Detailed information for compound 670462

Basic information

Technical information
  • TDR Targets ID: 670462
  • Name: 2-(4-chloro-2-methylphenoxy)-1-(2,6-dimethylp iperidin-1-yl)ethanone
  • MW: 295.804 | Formula: C16H22ClNO2
  • H donors: 0 H acceptors: 1 LogP: 4.12 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(c(c1)C)OCC(=O)N1C(C)CCCC1C
  • InChi: 1S/C16H22ClNO2/c1-11-9-14(17)7-8-15(11)20-10-16(19)18-12(2)5-4-6-13(18)3/h7-9,12-13H,4-6,10H2,1-3H3
  • InChiKey: YWNLOMZLBCZQCV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4-chloro-2-methyl-phenoxy)-1-(2,6-dimethyl-1-piperidyl)ethanone
  • 2-(4-chloro-2-methylphenoxy)-1-(2,6-dimethyl-1-piperidinyl)ethanone
  • 2-(4-chloro-2-methyl-phenoxy)-1-(2,6-dimethylpiperidin-1-yl)ethanone
  • SMR000072977
  • 1-[(4-chloro-2-methylphenoxy)acetyl]-2,6-dimethylpiperidine
  • MLS000062359

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens karyopherin (importin) beta 1 No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis D-aminoacylase, putative 0.0148 0.1382 0.2289
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0148 0.1382 0.2362
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0428 0.2782
Echinococcus multilocularis importin subunit beta 1 0.0035 0.016 0.0218
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0267 0.0365
Brugia malayi MH2 domain containing protein 0.0025 0.0053 0.0084
Mycobacterium tuberculosis Probable lipase LipE 0.0148 0.1382 0.0947
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0005 0.0008
Brugia malayi Hr1 repeat family protein 0.0029 0.0094 0.0153
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0415 0.4283 0.7339
Plasmodium falciparum importin beta, putative 0.0035 0.016 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0148 0.1382 0.1887
Loa Loa (eye worm) hypothetical protein 0.0148 0.1382 0.2362
Echinococcus multilocularis tumor protein p63 0.0695 0.7322 1
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0112 0.5234
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.048 0.0823
Onchocerca volvulus 0.0472 0.4904 1
Brugia malayi Bromodomain containing protein 0.0039 0.0208 0.0349
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0077 0.0617 0.1058
Echinococcus granulosus nervana 2 0.0027 0.0078 0.0107
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.3812 0.6532
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0789 0.1353
Brugia malayi PHD-finger family protein 0.0026 0.0059 0.0094
Schistosoma mansoni ran 0.0026 0.006 0.0103
Brugia malayi hypothetical protein 0.023 0.2272 0.389
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0033 0.0045
Leishmania major hypothetical protein, conserved 0.0148 0.1382 0.396
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0029 0.0094 0.0153
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0005 0.0006
Brugia malayi MH2 domain containing protein 0.0367 0.3763 0.6447
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0005 0.0006
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.016 0.0299
Schistosoma mansoni smad1 5 8 and 0.0025 0.0053 0.0092
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0005 0.0006
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.0094 0.0161
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0088 0.0049
Echinococcus granulosus NDR protein kinase 0.0029 0.0094 0.0128
Entamoeba histolytica protein kinase, putative 0.0056 0.039 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.016 0.0266
Loa Loa (eye worm) Smad1 0.0025 0.0053 0.0084
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0005 0.0006
Brugia malayi glutaminase DH11.1 0.0558 0.5834 1
Onchocerca volvulus 0.0146 0.1365 0.2776
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0005 0.0006
Entamoeba histolytica protein kinase, putative 0.0056 0.039 1
Entamoeba histolytica protein kinase, putative 0.0056 0.039 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0267 0.0359
Giardia lamblia Kinase, AGC PKA 0.0028 0.0088 0.0439
Plasmodium vivax SET domain protein, putative 0.006 0.0428 0.2782
Schistosoma mansoni smad1 5 8 and 0.0025 0.0053 0.0092
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0267 0.0621
Echinococcus multilocularis nervana 2 0.0027 0.0078 0.0107
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.0094 0.0161
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.0094 0.0161
Mycobacterium tuberculosis Conserved protein 0.0148 0.1382 0.0947
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0112 0.0999 0.1365
Loa Loa (eye worm) hypothetical protein 0.0029 0.0094 0.0153
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0158 0.1493 0.4294
Brugia malayi beta-lactamase family protein 0.0148 0.1382 0.2362
Mycobacterium leprae Probable lipase LipE 0.0148 0.1382 0.5
Echinococcus granulosus neuropeptide s receptor 0.0475 0.4926 0.6728
Echinococcus granulosus serine/threonine protein kinase 0.0028 0.0088 0.012
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0028 0.0088 0.0084
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0065 0.0482 0.0658
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0148 0.1382 0.0947
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0027 0.0078 0.0107
Mycobacterium ulcerans hypothetical protein 0.0148 0.1382 0.1684
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0047 0.0291 0.0691
Plasmodium vivax hypothetical protein, conserved 0.0148 0.1382 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.048 0.1259
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0112 0.0156
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.0999 0.1713
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0053 0.0073
Loa Loa (eye worm) hypothetical protein 0.0077 0.0617 0.1051
Loa Loa (eye worm) hypothetical protein 0.0102 0.0886 0.1512
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0112 0.0156
Leishmania major importin beta-1 subunit, putative 0.0028 0.0088 0.0085
Brugia malayi beta-lactamase 0.0148 0.1382 0.2362
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0789 0.1078
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0029 0.0094 0.0153
Loa Loa (eye worm) AGC/AKT protein kinase 0.0056 0.039 0.0661
Echinococcus granulosus protein kinase c iota type 0.0029 0.0094 0.0128
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0028 0.0088 0.0084
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0094 0.0059
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0005 0.0008
Schistosoma mansoni thyroid hormone receptor 0.0276 0.2774 0.4755
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0005 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0267 0.0359
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0267 0.0621
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0033 0.0045
Echinococcus multilocularis protein kinase c iota type 0.0029 0.0094 0.0128
Brugia malayi RNA, U transporter 1 0.0099 0.0856 0.146
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0005 0.0006
Loa Loa (eye worm) MH2 domain-containing protein 0.0367 0.3763 0.6447
Loa Loa (eye worm) hypothetical protein 0.0044 0.0257 0.0432
Brugia malayi Protein kinase domain containing protein 0.0029 0.0094 0.0153
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0005 0.0006
Mycobacterium tuberculosis Probable lipase LipD 0.0148 0.1382 0.0947
Mycobacterium leprae conserved hypothetical protein 0.0148 0.1382 0.5
Loa Loa (eye worm) hypothetical protein 0.003 0.0112 0.0185
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0404 0.0552
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0005 0.0008
Brugia malayi MH1 domain containing protein 0.0025 0.0053 0.0084
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0028 0.0088 0.2808
Toxoplasma gondii hypothetical protein 0.0054 0.0365 0.231
Entamoeba histolytica hypothetical protein 0.0028 0.0088 0.0857
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0452 0.4685 0.8029
Mycobacterium tuberculosis Conserved hypothetical protein 0.0176 0.1686 0.1267
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.006 0.0082
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0029 0.0094 0.0128
Trichomonas vaginalis AGC family protein kinase 0.0056 0.039 0.0571
Onchocerca volvulus 0.0148 0.1382 0.281
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0148 0.1382 0.2362
Schistosoma mansoni cellular tumor antigen P53 0.0102 0.0886 0.1518
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0005 0.0006
Brugia malayi Smad1 0.0025 0.0053 0.0084
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0112 0.0156
Trichomonas vaginalis AGC family protein kinase 0.0056 0.039 0.0571
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0158 0.1493 0.4294
Loa Loa (eye worm) hypothetical protein 0.0042 0.0235 0.0396
Echinococcus granulosus neuropeptide receptor A26 0.0475 0.4926 0.6728
Brugia malayi Pre-SET motif family protein 0.0415 0.4283 0.7339
Schistosoma mansoni glutaminase 0.0558 0.5834 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.016 0.0299
Brugia malayi Pre-SET motif family protein 0.006 0.0428 0.0726
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0065 0.0482 0.0002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0148 0.1382 0.2368
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0028 0.0088 0.0212
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0267 0.0451
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0428 0.0733
Giardia lamblia Kinase, AGC AKT 0.0084 0.0698 1
Schistosoma mansoni smad1 5 8 and 0.0025 0.0053 0.0092
Schistosoma mansoni atypical protein kinase C 0.0029 0.0094 0.0161
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0005 0.0008
Schistosoma mansoni importin beta-1 0.0035 0.016 0.0274
Loa Loa (eye worm) hypothetical protein 0.0148 0.1382 0.2362
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0065 0.0482 0.0003
Echinococcus multilocularis serine threonine protein kinase 0.0029 0.0094 0.0128
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.048 0.0656
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.0094 0.0161
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0112 0.0999 0.1707
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0027 0.0078 0.0107
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0005 0.0006
Trypanosoma cruzi hypothetical protein, conserved 0.0148 0.1382 0.396
Echinococcus multilocularis Smad4 0.0025 0.0053 0.0073
Onchocerca volvulus 0.0148 0.1382 0.281
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.006 0.0082
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0005 0.0006
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0005 0.0008
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0005 0.0008
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0789 0.1346
Echinococcus granulosus protein kinase c epsilon type 0.0029 0.0094 0.0128
Mycobacterium ulcerans beta-lactamase 0.0148 0.1382 0.1684
Brugia malayi Bromodomain containing protein 0.0077 0.0617 0.105
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0005 0.0006
Loa Loa (eye worm) AGC/NDR protein kinase 0.0029 0.0094 0.0153
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.2272 0.3104
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0077 0.0617 0.1058
Echinococcus multilocularis smad 0.0025 0.0053 0.0073
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0053 0.0084
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.0094 0.0161
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0267 0.3249
Echinococcus granulosus survival motor neuron protein 1 0.023 0.2272 0.3104
Trichomonas vaginalis AGC family protein kinase 0.0056 0.039 0.0571
Echinococcus granulosus Smad4 0.0025 0.0053 0.0073
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0088 0.0049
Brugia malayi Protein kinase domain containing protein 0.0452 0.4685 0.8029
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0267 0.0458
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0112 0.0999 0.1365
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.048 0.3179
Onchocerca volvulus 0.006 0.0428 0.0864
Echinococcus multilocularis serine:threonine protein kinase 38 0.0029 0.0094 0.0128
Trypanosoma cruzi Protein kinase B 0.0028 0.0088 0.0084
Loa Loa (eye worm) hypothetical protein 0.0148 0.1382 0.2362
Brugia malayi p70 ribosomal S6 kinase beta 0.0056 0.039 0.0661
Brugia malayi Importin beta-1 subunit 0.0035 0.016 0.0266
Loa Loa (eye worm) glutaminase 0.0558 0.5834 1
Echinococcus granulosus snurportin 1 0.0372 0.3812 0.5207
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0088 0.0049
Trichomonas vaginalis D-aminoacylase, putative 0.0148 0.1382 0.2289
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0428 0.0733
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0148 0.1382 0.2368
Echinococcus multilocularis rac serine:threonine kinase 0.0028 0.0088 0.012
Toxoplasma gondii AGC kinase 0.0056 0.039 0.2496
Schistosoma mansoni coup transcription factor 0.0021 0.0005 0.0008
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.016 0.0754
Trichomonas vaginalis AGC family protein kinase 0.0056 0.039 0.0571
Brugia malayi beta-lactamase family protein 0.0148 0.1382 0.2362
Echinococcus multilocularis protein kinase c epsilon type 0.0029 0.0094 0.0128
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0005 0.0006
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0267 0.0458
Echinococcus multilocularis neuropeptide receptor A26 0.0475 0.4926 0.6728
Mycobacterium tuberculosis Conserved protein 0.0148 0.1382 0.0947
Loa Loa (eye worm) hypothetical protein 0.0148 0.1382 0.2362
Plasmodium vivax importin-beta 2, putative 0.0035 0.016 0.0754
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0005 0.0008
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0028 0.0084 0.0042
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0333 0.3397 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0005 0.0006
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0056 0.039 0.0661
Mycobacterium ulcerans lipase LipD 0.0148 0.1382 0.1684
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0084 0.0698 0.1189
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0094 0.0059
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0005 0.0008
Echinococcus granulosus importin subunit beta 1 0.0035 0.016 0.0218
Toxoplasma gondii ABC1 family protein 0.0148 0.1382 1
Leishmania major hypothetical protein, conserved 0.003 0.0112 0.0156
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0088 0.0085
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0053 0.0092
Loa Loa (eye worm) hypothetical protein 0.0148 0.1382 0.2362
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0033 0.0057
Schistosoma mansoni thyroid hormone receptor 0.0276 0.2774 0.4755
Loa Loa (eye worm) hypothetical protein 0.0073 0.0569 0.0968
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0094 0.0059
Entamoeba histolytica protein kinase 2, putative 0.0028 0.0088 0.0849
Schistosoma mansoni serine/threonine protein kinase 0.0146 0.1365 0.234
Mycobacterium tuberculosis Probable esterase LipL 0.0148 0.1382 0.0947
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0158 0.1493 0.4294
Loa Loa (eye worm) hypothetical protein 0.0148 0.1382 0.2362
Echinococcus granulosus serine:threonine protein kinase N2 0.0029 0.0094 0.0128
Loa Loa (eye worm) glutaminase 2 0.0558 0.5834 1
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0112 0.0395
Mycobacterium tuberculosis Probable hydrolase 0.0148 0.1382 0.0947
Schistosoma mansoni smad 0.0025 0.0053 0.0092
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0029 0.0094 0.0128
Echinococcus granulosus rho-associated protein kinase 1 0.0146 0.1365 0.1864
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.006 0.0095
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0112 0.0395
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0255 0.2552 0.3485
Echinococcus multilocularis serine:threonine protein kinase N2 0.0029 0.0094 0.0128
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0446 0.061
Mycobacterium ulcerans hypothetical protein 0.0176 0.1686 0.2253
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0029 0.0094 0.0128
Loa Loa (eye worm) hypothetical protein 0.0039 0.0209 0.0351
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0057 0.0402 0.1024
Loa Loa (eye worm) beta-lactamase 0.0148 0.1382 0.2362
Onchocerca volvulus 0.0102 0.0886 0.1798
Schistosoma mansoni hypothetical protein 0.0021 0.0012 0.002
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0428 0.0584
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0148 0.1382 0.0947
Schistosoma mansoni hypothetical protein 0.0047 0.029 0.0497
Trichomonas vaginalis penicillin-binding protein, putative 0.0148 0.1382 0.2289
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0053 0.0073
Onchocerca volvulus 0.0047 0.029 0.0583
Brugia malayi Protein kinase domain containing protein 0.0056 0.039 0.0661
Entamoeba histolytica PH domain containing protein kinase, putative 0.0028 0.0088 0.0849
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0094 0.0059
Echinococcus granulosus serine threonine protein kinase nrc 0.0028 0.0088 0.012
Mycobacterium tuberculosis Conserved protein 0.0148 0.1382 0.0947
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0789 0.1346
Onchocerca volvulus 0.0145 0.1355 0.2756
Schistosoma mansoni Smad4 0.0025 0.0053 0.0092
Echinococcus granulosus protein kinase C gamma type 0.0029 0.0094 0.0128
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0435 0.0738
Trichomonas vaginalis AGC family protein kinase 0.0056 0.039 0.0571
Loa Loa (eye worm) hypothetical protein 0.0045 0.0267 0.0451
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0148 0.1382 0.0947
Trichomonas vaginalis AGC family protein kinase 0.0056 0.039 0.0571
Echinococcus multilocularis neuropeptide s receptor 0.0475 0.4926 0.6728
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0333 0.3397 1
Trichomonas vaginalis AGC family protein kinase 0.0056 0.039 0.0571
Loa Loa (eye worm) AGC/PKN protein kinase 0.0029 0.0094 0.0153
Loa Loa (eye worm) transcription factor SMAD2 0.0367 0.3763 0.6447
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0446 0.061
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0267 0.0365
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.0094 0.0161
Trypanosoma brucei hypothetical protein, conserved 0.0148 0.1382 0.396
Mycobacterium ulcerans glutaminase 0.0558 0.5834 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0182 0.0248
Mycobacterium ulcerans esterase/lipase LipP 0.0148 0.1382 0.1684
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0053 0.0084
Trichomonas vaginalis set domain proteins, putative 0.0472 0.4904 0.839
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0053 0.0073
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0267 0.0365
Trypanosoma brucei rac serine-threonine kinase, putative 0.0056 0.039 0.0988
Echinococcus multilocularis Glutaredoxin protein 5 0.0027 0.0078 0.0107
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0267 0.0365
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0267 0.0359
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0267 0.0621
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0047 0.0291 0.0691
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.029 0.049
Trichomonas vaginalis D-aminoacylase, putative 0.0148 0.1382 0.2289
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0291 0.0691
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.0482 0.0818
Trichomonas vaginalis glutaminase, putative 0.0558 0.5834 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0005 0.0006
Echinococcus multilocularis rho associated protein kinase 0.0146 0.1365 0.1864
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0005 0.0006
Onchocerca volvulus 0.0148 0.1382 0.281
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0012 0.0012
Schistosoma mansoni serine/threonine-protein kinase 0.0028 0.0088 0.0151
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0065 0.0482 0.1263
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0255 0.2552 0.3485
Loa Loa (eye worm) hypothetical protein 0.023 0.2272 0.389
Brugia malayi Protein kinase domain containing protein 0.0029 0.0094 0.0153
Brugia malayi hypothetical protein 0.003 0.0112 0.0185
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0789 0.1078
Leishmania major mitochondrial DNA polymerase beta 0.0333 0.3397 1
Schistosoma mansoni ran 0.0026 0.006 0.0103
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0005 0.0008
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0077 0.0617 0.0843
Schistosoma mansoni bromodomain containing protein 0.0065 0.0486 0.0833
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0065 0.0482 0.0658
Schistosoma mansoni serine/threonine-protein kinase 0.0028 0.0088 0.0151
Echinococcus granulosus beta LACTamase domain containing family member 0.0148 0.1382 0.1887
Trichomonas vaginalis esterase, putative 0.0148 0.1382 0.2289
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0148 0.1382 0.1684
Entamoeba histolytica PH domain containing protein kinase, putative 0.0028 0.0088 0.0849
Brugia malayi MH2 domain containing protein 0.0025 0.0053 0.0084
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0291 0.0691
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0789 0.1353
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0029 0.0094 0.0128
Trypanosoma cruzi hypothetical protein, conserved 0.0148 0.1382 0.396
Echinococcus granulosus nervana 2 0.0027 0.0078 0.0107
Trichomonas vaginalis penicillin-binding protein, putative 0.0148 0.1382 0.2289
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.048 0.0656
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0267 0.0365
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0267 0.0621
Entamoeba histolytica protein kinase, putative 0.0029 0.0094 0.103
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0333 0.3397 1
Brugia malayi MH1 domain containing protein 0.0025 0.0053 0.0084
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0028 0.0088 0.012
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0029 0.0094 0.0153
Schistosoma mansoni survival motor neuron protein 0.0047 0.029 0.0497
Schistosoma mansoni hypothetical protein 0.0255 0.2552 0.4374
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0789 0.1353
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.048 0.0823
Schistosoma mansoni serine/threonine kinase 0.0029 0.0094 0.0161
Echinococcus multilocularis nervana 2 0.0027 0.0078 0.0107
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0267 0.628
Echinococcus granulosus smad 0.0025 0.0053 0.0073
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0789 0.1078
Echinococcus granulosus Glutaredoxin protein 5 0.0027 0.0078 0.0107
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0065 0.0482 0.0826
Echinococcus multilocularis snurportin 1 0.0372 0.3812 0.5207
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0053 0.0073
Brugia malayi protein kinase C II. 0.0029 0.0094 0.0153
Echinococcus granulosus Protein kinase C brain isozyme 0.0029 0.0094 0.0128
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0084 0.0698 0.1911
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0182 0.0248
Echinococcus granulosus tumor protein p63 0.0695 0.7322 1
Echinococcus multilocularis serine:threonine protein kinase N2 0.0029 0.0094 0.0128
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0005 0.0006
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.006 0.0095
Schistosoma mansoni hypothetical protein 0.0372 0.3812 0.6535
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0267 0.0365
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0789 0.1078
Echinococcus granulosus histone lysine methyltransferase setb 0.0077 0.0617 0.0843
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0065 0.0482 0.0003
Echinococcus multilocularis thyroid hormone receptor alpha 0.0276 0.2774 0.3789
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0005 0.0006
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0028 0.0088 0.012
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0112 0.5234
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0029 0.0094 0.0128

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1472 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.0596 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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