Detailed information for compound 670760

Basic information

Technical information
  • TDR Targets ID: 670760
  • Name: N-(2-cyclohexylsulfanylethyl)-2-[(3,4-dimetho xyphenyl)-methylsulfonylamino]acetamide
  • MW: 430.582 | Formula: C19H30N2O5S2
  • H donors: 1 H acceptors: 3 LogP: 2.82 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)N(S(=O)(=O)C)CC(=O)NCCSC1CCCCC1
  • InChi: 1S/C19H30N2O5S2/c1-25-17-10-9-15(13-18(17)26-2)21(28(3,23)24)14-19(22)20-11-12-27-16-7-5-4-6-8-16/h9-10,13,16H,4-8,11-12,14H2,1-3H3,(H,20,22)
  • InChiKey: MCRYSWLLQVTFKZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-cyclohexylsulfanylethyl)-2-[(3,4-dimethoxyphenyl)-methylsulfonyl-amino]acetamide
  • N-[2-(cyclohexylthio)ethyl]-2-[(3,4-dimethoxyphenyl)-methylsulfonylamino]acetamide
  • N-[2-(cyclohexylthio)ethyl]-2-[(3,4-dimethoxyphenyl)-mesyl-amino]acetamide
  • N-(2-cyclohexylsulfanylethyl)-2-[(3,4-dimethoxyphenyl)-methylsulfonyl-amino]ethanamide
  • ZINC08396183
  • AH-487/41304159

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0026 0.0445 0.0408
Onchocerca volvulus 0.023 0.7303 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0736 0.0664
Toxoplasma gondii type I fatty acid synthase, putative 0.008 0.2244 0.6627
Schistosoma mansoni sex comb on midleg homolog 0.005 0.1237 0.1178
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.022 0.1511
Echinococcus multilocularis cpg binding protein 0.0062 0.1641 0.1575
Schistosoma mansoni leucyl-tRNA synthetase 0.002 0.0251 0.0186
Loa Loa (eye worm) hypothetical protein 0.0037 0.0815 0.078
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0226 0.0188
Mycobacterium ulcerans polyketide synthase 0.0075 0.2087 0.6023
Echinococcus granulosus dna polymerase kappa 0.0019 0.022 0.0144
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.058 0.123
Mycobacterium ulcerans thioesterase 0.0062 0.1667 0.4682
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.002 0.0251 0.0175
Schistosoma mansoni lamin 0.0026 0.0445 0.0381
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0736 0.0664
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1626 0.1571
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0019 0.0201 0.0125
Brugia malayi Muscleblind-like protein 0.0305 0.9827 1
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0738 0.0676
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0288 0.0756
Echinococcus granulosus lamin dm0 0.0026 0.0445 0.0371
Brugia malayi PHD-finger family protein 0.0027 0.0487 0.0458
Echinococcus granulosus methyl CpG binding domain protein 2 0.0016 0.0123 0.0046
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.008 0.2244 0.6541
Treponema pallidum methionyl-tRNA synthetase 0.002 0.0251 0.5
Schistosoma mansoni sex comb on midleg homolog 0.005 0.1237 0.1178
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0226 0.0161
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.022 0.0144
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0226 0.015
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0445 0.0408
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.1134 0.1065
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0077 0.0011
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.022 0.1193
Echinococcus multilocularis leucyl tRNA synthetase 0.002 0.0251 0.0175
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0019 0.0201 0.1049
Brugia malayi nuclear receptor NHR-88 0.002 0.0226 0.0191
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0226 0.015
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0226 0.015
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.022 0.0113
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0226 0.0188
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1626 0.1571
Brugia malayi Bromodomain containing protein 0.0076 0.2113 0.212
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.1237 0.1178
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0075 0.2087 0.6044
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.1237 0.1428
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0053 0.1355 0.3718
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.3637 0.3594
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0226 0.0161
Loa Loa (eye worm) fatty acid synthase 0.0074 0.2054 0.2023
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0053 0.1355 1
Trypanosoma brucei unspecified product 0.0019 0.022 0.1511
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0053 0.1355 0.1855
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0226 0.0161
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.1237 0.1168
Mycobacterium ulcerans Type I modular polyketide synthase 0.0075 0.2087 0.6023
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.003 0.0587 0.128
Toxoplasma gondii tRNA ligases class I (M) protein 0.002 0.0251 0.0161
Echinococcus multilocularis lamin 0.0026 0.0445 0.0371
Brugia malayi Methyltransferase-like protein 4 0.0023 0.0328 0.0296
Leishmania major hypothetical protein, conserved 0.0023 0.0328 0.2031
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.1467 0.1401
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0016 0.0123 0.0046
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.022 0.1193
Giardia lamblia Methyltransferase like 2 0.0023 0.0328 0.0951
Mycobacterium tuberculosis Hypothetical protein 0.0023 0.0328 0.0455
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.006 0.1595 0.4155
Mycobacterium ulcerans polyketide synthase Pks13 0.0112 0.3332 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.058 0.0507
Loa Loa (eye worm) hypothetical protein 0.005 0.1237 0.1203
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0061 0.1628 0.4587
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.005 0.1234 0.2941
Mycobacterium tuberculosis Polyketide synthase Pks12 0.008 0.2244 0.6541
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0075 0.2087 0.2093
Loa Loa (eye worm) hypothetical protein 0.002 0.0226 0.0188
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0112 0.3332 1
Brugia malayi protein ZK524.3 0.002 0.0251 0.0217
Schistosoma mansoni methionine-tRNA synthetase 0.0053 0.1355 0.1297
Onchocerca volvulus 0.013 0.3952 0.5265
Loa Loa (eye worm) TAR-binding protein 0.0061 0.1626 0.1594
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.1134 0.1075
Echinococcus multilocularis lamin dm0 0.0026 0.0445 0.0371
Trypanosoma brucei ISWI complex protein 0.0015 0.0066 0.036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0226 0.0188
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.022 0.0185
Loa Loa (eye worm) hypothetical protein 0.0039 0.0892 0.0857
Plasmodium vivax SET domain protein, putative 0.003 0.058 0.3285
Toxoplasma gondii methionyl-tRNA synthetase 0.0053 0.1355 0.3743
Brugia malayi methionyl-tRNA synthetase 0.0053 0.1355 0.1345
Entamoeba histolytica hypothetical protein 0.0035 0.0738 1
Onchocerca volvulus 0.0026 0.0445 0.031
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.1237 0.1168
Mycobacterium ulcerans polyketide synthase MbtD 0.0023 0.0343 0.0454
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0226 0.0191
Mycobacterium tuberculosis Conserved protein 0.0023 0.0328 0.0455
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0019 0.0201 0.0125
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.002 0.0251 0.0175
Schistosoma mansoni hypothetical protein 0.0302 0.9705 0.9703
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0142 0.4342 0.4396
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.022 0.1193
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0123 0.0057
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0362 0.0495
Echinococcus granulosus lamin 0.0026 0.0445 0.0371
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1626 0.1571
Brugia malayi hypothetical protein 0.0035 0.0738 0.0714
Brugia malayi methionyl-tRNA synthetase 0.002 0.0251 0.0217
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0226 0.015
Loa Loa (eye worm) acyl carrier protein 0.0034 0.0727 0.0691
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.007 0.1922 0.5519
Echinococcus multilocularis dna polymerase kappa 0.0019 0.022 0.0144
Trichomonas vaginalis ran, putative 0.0021 0.0288 0.0395
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0123 0.0057
Echinococcus multilocularis dna polymerase eta 0.0019 0.022 0.0144
Schistosoma mansoni thyroid hormone receptor 0.002 0.0226 0.0161
Plasmodium falciparum methionine--tRNA ligase 0.0053 0.1355 1
Leishmania major methionyl-tRNA synthetase, putative 0.0053 0.1355 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.022 0.1511
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0503 0.0429
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0248 0.0214
Entamoeba histolytica hypothetical protein 0.0035 0.0738 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0226 0.015
Leishmania major GTP-binding protein, putative 0.0021 0.0288 0.1725
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.022 0.1511
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0019 0.0201 0.0163
Mycobacterium leprae Probable polyketide synthase Pks1 0.008 0.2244 0.6337
Loa Loa (eye worm) hypothetical protein 0.0056 0.1467 0.1434
Entamoeba histolytica hypothetical protein 0.0035 0.0738 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0226 0.0191
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0193 0.0117
Brugia malayi nuclear hormone receptor 0.002 0.0226 0.0191
Schistosoma mansoni lamin 0.0026 0.0445 0.0381
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0546 0.112
Loa Loa (eye worm) hypothetical protein 0.0305 0.9827 0.9826
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0024 0.036 0.0558
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.058 0.0518
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0053 0.1355 0.3684
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0288 0.0283
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0226 0.015
Brugia malayi RNA binding protein 0.0061 0.1626 0.1622
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0226 0.0161
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0288 0.0251
Schistosoma mansoni methionine-tRNA synthetase 0.002 0.0251 0.0186
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0226 0.015
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0075 0.2087 0.6044
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.006 0.1595 0.4452
Plasmodium vivax methionine--tRNA ligase, putative 0.002 0.0251 0.043
Schistosoma mansoni hypothetical protein 0.002 0.0239 0.0174
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0195 0.614 0.611
Echinococcus granulosus muscleblind protein 0.0305 0.9827 0.9825
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.005 0.1234 0.3299
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0062 0.1667 0.4398
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.022 0.0144
Loa Loa (eye worm) AMP-binding enzyme family protein 0.007 0.1922 0.1891
Giardia lamblia Leucyl-tRNA synthetase 0.002 0.0251 0.0273
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0226 0.0188
Toxoplasma gondii type I fatty acid synthase, putative 0.0053 0.1362 0.3765
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.1467 0.1401
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0546 0.3953
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.022 0.1511
Onchocerca volvulus 0.005 0.1237 0.1428
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.022 0.1511
Giardia lamblia Methionyl-tRNA synthetase 0.0053 0.1355 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.031 1 1
Loa Loa (eye worm) MBCTL1 0.0056 0.1467 0.1434
Brugia malayi intermediate filament protein 0.0026 0.0445 0.0415
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0053 0.1355 1
Brugia malayi CXXC zinc finger family protein 0.0057 0.147 0.1463
Schistosoma mansoni hypothetical protein 0.031 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.022 0.1511
Echinococcus granulosus importin subunit beta 1 0.0029 0.0546 0.0473
Brugia malayi MH2 domain containing protein 0.0124 0.3742 0.3784
Brugia malayi ecdysteroid receptor 0.002 0.0226 0.0191
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0362 0.0495
Mycobacterium ulcerans polyketide synthase Pks9 0.005 0.1234 0.3299
Loa Loa (eye worm) hypothetical protein 0.0044 0.1063 0.1028
Echinococcus granulosus zinc finger protein 0.0022 0.0313 0.0238
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0362 0.2293
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.1467 0.146
Brugia malayi Bromodomain containing protein 0.0037 0.0813 0.0791
Loa Loa (eye worm) hypothetical protein 0.0019 0.022 0.0182
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.041 0.0335
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0023 0.0343 0.0505
Leishmania major importin beta-1 subunit, putative 0.0024 0.0362 0.2293
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.041 0.0335
Trichomonas vaginalis set domain proteins, putative 0.023 0.7303 1
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.022 0.006
Mycobacterium leprae Polyketide synthase Pks13 0.0112 0.3332 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0226 0.0191
Onchocerca volvulus 0.003 0.058 0.0501
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.1467 0.1401
Brugia malayi AMP-binding enzyme family protein 0.007 0.1922 0.1924
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0288 0.1725
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0226 0.0191
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0226 0.0191
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0075 0.2087 0.581
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0019 0.0201 0.0166
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0226 0.0161
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.1626 0.1622
Schistosoma mansoni hypothetical protein 0.0035 0.0738 0.0676
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0226 0.015
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0019 0.0201 0.1049
Echinococcus multilocularis muscleblind protein 0.0305 0.9827 0.9825
Onchocerca volvulus 0.0026 0.0445 0.031
Echinococcus granulosus intermediate filament protein 0.0026 0.0445 0.0371
Echinococcus multilocularis tar DNA binding protein 0.0061 0.1626 0.1561
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.022 0.1511
Treponema pallidum leucyl-tRNA synthetase 0.002 0.0251 0.5
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.3742 0.3718
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.022 0.1511
Schistosoma mansoni importin beta-1 0.0029 0.0546 0.0483
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.008 0.2244 0.6522
Loa Loa (eye worm) RNA binding protein 0.0061 0.1626 0.1594
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0038 0.0842 0.2078
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0075 0.2087 0.581
Plasmodium falciparum methionine--tRNA ligase, putative 0.002 0.0251 0.043
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0053 0.1355 0.1321
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.022 0.0301
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0328 0.0449
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0226 0.0191
Echinococcus granulosus FTZ F1 alpha 0.002 0.0226 0.015
Brugia malayi Pre-SET motif family protein 0.0202 0.6369 0.6468
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.022 0.1511
Brugia malayi mbt repeat family protein 0.005 0.1237 0.1224
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.022 0.006
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0019 0.0201 0.0136
Echinococcus multilocularis zinc finger protein 0.0022 0.0313 0.0238
Schistosoma mansoni cpg binding protein 0.0062 0.1641 0.1585
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1626 0.1571
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0738 0.0666
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0226 0.0191
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0112 0.3332 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.147 0.1437
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0226 0.0191
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0226 0.015
Echinococcus multilocularis musashi 0.0026 0.0445 0.0371
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0054 0.1378 0.3791
Plasmodium vivax hypothetical protein, conserved 0.002 0.0251 0.043
Schistosoma mansoni cpg binding protein 0.0062 0.1641 0.1585
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.1467 0.1411
Loa Loa (eye worm) hypothetical protein 0.0029 0.0546 0.051
Mycobacterium ulcerans Type I modular polyketide synthase 0.0075 0.2087 0.6023
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0226 0.0191
Loa Loa (eye worm) hypothetical protein 0.0047 0.1134 0.11
Schistosoma mansoni cpg binding protein 0.0057 0.147 0.1413
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0226 0.015
Loa Loa (eye worm) mbt repeat family protein 0.005 0.1237 0.1203
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.008 0.2244 0.6541
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0362 0.0495
Loa Loa (eye worm) hypothetical protein 0.0305 0.9827 0.9826
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0239 0.0202
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.022 0.1193
Loa Loa (eye worm) hypothetical protein 0.002 0.0226 0.0188
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.1134 0.1075
Mycobacterium ulcerans fatty acid synthase Fas 0.0024 0.036 0.0508
Loa Loa (eye worm) hypothetical protein 0.002 0.0251 0.0213
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0226 0.0191
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0226 0.0191
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0226 0.0191
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.022 0.1511
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0738 0.0666
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0143 0.0105
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0343 0.0312
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0226 0.0161
Brugia malayi RNA, U transporter 1 0.0083 0.2348 0.2359
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0288 0.2023
Echinococcus multilocularis muscleblind protein 1 0.0305 0.9827 0.9825
Onchocerca volvulus 0.0057 0.147 0.1758
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.0053 0.1355 0.3346
Mycobacterium ulcerans thioesterase TesA 0.0062 0.1667 0.4682
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0288 0.1725
Loa Loa (eye worm) hypothetical protein 0.002 0.0226 0.0188
Loa Loa (eye worm) hypothetical protein 0.002 0.0226 0.0188
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.022 0.1511
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0226 0.015
Plasmodium vivax importin-beta 2, putative 0.0029 0.0546 0.2992
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0073 0.201 0.5799
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.1616 0.1551
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.022 0.0155
Loa Loa (eye worm) hypothetical protein 0.002 0.0226 0.0188
Plasmodium falciparum importin beta, putative 0.0029 0.0546 0.2992
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0226 0.0191
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.008 0.2244 0.6337
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0195 0.614 0.611
Echinococcus granulosus cpg binding protein 0.0062 0.1641 0.1575
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0019 0.0201 0.1049
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.1467 0.1401
Leishmania major DNA polymerase eta, putative 0.0019 0.022 0.1193
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.008 0.2244 0.6337
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0075 0.2087 0.6023
Mycobacterium tuberculosis Probable thioesterase TesA 0.0062 0.1667 0.4711
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0226 0.015
Mycobacterium ulcerans leucyl-tRNA synthetase 0.002 0.0251 0.0158
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0226 0.0161
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0226 0.0188
Echinococcus granulosus polycomb protein SCMH1 0.005 0.1237 0.1168
Echinococcus granulosus dna polymerase eta 0.0019 0.022 0.0144
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0019 0.0201 0.1371
Onchocerca volvulus Fatty acid synthase homolog 0.0135 0.4108 0.5486
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0546 0.0473
Brugia malayi TAR-binding protein 0.0061 0.1626 0.1622
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0445 0.0408
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0226 0.015
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.022 0.1511
Brugia malayi steroid hormone receptor 0.002 0.0226 0.0191
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.1626 0.1594
Echinococcus granulosus tar DNA binding protein 0.0061 0.1626 0.1561
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0226 0.0188
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.058 0.0518
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.1616 0.1551
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.022 0.0182
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0049 0.1203 0.3249
Loa Loa (eye worm) hypothetical protein 0.0068 0.1866 0.1835
Chlamydia trachomatis methionine--tRNA ligase 0.002 0.0251 1
Mycobacterium ulcerans polyketide synthase 0.008 0.2244 0.6522
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0226 0.015
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0546 0.3953
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.022 0.1193
Schistosoma mansoni ran 0.0021 0.0288 0.0224
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.022 0.0301
Schistosoma mansoni coup transcription factor 0.002 0.0226 0.0161
Schistosoma mansoni thyroid hormone receptor 0.002 0.0226 0.0161
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0193 0.0117
Entamoeba histolytica Ran family GTPase 0.0021 0.0288 0.1323
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0226 0.0161
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.022 0.0155
Schistosoma mansoni ran 0.0021 0.0288 0.0224
Mycobacterium ulcerans Type I modular polyketide synthase 0.0075 0.2087 0.6023
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.6369 0.6355
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.022 0.0113
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.022 0.1511
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0193 0.0155
Echinococcus multilocularis methionine tRNA synthetase 0.0053 0.1355 0.1288
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.1237 0.1168
Schistosoma mansoni zinc finger protein 0.0022 0.0313 0.0249
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.008 0.2244 0.6522
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0226 0.0191
Leishmania major leucyl-tRNA synthetase, putative 0.002 0.0251 0.1434
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0445 0.0415
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0288 0.0213
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.022 0.0185
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.006 0.1595 0.4452
Loa Loa (eye worm) tyrosyl-tRNA synthetase 0.0033 0.0673 0.0637
Entamoeba histolytica hypothetical protein 0.0024 0.0362 0.2737
Brugia malayi mbt repeat family protein 0.005 0.1237 0.1224
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0226 0.015
Schistosoma mansoni intermediate filament proteins 0.0026 0.0445 0.0381
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0226 0.0191
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0043 0.1001 0.2593
Chlamydia trachomatis leucine--tRNA ligase 0.002 0.0251 1
Leishmania major DNA polymerase kappa, putative 0.0019 0.022 0.1193
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0226 0.015
Loa Loa (eye worm) hypothetical protein 0.0126 0.3799 0.3775
Schistosoma mansoni nuclear hormone receptor 0.002 0.0226 0.0161
Loa Loa (eye worm) hypothetical protein 0.002 0.0251 0.0213
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0288 0.0213
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0053 0.1355 1
Echinococcus multilocularis snurportin 1 0.031 1 1
Wolbachia endosymbiont of Brugia malayi leucyl-tRNA synthetase 0.002 0.0251 0.043
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0288 0.0604
Loa Loa (eye worm) hypothetical protein 0.002 0.0226 0.0188
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0226 0.0161
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.1134 0.1065
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.022 0.1193
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0073 0.201 0.5799
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.002 0.0251 0.0598
Loa Loa (eye worm) hypothetical protein 0.0026 0.0429 0.0392
Schistosoma mansoni bromodomain containing protein 0.0064 0.1733 0.1678
Loa Loa (eye worm) hypothetical protein 0.002 0.0251 0.0213
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0226 0.015
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1626 0.1571
Loa Loa (eye worm) hypothetical protein 0.0042 0.098 0.0945
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.3742 0.3718
Plasmodium vivax methionine--tRNA ligase, putative 0.0053 0.1355 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0226 0.0188
Brugia malayi Importin beta-1 subunit 0.0029 0.0546 0.0519
Onchocerca volvulus 0.0033 0.0673 0.0632
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0288 0.0756
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.022 0.1511
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0288 0.0255
Brugia malayi Pre-SET motif family protein 0.003 0.058 0.0554
Onchocerca volvulus 0.007 0.1922 0.2396
Schistosoma mansoni methyltransferase-related 0.0023 0.0328 0.0263
Loa Loa (eye worm) hypothetical protein 0.002 0.0226 0.0188
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0026 0.0435 0.0795
Entamoeba histolytica hypothetical protein 0.0035 0.0738 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0075 0.2087 0.6044
Echinococcus granulosus methionine tRNA synthetase 0.0053 0.1355 0.1288
Loa Loa (eye worm) hypothetical protein 0.002 0.0226 0.0188
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.041 0.0346
Toxoplasma gondii histone lysine methyltransferase SET1 0.011 0.3283 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0226 0.0188
Schistosoma mansoni DNA polymerase eta 0.0019 0.022 0.0155
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0226 0.0191

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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