0.3504
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0044 0.0279 0.0279
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0116 0.0996
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0037 0.0004
Trichomonas vaginalis glucosylceramidase, putative 0.028 0.2792 0.2765
Onchocerca volvulus 0.01 0.0876 0.0845
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0101 0.0064
Echinococcus granulosus 6 phosphofructokinase 0.0105 0.0934 0.0903
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0136 0.1264 0.1234
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0034 0.0026
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0114 0.103 0.0999
Schistosoma mansoni rotamase 0.0036 0.0194 0.016
Schistosoma mansoni tar DNA-binding protein 0.0062 0.047 0.0437
Leishmania major DNA polymerase kappa, putative 0.0087 0.0735 0.0735
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0021 0.0034 0.0001
Plasmodium falciparum glutathione reductase 0.0126 0.1157 1
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0037 0.0003
Loa Loa (eye worm) hypothetical protein 0.0054 0.0384 0.0351
Onchocerca volvulus 0.0024 0.007 0.0036
Entamoeba histolytica hypothetical protein 0.008 0.066 0.0625
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.1873 0.1842
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0035 0.0185 0.0148
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0037 0.0029
Schistosoma mansoni integrin alpha 0.0094 0.0809 0.0778
Mycobacterium tuberculosis Probable reductase 0.0288 0.288 0.8936
Loa Loa (eye worm) integrin alpha pat-2 0.0094 0.0809 0.0779
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.1767 0.1737
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0577 0.0569
Plasmodium falciparum DNA repair protein REV1, putative 0.0087 0.0735 0.6346
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0279 0.2782 0.2782
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0054 0.0384 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0335 0.0302
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0044 0.0279 0.0245
Onchocerca volvulus 0.0089 0.0765 0.0733
Toxoplasma gondii NADPH-glutathione reductase 0.0044 0.0279 0.1106
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0034 0.0001
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.0384 0.1261
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0037 0.0037
Mycobacterium tuberculosis Toxin MazF2 0.0154 0.1449 0.4487
Echinococcus multilocularis peregrin 0.0032 0.0149 0.0115
Mycobacterium tuberculosis Possible toxin MazF5 0.0154 0.1449 0.4487
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0103 0.0914 0.0883
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.0281 0.0247
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0037 0.0097
Schistosoma mansoni tar DNA-binding protein 0.0062 0.047 0.0437
Brugia malayi Flap endonuclease-1 0.0027 0.0098 0.009
Echinococcus granulosus cpg binding protein 0.0126 0.1157 0.1126
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.032 0.3222 1
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.0934 0.0901
Trichomonas vaginalis CAMK family protein kinase 0.0957 1 1
Loa Loa (eye worm) hypothetical protein 0.0179 0.1717 0.169
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0098 0.0061
Loa Loa (eye worm) oxidoreductase 0.0021 0.0037 0.0004
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0279 0.2782 0.2758
Brugia malayi hypothetical protein 0.008 0.066 0.0652
Loa Loa (eye worm) hypothetical protein 0.0072 0.0577 0.0545
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0034 0.0026
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0037 0.0318
Brugia malayi EGF-like domain containing protein 0.0024 0.007 0.0062
Onchocerca volvulus 0.0072 0.0577 0.0544
Loa Loa (eye worm) hypothetical protein 0.0021 0.0037 0.0004
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0037 0.0037
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.047 0.0462
Trichomonas vaginalis mercuric reductase, putative 0.0044 0.0279 0.0243
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.028 0.2792 0.2767
Brugia malayi steroid hormone receptor 0.0021 0.0034 0.0026
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0044 0.0279 0.5
Schistosoma mansoni glutaminase 0.0266 0.2643 0.2617
Onchocerca volvulus Alhambra homolog 0.0032 0.0149 0.0115
Echinococcus granulosus integrin beta 2 0.0556 0.573 0.5715
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.0934 0.0903
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.028 0.2792 0.2786
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0934 0.0901
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0024 0.007 0.0033
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0037 0.0097
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0044 0.0279 0.0279
Echinococcus multilocularis thioredoxin glutathione reductase 0.0128 0.1175 0.1145
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.008 0.066 0.0628
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0028 0.0116 0.0079
Schistosoma mansoni cpg binding protein 0.0126 0.1157 0.1126
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0045 0.0291 0.0282
Trichomonas vaginalis CAMK family protein kinase 0.0474 0.4856 0.4837
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0037 0.0003
Loa Loa (eye worm) hypothetical protein 0.0106 0.0942 0.0911
Schistosoma mansoni hypothetical protein 0.0106 0.0942 0.091
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0098 0.0064
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0136 0.1264 0.1256
Brugia malayi MH2 domain containing protein 0.0116 0.1045 0.1037
Onchocerca volvulus 0.0119 0.1085 0.1054
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0116 0.0359
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0116 0.0999
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0087 0.0735 0.3193
Trypanosoma brucei trypanothione reductase 0.0126 0.1157 0.1124
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0116 0.0079
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0044 0.0279 0.0848
Schistosoma mansoni integrin alpha-4 0.04 0.4074 0.4054
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0044 0.0279 0.0279
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0735 0.07
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.032 0.3222 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0136 0.1264 0.1233
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0098 0.0098
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0735 0.07
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0032 0.0155 0.0147
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0279 0.2782 0.8634
Echinococcus granulosus flap endonuclease 1 0.0027 0.0098 0.0064
Loa Loa (eye worm) hypothetical protein 0.0049 0.0335 0.0303
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0033 0.0169 0.0169
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0034 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0101 0.0064
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.0279 0.0279
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.0069 0.0032
Trichomonas vaginalis CAMK family protein kinase 0.0957 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0034 0.0026
Mycobacterium tuberculosis Probable dehydrogenase 0.0288 0.288 0.8936
Toxoplasma gondii phosphofructokinase PFKII 0.0028 0.0116 0.0361
Entamoeba histolytica acyl-coA synthetase, putative 0.0072 0.0577 0.0541
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0526 0.5414 0.5399
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0044 0.0279 0.0243
Echinococcus multilocularis fibrillin 2 0.0024 0.007 0.0036
Echinococcus multilocularis integrin alpha ps 0.0045 0.0291 0.0257
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0577 0.1965
Trypanosoma cruzi trypanothione reductase, putative 0.0126 0.1157 0.1157
Schistosoma mansoni flap endonuclease-1 0.0024 0.0071 0.0037
Entamoeba histolytica hypothetical protein 0.0024 0.0069 0.0032
Schistosoma mansoni jumonji/arid domain-containing protein 0.0045 0.0293 0.0259
Loa Loa (eye worm) hypothetical protein 0.0021 0.0034 0.0001
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0044 0.0279 0.088
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0034 0.0001
Trichomonas vaginalis glucosylceramidase, putative 0.028 0.2792 0.2765
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0101 0.0064
Loa Loa (eye worm) histone methyltransferase 0.0037 0.0206 0.0174
Trypanosoma brucei hypothetical protein, conserved 0.0087 0.0735 0.07
Trichomonas vaginalis CAMK family protein kinase 0.0957 1 1
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0033 0.0169 0.1459
Leishmania major DNA polymerase kappa, putative 0.0279 0.2782 0.2782
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0044 0.0279 0.088
Toxoplasma gondii hypothetical protein 0.0024 0.007 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0101 0.0064
Echinococcus multilocularis dnaJ subfamily B 0.0864 0.9011 0.9007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0101 0.0064
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0116 0.0079
Trichomonas vaginalis glucosylceramidase, putative 0.028 0.2792 0.2765
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0037 0.0097
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0101 0.0064
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0335 0.0327
Loa Loa (eye worm) hypothetical protein 0.0021 0.0034 0.0001
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0114 0.103 0.8898
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0037 0.0029
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.0279 0.0279
Schistosoma mansoni DNA polymerase IV / kappa 0.0087 0.0735 0.0703
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0136 0.1264 0.1233
Echinococcus multilocularis fibrillin 1 0.0024 0.007 0.0036
Toxoplasma gondii FATC domain-containing protein 0.0024 0.0069 0.0147
Plasmodium falciparum thioredoxin reductase 0.0126 0.1157 1
Treponema pallidum NADH oxidase 0.0044 0.0279 0.199
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0034 0.0001
Echinococcus granulosus dnaJ subfamily B 0.0864 0.9011 0.9007
Loa Loa (eye worm) phosphofructokinase 0.0105 0.0934 0.0904
Echinococcus granulosus mixed lineage leukemia protein mll 0.003 0.0129 0.0095
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0035 0.0185 0.0185
Plasmodium falciparum glutathione reductase 0.0044 0.0279 0.2407
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0116 0.0079
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0037 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0034 0.0026
Mycobacterium tuberculosis Possible toxin MazF4 0.0154 0.1449 0.4487
Trichomonas vaginalis helicase, putative 0.0027 0.0101 0.0064
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0037 0.0029
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0577 0.0541
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.0934 0.0903
Leishmania major hypothetical protein, conserved 0.0028 0.0116 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0101 0.0064
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0116 0.0999
Mycobacterium tuberculosis Toxin MazF9 0.0154 0.1449 0.4487
Mycobacterium ulcerans glutaminase 0.0266 0.2643 0.9491
Schistosoma mansoni hypothetical protein 0.0864 0.9011 0.9007
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0044 0.0279 0.0279
Trypanosoma cruzi DNA damage repair protein, putative 0.0087 0.0735 0.0735
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0037 0.0097
Brugia malayi Kelch motif family protein 0.0114 0.1027 0.1019
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0116 0.0996
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0101 0.0064
Loa Loa (eye worm) hypothetical protein 0.0054 0.0384 0.0351
Loa Loa (eye worm) RNA binding protein 0.0062 0.047 0.0438
Brugia malayi EGF-like domain containing protein 0.0024 0.007 0.0062
Loa Loa (eye worm) CXXC zinc finger family protein 0.0119 0.1085 0.1055
Brugia malayi Bromodomain containing protein 0.0032 0.0149 0.0141
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0149 0.0115
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0087 0.0735 0.3193
Entamoeba histolytica deoxycytidyl transferase, putative 0.0279 0.2782 0.2756
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0577 0.0577
Loa Loa (eye worm) hypothetical protein 0.0024 0.007 0.0037
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0101 0.0064
Loa Loa (eye worm) hypothetical protein 0.0045 0.0291 0.0258
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0072 0.0577 0.1774
Trypanosoma cruzi DNA polymerase kappa, putative 0.0279 0.2782 0.2782
Schistosoma mansoni hypothetical protein 0.0049 0.0335 0.0302
Brugia malayi polk-prov protein 0.0087 0.0735 0.0727
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0253 0.251 0.2484
Trichomonas vaginalis CAMK family protein kinase 0.0474 0.4856 0.4837
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.1767 0.1737
Schistosoma mansoni hypothetical protein 0.0349 0.3527 0.3504
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0034 0.0001
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.1767 0.1737
Brugia malayi Calcitonin receptor-like protein seb-1 0.0155 0.1464 0.1457
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0526 0.5414 0.5399
Schistosoma mansoni tar DNA-binding protein 0.0062 0.047 0.0437
Brugia malayi jmjC domain containing protein 0.0045 0.0293 0.0284
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.0577 0.1774
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0114 0.1027 0.0997
Loa Loa (eye worm) thioredoxin reductase 0.0126 0.1157 0.1128
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0114 0.103 0.0966
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0155 0.1464 0.1435
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.0279 0.0279
Trypanosoma cruzi DNA polymerase kappa, putative 0.0279 0.2782 0.2782
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0114 0.103 0.0996
Echinococcus granulosus peregrin 0.0032 0.0149 0.0115
Loa Loa (eye worm) hypothetical protein 0.0028 0.0116 0.0083
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0037 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0034 0.0026
Echinococcus multilocularis integrin beta 2 0.0556 0.573 0.5715
Mycobacterium ulcerans 6-phosphofructokinase 0.0105 0.0934 0.3268
Schistosoma mansoni mixed-lineage leukemia protein mll 0.004 0.0239 0.0205
Loa Loa (eye worm) hepatopoietin HPO2 0.0033 0.0169 0.0136
Echinococcus multilocularis integrin alpha ps 0.0094 0.0809 0.0778
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0934 0.0901
Mycobacterium tuberculosis Toxin MazF6 0.0154 0.1449 0.4487
Loa Loa (eye worm) hypothetical protein 0.01 0.0876 0.0846
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0044 0.0279 0.2407
Plasmodium falciparum acyl-CoA synthetase 0.0054 0.0384 0.3311
Loa Loa (eye worm) hypothetical protein 0.0054 0.0384 0.0351
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0034 0.0001
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0072 0.0577 0.1965
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0149 0.0115
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0037 0.0037
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0116 0.0079
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0352 0.1077
Trypanosoma brucei DNA polymerase kappa, putative 0.0279 0.2782 0.2756
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.1873 0.1842
Entamoeba histolytica hypothetical protein 0.008 0.066 0.0625
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.1264 0.1233

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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