Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | dihydrofolate reductase | 0.8928 | 0.8821 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.8928 | 0.8821 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.8928 | 0.8821 | 1 |
Onchocerca volvulus | 0.5299 | 0.3825 | 0.5 | |
Brugia malayi | thymidylate synthase | 0.5299 | 0.3825 | 0.4336 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.9784 | 1 | 0.5 |
Brugia malayi | dihydrofolate reductase family protein | 0.8928 | 0.8821 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.8928 | 0.8821 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.9784 | 1 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.8928 | 0.8821 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.2521 | 0 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.9784 | 1 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.9784 | 1 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.9784 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.8928 | 0.8821 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.8928 | 0.8821 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.8928 | 0.8821 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.8928 | 0.8821 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.5299 | 0.3825 | 0.4336 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | In vitro inhibition of [3H]-AMPA binding to Ionotropic glutamate receptor AMPA. | ChEMBL. | 8648608 |
IC50 (binding) | > 100 uM | In vitro inhibition of [3H]-CNQX binding to Ionotropic glutamate receptor AMPA. | ChEMBL. | 8648608 |
IC50 (binding) | > 100 uM | In vitro inhibition of [3H]-CPP binding to NMDA receptor. | ChEMBL. | 8648608 |
IC50 (binding) | > 100 uM | In vitro inhibition of [3H]-KAIN binding to Ionotropic glutamate receptor kainate. | ChEMBL. | 8648608 |
IC50 (binding) | > 100 uM | In vitro inhibition of [3H]-AMPA binding to Ionotropic glutamate receptor AMPA. | ChEMBL. | 8648608 |
IC50 (binding) | > 100 uM | In vitro inhibition of [3H]-CNQX binding to Ionotropic glutamate receptor AMPA. | ChEMBL. | 8648608 |
IC50 (binding) | > 100 uM | In vitro inhibition of [3H]-CPP binding to NMDA receptor. | ChEMBL. | 8648608 |
IC50 (binding) | > 100 uM | In vitro inhibition of [3H]-KAIN binding to Ionotropic glutamate receptor kainate. | ChEMBL. | 8648608 |
IC50 (functional) | > 1000 uM | Inhibition of AMPA induced electrophysiological responses in rat cortical slices. | ChEMBL. | 8648608 |
IC50 (functional) | > 1000 uM | Inhibition of AMPA induced electrophysiological responses in rat cortical slices. | ChEMBL. | 8648608 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.