Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0148 | 0.866 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.1962 | 0.2265 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0095 | 0.4466 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0148 | 0.866 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0085 | 0.3725 | 0.8342 |
Brugia malayi | RNA binding protein | 0.0062 | 0.1962 | 0.2265 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0037 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.866 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 1 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.1962 | 0.193 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0148 | 0.866 | 0.8333 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.1962 | 0.193 |
Plasmodium falciparum | thioredoxin reductase | 0.0037 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.1962 | 0.2265 |
Loa Loa (eye worm) | carboxylesterase | 0.0148 | 0.866 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0148 | 0.866 | 0.8655 |
Plasmodium vivax | glutathione reductase, putative | 0.0037 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0148 | 0.866 | 1 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.1962 | 0.2265 |
Echinococcus multilocularis | acetylcholinesterase | 0.0148 | 0.866 | 0.8655 |
Toxoplasma gondii | thioredoxin reductase | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0148 | 0.866 | 0.8655 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0095 | 0.4466 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0148 | 0.866 | 0.8655 |
Echinococcus multilocularis | geminin | 0.0166 | 1 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0085 | 0.3725 | 0.8342 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.1962 | 0.2265 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0085 | 0.3725 | 0.8342 |
Leishmania major | trypanothione reductase | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0148 | 0.866 | 0.8655 |
Echinococcus multilocularis | acetylcholinesterase | 0.0148 | 0.866 | 0.8655 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.866 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0085 | 0.3725 | 0.8342 |
Plasmodium falciparum | glutathione reductase | 0.0037 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.1962 | 0.2265 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0085 | 0.3725 | 0.8342 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0095 | 0.4466 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0085 | 0.3725 | 0.8342 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0095 | 0.4466 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.