TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 511.439 | Formula: C20H25N5O11
H donors: 9 H acceptors: 11 LogP: -6.34 Rotable bonds: 10
Rule of 5 violations (Lipinski): 4
SMILES: OCc1cn(c(=O)[nH]c1=O)C1OC(C(C1O)O)C(C(=O)O)NC(=O)C(CC(c1ccc(cn1)O)O)N
InChi: 1S/C20H25N5O11/c21-9(3-11(28)10-2-1-8(27)4-22-10)17(32)23-12(19(33)34)15-13(29)14(30)18(36-15)25-5-7(6-26)16(31)24-20(25)35/h1-2,4-5,9,11-15,18,26-30H,3,6,21H2,(H,23,32)(H,33,34)(H,24,31,35)
InChiKey: FJTHNEYYXPTOHD-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0223	0.0809	0.0808
Schistosoma mansoni	hypothetical protein	0.0188	0.0677	0.1943
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0167	0.0167
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0223	0.0809	0.232
Loa Loa (eye worm)	hypothetical protein	0.0223	0.0809	0.0809
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0054	0.016	0.0159
Echinococcus multilocularis	geminin	0.0188	0.0677	0.2233
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0223	0.0809	0.0808
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0223	0.0809	0.0808
Brugia malayi	tailless protein	0.0105	0.0357	0.0357
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0142	0.0498	0.1642
Schistosoma mansoni	nuclear hormone receptor	0.0223	0.0809	0.2319
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0357	0.0357
Entamoeba histolytica	protein kinase, putative	0.0202	0.0729	1
Echinococcus multilocularis	nuclear receptor nhr 48	0.0105	0.0357	0.1177
Entamoeba histolytica	protein kinase domain containing protein	0.0202	0.0729	1
Onchocerca volvulus		0.0105	0.0357	0.0357
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0223	0.0809	0.0809
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	0.0012	0.0001	0.5
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0223	0.0809	0.232
Echinococcus multilocularis	survival motor neuron protein 1	0.0263	0.0964	0.3177
Loa Loa (eye worm)	DR-78	0.0105	0.0357	0.0357
Loa Loa (eye worm)	cytochrome P450 family protein	0.0027	0.0057	0.0057
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0016	0.0016	0.5
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0357	0.0357
Echinococcus granulosus	FTZ F1 alpha	0.0223	0.0809	0.232
Brugia malayi	Nuclear hormone receptor-like 1	0.0118	0.0405	0.0405
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0105	0.0357	0.0357
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0223	0.0809	0.2665
Schistosoma mansoni	nuclear hormone receptor	0.0105	0.0357	0.1023
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0223	0.0809	0.2319
Brugia malayi	photoreceptor-specific nuclear receptor	0.0223	0.0809	0.0808
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0042	0.0114	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0223	0.0809	0.0808
Loa Loa (eye worm)	hypothetical protein	0.0223	0.0809	0.0809
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0042	0.0114	1
Schistosoma mansoni	nuclear hormone receptor	0.0105	0.0357	0.1023
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0012	0.0001	0.0002
Brugia malayi	hypothetical protein	0.0105	0.0357	0.0357
Onchocerca volvulus		0.0054	0.016	0.0159
Schistosoma mansoni	cyclin-dependent kinase 5 activator	0.0579	0.2177	0.6246
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0042	0.0114	1
Schistosoma mansoni	zinc finger protein	0.0105	0.0357	0.1023
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0223	0.0809	0.2665
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0223	0.0809	0.0808
Schistosoma mansoni	retinoic acid receptor RXR	0.0919	0.3485	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0223	0.0809	0.2319
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0223	0.0809	0.0808
Brugia malayi	nuclear hormone receptor	0.0105	0.0357	0.0357
Brugia malayi	Cytochrome P450 family protein	0.0027	0.0057	0.0056
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0223	0.0809	0.232
Brugia malayi	nuclear hormone receptor	0.0223	0.0809	0.0808
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0223	0.0809	0.2665
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0012	0.0001	0.0002
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0105	0.0357	0.1024
Brugia malayi	latrophilin 2 splice variant baaae	0.0038	0.0099	0.0099
Echinococcus granulosus	nuclear receptor nhr 48	0.0105	0.0357	0.1024
Brugia malayi	hypothetical protein	0.0277	0.1018	0.1018
Loa Loa (eye worm)	steroid hormone receptor	0.0223	0.0809	0.0809
Brugia malayi	Nuclear hormone receptor E75	0.0105	0.0357	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0357	0.0357
Schistosoma mansoni	hypothetical protein	0.0188	0.0677	0.1943
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0105	0.0357	0.0357
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0223	0.0809	0.232
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0105	0.0357	0.1024
Brugia malayi	hypothetical protein	0.0263	0.0964	0.0963
Brugia malayi	Nuclear hormone receptor-like 1	0.0118	0.0405	0.0405
Giardia lamblia	Histone acetyltransferase GCN5	0.0038	0.0101	0.5
Echinococcus multilocularis	ecdysone induced protein 78C	0.0223	0.0809	0.2665
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0105	0.0357	0.0357
Onchocerca volvulus	Protein ultraspiracle homolog	0.0223	0.0809	0.0808
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0357	0.0357
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0105	0.0357	0.1024
Brugia malayi	Nuclear hormone receptor-like 1	0.0223	0.0809	0.0808
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0012	0.0001	0.0002
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0223	0.0809	0.2319
Loa Loa (eye worm)	acetyltransferase	0.0142	0.0498	0.0498
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0142	0.0498	0.1428
Brugia malayi	nuclear receptor NHR-88	0.0223	0.0809	0.0808
Schistosoma mansoni	RAR-like nuclear receptor	0.0223	0.0809	0.2319
Echinococcus granulosus	multidrug resistance protein 1	0.0012	0.0001	0.0001
Echinococcus granulosus	cyclin dependent kinase 5 activator 1	0.0579	0.2177	0.6246
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0357	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0223	0.0809	0.0809
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.0202	0.0729	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0223	0.0809	0.232
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0223	0.0809	0.2319
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0105	0.0357	0.0357
Brugia malayi	nuclear receptor NHR-88	0.0105	0.0357	0.0357
Echinococcus multilocularis	GPCR, family 2	0.0018	0.0021	0.007
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0223	0.0809	0.0808
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0223	0.0809	0.2319
Brugia malayi	Protein kinase domain containing protein	0.0202	0.0729	0.0729
Schistosoma mansoni	nuclear receptor	0.0105	0.0357	0.1023
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.0012	0.0001	0.5
Loa Loa (eye worm)	nuclear hormone receptor	0.0105	0.0357	0.0357
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.0021	0.0061
Echinococcus multilocularis	cyclin dependent kinase 5 activator 1	0.0579	0.2177	0.7176
Brugia malayi	Cytochrome P450 family protein	0.0016	0.0016	0.0016
Brugia malayi	Cytochrome P450 family protein	0.0016	0.0016	0.0016
Loa Loa (eye worm)	cytochrome P450 family protein	0.0016	0.0016	0.0016
Schistosoma mansoni	hypothetical protein	0.0018	0.0021	0.0059
Schistosoma mansoni	serine/threonine protein kinase	0.0202	0.0729	0.2091
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0223	0.0809	0.0809
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0118	0.0405	0.1163
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0357	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0223	0.0809	0.0809
Schistosoma mansoni	hypothetical protein	0.0054	0.016	0.0457
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0118	0.0405	0.1336
Onchocerca volvulus		0.0105	0.0357	0.0357
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0223	0.0809	0.0809
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0405	0.0405
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0202	0.0729	1
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0357	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0405	0.0405
Schistosoma mansoni	coup transcription factor	0.0223	0.0809	0.2319
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0405	0.0405
Loa Loa (eye worm)	multidrug resistance protein 3	0.0012	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0223	0.0809	0.0809
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0001	0.0001
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0202	0.0729	0.0729
Loa Loa (eye worm)	hypothetical protein	0.0263	0.0964	0.0964
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0012	0.0001	0.0002
Echinococcus granulosus	GPCR family 2	0.0018	0.0021	0.0061
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0012	0.0001	0.0002
Brugia malayi	ecdysone receptor	0.0105	0.0357	0.0357
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0118	0.0405	0.1162
Brugia malayi	nuclear receptor RXR	0.0105	0.0357	0.0357
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0802	0.3034	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0001	0.0001
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0012	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0021	0.0021
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0055	0.0167	0.0166
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0223	0.0809	0.0808
Loa Loa (eye worm)	hypothetical protein	0.0201	0.0725	0.0725
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0105	0.0357	0.1024
Brugia malayi	nuclear hormone receptor family member odr-7	0.0105	0.0357	0.0357
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0223	0.0809	0.2665
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0357	0.0357
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0223	0.0809	0.2665
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0223	0.0809	0.0809
Schistosoma mansoni	survival motor neuron protein	0.0054	0.016	0.0457
Brugia malayi	hypothetical protein	0.0105	0.0357	0.0357
Brugia malayi	nuclear receptor RXR	0.0118	0.0405	0.0405
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0223	0.0809	0.0808
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0118	0.0405	0.1162
Brugia malayi	steroid hormone receptor	0.0223	0.0809	0.0808
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0099	0.0099
Echinococcus granulosus	multidrug resistance protein 1	0.0012	0.0001	0.0001
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0105	0.0357	0.1177
Brugia malayi	orphan nuclear receptor NR2E1	0.0105	0.0357	0.0357
Schistosoma mansoni	nuclear receptor nhr-48	0.0105	0.0357	0.1023
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0055	0.0167	0.0166
Echinococcus granulosus	ecdysone induced protein 78C	0.0223	0.0809	0.232
Echinococcus multilocularis	FTZ F1 alpha	0.0223	0.0809	0.2665
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0223	0.0809	0.2665
Loa Loa (eye worm)	hypothetical protein	0.0223	0.0809	0.0809
Schistosoma mansoni	hypothetical protein	0.0018	0.0021	0.0059
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0042	0.0114	0.0327
Onchocerca volvulus		0.0223	0.0809	0.0808
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0012	0.0001	0.0001
Loa Loa (eye worm)	cytochrome P450 family protein	0.0016	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0277	0.1018	0.1018
Schistosoma mansoni	nuclear receptor	0.0105	0.0357	0.1023
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0042	0.0114	1
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0357	0.0357
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0223	0.0809	0.232
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0223	0.0809	0.0808
Brugia malayi	Steroid receptor seven-up type 2	0.0223	0.0809	0.0808
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0118	0.0405	0.0405
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0202	0.0729	1
Schistosoma mansoni	thyroid hormone receptor	0.0223	0.0809	0.2319
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0223	0.0809	0.2319
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0223	0.0809	0.2319
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0042	0.0114	1
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0105	0.0357	0.0357
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0223	0.0809	0.0809
Schistosoma mansoni	hypothetical protein	0.0018	0.0021	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0405	0.0405
Loa Loa (eye worm)	hypothetical protein	0.0277	0.1018	0.1018
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.0021	0.0021
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.0021	0.0061
Loa Loa (eye worm)	CYP4Cod1	0.0016	0.0016	0.0016
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.0021	0.007
Brugia malayi	Nuclear hormone receptor E75	0.0105	0.0357	0.0357
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0012	0.0001	0.0001
Leishmania major	cytochrome p450-like protein	0.0016	0.0016	0.0215
Brugia malayi	nuclear receptor NHR-67	0.0105	0.0357	0.0357
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0223	0.0809	0.0808
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0055	0.0167	0.0167
Echinococcus granulosus	geminin	0.0188	0.0677	0.1944
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0105	0.0357	0.1023
Echinococcus granulosus	multidrug resistance protein 1	0.0012	0.0001	0.0001
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.0021	0.007
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0357	0.0357
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0223	0.0809	0.0809
Echinococcus multilocularis	multidrug resistance protein 1	0.0012	0.0001	0.0002
Schistosoma mansoni	hypothetical protein	0.0018	0.0021	0.0059
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0105	0.0357	0.0357
Brugia malayi	acetyltransferase, GNAT family protein	0.0142	0.0498	0.0498
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0357	0.0357
Echinococcus granulosus	dual specificity	0.0202	0.0729	0.2092
Echinococcus granulosus	thyroid hormone receptor alpha	0.0105	0.0357	0.1024
Schistosoma mansoni	thyroid hormone receptor	0.0223	0.0809	0.2319
Echinococcus multilocularis	dual specificity	0.0202	0.0729	0.2403
Entamoeba histolytica	acetyltransferase, GNAT family	0.0038	0.0101	0.1373
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0138	0.0483	0.1385
Loa Loa (eye worm)	hypothetical protein	0.2615	1	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0223	0.0809	0.0808
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0223	0.0809	0.0808
Brugia malayi	hypothetical protein	0.0118	0.0405	0.0405
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0919	0.3485	1
Entamoeba histolytica	hypothetical protein	0.0202	0.0729	1
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.0021	0.0021
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.0012	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0357	0.0357
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0105	0.0357	0.1177
Onchocerca volvulus	Bile acid receptor homolog	0.2615	1	1
Brugia malayi	conserved hypotetical protein	0.0105	0.0357	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0201	0.0725	0.0725
Echinococcus multilocularis	multidrug resistance protein 1	0.0012	0.0001	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0405	0.0405
Brugia malayi	hypothetical protein	0.0118	0.0405	0.0405
Loa Loa (eye worm)	hypothetical protein	0.0223	0.0809	0.0809
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.0021	0.0021
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0105	0.0357	0.1177
Schistosoma mansoni	hypothetical protein	0.0038	0.0099	0.0284
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0357	0.0357
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0223	0.0809	0.0808
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0012	0.0001	0.0001
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0105	0.0357	0.1177
Plasmodium falciparum	histone acetyltransferase GCN5	0.0038	0.0101	1
Entamoeba histolytica	protein kinase, putative	0.0202	0.0729	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0223	0.0809	0.2665
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0105	0.0357	0.1023
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0202	0.0729	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0223	0.0809	0.0809
Echinococcus granulosus	survival motor neuron protein 1	0.0263	0.0964	0.2765
Loa Loa (eye worm)	hypothetical protein	0.0579	0.2177	0.2177

Activities

Activity type	Activity value	Assay description	Source	Reference
Zone size (functional)	= 25 mM	Activity against Candida albicans ATCC 26278 strain in YNB medium after incorporation of 10 ug of the compound per disk expressed as zone size	ChEMBL.	3309312
Zone size (functional)	= 28 mM	Activity against Candida albicans ATCC 26278 strain in YNB medium after incorporation of 20 ug of the compound per disk expressed as zone size	ChEMBL.	3309312

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 170699

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 67027