Detailed information for compound 670072

Basic information

Technical information
  • TDR Targets ID: 670072
  • Name: 2-(2-ethoxy-4-formylphenoxy)-N-(2-phenylethyl )acetamide
  • MW: 327.374 | Formula: C19H21NO4
  • H donors: 1 H acceptors: 2 LogP: 2.99 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cc(C=O)ccc1OCC(=O)NCCc1ccccc1
  • InChi: 1S/C19H21NO4/c1-2-23-18-12-16(13-21)8-9-17(18)24-14-19(22)20-11-10-15-6-4-3-5-7-15/h3-9,12-13H,2,10-11,14H2,1H3,(H,20,22)
  • InChiKey: JTPCUYBKBMCLAV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2-ethoxy-4-formyl-phenoxy)-N-(2-phenylethyl)acetamide
  • 2-(2-ethoxy-4-methanoyl-phenoxy)-N-(2-phenylethyl)ethanamide
  • ZINC00465996

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0015 0.0015
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0014 0.0014
Wolbachia endosymbiont of Brugia malayi bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 0.0021 0.0003 0.0186
Mycobacterium ulcerans methylmalonate semialdehyde dehydrogenase, MmsA 0.0021 0.0003 0.0042
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0027 0.0007 0.0048
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0102 0.0058 1
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0027 0.0007 0.0363
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0023 0.0022
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0006 0.0229
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0102 0.0058 0.2233
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0021 0.0003 0.0156
Brugia malayi Aldehyde dehydrogenase protein 4 0.0021 0.0003 0.0003
Mycobacterium tuberculosis Probable aldehyde dehydrogenase AldC 0.0021 0.0003 0.0021
Brugia malayi steroid hormone receptor 0.0065 0.0033 0.0033
Brugia malayi Steroid receptor seven-up type 2 0.0065 0.0033 0.0033
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.002 0.0019
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0027 0.0007 0.01
Trypanosoma cruzi NADH dehydrogenase, putative 0.0027 0.0007 0.0363
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.003 0.001 0.0009
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0023 0.0022
Echinococcus multilocularis ecdysone induced protein 78C 0.0065 0.0033 0.0032
Mycobacterium ulcerans glutaminase 0.0295 0.019 0.7522
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0065 0.0033 0.0032
Entamoeba histolytica aldehyde dehydrogenase 1, putative 0.0021 0.0003 0.0508
Chlamydia trachomatis thioredoxin reductase 0.0027 0.0007 0.0221
Loa Loa (eye worm) hypothetical protein 0.0039 0.0015 0.0015
Loa Loa (eye worm) pyruvate kinase 0.0071 0.0037 0.0037
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0027 0.0007 0.0363
Loa Loa (eye worm) hypothetical protein 0.005 0.0023 0.0022
Schistosoma mansoni nuclear receptor 0.003 0.001 0.0009
Echinococcus multilocularis sodium bile acid cotransporter 1.4712 1 1
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.0006 0.0677
Loa Loa (eye worm) hypothetical protein 0.0065 0.0033 0.0032
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0027 0.0007 0.0274
Brugia malayi Nuclear hormone receptor E75 0.003 0.001 0.001
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0027 0.0027
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0027 0.0007 0.0048
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0027 0.0007 0.0007
Echinococcus granulosus Nuclear hormone receptor HR96 0.003 0.001 0.0009
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0027 0.0007 0.0079
Loa Loa (eye worm) pyruvate kinase 0.0071 0.0037 0.0037
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0015 0.0128
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0065 0.0033 0.0032
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0065 0.0033 0.0032
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0021 0.0003 0.0042
Loa Loa (eye worm) aldehyde dehydrogenase 0.0021 0.0003 0.0003
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0027 0.0007 0.0007
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0102 0.0058 0.3064
Echinococcus multilocularis thyroid hormone receptor alpha 0.0065 0.0033 0.0032
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.003 0.001 0.0009
Toxoplasma gondii aldehyde dehydrogenase 0.0386 0.0252 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0065 0.0033 0.0032
Toxoplasma gondii selenide, water dikinase 0.0027 0.0007 0.0274
Schistosoma mansoni jumonji domain containing protein 0.0064 0.0032 0.0032
Entamoeba histolytica hypothetical protein 0.0037 0.0014 0.5914
Toxoplasma gondii pyruvate kinase PyKII 0.0037 0.0014 0.0535
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.0021 0.0003 0.0003
Brugia malayi hypothetical protein 0.0034 0.0012 0.0012
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0027 0.0007 0.241
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0027 0.0007 0.0007
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0027 0.0007 0.0007
Echinococcus granulosus thyroid hormone receptor alpha 0.003 0.001 0.0009
Echinococcus multilocularis tar DNA binding protein 0.027 0.0172 0.0172
Leishmania major aldehyde dehydrogenase, putative 0.0021 0.0003 0.0117
Entamoeba histolytica hypothetical protein 0.0025 0.0006 0.1847
Plasmodium falciparum ferrodoxin reductase-like protein 0.0027 0.0007 0.0363
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0027 0.0007 0.0007
Mycobacterium ulcerans aldehyde dehydrogenase 0.0386 0.0252 1
Mycobacterium ulcerans gamma-glutamyl phosphate reductase 0.0021 0.0003 0.0042
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0015 0.0015
Echinococcus granulosus betaine aldehyde dehydrogenase 0.0021 0.0003 0.0003
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0027 0.0007 0.0274
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0071 0.0037 0.0713
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0027 0.0007 0.0363
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0065 0.0033 0.0033
Plasmodium vivax pyruvate kinase 2, putative 0.0037 0.0014 0.0712
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.002 0.0019
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0027 0.0007 0.0079
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0027 0.0007 0.0048
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0027 0.0007 0.0007
Schistosoma mansoni nuclear hormone receptor 0.003 0.001 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0065 0.0033 0.0033
Brugia malayi tailless protein 0.003 0.001 0.001
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.0021 0.0003 0.0003
Echinococcus granulosus geminin 0.0544 0.0359 0.0359
Onchocerca volvulus Pyruvate kinase homolog 0.0071 0.0037 0.0034
Plasmodium vivax SET domain protein, putative 0.0191 0.0119 0.6302
Trichomonas vaginalis apoptosis inducing factor, putative 0.0027 0.0007 0.0048
Plasmodium vivax thioredoxin reductase, putative 0.0293 0.0188 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0065 0.0033 0.0033
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0102 0.0058 0.3064
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0065 0.0033 0.0032
Mycobacterium ulcerans monoxygenase 0.0027 0.0007 0.0197
Loa Loa (eye worm) hypothetical protein 0.0065 0.0033 0.0032
Trichomonas vaginalis glutaminase, putative 0.0295 0.019 0.1843
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0027 0.0007 0.0048
Brugia malayi ecdysteroid receptor 0.0065 0.0033 0.0033
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0386 0.0252 0.0251
Schistosoma mansoni tar DNA-binding protein 0.027 0.0172 0.0172
Mycobacterium ulcerans aldehyde dehydrogenase 0.0386 0.0252 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0064 0.0032 0.0032
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0015 0.0265
Onchocerca volvulus 0.1515 0.102 0.1017
Brugia malayi beta-lactamase family protein 0.0039 0.0015 0.0015
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0027 0.0007 0.0363
Treponema pallidum NADH oxidase 0.0102 0.0058 1
Schistosoma mansoni sulfide quinone reductase 0.0027 0.0007 0.0007
Loa Loa (eye worm) MBCTL1 0.0057 0.0027 0.0027
Plasmodium falciparum pyruvate kinase 2 0.0037 0.0014 0.0712
Schistosoma mansoni glutaminase 0.0295 0.019 0.0189
Echinococcus multilocularis Nuclear hormone receptor HR96 0.003 0.001 0.0009
Trypanosoma cruzi trypanothione reductase, putative 0.0293 0.0188 1
Mycobacterium tuberculosis Conserved protein 0.0039 0.0015 0.0265
Echinococcus granulosus L aminoadipate semialdehyde 0.009 0.005 0.005
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0021 0.0003 0.0003
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0015 0.0523
Brugia malayi nuclear hormone receptor family member nhr-6 0.003 0.001 0.001
Leishmania major aldehyde dehydrogenase, putative 0.0021 0.0003 0.0117
Mycobacterium tuberculosis Conserved protein 0.0039 0.0015 0.0265
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0021 0.0003 0.0042
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0006 0.0229
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0668 0.0444 0.8969
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.002 0.0019
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0021 0.0003 0.0156
Echinococcus granulosus pyruvate kinase 0.0037 0.0014 0.0013
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0102 0.0058 0.0058
Trichomonas vaginalis glutathione reductase, putative 0.0102 0.0058 0.0547
Echinococcus multilocularis pyruvate kinase 0.0037 0.0014 0.0013
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0293 0.0188 0.3779
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0012 0.0012
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0102 0.0058 0.3064
Onchocerca volvulus Protein ultraspiracle homolog 0.0065 0.0033 0.003
Echinococcus multilocularis pyruvate kinase 0.0071 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.003 0.001 0.0009
Leishmania major delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0021 0.0003 0.0117
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0034 0.0012 0.0012
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0065 0.0033 0.0032
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, PutA_2 0.0021 0.0003 0.0042
Brugia malayi hypothetical protein 0.0026 0.0006 0.0006
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0034 0.0012 0.0012
Loa Loa (eye worm) pyruvate kinase 0.0071 0.0037 0.0037
Mycobacterium tuberculosis Possible succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD2 0.0021 0.0003 0.0021
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0102 0.0058 0.2294
Loa Loa (eye worm) hypothetical protein 0.0039 0.0015 0.0015
Giardia lamblia Pyruvate kinase 0.0071 0.0037 0.6302
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0027 0.0007 0.0363
Loa Loa (eye worm) hypothetical protein 0.0039 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.003 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.003 0.001 0.0009
Echinococcus multilocularis pyruvate kinase 0.0071 0.0037 0.0037
Mycobacterium ulcerans gamma-aminobutyraldehyde dehydrogenase 0.0021 0.0003 0.0042
Loa Loa (eye worm) hypothetical protein 0.0065 0.0033 0.0032
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0006 0.0301
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0065 0.0033 0.0033
Schistosoma mansoni tar DNA-binding protein 0.027 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0034 0.0012 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0065 0.0033 0.0032
Loa Loa (eye worm) hypothetical protein 0.0065 0.0033 0.0032
Treponema pallidum gamma-glutamyl phosphate reductase 0.0021 0.0003 0.0186
Schistosoma mansoni disulfide oxidoreductase 0.0027 0.0007 0.0007
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0021 0.0003 0.0156
Echinococcus granulosus FTZ F1 alpha 0.0065 0.0033 0.0032
Loa Loa (eye worm) hypothetical protein 0.003 0.001 0.0009
Mycobacterium tuberculosis Conserved protein 0.0039 0.0015 0.0265
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0075 0.004 0.004
Schistosoma mansoni pyruvate kinase 0.0071 0.0037 0.0037
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.02 0.0125 0.0124
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0668 0.0444 0.8969
Echinococcus multilocularis glutamate synthase 0.0027 0.0007 0.0007
Brugia malayi mbt repeat family protein 0.005 0.0023 0.0023
Onchocerca volvulus 0.0039 0.0015 0.0012
Plasmodium vivax glutathione reductase, putative 0.0293 0.0188 1
Loa Loa (eye worm) glutaminase 0.0295 0.019 0.0189
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0027 0.0007 0.0883
Echinococcus granulosus pyruvate kinase 0.0037 0.0014 0.0013
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0002 0.0002
Toxoplasma gondii gamma-glutamyl phosphate reductase, putative 0.0021 0.0003 0.012
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0014 0.0014
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0021 0.0003 0.0156
Toxoplasma gondii exonuclease III APE 0.002 0.0002 0.0079
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0743 0.0494 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.003 0.001 0.0006
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0021 0.0003 0.0003
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0102 0.0058 1
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0027 0.0007 0.01
Trypanosoma brucei pyruvate kinase 1, putative 0.0071 0.0037 0.1968
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0 0.0003
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.0021 0.0003 0.0003
Onchocerca volvulus 0.0027 0.0007 0.0004
Echinococcus multilocularis sodium bile acid cotransporter 1.4712 1 1
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0006 0.0036
Treponema pallidum thioredoxin reductase (trxB) 0.0027 0.0007 0.0883
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0021 0.0003 0.0508
Brugia malayi nuclear receptor RXR 0.003 0.001 0.001
Schistosoma mansoni aldehyde dehydrogenase 0.0021 0.0003 0.0003
Schistosoma mansoni sodium-bile acid cotransporter related 1.4712 1 1
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0022 0.0003 0.0003
Schistosoma mansoni nuclear hormone receptor 0.0065 0.0033 0.0032
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0027 0.0027
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0065 0.0033 0.0032
Schistosoma mansoni coup transcription factor 0.0065 0.0033 0.0032
Plasmodium falciparum thioredoxin reductase 0.0102 0.0058 0.3064
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0027 0.0007 0.241
Trichomonas vaginalis pyruvate kinase, putative 0.0071 0.0037 0.0345
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0065 0.0033 0.0032
Schistosoma mansoni aldehyde dehydrogenase 0.0021 0.0003 0.0003
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0007 0.0363
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0027 0.0007 0.0048
Brugia malayi beta-lactamase family protein 0.0039 0.0015 0.0015
Echinococcus multilocularis geminin 0.0544 0.0359 0.0359
Echinococcus multilocularis thioredoxin glutathione reductase 0.0296 0.019 0.019
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 0.0021 0.0003 0.0021
Mycobacterium ulcerans dehydrogenase 0.0027 0.0007 0.0197
Onchocerca volvulus 0.003 0.001 0.0006
Loa Loa (eye worm) hypothetical protein 0.0034 0.0012 0.0012
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0191 0.0119 0.0118
Echinococcus multilocularis FTZ F1 alpha 0.0065 0.0033 0.0032
Toxoplasma gondii ABC1 family protein 0.0039 0.0015 0.0598
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0027 0.0007 0.0007
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0002 0.0002
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0006 0.0006
Onchocerca volvulus Pyruvate kinase homolog 0.0071 0.0037 0.0034
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0021 0.0003 0.0003
Loa Loa (eye worm) pyruvate kinase-PB 0.005 0.0023 0.0022
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0027 0.0007 0.241
Echinococcus granulosus pyruvate kinase 0.0037 0.0014 0.0013
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0002 0.0002
Loa Loa (eye worm) nuclear hormone receptor 0.003 0.001 0.0009
Entamoeba histolytica hypothetical protein 0.0037 0.0014 0.5914
Schistosoma mansoni tar DNA-binding protein 0.027 0.0172 0.0172
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0006 0.0006
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0006 0.0077
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0027 0.0007 0.0048
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0021 0.0003 0.0042
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0027 0.0007 0.0197
Leishmania major hypothetical protein, conserved 0.0027 0.0007 0.0271
Echinococcus multilocularis sodium bile acid cotransporter 1.4712 1 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0032 0.0032
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0027 0.0007 0.0048
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0034 0.0012 0.0012
Entamoeba histolytica thioredoxin reductase, putative 0.0027 0.0007 0.241
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0015 0.0795
Brugia malayi ecdysone receptor 0.003 0.001 0.001
Echinococcus multilocularis L aminoadipate semialdehyde 0.009 0.005 0.005
Leishmania major hypothetical protein, conserved 0.0027 0.0007 0.0271
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0065 0.0033 0.0032
Giardia lamblia NADH oxidase lateral transfer candidate 0.0102 0.0058 1
Schistosoma mansoni microtubule-associated protein tau 0.2168 0.1464 0.1464
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0021 0.0003 0.0156
Schistosoma mansoni nuclear receptor nhr-48 0.003 0.001 0.0009
Brugia malayi Pyruvate kinase, M2 isozyme 0.0071 0.0037 0.0037
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0102 0.0058 0.2233
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0027 0.0007 0.0007
Schistosoma mansoni sulfide quinone reductase 0.0027 0.0007 0.0007
Onchocerca volvulus 0.0039 0.0015 0.0012
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0027 0.0007 0.0197
Schistosoma mansoni aldehyde dehydrogenase 0.0386 0.0252 0.0251
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0027 0.0007 0.0363
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0027 0.0007 0.0274
Entamoeba histolytica hypothetical protein 0.0037 0.0014 0.5914
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0002 0.0101
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0027 0.0007 0.0883
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0015 0.0015
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0191 0.0119 0.0118
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0743 0.0494 1
Leishmania major hypothetical protein, conserved 0.0026 0.0006 0.0232
Echinococcus multilocularis microtubule associated protein 2 0.2168 0.1464 0.1464
Giardia lamblia Alcohol dehydrogenase 0.0021 0.0003 0.0186
Onchocerca volvulus 0.005 0.0023 0.0019
Entamoeba histolytica disulphide oxidoreductase, putative 0.0027 0.0007 0.241
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0027 0.0007 0.0007
Echinococcus granulosus sodium bile acid cotransporter 1.4712 1 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0037 0.0037
Onchocerca volvulus 0.0039 0.0015 0.0012
Schistosoma mansoni hypothetical protein 0.0544 0.0359 0.0359
Loa Loa (eye worm) hypothetical protein 0.0027 0.0007 0.0007
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.002 0.0019
Echinococcus granulosus histone lysine methyltransferase setb 0.0191 0.0119 0.0118
Mycobacterium tuberculosis Probable pyrroline-5-carboxylate dehydrogenase RocA 0.0021 0.0003 0.0021
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0065 0.0033 0.0032
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0027 0.0007 0.0363
Echinococcus granulosus microtubule associated protein 2 0.2168 0.1464 0.1464
Loa Loa (eye worm) hypothetical protein 0.003 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0065 0.0033 0.0032
Loa Loa (eye worm) hypothetical protein 0.0021 0.0003 0.0003
Schistosoma mansoni pyruvate kinase 0.0037 0.0014 0.0013
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0002 0.0101
Loa Loa (eye worm) hypothetical protein 0.0039 0.0015 0.0015
Echinococcus multilocularis pyruvate kinase 0.0037 0.0014 0.0013
Brugia malayi nuclear receptor NHR-88 0.003 0.001 0.001
Mycobacterium tuberculosis Probable gamma-glutamyl phosphate reductase protein ProA (GPR) (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialde 0.0021 0.0003 0.0021
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0184 0.0114 0.0114
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0027 0.0007 0.0363
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0015 0.0015
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0006 0.0036
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0027 0.0007 0.0271
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0027 0.0007 0.0048
Trichomonas vaginalis mercuric reductase, putative 0.0102 0.0058 0.0547
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0027 0.0007 0.0363
Echinococcus granulosus ecdysone induced protein 78C 0.0065 0.0033 0.0032
Loa Loa (eye worm) thioredoxin reductase 0.0293 0.0188 0.0188
Mycobacterium ulcerans piperideine-6-carboxilic acid dehydrogenase Pcd 0.0021 0.0003 0.0042
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0065 0.0033 0.0033
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.009 0.005 0.005
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.0021 0.0003 0.0003
Brugia malayi beta-lactamase 0.0039 0.0015 0.0015
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0032 0.0032
Mycobacterium tuberculosis Probable dehydrogenase 0.0668 0.0444 0.8969
Mycobacterium ulcerans beta-lactamase 0.0039 0.0015 0.0523
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0023 0.0022
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0668 0.0444 0.8969
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0021 0.0003 0.0156
Brugia malayi RNA recognition motif domain containing protein 0.027 0.0172 0.0172
Mycobacterium ulcerans ferredoxin reductase 0.0027 0.0007 0.0197
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0027 0.0007 0.0197
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0027 0.0007 0.01
Brugia malayi nuclear hormone receptor 0.003 0.001 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0065 0.0033 0.0032
Mycobacterium ulcerans aldehyde dehydrogenase (NAD+) dependent 0.0021 0.0003 0.0042
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0065 0.0033 0.0032
Brugia malayi Pre-SET motif family protein 0.1331 0.0895 0.0895
Trypanosoma brucei trypanothione reductase 0.0293 0.0188 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0065 0.0033 0.0032
Brugia malayi nuclear receptor NHR-88 0.0065 0.0033 0.0033
Trypanosoma brucei NADH dehydrogenase 0.0027 0.0007 0.0363
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0015 0.0245
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0015 0.0795
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0027 0.0007 0.0883
Leishmania major pyrroline-5-carboxylate synthetase-like protein 0.0021 0.0003 0.0117
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0065 0.0033 0.0032
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0027 0.0007 0.01
Loa Loa (eye worm) hypothetical protein 0.0191 0.0119 0.0118
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0021 0.0003 0.0156
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.0021 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.005 0.0023 0.0022
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0021 0.0003 0.0156
Loa Loa (eye worm) hypothetical protein 0.0065 0.0033 0.0032
Brugia malayi glutamate synthase 0.0027 0.0007 0.0007
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0015 0.0128
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0065 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.003 0.001 0.0009
Echinococcus granulosus bloom syndrome protein 0.0025 0.0006 0.0006
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0006 0.0301
Plasmodium falciparum glutathione reductase 0.0102 0.0058 0.3064
Schistosoma mansoni aldehyde dehydrogenase 0.0021 0.0003 0.0003
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0006 0.031
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0021 0.0003 0.0042
Mycobacterium ulcerans pyruvate kinase 0.0071 0.0037 0.1407
Toxoplasma gondii aldehyde dehydrogenase (NAD) family protein 0.0021 0.0003 0.012
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0743 0.0494 1
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0023 0.0022
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0386 0.0252 0.0251
Loa Loa (eye worm) TAR-binding protein 0.027 0.0172 0.0172
Mycobacterium tuberculosis Probable methylmalonate-semialdehyde dehydrogenase MmsA (methylmalonic acid semialdehyde dehydrogenase) (MMSDH) 0.0021 0.0003 0.0021
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0021 0.0003 0.0156
Loa Loa (eye worm) hypothetical protein 0.003 0.001 0.0009
Schistosoma mansoni sodium-bile acid cotransporter 0.8746 0.5941 0.594
Brugia malayi RNA binding protein 0.027 0.0172 0.0172
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0002 0.0101
Mycobacterium tuberculosis Probable aldehyde dehydrogenase (NAD+) dependent 0.0021 0.0003 0.0021
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0002 0.0002
Plasmodium falciparum thioredoxin reductase 0.0293 0.0188 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0102 0.0058 0.3064
Trypanosoma cruzi pyruvate kinase 2, putative 0.0071 0.0037 0.1968
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0102 0.0058 0.3064
Brugia malayi Pyruvate kinase, muscle isozyme 0.0071 0.0037 0.0037
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0065 0.0033 0.0032
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0027 0.0007 0.241
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0023 0.0022
Schistosoma mansoni sodium-bile acid cotransporter related 0.5966 0.4048 0.4048
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0015 0.0128
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0065 0.0033 0.0032
Loa Loa (eye worm) hypothetical protein 0.003 0.001 0.0009
Brugia malayi hypothetical protein 0.003 0.001 0.001
Toxoplasma gondii pyruvate kinase PyK1 0.0071 0.0037 0.1475
Toxoplasma gondii NADPH-glutathione reductase 0.0102 0.0058 0.2294
Echinococcus granulosus endonuclease exonuclease phosphatase 0.02 0.0125 0.0124
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.027 0.0172 0.0172
Leishmania major hypothetical protein, conserved 0.0039 0.0015 0.0595
Schistosoma mansoni aldehyde dehydrogenase 0.0386 0.0252 0.0251
Toxoplasma gondii methylmalonate-semialdehyde dehydrogenase [acylating], putative 0.0021 0.0003 0.012
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0021 0.0003 0.0156
Brugia malayi jmjC domain containing protein 0.0064 0.0032 0.0032
Loa Loa (eye worm) programmed cell death 8 0.0027 0.0007 0.0007
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.002 0.002
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0027 0.0007 0.0274
Plasmodium vivax ferrodoxin reductase, putative 0.0027 0.0007 0.0363
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0015 0.0128
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0002 0.0101
Loa Loa (eye worm) hypothetical protein 0.003 0.001 0.0009
Mycobacterium ulcerans hypothetical protein 0.0027 0.0007 0.0197
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0027 0.0007 0.0007
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0249 0.0158 0.3163
Loa Loa (eye worm) nuclear receptor NHR-67 0.003 0.001 0.0009
Trypanosoma brucei pyruvate kinase 1 0.0071 0.0037 0.1968
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.001 0.0009
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0012 0.0012
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0006 0.031
Schistosoma mansoni hypothetical protein 0.0037 0.0014 0.0014
Brugia malayi TAR-binding protein 0.027 0.0172 0.0172
Echinococcus multilocularis Nuclear hormone receptor HR96 0.003 0.001 0.0009
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0006 0.0235
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.0021 0.0003 0.0003
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0021 0.0003 0.0508
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0021 0.0003 0.0508
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0386 0.0252 1
Loa Loa (eye worm) RecQ helicase 0.0025 0.0006 0.0006
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0102 0.0058 0.3064
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0007 0.0363
Loa Loa (eye worm) hypothetical protein 0.0034 0.0012 0.0012
Schistosoma mansoni ap endonuclease 0.002 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 1.4712 1 1
Echinococcus granulosus pyruvate kinase 0.0071 0.0037 0.0037
Onchocerca volvulus 1.4712 1 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0102 0.0058 1
Leishmania major trypanothione reductase 0.0293 0.0188 0.7478
Brugia malayi photoreceptor-specific nuclear receptor 0.0065 0.0033 0.0033
Trichomonas vaginalis pyruvate kinase, putative 0.0071 0.0037 0.0345
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0065 0.0033 0.0033
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0027 0.0007 0.0007
Echinococcus multilocularis lysine specific demethylase 5A 0.0064 0.0032 0.0032
Schistosoma mansoni hypothetical protein 0.0306 0.0197 0.0197
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0102 0.0058 0.2233
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0027 0.0027
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0027 0.0027
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0027 0.0007 0.0271
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0002 0.0002
Mycobacterium ulcerans NADH dehydrogenase 0.0027 0.0007 0.0197
Trypanosoma cruzi pyruvate kinase 2, putative 0.0071 0.0037 0.1968
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0027 0.0007 0.0197
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0006 0.031
Mycobacterium ulcerans bifunctional acetaldehyde-CoA/alcohol dehydrogenase 0.0021 0.0003 0.0042
Schistosoma mansoni thyroid hormone receptor 0.0065 0.0033 0.0032
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0025 0.0006 0.0677
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0015 0.0015
Leishmania major pyruvate kinase 0.0071 0.0037 0.1472
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.009 0.005 0.005
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0021 0.0003 0.0156
Schistosoma mansoni glutamate synthase 0.0027 0.0007 0.0007
Leishmania major aldehyde dehydrogenase, putative 0.0021 0.0003 0.0117
Loa Loa (eye worm) beta-lactamase 0.0039 0.0015 0.0015
Entamoeba histolytica pyruvate kinase, putative 0.005 0.0023 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0065 0.0033 0.003
Onchocerca volvulus Bile acid receptor homolog 0.0065 0.0033 0.003
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0015 0.0795
Toxoplasma gondii NADP-dependent succinate-semialdehyde dehydrogenase 0.0021 0.0003 0.012
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.003 0.001 0.0009
Trypanosoma cruzi trypanothione reductase, putative 0.0102 0.0058 0.3064
Schistosoma mansoni nuclear hormone receptor 0.003 0.001 0.0009
Leishmania major NADH dehydrogenase, putative 0.0027 0.0007 0.0271
Onchocerca volvulus 0.009 0.005 0.0047
Mycobacterium tuberculosis Probable aldehyde dehydrogenase NAD dependent AldA (aldehyde dehydrogenase [NAD+]) 0.0021 0.0003 0.0021
Mycobacterium ulcerans lipase LipD 0.0039 0.0015 0.0523
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0015 0.0265
Loa Loa (eye worm) hypothetical protein 0.009 0.005 0.005
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.001 0.0009
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0102 0.0058 0.3064
Brugia malayi Nuclear hormone receptor-like 1 0.0065 0.0033 0.0033
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0027 0.0007 0.0007
Schistosoma mansoni zinc finger protein 0.003 0.001 0.0009
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0027 0.0027
Trypanosoma cruzi NADH dehydrogenase, putative 0.0027 0.0007 0.0363
Leishmania major hypothetical protein, conserved 0.0027 0.0007 0.0271
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0023 0.0019
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0004 0.0187
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0015 0.0523
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.0074 0.0074
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0102 0.0058 0.2292
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0191 0.0119 0.0118
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.003 0.001 0.0006
Onchocerca volvulus 0.0191 0.0119 0.0116
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0006 0.0225
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0191 0.0119 0.0118
Leishmania major pyruvate kinase 0.0071 0.0037 0.1472
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0065 0.0033 0.0032
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0021 0.0003 0.0156
Brugia malayi Nuclear hormone receptor E75 0.003 0.001 0.001
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0065 0.0033 0.0032
Toxoplasma gondii thioredoxin reductase 0.0293 0.0188 0.7479
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1331 0.0895 0.0894
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0027 0.0007 0.0363
Schistosoma mansoni hypothetical protein 0.0021 0.0003 0.0003
Echinococcus granulosus Nuclear hormone receptor HR96 0.003 0.001 0.0009
Brugia malayi Thioredoxin reductase 0.0293 0.0188 0.0188
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0065 0.0033 0.0032
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0034 0.0012 0.0012
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.003 0.001 0.0009
Schistosoma mansoni glutamate synthase 0.0027 0.0007 0.0007
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0006 0.0301
Loa Loa (eye worm) hypothetical protein 0.0026 0.0006 0.0006
Giardia lamblia Thioredoxin reductase 0.0027 0.0007 0.0883
Trichomonas vaginalis glutamate synthase, putative 0.0027 0.0007 0.0048
Echinococcus granulosus thioredoxin glutathione reductase 0.0296 0.019 0.019
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.003 0.001 0.001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.002 0.0019
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0006 0.031
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0102 0.0058 0.2292
Plasmodium vivax pyruvate kinase, putative 0.0071 0.0037 0.1968
Trichomonas vaginalis glutamate synthase, putative 0.0027 0.0007 0.0048
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0023 0.0022
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0027 0.0007 0.01
Mycobacterium ulcerans aldehyde dehydrogenase 0.0386 0.0252 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0027 0.0027
Mycobacterium ulcerans glutamate synthase subunit beta 0.0027 0.0007 0.0197
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0027 0.0007 0.0079
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0102 0.0058 0.3064
Mycobacterium ulcerans pyrroline-5-carboxylate dehydrogenase, RocA 0.0021 0.0003 0.0042
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.0021 0.0003 0.0003
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0032 0.0032
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0023 0.0022
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0102 0.0058 0.3064
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, GabD1 0.0021 0.0003 0.0042
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0021 0.0003 0.0156
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.002 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0065 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0065 0.0033 0.0032
Mycobacterium ulcerans aldehyde dehydrogenase 0.0021 0.0003 0.0042
Brugia malayi MH2 domain containing protein 0.0125 0.0074 0.0074
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0027 0.0007 0.0883
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0006 0.0056
Schistosoma mansoni hypothetical protein 0.0027 0.0007 0.0007
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0027 0.0007 0.0048
Loa Loa (eye worm) nuclear receptor nhr-7B 0.003 0.001 0.0009
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0027 0.0007 0.0197
Schistosoma mansoni steroid hormone receptor ad4bp 0.0065 0.0033 0.0032
Loa Loa (eye worm) hypothetical protein 0.0039 0.0015 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0065 0.0033 0.0033
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0027 0.0007 0.0079
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0668 0.0444 0.8967
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0 0.0003
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0027 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0065 0.0033 0.0033
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0102 0.0058 0.2292
Loa Loa (eye worm) glutaminase 2 0.0295 0.019 0.0189
Schistosoma mansoni tar DNA-binding protein 0.027 0.0172 0.0172
Brugia malayi nuclear receptor RXR 0.0034 0.0012 0.0012
Brugia malayi glutaminase DH11.1 0.0295 0.019 0.019
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0015 0.0265
Loa Loa (eye worm) glutathione reductase 0.0293 0.0188 0.0188
Echinococcus multilocularis pyruvate kinase 0.0056 0.0027 0.0027
Schistosoma mansoni ap endonuclease 0.002 0.0002 0.0002
Echinococcus granulosus lysine specific demethylase 5A 0.0064 0.0032 0.0032
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0002 0.0075
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0015 0.0265
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0668 0.0444 0.8969
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0027 0.0007 0.0197
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0027 0.0007 0.0007
Brugia malayi nuclear hormone receptor family member odr-7 0.003 0.001 0.001
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0102 0.0058 0.3064
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.002 0.0019
Schistosoma mansoni thyroid hormone receptor 0.0065 0.0033 0.0032
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0027 0.0007 0.241
Schistosoma mansoni aldehyde dehydrogenase 0.0021 0.0003 0.0003
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0027 0.0007 0.01
Loa Loa (eye worm) hypothetical protein 0.0034 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0057 0.0027 0.0027
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0102 0.0058 0.3064
Onchocerca volvulus Pyruvate kinase homolog 0.0071 0.0037 0.0034
Onchocerca volvulus 0.003 0.001 0.0006
Echinococcus granulosus sodium bile acid cotransporter 1.4712 1 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0191 0.0119 0.0118
Brugia malayi Pre-SET motif family protein 0.0191 0.0119 0.0119
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0021 0.0003 0.0156
Schistosoma mansoni tar DNA-binding protein 0.027 0.0172 0.0172
Schistosoma mansoni nuclear receptor 0.003 0.001 0.0009
Plasmodium falciparum glutathione reductase 0.0293 0.0188 1
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.0021 0.0003 0.001
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0027 0.0007 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0191 0.0119 0.0118
Mycobacterium leprae Probable lipase LipE 0.0039 0.0015 0.0245
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0102 0.0058 0.1131
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0006 0.031
Brugia malayi jmjC domain containing protein 0.0064 0.0032 0.0032
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.0021 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0039 0.0015 0.0015
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0006 0.0151
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0015 0.0795
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0027 0.0007 0.0197
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0015 0.0128
Entamoeba histolytica hypothetical protein 0.0037 0.0014 0.5914
Brugia malayi orphan nuclear receptor NR2E1 0.003 0.001 0.001
Treponema pallidum oxidoreductase 0.0027 0.0007 0.0883
Onchocerca volvulus 0.0065 0.0033 0.003
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0027 0.0007 0.0363
Plasmodium falciparum pyruvate kinase 0.0071 0.0037 0.1968
Echinococcus granulosus nuclear receptor nhr 48 0.003 0.001 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0065 0.0033 0.0033
Brugia malayi glutathione reductase 0.0293 0.0188 0.0188
Trichomonas vaginalis esterase, putative 0.0039 0.0015 0.0128
Echinococcus granulosus tar DNA binding protein 0.027 0.0172 0.0172
Schistosoma mansoni hypothetical protein 0.0544 0.0359 0.0359
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0027 0.0007 0.0363
Loa Loa (eye worm) hypothetical protein 0.0034 0.0012 0.0012
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0065 0.0033 0.0032
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0064 0.0032 0.0032
Loa Loa (eye worm) steroid hormone receptor 0.0065 0.0033 0.0032
Echinococcus granulosus glutamate synthase 0.0027 0.0007 0.0007
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0075 0.004 0.004
Brugia malayi hypothetical protein 0.003 0.001 0.001
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0102 0.0058 0.0058
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0027 0.0007 0.0274
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0102 0.0058 0.0058
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0102 0.0058 0.3064
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0027 0.0007 0.0363
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.0021 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.003 0.001 0.0009
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0102 0.0058 0.2292
Loa Loa (eye worm) hypothetical protein 0.0065 0.0033 0.0032
Trypanosoma brucei delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0021 0.0003 0.0156
Schistosoma mansoni pyruvate kinase 0.0071 0.0037 0.0037
Schistosoma mansoni retinoic acid receptor RXR 0.0065 0.0033 0.0032
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.002 0.0019
Schistosoma mansoni RAR-like nuclear receptor 0.0065 0.0033 0.0032
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.003 0.001 0.0009
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0021 0.0003 0.0156
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0065 0.0033 0.0032
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0021 0.0003 0.0003
Loa Loa (eye worm) DR-78 0.003 0.001 0.0009
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0021 0.0003 0.0003
Brugia malayi nuclear receptor NHR-67 0.003 0.001 0.001
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0012 0.0012
Brugia malayi conserved hypotetical protein 0.003 0.001 0.001
Schistosoma mansoni glutamate synthase 0.0027 0.0007 0.0007
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0065 0.0033 0.0032
Schistosoma mansoni aldehyde dehydrogenase 0.0021 0.0003 0.0003
Mycobacterium tuberculosis Probable oxidoreductase 0.0743 0.0494 1
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0015 0.0265
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0006 0.031
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0102 0.0058 0.3064
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0015 0.0265
Echinococcus multilocularis nuclear receptor nhr 48 0.003 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.003 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0127 0.0075 0.0075
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0102 0.0058 0.0058
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0002 0.0101
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0015 0.0265
Echinococcus granulosus pyruvate kinase 0.0071 0.0037 0.0037
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0065 0.0033 0.0032
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.0021 0.0003 0.0003
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0386 0.0252 0.5066
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0021 0.0003 0.0021
Brugia malayi hypothetical protein 0.0037 0.0014 0.0014
Brugia malayi nuclear hormone receptor 0.0065 0.0033 0.0033
Loa Loa (eye worm) RNA binding protein 0.027 0.0172 0.0172
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0014 0.0014
Mycobacterium leprae Probable pyruvate kinase PykA 0.0071 0.0037 0.0693
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0065 0.0033 0.0032
Chlamydia trachomatis pyruvate kinase 0.0071 0.0037 0.6033
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0021 0.0003 0.0156
Echinococcus multilocularis pyruvate kinase 0.0037 0.0014 0.0013
Giardia lamblia Glutamate synthase 0.0027 0.0007 0.0883
Mycobacterium tuberculosis Probable reductase 0.0668 0.0444 0.8969
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0065 0.0033 0.0033
Giardia lamblia Pyruvate kinase 0.0037 0.0014 0.2061
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.003 0.001 0.0009
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0102 0.0058 0.3064
Mycobacterium ulcerans hypothetical protein 0.0039 0.0015 0.0523
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0102 0.0058 0.3064
Loa Loa (eye worm) hypothetical protein 0.003 0.001 0.0009
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0027 0.0007 0.0048
Brugia malayi aldehyde dehydrogenase 0.0021 0.0003 0.0003
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0023 0.0022
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0191 0.0119 0.4715
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0102 0.0058 0.3064
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0006 0.0151
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0065 0.0033 0.0032
Echinococcus granulosus sodium bile acid cotransporter 1.4712 1 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0065 0.0033 0.0033
Brugia malayi mbt repeat family protein 0.005 0.0023 0.0023
Brugia malayi hypothetical protein 0.0034 0.0012 0.0012
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0027 0.0007 0.0007
Trichomonas vaginalis set domain proteins, putative 0.1515 0.102 1
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0007 0.0363

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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