Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0021 | 0.0384 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0056 | 1 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0056 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0027 | 0.2117 | 0.1802 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0027 | 0.2117 | 0.1802 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0056 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.0384 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0056 | 1 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0384 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0056 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0056 | 1 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0056 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0056 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0056 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0056 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0027 | 0.2117 | 0.2117 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.0384 | 0.0384 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0056 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0027 | 0.2117 | 0.1802 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0384 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0027 | 0.2117 | 0.1802 |
Brugia malayi | Cytochrome P450 family protein | 0.0027 | 0.2117 | 0.1802 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0027 | 0.2117 | 0.2117 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0056 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.0384 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0056 | 1 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0056 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0027 | 0.2117 | 0.1802 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0056 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0056 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0027 | 0.2117 | 0.2117 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0027 | 0.2117 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0021 | 0.0384 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Delta pCa50 (binding) | = 0.1 | Change in calcium-induced activation of cannine cardiac myofibrillar ATPase at 200 uM | ChEMBL. | 1310113 |
Delta pCa50 (binding) | = 0.1 | Change in calcium-induced activation of cannine cardiac myofibrillar ATPase at 200 uM | ChEMBL. | 1310113 |
IC50 (binding) | = 18 uM | Inhibition of dog left ventricle sarcoplasmic reticulum bound low-Km c-AMP phosphodiesterase | ChEMBL. | 1310113 |
Inotropic effect (functional) | Inotropic effect by direct or indirect activation of beta-1 adrenergic receptor; ND is no data | ChEMBL. | 3027335 | |
Inotropic effect (functional) | 0 | Inotropic effect by direct or indirect activation of beta-1 adrenergic receptor; ND is no data | ChEMBL. | 3027335 |
Mechanistic reference (functional) | = 62 | Compound was evaluated for its inotropic activity by its ability to increase Myofibrillar Ca++ sensitivity. | ChEMBL. | 3027335 |
PDE inhibition (binding) | = 62 | Inhibition of cAMP Phosphodiesterase enzyme. | ChEMBL. | 3027335 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.