Detailed information for compound 670475

Basic information

Technical information
  • TDR Targets ID: 670475
  • Name: 2-[2-[(2-iodophenyl)carbamoyl]phenyl]benzoic acid
  • MW: 443.235 | Formula: C20H14INO3
  • H donors: 2 H acceptors: 3 LogP: 4.56 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Ic1ccccc1NC(=O)c1ccccc1c1ccccc1C(=O)O
  • InChi: 1S/C20H14INO3/c21-17-11-5-6-12-18(17)22-19(23)15-9-3-1-7-13(15)14-8-2-4-10-16(14)20(24)25/h1-12H,(H,22,23)(H,24,25)
  • InChiKey: VVYRHBCWXYNIFZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[2-[[(2-iodophenyl)amino]-oxomethyl]phenyl]benzoic acid
  • STK224385

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi MH1 domain containing protein 0.0025 0.0429 0.0429
Schistosoma mansoni tar DNA-binding protein 0.014 0.3588 1
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0164 1
Brugia malayi MH2 domain containing protein 0.0025 0.0429 0.0429
Loa Loa (eye worm) nuclear factor I 0.0014 0.0116 0.0116
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0429 0.1196
Schistosoma mansoni tar DNA-binding protein 0.014 0.3588 1
Loa Loa (eye worm) hypothetical protein 0.0111 0.2796 0.2796
Echinococcus granulosus GPCR family 2 0.0052 0.1149 0.3202
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0052 0.1149 0.3202
Brugia malayi RNA binding protein 0.014 0.3588 0.3588
Schistosoma mansoni hypothetical protein 0.0052 0.1149 0.3202
Schistosoma mansoni smad 0.0011 0.0042 0.0118
Loa Loa (eye worm) MH2 domain-containing protein 0.0373 1 1
Schistosoma mansoni smad1 5 8 and 0.0025 0.0429 0.1196
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0164 0.5
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0052 0.1149 0.3202
Brugia malayi MH1 domain containing protein 0.0014 0.0116 0.0116
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0163 0.4215 0.4215
Echinococcus granulosus Smad4 0.0025 0.0429 0.1196
Schistosoma mansoni Smad4 0.0011 0.0042 0.0118
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0429 0.1196
Schistosoma mansoni tar DNA-binding protein 0.014 0.3588 1
Echinococcus granulosus tar DNA binding protein 0.014 0.3588 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0052 0.1149 0.3202
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0164 0.0456
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0011 0.0042 0.0081
Loa Loa (eye worm) hypothetical protein 0.0163 0.4215 0.4215
Brugia malayi MH2 domain containing protein 0.0011 0.0042 0.0042
Loa Loa (eye worm) transcription factor SMAD2 0.0373 1 1
Brugia malayi MH1 domain containing protein 0.0025 0.0429 0.0429
Schistosoma mansoni Smad4 0.0011 0.0042 0.0118
Brugia malayi N-terminal motif family protein 0.02 0.5228 0.5228
Loa Loa (eye worm) MH1 domain-containing protein 0.0011 0.0042 0.0042
Echinococcus granulosus smad 0.0025 0.0429 0.1196
Echinococcus granulosus mothers against decapentaplegic 6 0.0011 0.0042 0.0118
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0052 0.1149 0.1149
Loa Loa (eye worm) hypothetical protein 0.0011 0.0042 0.0042
Loa Loa (eye worm) TAR-binding protein 0.014 0.3588 0.3588
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0163 0.4215 0.4215
Echinococcus multilocularis mothers against decapentaplegic 2 0.0011 0.0042 0.0118
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0164 0.5
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0429 0.1196
Echinococcus multilocularis GPCR, family 2 0.0052 0.1149 0.3202
Schistosoma mansoni smad1 5 8 and 0.0025 0.0429 0.1196
Loa Loa (eye worm) MH2 domain-containing protein 0.0011 0.0042 0.0042
Schistosoma mansoni tar DNA-binding protein 0.014 0.3588 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.02 0.5228 1
Brugia malayi MH1 domain containing protein 0.0014 0.0116 0.0116
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0429 0.0429
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0429 0.1196
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0164 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0164 0.0456
Schistosoma mansoni hypothetical protein 0.0052 0.1149 0.3202
Echinococcus granulosus mothers against decapentaplegic 2 0.0011 0.0042 0.0118
Brugia malayi MH2 domain containing protein 0.0025 0.0429 0.0429
Loa Loa (eye worm) hypothetical protein 0.0014 0.0116 0.0116
Brugia malayi TAR-binding protein 0.014 0.3588 0.3588
Brugia malayi latrophilin 2 splice variant baaae 0.0111 0.2796 0.2796
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0164 0.5
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0429 0.0429
Brugia malayi Smad1 0.0025 0.0429 0.0429
Loa Loa (eye worm) Smad1 0.0025 0.0429 0.0429
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0164 0.0456
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0429 0.1196
Loa Loa (eye worm) hypothetical protein 0.0052 0.1149 0.1149
Brugia malayi RNA recognition motif domain containing protein 0.014 0.3588 0.3588
Brugia malayi mothers against decapentaplegic homolog 3 0.0011 0.0042 0.0042
Schistosoma mansoni hypothetical protein 0.0052 0.1149 0.3202
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0164 0.5
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0164 0.0456
Loa Loa (eye worm) hypothetical protein 0.02 0.5228 0.5228
Echinococcus multilocularis tar DNA binding protein 0.014 0.3588 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0164 0.5
Schistosoma mansoni smad 0.0025 0.0429 0.1196
Brugia malayi Calcitonin receptor-like protein seb-1 0.0163 0.4215 0.4215
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0164 0.5
Loa Loa (eye worm) latrophilin receptor protein 2 0.0052 0.1149 0.1149
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0164 0.5
Schistosoma mansoni hypothetical protein 0.0111 0.2796 0.7793
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0164 0.0164
Schistosoma mansoni hypothetical protein 0.0052 0.1149 0.3202
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0164 0.0456
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.014 0.3588 0.3588
Brugia malayi isocitrate dehydrogenase 0.0016 0.0164 0.0164
Brugia malayi Latrophilin receptor protein 2 0.0052 0.1149 0.1149
Echinococcus multilocularis mothers against decapentaplegic 6 0.0011 0.0042 0.0118
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0052 0.1149 0.3202
Schistosoma mansoni Smad4 0.0025 0.0429 0.1196
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0164 0.0164
Echinococcus multilocularis smad 0.0025 0.0429 0.1196
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0164 0.0456
Schistosoma mansoni smad1 5 8 and 0.0025 0.0429 0.1196
Loa Loa (eye worm) RNA binding protein 0.014 0.3588 0.3588
Schistosoma mansoni tar DNA-binding protein 0.014 0.3588 1
Echinococcus multilocularis Smad4 0.0025 0.0429 0.1196
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0164 0.0456
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0164 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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