Detailed information for compound 670254

Basic information

Technical information
  • TDR Targets ID: 670254
  • Name: methyl 2-[5-[(6-bromo-1,3-benzodioxol-5-yl)me thylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]pro panoate
  • MW: 414.228 | Formula: C15H12BrNO6S
  • H donors: 0 H acceptors: 3 LogP: 3.21 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(C(=O)OC)N1C(=O)C(=Cc2cc3OCOc3cc2Br)SC1=O
  • InChi: 1S/C15H12BrNO6S/c1-7(14(19)21-2)17-13(18)12(24-15(17)20)4-8-3-10-11(5-9(8)16)23-6-22-10/h3-5,7H,6H2,1-2H3/b12-4-
  • InChiKey: FTLHWWLVYWEZGF-QCDXTXTGSA-N  

Network

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Synonyms

  • methyl 2-[(5Z)-5-[(6-bromo-1,3-benzodioxol-5-yl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]propanoate
  • methyl 2-[(5Z)-5-[(6-bromo-1,3-benzodioxol-5-yl)methylene]-2,4-dioxo-thiazolidin-3-yl]propanoate
  • methyl 2-[5-[(6-bromo-1,3-benzodioxol-5-yl)methylene]-2,4-dioxo-thiazolidin-3-yl]propanoate
  • 2-[(5Z)-5-[(6-bromo-1,3-benzodioxol-5-yl)methylene]-2,4-dioxo-3-thiazolidinyl]propanoic acid methyl ester
  • 2-[5-[(6-bromo-1,3-benzodioxol-5-yl)methylene]-2,4-dioxo-3-thiazolidinyl]propanoic acid methyl ester
  • 2-[5-[(6-bromo-1,3-benzodioxol-5-yl)methylene]-2,4-diketo-thiazolidin-3-yl]propionic acid methyl ester
  • 2-[(5Z)-5-[(6-bromo-1,3-benzodioxol-5-yl)methylene]-2,4-diketo-thiazolidin-3-yl]propionic acid methyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0086 0.025
Mycobacterium ulcerans ferredoxin reductase 0.0173 0.0866 0.252
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.034 0.034
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0033 0.0033
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0086 0.0402 0.0401
Echinococcus multilocularis dna polymerase eta 0.0019 0.0042 0.0042
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0025 0.0021
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0093 0.0093
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0173 0.0866 0.0865
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0652 0.3427 0.3424
Loa Loa (eye worm) hypothetical protein 0.003 0.0102 0.0102
Mycobacterium tuberculosis Probable dehydrogenase 0.0173 0.0866 0.0863
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0173 0.0866 0.0866
Schistosoma mansoni lamin 0.0028 0.0093 0.0093
Echinococcus multilocularis Chromo domain 0.0011 0.0001 0.0001
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0025 0.0025
Trypanosoma brucei trypanothione reductase 0.1881 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0053 0.0053
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0014 0.0014
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0173 0.0866 0.2436
Loa Loa (eye worm) RNA binding protein 0.0062 0.0274 0.0274
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0057 0.0243 0.07
Loa Loa (eye worm) programmed cell death 8 0.0173 0.0866 0.0866
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0274 0.0274
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0035 0.01
Schistosoma mansoni chromobox protein 0.0069 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Plasmodium falciparum thioredoxin reductase 0.0652 0.3427 0.3426
Trichomonas vaginalis glutathione reductase, putative 0.0652 0.3427 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0652 0.3427 0.3424
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0173 0.0866 0.0865
Echinococcus granulosus Chromo domain 0.0011 0.0001 0.0001
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0173 0.0866 1
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0009 0.0009
Brugia malayi CHD4 protein 0.0013 0.0009 0.0009
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0173 0.0866 0.252
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0053 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0053 0.0053
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0042 0.0038
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0025 0.0024
Brugia malayi Protein cec-1. 0.0011 0.0001 0.0001
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0255 0.0255
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0057 0.0243 0.024
Trypanosoma brucei NADH dehydrogenase 0.0173 0.0866 0.0863
Echinococcus multilocularis chromobox protein 1 0.0069 0.0308 0.0308
Mycobacterium ulcerans dehydrogenase 0.0173 0.0866 0.252
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0053 0.0053
Echinococcus multilocularis musashi 0.0028 0.0093 0.0093
Leishmania major trypanothione reductase 0.1881 1 1
Echinococcus multilocularis 0.0012 0.0003 0.0003
Trypanosoma brucei unspecified product 0.0013 0.001 0.0007
Schistosoma mansoni hypothetical protein 0.0166 0.0826 0.0826
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.034 0.034
Schistosoma mansoni peptidase Clp (S14 family) 0.0086 0.0402 0.0402
Schistosoma mansoni coup transcription factor 0.0021 0.0053 0.0053
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0123 0.0597 0.0597
Brugia malayi jmjC domain containing protein 0.0016 0.0025 0.0025
Treponema pallidum oxidoreductase 0.0173 0.0866 0.2304
Trypanosoma cruzi NADH dehydrogenase, putative 0.0173 0.0866 0.0863
Loa Loa (eye worm) cytochrome P450 family protein 0.0054 0.0228 0.0228
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0053 0.0053
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0042 0.0038
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0173 0.0866 0.0866
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.0679 0.0679
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0003 0.0003
Schistosoma mansoni sulfide quinone reductase 0.0173 0.0866 0.0866
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0086 0.0402 0.0908
Echinococcus multilocularis thioredoxin glutathione reductase 0.1881 1 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.009 0.009
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0123 0.0597 0.0597
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0173 0.0866 0.0866
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0173 0.0866 0.0863
Schistosoma mansoni hypothetical protein 0.0012 0.0003 0.0003
Brugia malayi intermediate filament protein 0.0028 0.0093 0.0093
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.1881 1 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0042 0.0038
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0679 0.0679
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0086 0.0402 0.0402
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0053 0.0053
Echinococcus granulosus intermediate filament protein 0.0028 0.0093 0.0093
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0652 0.3427 0.3426
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0021 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0021 0.0053 0.0053
Loa Loa (eye worm) glutathione reductase 0.1881 1 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0086 0.0402 0.0401
Echinococcus granulosus lamin 0.0028 0.0093 0.0093
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0035 0.01
Brugia malayi Thioredoxin reductase 0.1881 1 1
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0162 0.0471
Trichomonas vaginalis glutamate synthase, putative 0.0173 0.0866 0.2526
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0003 0.0003
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0274 0.0274
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.001 0.0007
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0173 0.0866 0.2526
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0652 0.3427 0.3426
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0173 0.0866 0.0863
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0173 0.0866 0.0865
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0173 0.0866 0.1534
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0042 0.0038
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0173 0.0866 0.0866
Plasmodium falciparum thioredoxin reductase 0.1881 1 1
Echinococcus granulosus cpg binding protein 0.003 0.0101 0.0101
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0173 0.0866 0.0863
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0652 0.3427 0.3424
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0004 0.0004
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0025 0.0024
Schistosoma mansoni chromobox protein 0.0069 0.0308 0.0308
Mycobacterium ulcerans monoxygenase 0.0173 0.0866 0.252
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0053 0.0053
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0009 0.0009
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0042 0.0038
Brugia malayi SET domain containing protein 0.0012 0.0004 0.0004
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0021 0.0053 0.0053
Mycobacterium ulcerans NADH dehydrogenase 0.0173 0.0866 0.252
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0173 0.0866 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0042 0.0042
Schistosoma mansoni DNA polymerase eta 0.0019 0.0042 0.0042
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.0679 0.0679
Brugia malayi Valyl-tRNA synthetase 0.0011 0.0001 0.0001
Onchocerca volvulus 0.0028 0.0093 0.1063
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0162 0.0471
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0173 0.0866 0.0863
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0025 0.0025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0053 0.0053
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0173 0.0866 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0173 0.0866 0.0863
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0479 0.2501 0.2501
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0173 0.0866 0.0863
Echinococcus multilocularis Chromobox protein 3 0.0011 0.0001 0.0001
Toxoplasma gondii NADPH-glutathione reductase 0.0652 0.3427 0.3426
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0042 0.0038
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0173 0.0866 0.2526
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0173 0.0866 0.0863
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0053 0.0053
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.0001 0.0001
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0274 0.0274
Plasmodium falciparum glutathione reductase 0.1881 1 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0053 0.0053
Onchocerca volvulus 0.0173 0.0866 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0042 0.0042
Brugia malayi steroid hormone receptor 0.0021 0.0053 0.0053
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0042 0.0038
Schistosoma mansoni hypothetical protein 0.0075 0.034 0.034
Brugia malayi nuclear hormone receptor 0.0021 0.0053 0.0053
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0053 0.0603
Schistosoma mansoni intermediate filament proteins 0.0028 0.0093 0.0093
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0086 0.0402 0.1164
Giardia lamblia Thioredoxin reductase 0.0173 0.0866 0.2436
Schistosoma mansoni thyroid hormone receptor 0.0144 0.071 0.071
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0042 0.0038
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.0679 0.0679
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0025 0.0021
Brugia malayi hypothetical protein 0.0075 0.034 0.034
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0093 0.0093
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0173 0.0866 0.252
Schistosoma mansoni lamin 0.0028 0.0093 0.0093
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0035 0.01
Trichomonas vaginalis mercuric reductase, putative 0.0652 0.3427 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0086 0.0402 0.0401
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0042 0.0038
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0308 0.0308
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0035 0.01
Echinococcus multilocularis glutamate synthase 0.0173 0.0866 0.0866
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0009 0.0009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0053 0.0053
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0173 0.0866 0.2526
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0053 0.0053
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0652 0.3427 0.3424
Loa Loa (eye worm) hypothetical protein 0.0028 0.0093 0.0093
Brugia malayi jmjC domain containing protein 0.0059 0.0255 0.0255
Onchocerca volvulus 0.0012 0.0004 0.0038
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0652 0.3427 0.3427
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0855 0.4514 0.4514
Loa Loa (eye worm) hypothetical protein 0.0021 0.0053 0.0053
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0173 0.0866 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0053 0.0053
Schistosoma mansoni thyroid hormone receptor 0.0144 0.071 0.071
Echinococcus granulosus chromobox protein 1 0.0069 0.0308 0.0308
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0652 0.3427 0.3424
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0173 0.0866 0.2526
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0042 0.0038
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0025
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0255 0.0255
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0053 0.0053
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0053 0.0053
Entamoeba histolytica hypothetical protein 0.0075 0.034 0.3926
Brugia malayi RNA binding protein 0.0062 0.0274 0.0274
Schistosoma mansoni hypothetical protein 0.0173 0.0866 0.0866
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0173 0.0866 0.2526
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0173 0.0866 0.0863
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.0001 0.0001
Echinococcus granulosus thioredoxin glutathione reductase 0.1881 1 1
Giardia lamblia Glutamate synthase 0.0173 0.0866 0.2436
Echinococcus granulosus dna polymerase kappa 0.0019 0.0042 0.0042
Brugia malayi jmjC domain containing protein 0.0016 0.0025 0.0025
Mycobacterium tuberculosis Probable reductase 0.0173 0.0866 0.0863
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0255 0.0255
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0274 0.0274
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0021 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0021 0.0053 0.0053
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0173 0.0866 0.252
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0025 0.0025
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0173 0.0866 0.2526
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0173 0.0866 0.0866
Trichomonas vaginalis apoptosis inducing factor, putative 0.0173 0.0866 0.2526
Trichomonas vaginalis conserved hypothetical protein 0.019 0.0957 0.279
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Echinococcus multilocularis lamin 0.0028 0.0093 0.0093
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0173 0.0866 0.2526
Toxoplasma gondii thioredoxin reductase 0.1881 1 1
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0053 0.0053
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0025 0.0025
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.003 0.01 0.0099
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.003 0.01 0.0281
Loa Loa (eye worm) cytochrome P450 0.0012 0.0003 0.0003
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Trypanosoma brucei hypothetical protein, conserved 0.0173 0.0866 0.0863
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0679 0.0679
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0173 0.0866 0.0865
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0053 0.0053
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0025
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0227 0.0227
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0042 0.0119
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0025 0.0025
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0173 0.0866 0.0863
Loa Loa (eye worm) thioredoxin reductase 0.1881 1 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0017 0.0046
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0042 0.0471
Echinococcus granulosus lysine specific demethylase 5A 0.006 0.0264 0.0264
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0053 0.0053
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0053 0.0053
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0173 0.0866 0.2526
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0173 0.0866 0.0866
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0274 0.0274
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0035 0.01
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0652 0.3427 0.3424
Leishmania major DNA polymerase eta, putative 0.0019 0.0042 0.0038
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0173 0.0866 0.0866
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0146 0.0425
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0025 0.0025
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0173 0.0866 0.0863
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0092 0.0092
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0042 0.0119
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0264 0.0264
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0053 0.0053
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0042 0.0112
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0042 0.0042
Trypanosoma brucei unspecified product 0.0013 0.001 0.0007
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0053 0.0053
Brugia malayi hypothetical protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0003 0.0003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0652 0.3427 0.3424
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0025 0.0025
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0308 0.0896
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.001 0.0007
Schistosoma mansoni hypothetical protein 0.0011 0.0001 0.0001
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0652 0.3427 0.3424
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0173 0.0866 0.0865
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0274 0.0274
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0652 0.3427 0.3424
Echinococcus multilocularis peptidase Clp (S14 family) 0.0057 0.0243 0.0243
Echinococcus multilocularis thyroid hormone receptor alpha 0.0144 0.071 0.071
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0652 0.3427 0.3427
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0173 0.0866 0.0863
Giardia lamblia NADH oxidase lateral transfer candidate 0.0652 0.3427 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0086 0.0402 0.1164
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.0679 0.0679
Loa Loa (eye worm) hypothetical protein 0.0195 0.0985 0.0985
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0173 0.0866 0.0863
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0652 0.3427 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0146 0.0146
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0652 0.3427 0.3426
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0042 0.0038
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0138 0.0679 0.0679
Trypanosoma cruzi NADH dehydrogenase, putative 0.0173 0.0866 0.0863
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0173 0.0866 0.0863
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0652 0.3427 1
Schistosoma mansoni cpg binding protein 0.003 0.0101 0.0101
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0262 0.0262
Plasmodium vivax ferrodoxin reductase, putative 0.0173 0.0866 0.0865
Brugia malayi jmjC domain containing protein 0.0016 0.0025 0.0025
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0035 0.01
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0042 0.0038
Toxoplasma gondii hypothetical protein 0.003 0.01 0.0099
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0173 0.0866 0.0866
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0022 0.0022
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0053 0.0053
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0053 0.0053
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0042 0.0042
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0652 0.3427 0.3424
Plasmodium falciparum ferrodoxin reductase-like protein 0.0173 0.0866 0.0865
Echinococcus granulosus geminin 0.0166 0.0826 0.0826
Entamoeba histolytica disulphide oxidoreductase, putative 0.0173 0.0866 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0086 0.0402 0.1164
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0652 0.3427 1
Schistosoma mansoni cytochrome P450 0.0012 0.0003 0.0003
Echinococcus granulosus chromobox protein 1 0.0069 0.0308 0.0308
Brugia malayi Cytochrome P450 family protein 0.0012 0.0003 0.0003
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0053 0.0053
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0053 0.0053
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0053 0.0053
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0173 0.0866 0.0863
Toxoplasma gondii selenide, water dikinase 0.0173 0.0866 0.0865
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0019 0.0054
Onchocerca volvulus 0.0028 0.0092 0.1054
Trypanosoma cruzi hypothetical protein, conserved 0.0173 0.0866 0.0863
Brugia malayi cytochrome P450 0.0012 0.0003 0.0003
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0022 0.0022
Entamoeba histolytica hypothetical protein 0.0075 0.034 0.3926
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0264 0.0264
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0053 0.0053
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0053 0.0053
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0086 0.025
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0053 0.0053
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0173 0.0866 0.252
Schistosoma mansoni glutamate synthase 0.0173 0.0866 0.0866
Schistosoma mansoni chromobox protein 0.0011 0.0001 0.0001
Schistosoma mansoni glutamate synthase 0.0173 0.0866 0.0866
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0173 0.0866 0.0866
Treponema pallidum thioredoxin reductase (trxB) 0.0173 0.0866 0.2304
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.0001 0.0001
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0173 0.0866 0.0866
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0173 0.0866 0.252
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.034 0.034
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0652 0.3427 1
Echinococcus granulosus Chromobox protein 3 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0021 0.0053 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0042 0.0038
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0035 0.01
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0173 0.0866 0.0863
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0173 0.0866 0.0865
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0053 0.0053
Brugia malayi CXXC zinc finger family protein 0.0028 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Toxoplasma gondii cytochrome p450 superfamily protein 0.0012 0.0003 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0053 0.0053
Trypanosoma cruzi trypanothione reductase, putative 0.1881 1 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0042
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0053 0.0053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0053 0.0053
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0173 0.0866 0.0866
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0053 0.0053
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0173 0.0866 0.0866
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0652 0.3427 0.3427
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0025 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0146 0.0425
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0173 0.0866 0.0865
Entamoeba histolytica hypothetical protein 0.0075 0.034 0.3926
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0042 0.0038
Echinococcus granulosus phd:f box containing protein 0.0016 0.0025 0.0025
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0173 0.0866 0.0865
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0053 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0042 0.0038
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0053 0.0053
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0001 0.0001
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0138 0.0679 0.0679
Echinococcus multilocularis lamin dm0 0.0028 0.0093 0.0093
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0025 0.0025
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0652 0.3427 0.3424
Brugia malayi chromobox protein homolog 3 0.0038 0.0146 0.0146
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0173 0.0866 0.252
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0274 0.0274
Echinococcus granulosus tar DNA binding protein 0.0062 0.0274 0.0274
Loa Loa (eye worm) helicase 0.0011 0.0001 0.0001
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0173 0.0866 0.0866
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.003 0.01 0.0099
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0053 0.0053
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0086 0.0402 0.0402
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0274 0.0274
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0086 0.0402 0.0401
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0014 0.0014
Echinococcus granulosus chromobox protein 2 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0014
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0652 0.3427 0.3424
Leishmania major hypothetical protein, conserved 0.0016 0.0025 0.0021
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0652 0.3427 1
Brugia malayi jmjC domain containing protein 0.006 0.0264 0.0264
Schistosoma mansoni chromobox protein 0.0011 0.0001 0.0001
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0173 0.0866 0.2526
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0173 0.0866 0.0866
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0195 0.0985 0.0985
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0173 0.0866 0.0863
Trypanosoma cruzi trypanothione reductase, putative 0.0652 0.3427 0.3424
Leishmania major NADH dehydrogenase, putative 0.0173 0.0866 0.0863
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0479 0.2501 0.2501
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0652 0.3427 0.3424
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0679 0.0679
Brugia malayi Cytochrome P450 family protein 0.0054 0.0228 0.0228
Brugia malayi glutamate synthase 0.0173 0.0866 0.0866
Brugia malayi Probable ClpP-like protease 0.0086 0.0402 0.0402
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0042 0.0042
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0173 0.0866 0.252
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0042 0.0038
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0652 0.3427 1
Echinococcus granulosus cytochrome P450 2K1 0.0012 0.0003 0.0003
Onchocerca volvulus 0.0028 0.0093 0.1063
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0025 0.0021
Plasmodium falciparum glutathione reductase 0.0652 0.3427 0.3426
Brugia malayi M-phase phosphoprotein, mpp8 0.0011 0.0001 0.0001
Entamoeba histolytica hypothetical protein 0.0075 0.034 0.3926
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0173 0.0866 0.0866
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0053 0.0053
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0053 0.0053
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0042 0.0042
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0652 0.3427 0.3426
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0173 0.0866 0.252
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0053 0.0053
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0652 0.3427 1
Plasmodium vivax glutathione reductase, putative 0.1881 1 1
Entamoeba histolytica thioredoxin reductase, putative 0.0173 0.0866 1
Leishmania major hypothetical protein, conserved 0.0173 0.0866 0.0863
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.001 0.0007
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0053 0.0053
Onchocerca volvulus 0.003 0.0102 0.117
Trichomonas vaginalis glutamate synthase, putative 0.0173 0.0866 0.2526
Brugia malayi TAR-binding protein 0.0062 0.0274 0.0274
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0025 0.0025
Echinococcus granulosus lamin dm0 0.0028 0.0093 0.0093
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0025 0.0025
Leishmania major hypothetical protein, conserved 0.0173 0.0866 0.0863
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0173 0.0866 0.252
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0035 0.01
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0173 0.0866 0.252
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0042 0.0038
Echinococcus granulosus dna polymerase eta 0.0019 0.0042 0.0042
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0042 0.0112
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0652 0.3427 0.3424
Brugia malayi ecdysteroid receptor 0.0021 0.0053 0.0053
Leishmania major DNA polymerase kappa, putative 0.0019 0.0042 0.0038
Onchocerca volvulus 0.0021 0.0053 0.0603
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0652 0.3427 0.3424
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0173 0.0866 0.1534
Plasmodium vivax thioredoxin reductase, putative 0.1881 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0053 0.0053
Leishmania major hypothetical protein, conserved 0.0173 0.0866 0.0863
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0173 0.0866 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0042 0.0038
Echinococcus granulosus peptidase Clp S14 family 0.0057 0.0243 0.0243
Schistosoma mansoni cpg binding protein 0.0028 0.0092 0.0092
Brugia malayi jmjC domain containing protein 0.0016 0.0025 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0042 0.0038
Schistosoma mansoni sulfide quinone reductase 0.0173 0.0866 0.0866
Brugia malayi Cytochrome P450 family protein 0.0012 0.0003 0.0003
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0053 0.0053
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0053 0.0053
Echinococcus multilocularis cpg binding protein 0.003 0.0101 0.0101
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0652 0.3427 0.3424
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0042 0.0038
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0173 0.0866 0.0866
Mycobacterium ulcerans hypothetical protein 0.0173 0.0866 0.252
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0053 0.0603
Echinococcus multilocularis chromobox protein 1 0.0069 0.0308 0.0308
Schistosoma mansoni hypothetical protein 0.0123 0.0597 0.0597
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0042 0.0038
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0025
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0025 0.0025
Brugia malayi Cytochrome P450 family protein 0.0012 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0173 0.0866 0.0866
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0146 0.1684
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0173 0.0866 0.2526
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0274 0.0274
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0308 0.0896
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0093 0.0093
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0042 0.0038
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0173 0.0866 0.0863
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0173 0.0866 0.1534
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0162 0.1864
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0173 0.0866 0.0863
Schistosoma mansoni cpg binding protein 0.003 0.0101 0.0101
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0173 0.0866 0.252
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0057 0.0243 0.024
Plasmodium vivax JmjC domain containing protein 0.0016 0.0025 0.0024
Schistosoma mansoni glutamate synthase 0.0173 0.0866 0.0866
Mycobacterium tuberculosis Probable oxidoreductase 0.0652 0.3427 0.3424
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0053 0.0053
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0019 0.0054
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0652 0.3427 0.3426
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0173 0.0866 0.0863
Echinococcus multilocularis chromobox protein 2 0.0011 0.0001 0.0001
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0053 0.0053
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0652 0.3427 0.3424
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0053 0.0053
Brugia malayi nuclear receptor NHR-88 0.0021 0.0053 0.0053
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0025 0.0025
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0652 0.3427 0.3424
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0033 0.0033
Trypanosoma brucei unspecified product 0.0019 0.0042 0.0038
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0652 0.3427 0.3424
Trypanosoma cruzi hypothetical protein, conserved 0.0173 0.0866 0.0863
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0053 0.0053
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0173 0.0866 0.0863
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0173 0.0866 0.252
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0025 0.0025
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0053 0.0603
Chlamydia trachomatis thioredoxin reductase 0.0173 0.0866 0.1534
Schistosoma mansoni disulfide oxidoreductase 0.0173 0.0866 0.0866
Treponema pallidum NADH oxidase 0.0652 0.3427 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0652 0.3427 0.3427
Echinococcus multilocularis geminin 0.0166 0.0826 0.0826
Mycobacterium ulcerans glutamate synthase subunit beta 0.0173 0.0866 0.252
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0173 0.0866 0.0863
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0042 0.0042
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0255 0.0255
Loa Loa (eye worm) hypothetical protein 0.0086 0.0402 0.0402
Echinococcus granulosus glutamate synthase 0.0173 0.0866 0.0866
Brugia malayi Heterochromatin protein 1 0.0069 0.0308 0.0308
Schistosoma mansoni hypothetical protein 0.0166 0.0826 0.0826
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0025 0.0025
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0264 0.0264
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0053 0.0053
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0173 0.0866 0.0865

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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