Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0068 | 0.0543 | 0.0018 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0106 | 0.1708 | 0.327 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0059 | 0.0279 | 0.0285 |
Echinococcus granulosus | thymidylate synthase | 0.0106 | 0.1708 | 0.1247 |
Brugia malayi | dihydrofolate reductase family protein | 0.0212 | 0.4989 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0092 | 0.1269 | 0.237 |
Trypanosoma cruzi | peptidase with unknown catalytic mechanism (family U48) | 0.0102 | 0.1582 | 0.3147 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0214 | 0.5028 | 0.5 |
Onchocerca volvulus | 0.0106 | 0.1708 | 1 | |
Schistosoma mansoni | dihydrofolate reductase | 0.0212 | 0.4989 | 1 |
Brugia malayi | hypoxia-induced factor 1 | 0.0167 | 0.3597 | 0.7209 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0068 | 0.0543 | 0.0039 |
Echinococcus granulosus | CAAX prenyl protease 2 | 0.0102 | 0.1582 | 0.1115 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0068 | 0.0543 | 0.1089 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0055 | 0.0141 | 0.0057 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0106 | 0.1708 | 0.3423 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.1582 | 0.2973 |
Echinococcus granulosus | dihydrofolate reductase | 0.0212 | 0.4989 | 0.4711 |
Entamoeba histolytica | CAAX prenyl protease family | 0.0102 | 0.1582 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0067 | 0.0526 | 0.1054 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0212 | 0.4989 | 1 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0068 | 0.0543 | 0.0882 |
Echinococcus multilocularis | CAAX prenyl protease 2 | 0.0102 | 0.1582 | 0.1115 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0212 | 0.4989 | 0.4711 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0067 | 0.0526 | 0.0846 |
Echinococcus granulosus | kinesin family 1 | 0.0199 | 0.4568 | 0.4267 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0214 | 0.5028 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0212 | 0.4989 | 1 |
Brugia malayi | CAAX amino terminal protease family protein | 0.0102 | 0.1582 | 0.3172 |
Echinococcus multilocularis | thymidylate synthase | 0.0106 | 0.1708 | 0.1247 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0167 | 0.3597 | 0.7128 |
Mycobacterium ulcerans | thymidylate synthase | 0.0106 | 0.1708 | 0.2648 |
Brugia malayi | Cytochrome P450 family protein | 0.0058 | 0.0239 | 0.0478 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0214 | 0.5028 | 0.5 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0131 | 0.2482 | 0.2064 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.3773 | 0.7507 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0068 | 0.0543 | 0.1089 |
Giardia lamblia | Hypothetical protein | 0.0102 | 0.1582 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0214 | 0.5028 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0131 | 0.2482 | 0.4858 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.4029 | 0.8019 |
Brugia malayi | PAS domain containing protein | 0.0054 | 0.0113 | 0.0227 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0068 | 0.0543 | 0.0039 |
Echinococcus multilocularis | kinesin family 1 | 0.0199 | 0.4568 | 0.4267 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0068 | 0.0543 | 0.0039 |
Brugia malayi | Dihydrofolate reductase | 0.0212 | 0.4989 | 1 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.0102 | 0.1582 | 0.3013 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0212 | 0.4989 | 1 |
Brugia malayi | thymidylate synthase | 0.0106 | 0.1708 | 0.3423 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0131 | 0.2482 | 0.2064 |
Loa Loa (eye worm) | thymidylate synthase | 0.0106 | 0.1708 | 0.3232 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0212 | 0.4989 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0212 | 0.4989 | 1 |
Leishmania major | CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) | 0.0102 | 0.1582 | 0.2347 |
Trypanosoma cruzi | CAAX prenyl protease 2, putative | 0.0102 | 0.1582 | 0.3147 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0058 | 0.0239 | 0.0202 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0067 | 0.0526 | 0.0846 |
Trichomonas vaginalis | Clan U, family U48, CaaX prenyl peptidase 2-like | 0.0102 | 0.1582 | 1 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.0102 | 0.1582 | 0.3013 |
Brugia malayi | hypothetical protein | 0.0181 | 0.4029 | 0.8075 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0214 | 0.5028 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0375 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0214 | 0.5028 | 1 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0068 | 0.0543 | 0.0018 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.