Detailed information for compound 67078

Basic information

Technical information
  • TDR Targets ID: 67078
  • Name: 1-[4-[5-[(2,4-dichlorophenyl)methylsulfanyl]- 4-methyl-1,2,4-triazol-3-yl]phenyl]-3-prop-2- enylthiourea
  • MW: 464.434 | Formula: C20H19Cl2N5S2
  • H donors: 2 H acceptors: 2 LogP: 4.93 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCNC(=S)Nc1ccc(cc1)c1nnc(n1C)SCc1ccc(cc1Cl)Cl
  • InChi: 1S/C20H19Cl2N5S2/c1-3-10-23-19(28)24-16-8-5-13(6-9-16)18-25-26-20(27(18)2)29-12-14-4-7-15(21)11-17(14)22/h3-9,11H,1,10,12H2,2H3,(H2,23,24,28)
  • InChiKey: QQXGLUFZFSSNBW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-allyl-3-[4-[5-[(2,4-dichlorophenyl)methylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]phenyl]thiourea
  • 1-allyl-3-[4-[5-[(2,4-dichlorophenyl)methylthio]-4-methyl-1,2,4-triazol-3-yl]phenyl]thiourea
  • 1-[4-[5-[(2,4-dichlorophenyl)methylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]phenyl]-3-prop-2-enyl-thiourea
  • 1-allyl-3-[4-[5-[(2,4-dichlorobenzyl)thio]-4-methyl-1,2,4-triazol-3-yl]phenyl]thiourea
  • 3-allyl-1-[4-[5-[(2,4-dichlorophenyl)methylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]phenyl]thiourea
  • 3-allyl-1-[4-[5-[(2,4-dichlorophenyl)methylthio]-4-methyl-1,2,4-triazol-3-yl]phenyl]thiourea
  • 3-allyl-1-[4-[5-[(2,4-dichlorobenzyl)thio]-4-methyl-1,2,4-triazol-3-yl]phenyl]thiourea
  • AIDS-040538
  • AIDS040538
  • N-allyl-N'-{4-[3-(2,4-dichlorobenzylthio)-4-methyl-4H-1,2,4-triazole-5yl]phenyl}thiourea

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis discoidin domain containing receptor 2 0.00267599 0.000347556 0.000123387
Toxoplasma gondii F5/8 type C domain-containing protein 0.00267599 0.000347556 0.00567952
Brugia malayi hypothetical protein 0.00350718 0.00113585 0.000879733
Mycobacterium ulcerans thioesterase TesA 0.0033804 0.00101561 0.0237285
Loa Loa (eye worm) aspartic protease BmAsp-1 0.00350718 0.00113585 0.000956227
Brugia malayi Calcium binding EGF domain containing protein 0.00276614 0.000433053 0.000176752
Giardia lamblia Hypothetical protein 0.038946 0.0347459 0.13171
Trichomonas vaginalis conserved hypothetical protein 0.00410407 0.00170194 0.00318032
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.038946 0.0347459 0.0807733
Brugia malayi Protein kinase domain containing protein 0.00463395 0.00220448 0.00194863
Toxoplasma gondii histone lysine-specific demethylase 0.00695071 0.00440169 0.100064
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0069166 0.00436933 0.066526
Toxoplasma gondii subtilisin SUB2 0.0234387 0.0200388 0.464115
Plasmodium vivax hypothetical protein, conserved 0.00695071 0.00440169 0.0880653
Plasmodium vivax subtilisin-like protease 1 0.0234387 0.0200388 0.427741
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.149585 0.139676 0.327167
Loa Loa (eye worm) proprotein convertase 2 0.173024 0.161905 0.161754
Schistosoma mansoni serine/threonine protein kinase 0.00860698 0.00597249 0.0083662
Echinococcus multilocularis disintegrin and metalloproteinase 0.0100087 0.00730191 0.00953119
Trichomonas vaginalis conserved hypothetical protein 0.149585 0.139676 0.327167
Echinococcus multilocularis Furin 1 0.173024 0.161905 0.218677
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0234387 0.0200388 0.0462385
Echinococcus multilocularis integrin beta 2 0.782012 0.739468 1
Loa Loa (eye worm) WD40 repeat protein 0.0090561 0.00639844 0.00621975
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.00334497 0.000982014 0.0222202
Toxoplasma gondii aspartyl protease 0.00350718 0.00113585 0.024032
Brugia malayi EGF-like domain containing protein 0.0310462 0.0272538 0.0270043
Trichomonas vaginalis conserved hypothetical protein 0.00410407 0.00170194 0.00318032
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0069166 0.00436933 0.182783
Brugia malayi celfurPC protein 0.60545 0.572018 0.571908
Trichomonas vaginalis conserved hypothetical protein 0.149585 0.139676 0.327167
Echinococcus multilocularis membrane bound transcription factor site 1 0.0234387 0.0200388 0.0267616
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.038946 0.0347459 1
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0062035 0.00369303 0.152733
Loa Loa (eye worm) hypothetical protein 0.00350718 0.00113585 0.000956227
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0069166 0.00436933 0.00944383
Onchocerca volvulus 0.00350718 0.00113585 0.0206885
Toxoplasma gondii kringle domain-containing protein 0.00463395 0.00220448 0.0489109
Loa Loa (eye worm) hypothetical protein 0.00350718 0.00113585 0.000956227
Brugia malayi hypothetical protein 0.00350718 0.00113585 0.000879733
Loa Loa (eye worm) hypothetical protein 0.079543 0.0732481 0.0730815
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.00344069 0.00107279 0.0363084
Echinococcus granulosus serine:threonine protein kinase N2 0.00709081 0.00453456 0.00578754
Toxoplasma gondii subtilisin SUB12 0.0234387 0.0200388 0.464115
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0234387 0.0200388 0.0462385
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.00428655 0.00187501 0.0623105
Echinococcus granulosus Tolloid protein 1 0.00271618 0.000385671 0.00017495
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0234387 0.0200388 0.0462385
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.038946 0.0347459 1
Echinococcus multilocularis discoidin domain containing receptor 2 0.00267599 0.000347556 0.000123387
Schistosoma mansoni btb and poz domain-containing protein 0.00267599 0.000347556 0.000486852
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0069166 0.00436933 0.00944383
Plasmodium vivax NAD-dependent deacetylase, putative 0.0069166 0.00436933 0.0873626
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.755035 0.713884 1
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.00766695 0.00508097 0.00482586
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0234387 0.0200388 0.879021
Onchocerca volvulus Putative cubilin 0.00276614 0.000433053 0.00415663
Trypanosoma cruzi subtilisin peptidase 0.0234387 0.0200388 0.548051
Trichomonas vaginalis conserved hypothetical protein 0.149585 0.139676 0.327167
Trichomonas vaginalis conserved hypothetical protein 0.149585 0.139676 0.327167
Schistosoma mansoni chromatin regulatory protein sir2 0.0069166 0.00436933 0.00612051
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0327452 0.0288651 0.819282
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.038946 0.0347459 1
Giardia lamblia High cysteine protein 0.0310462 0.0272538 0.103099
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.00350718 0.00113585 0.00159109
Plasmodium vivax protoporphyrinogen oxidase, putative 0.00695071 0.00440169 0.0880653
Schistosoma mansoni glutamate receptor AMPA 0.00325616 0.000897783 0.0012576
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.00407515 0.00167452 0.0630447
Giardia lamblia High cysteine protein 0.0310462 0.0272538 0.103099
Schistosoma mansoni serine protease inhibitors serpins 0.00257982 0.000256346 0.000359087
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.00350718 0.00113585 0.00159109
Schistosoma mansoni hypothetical protein 0.149585 0.139676 0.195656
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0248645 0.0213911 0.589606
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.00325616 0.000897783 0.000867731
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0234387 0.0200388 0.0462385
Toxoplasma gondii PA14 domain-containing protein 0.00267599 0.000347556 0.00567952
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.00350718 0.00113585 0.00159109
Plasmodium vivax plasmepsin IV, putative 0.00350718 0.00113585 0.0171237
Trichomonas vaginalis conserved hypothetical protein 0.0234387 0.0200388 0.0462385
Plasmodium falciparum plasmepsin III 0.00350718 0.00113585 0.0171237
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.00428655 0.00187501 0.0681471
Loa Loa (eye worm) hypothetical protein 0.0856098 0.0790019 0.0788362
Echinococcus granulosus fibrillin 2 0.0310462 0.0272538 0.0365219
Plasmodium falciparum plasmepsin VII 0.00350718 0.00113585 0.0171237
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0234387 0.0200388 0.878525
Schistosoma mansoni chromatin regulatory protein sir2 0.038946 0.0347459 0.0486717
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0234387 0.0200388 0.0462385
Schistosoma mansoni chromatin regulatory protein sir2 0.0069166 0.00436933 0.00612051
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0234387 0.0200388 0.0462385
Schistosoma mansoni site-1 peptidase (S08 family) 0.0234387 0.0200388 0.0280702
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0234387 0.0200388 0.0280702
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.00407515 0.00167452 0.0533096
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0237421 0.0203266 0.0201504
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0069166 0.00436933 0.00556402
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.45171 0.426211 0.576228
Plasmodium vivax aspartyl protease, putative 0.00350718 0.00113585 0.0171237
Echinococcus granulosus discoidin domain containing receptor 2 0.00267599 0.000347556 0.000123387
Schistosoma mansoni ATP-binding cassette transporter 0.00344935 0.00108101 0.00151427
Onchocerca volvulus 0.00370439 0.00132288 0.0250879
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0234387 0.0200388 0.0462385
Echinococcus multilocularis chromatin regulatory protein sir2 0.038946 0.0347459 0.0466572
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0234387 0.0200388 0.0462385
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0061702 0.00366145 0.0046064
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0061702 0.00366145 0.00512892
Trichomonas vaginalis conserved hypothetical protein 0.0234387 0.0200388 0.0462385
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0234387 0.0200388 0.0462385
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0069166 0.00436933 0.00944383
Schistosoma mansoni serine protease inhibitors serpins 0.00257982 0.000256346 0.000359087
Loa Loa (eye worm) metalloprotease 0.00667249 0.00413783 0.00395874
Loa Loa (eye worm) hypothetical protein 0.00687511 0.00432999 0.00415094
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.45171 0.426211 1
Mycobacterium tuberculosis Probable thioesterase TesA 0.0033804 0.00101561 0.0337678
Onchocerca volvulus 0.00350718 0.00113585 0.0206885
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.00428655 0.00187501 0.0681471
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0234387 0.0200388 0.877764
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.0263095 0.0227616 0.052632
Schistosoma mansoni serine protease inhibitors serpins 0.00257982 0.000256346 0.000359087
Echinococcus multilocularis integrin alpha ps 0.155984 0.145745 0.196816
Schistosoma mansoni tyrosine kinase 0.0313327 0.0275256 0.0385575
Loa Loa (eye worm) hypothetical protein 0.00539218 0.00292358 0.00274427
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0234387 0.0200388 0.548051
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.00271618 0.000385671 0.000540244
Giardia lamblia hypothetical protein 0.0310462 0.0272538 0.103099
Plasmodium falciparum cysteine repeat modular protein 1 0.00463395 0.00220448 0.0403368
Loa Loa (eye worm) serpin 0.00257982 0.000256346 0.0000765613
Toxoplasma gondii F5/8 type C domain-containing protein 0.00267599 0.000347556 0.00567952
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0234387 0.0200388 0.0280702
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.00325616 0.000897783 0.000867731
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0127536 0.00990514 0.00965127
Echinococcus multilocularis fibrillin 2 0.0310462 0.0272538 0.0365219
Schistosoma mansoni chromatin regulatory protein sir2 0.038946 0.0347459 0.0486717
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.00350718 0.00113585 0.00185106
Loa Loa (eye worm) hypothetical protein 0.0310462 0.0272538 0.0270788
Brugia malayi ADAM-TS Spacer 1 family protein 0.014117 0.0111982 0.0109446
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0234387 0.0200388 0.0462385
Echinococcus granulosus membrane bound transcription factor site 1 0.0234387 0.0200388 0.0267616
Schistosoma mansoni glutamate receptor AMPA 0.00325616 0.000897783 0.0012576
Loa Loa (eye worm) transcriptional regulator 0.0069166 0.00436933 0.00419029
Plasmodium vivax aspartyl protease, putative 0.00350718 0.00113585 0.0171237
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0234387 0.0200388 0.0462385
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.00695071 0.00440169 0.0880653
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.00860698 0.00597249 0.00579373
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.038946 0.0347459 1
Toxoplasma gondii histone deacetylase SIR2-like 0.0069166 0.00436933 0.0993111
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0433008 0.038876 0.0544571
Loa Loa (eye worm) hypothetical protein 0.00271618 0.000385671 0.00020591
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.173024 0.161905 0.379364
Echinococcus granulosus adam 17 protease 0.0100087 0.00730191 0.00953119
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.00370439 0.00132288 0.0474207
Echinococcus multilocularis protein jagged 2 0.0310462 0.0272538 0.0365219
Mycobacterium tuberculosis Conserved hypothetical protein 0.00695071 0.00440169 0.18422
Mycobacterium ulcerans thioesterase 0.0033804 0.00101561 0.0237285
Brugia malayi Integrin alpha cytoplasmic region family protein 0.223887 0.210143 0.209941
Brugia malayi SWIRM domain containing protein 0.00410407 0.00170194 0.00144596
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.0263095 0.0227616 0.5
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.0263095 0.0227616 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.00350718 0.00113585 0.00159109
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0234387 0.0200388 0.0462385
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.0327452 0.0288651 1
Loa Loa (eye worm) hypothetical protein 0.00463395 0.00220448 0.00202505
Brugia malayi Disintegrin family protein 0.0100087 0.00730191 0.00704737
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.00267599 0.000347556 0.000123387
Loa Loa (eye worm) sirtuin 4 0.0069166 0.00436933 0.00419029
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0234387 0.0200388 0.0462385
Loa Loa (eye worm) hypothetical protein 0.00257982 0.000256346 0.0000765613
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0069166 0.00436933 0.066526
Loa Loa (eye worm) hypothetical protein 0.00257982 0.000256346 0.0000765613
Plasmodium vivax subtilisin-like serine protease, putative 0.0234387 0.0200388 0.427741
Entamoeba histolytica SWIRM domain protein 0.00410407 0.00170194 0.0419139
Plasmodium vivax hypothetical protein, conserved 0.0069166 0.00436933 0.0873626
Toxoplasma gondii subtilisin SUB1 0.0234387 0.0200388 0.464115
Echinococcus granulosus lysine specific histone demethylase 1A 0.00695071 0.00440169 0.00560779
Schistosoma mansoni serine protease inhibitors serpins 0.00257982 0.000256346 0.000359087
Loa Loa (eye worm) apoptosis regulator protein 0.0061702 0.00366145 0.00348228
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0069166 0.00436933 0.00556402
Schistosoma mansoni hypothetical protein 0.0061702 0.00366145 0.00512892
Leishmania major UDP-galactopyranose mutase 0.00695071 0.00440169 0.0675202
Schistosoma mansoni apoptosis regulator bax 0.0061702 0.00366145 0.00512892
Giardia lamblia hypothetical protein 0.00410407 0.00170194 0.00552049
Leishmania major silent information regulator 2, putative 0.038946 0.0347459 1
Leishmania major subtilisin-like serine peptidase 0.0234387 0.0200388 0.548051
Schistosoma mansoni chromatin regulatory protein sir2 0.038946 0.0347459 0.0486717
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0069166 0.00436933 0.00556402
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.00410407 0.00170194 0.00195559
Brugia malayi Furin-like cysteine rich region family protein 0.0313327 0.0275256 0.0272762
Mycobacterium leprae Probable polyketide synthase Pks1 0.00428655 0.00187501 0.0681471
Entamoeba histolytica PH domain containing protein kinase, putative 0.00709081 0.00453456 0.124044
Loa Loa (eye worm) hypothetical protein 0.0268751 0.023298 0.0231223
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.00407515 0.00167452 0.0630447
Echinococcus granulosus discoidin domain containing receptor 2 0.00267599 0.000347556 0.000123387
Brugia malayi Stress-activated protein kinase jnk-1 0.0237421 0.0203266 0.0200754
Loa Loa (eye worm) hypothetical protein 0.00257982 0.000256346 0.0000765613
Echinococcus multilocularis integrin alpha 3 0.256498 0.241072 0.325773
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0625717 0.0571526 0.0769688
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.149585 0.139676 0.327167
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.173024 0.161905 0.379364
Echinococcus multilocularis tissue type plasminogen activator 0.00463395 0.00220448 0.00263542
Loa Loa (eye worm) TK/EGFR protein kinase 0.0313327 0.0275256 0.0273507
Toxoplasma gondii aspartyl protease ASP3 0.00350718 0.00113585 0.024032
Brugia malayi Will die slowly protein 0.0090561 0.00639844 0.00614366
Echinococcus multilocularis epidermal growth factor receptor 0.0313327 0.0275256 0.0368896
Toxoplasma gondii subtilisin SUB10 0.0234387 0.0200388 0.464115
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.0327452 0.0288651 0.0286905
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.173024 0.161905 0.379364
Loa Loa (eye worm) serpin 0.00257982 0.000256346 0.0000765613
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.038946 0.0347459 0.0466572
Loa Loa (eye worm) TK/ROR protein kinase 0.00463395 0.00220448 0.00202505
Schistosoma mansoni hypothetical protein 0.0061702 0.00366145 0.00512892
Loa Loa (eye worm) hypothetical protein 0.00695071 0.00440169 0.00422265
Mycobacterium ulcerans oxidoreductase 0.00695071 0.00440169 0.175744
Trichomonas vaginalis conserved hypothetical protein 0.0234387 0.0200388 0.0462385
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.00350718 0.00113585 0.00159109
Mycobacterium ulcerans protoporphyrinogen oxidase 0.00695071 0.00440169 0.175744
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0433008 0.038876 0.0522444
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.00267599 0.000347556 0.000123387
Toxoplasma gondii subtilisin SUB4 0.0234387 0.0200388 0.464115
Trichomonas vaginalis conserved hypothetical protein 0.149585 0.139676 0.327167
Plasmodium falciparum plasmepsin II 0.00350718 0.00113585 0.0171237
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.00695071 0.00440169 0.100064
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.00334497 0.000982014 0.0222202
Loa Loa (eye worm) serpin 0.00257982 0.000256346 0.0000765613
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0069166 0.00436933 0.0873626
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.00695071 0.00440169 0.175744
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.00428655 0.00187501 0.071953
Loa Loa (eye worm) hypothetical protein 0.0110548 0.00829398 0.00811564
Plasmodium falciparum subtilisin-like protease 1 0.0234387 0.0200388 0.427741
Brugia malayi aspartic protease BmAsp-1, identical 0.00350718 0.00113585 0.000879733
Loa Loa (eye worm) subtilase 0.0234387 0.0200388 0.0198626
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0234387 0.0200388 0.0462385
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.00410407 0.00170194 0.00195559
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.0263095 0.0227616 1
Leishmania major sir2-family protein-like protein 0.0069166 0.00436933 0.066526
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.00350718 0.00113585 0.024032
Plasmodium vivax cysteine repeat modular protein 1, putative 0.00463395 0.00220448 0.0403368
Brugia malayi Reprolysin 0.0168664 0.0138057 0.0135528
Loa Loa (eye worm) fatty acid synthase 0.00396084 0.0015661 0.00138655
Mycobacterium ulcerans NAD-dependent deacetylase 0.0069166 0.00436933 0.174292
Toxoplasma gondii serpin (serine proteinase inhibitor) superfamily protein 0.00257982 0.000256346 0.00355606
Entamoeba histolytica hypothetical protein 0.00410407 0.00170194 0.0419139
Plasmodium falciparum plasmepsin V 0.0512162 0.046383 1
Schistosoma mansoni protein kinase 0.014588 0.0116449 0.016312
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0268751 0.023298 0.0326355
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.00350718 0.00113585 0.00159109
Loa Loa (eye worm) hypothetical protein 0.0091686 0.00650513 0.00632647
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0234387 0.0200388 0.0462385
Giardia lamblia High cysteine membrane protein Group 2 0.278687 0.262116 1
Plasmodium falciparum plasmepsin X 0.00350718 0.00113585 0.0171237
Echinococcus multilocularis integrin alpha ps 0.146816 0.137049 0.185052
Brugia malayi AMP-binding enzyme family protein 0.00370439 0.00132288 0.00106681
Schistosoma mansoni dock 0.00267599 0.000347556 0.000486852
Brugia malayi EGF-like domain containing protein 0.0310462 0.0272538 0.0270043
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0028231 0.00048707 0.00622442
Trichomonas vaginalis hypothetical protein 0.0310462 0.0272538 0.0631804
Trypanosoma cruzi UDP-galactopyranose mutase 0.00695071 0.00440169 0.0675202
Brugia malayi hypothetical protein 0.161035 0.150535 0.150317
Brugia malayi aspartic protease BmAsp-2, identical 0.00350718 0.00113585 0.000879733
Trichomonas vaginalis hypothetical protein 0.149585 0.139676 0.327167
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0100087 0.00730191 0.00953119
Loa Loa (eye worm) hypothetical protein 0.0310462 0.0272538 0.0270788
Schistosoma mansoni hypothetical protein 0.00463395 0.00220448 0.00308801
Plasmodium falciparum plasmepsin VIII, putative 0.00350718 0.00113585 0.0171237
Schistosoma mansoni dihydroceramide desaturase 0.0100087 0.00730191 0.0102284
Onchocerca volvulus 0.0234387 0.0200388 0.465339
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0069166 0.00436933 0.0873626
Schistosoma mansoni integrin alpha-ps 0.0856098 0.0790019 0.110665
Brugia malayi amine oxidase, flavin-containing family protein 0.0110548 0.00829398 0.00803969
Giardia lamblia Tenascin-37 0.0310462 0.0272538 0.103099
Schistosoma mansoni septate junction protein 0.00401628 0.00161868 0.00226742
Echinococcus multilocularis Tolloid protein 1 0.00271618 0.000385671 0.00017495
Echinococcus granulosus tissue type plasminogen activator 0.00463395 0.00220448 0.00263542
Schistosoma mansoni integrin beta subunit 0.620976 0.586743 0.821902
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0069166 0.00436933 0.00556402
Schistosoma mansoni chromatin regulatory protein sir2 0.0069166 0.00436933 0.00612051
Brugia malayi EGF-like domain containing protein 0.0310462 0.0272538 0.0270043
Mycobacterium ulcerans Type I modular polyketide synthase 0.00407515 0.00167452 0.0533096
Loa Loa (eye worm) angiogenesis inhibito 0.00667249 0.00413783 0.00395874
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0069166 0.00436933 0.066526
Plasmodium falciparum subtilisin-like protease 2 0.0234387 0.0200388 0.427741
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.00695071 0.00440169 0.175744
Loa Loa (eye worm) hypothetical protein 0.00257982 0.000256346 0.0000765613
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.00407515 0.00167452 0.0630447
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.00325616 0.000897783 0.000867731
Loa Loa (eye worm) hypothetical protein 0.00267599 0.000347556 0.000167787
Loa Loa (eye worm) aspartyl protease 6 0.00350718 0.00113585 0.000956227
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0268751 0.023298 0.0311705
Trichomonas vaginalis WD repeat domain, putative 0.0090561 0.00639844 0.0142085
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.014588 0.0116449 0.0154063
Loa Loa (eye worm) hypothetical protein 0.00257982 0.000256346 0.0000765613
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.45171 0.426211 0.576228
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0343197 0.0303583 0.0425256
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0234387 0.0200388 0.0197876
Schistosoma mansoni glutamate receptor kainate 0.00325616 0.000897783 0.0012576
Schistosoma mansoni serine protease inhibitors serpins 0.00257982 0.000256346 0.000359087
Loa Loa (eye worm) hypothetical protein 0.0310462 0.0272538 0.0270788
Plasmodium falciparum plasmepsin IV 0.00350718 0.00113585 0.0171237
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0234387 0.0200388 0.0462385
Loa Loa (eye worm) hypothetical protein 0.014117 0.0111982 0.0110204
Brugia malayi transcriptional regulator, Sir2 family protein 0.0069166 0.00436933 0.00411404
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0268751 0.023298 0.0326355
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0234387 0.0200388 0.879021
Plasmodium vivax hypothetical protein, conserved 0.00695071 0.00440169 0.0880653
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0061702 0.00366145 0.0046064
Brugia malayi NAD-dependent deacetylase SIRT1 0.0069166 0.00436933 0.00411404
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.173024 0.161905 0.379364
Onchocerca volvulus 0.00267599 0.000347556 0.0021455
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.00695071 0.00440169 0.0880653
Toxoplasma gondii F5/8 type C domain-containing protein 0.00267599 0.000347556 0.00567952
Schistosoma mansoni discoidin domain receptor 0.00267599 0.000347556 0.000486852
Schistosoma mansoni glutamate receptor kainate 0.00325616 0.000897783 0.0012576
Loa Loa (eye worm) hypothetical protein 0.00267599 0.000347556 0.000167787
Schistosoma mansoni glutamate receptor NMDA 0.00325616 0.000897783 0.0012576
Echinococcus multilocularis serine:threonine protein kinase N2 0.00793799 0.00533803 0.00687446
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.00325616 0.000897783 0.000867731
Loa Loa (eye worm) glutamate receptor 1 0.00325616 0.000897783 0.000718114
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0234387 0.0200388 0.878525
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0234387 0.0200388 0.0267616
Toxoplasma gondii protease inhibitor PI1 0.00257982 0.000256346 0.00355606
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0061702 0.00366145 0.00340598
Loa Loa (eye worm) serpin protein 6 0.00257982 0.000256346 0.0000765613
Mycobacterium tuberculosis Probable transcriptional regulatory protein NrdR 0.00643561 0.00391317 0.162514
Mycobacterium ulcerans polyketide synthase Pks13 0.0062035 0.00369303 0.14393
Brugia malayi protein kinase C II. 0.00860698 0.00597249 0.00571761
Schistosoma mansoni hypothetical protein 0.0090561 0.00639844 0.00896285
Toxoplasma gondii histone deacetylase SIR2 0.0069166 0.00436933 0.0993111
Schistosoma mansoni chromatin regulatory protein sir2 0.0069166 0.00436933 0.00612051
Echinococcus granulosus epidermal growth factor receptor 0.0313327 0.0275256 0.0368896
Echinococcus granulosus chromatin regulatory protein sir2 0.038946 0.0347459 0.0466572
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.0327452 0.0288651 0.0286161
Loa Loa (eye worm) transcriptional regulator 0.038946 0.0347459 0.0345723
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0069166 0.00436933 0.00944383
Echinococcus multilocularis discoidin domain receptor 0.00267599 0.000347556 0.000123387
Loa Loa (eye worm) kelch domain-containing protein family protein 0.162461 0.151888 0.151735
Loa Loa (eye worm) hypothetical protein 0.186123 0.174329 0.17418
Entamoeba histolytica SWIRM domain protein 0.00410407 0.00170194 0.0419139
Plasmodium vivax aspartyl proteinase, putative 0.00350718 0.00113585 0.0171237
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0234387 0.0200388 0.877764
Loa Loa (eye worm) hypothetical protein 0.00350718 0.00113585 0.000956227
Onchocerca volvulus 0.00674054 0.00420236 0.0928212
Loa Loa (eye worm) hypothetical protein 0.0061702 0.00366145 0.00348228
Schistosoma mansoni hypothetical protein 0.0061702 0.00366145 0.00512892
Trichomonas vaginalis conserved hypothetical protein 0.149585 0.139676 0.327167
Schistosoma mansoni glutamate receptor NMDA 0.00325616 0.000897783 0.0012576
Echinococcus multilocularis protein will die slowly 0.0090561 0.00639844 0.00830897
Loa Loa (eye worm) hypothetical protein 0.014117 0.0111982 0.0110204
Loa Loa (eye worm) integrin beta-2 1.05672 1 1
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0069166 0.00436933 0.00556402
Trichomonas vaginalis conserved hypothetical protein 0.149585 0.139676 0.327167
Toxoplasma gondii SWIRM domain-containing protein 0.00410407 0.00170194 0.0372111
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.00350718 0.00113585 0.00159109
Echinococcus granulosus integrin alpha ps 0.0703744 0.0645526 0.0869796
Toxoplasma gondii type I fatty acid synthase, putative 0.00428655 0.00187501 0.0412403
Echinococcus multilocularis neuroendocrine convertase 2 0.476349 0.449578 0.607839
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0234387 0.0200388 0.0197876
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0234387 0.0200388 0.0462385
Toxoplasma gondii subtilisin SUB7 0.0234387 0.0200388 0.464115
Loa Loa (eye worm) transcriptional regulator 0.0069166 0.00436933 0.00419029
Echinococcus multilocularis glutamate receptor 2 0.00325616 0.000897783 0.000867731
Mycobacterium ulcerans monoamine oxidase 0.00695071 0.00440169 0.175744
Loa Loa (eye worm) hypothetical protein 0.00410407 0.00170194 0.00152241
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.00350718 0.00113585 0.00159109
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0100087 0.00730191 0.00953119
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.0327452 0.0288651 0.619469
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.45171 0.426211 1
Brugia malayi ADAMTS-like protease 0.014117 0.0111982 0.0109446
Loa Loa (eye worm) hypothetical protein 0.161035 0.150535 0.150383
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.00325616 0.000897783 0.000867731
Brugia malayi neuroendocrine convertase 1 precursor 0.476349 0.449578 0.449437
Brugia malayi Eukaryotic aspartyl protease family protein 0.00350718 0.00113585 0.000879733
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.038946 0.0347459 0.0807733
Echinococcus granulosus discoidin domain containing receptor 2 0.00267599 0.000347556 0.000123387
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.0327452 0.0288651 0.0387017
Giardia lamblia Sirtuin type 2 0.0069166 0.00436933 0.0157069
Brugia malayi transcriptional regulator, Sir2 family protein 0.0069166 0.00436933 0.00411404
Schistosoma mansoni amine oxidase 0.00695071 0.00440169 0.00616583
Onchocerca volvulus Fatty acid synthase homolog 0.00695193 0.00440285 0.0975373
Toxoplasma gondii subtilisin SUB5 0.0234387 0.0200388 0.464115
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0248645 0.0213911 0.560359
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.00350718 0.00113585 0.00118979
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0069166 0.00436933 0.119253
Echinococcus multilocularis glutamate receptor 2 0.00325616 0.000897783 0.000867731
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0234387 0.0200388 0.0462385
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.0327452 0.0288651 0.0387017
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.173024 0.161905 0.379364
Echinococcus multilocularis integrin alpha ps 0.0703744 0.0645526 0.0869796
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.00695071 0.00440169 0.180875
Giardia lamblia Neurogenic locus notch-like protein 0.0310462 0.0272538 0.103099
Schistosoma mansoni protein kinase 0.014588 0.0116449 0.016312
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0234387 0.0200388 0.0462385
Trichomonas vaginalis conserved hypothetical protein 0.149585 0.139676 0.327167
Plasmodium falciparum plasmepsin VI 0.00350718 0.00113585 0.0171237
Loa Loa (eye worm) endoprotease bli-4 0.755035 0.713884 0.713832
Echinococcus granulosus neuroendocrine convertase 2 0.476349 0.449578 0.607839
Loa Loa (eye worm) hypothetical protein 0.0433008 0.038876 0.0387032
Brugia malayi transcriptional regulator, Sir2 family protein 0.038946 0.0347459 0.0344984
Loa Loa (eye worm) hypothetical protein 0.00257982 0.000256346 0.0000765613
Plasmodium vivax plasmepsin V, putative 0.0512162 0.046383 1
Schistosoma mansoni serine/threonine protein kinase 0.0237421 0.0203266 0.0284733
Schistosoma mansoni discoidin domain receptor 0.00267599 0.000347556 0.000486852
Echinococcus multilocularis fibrillin 1 0.0324316 0.0285677 0.0382994
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0234387 0.0200388 0.0462385
Loa Loa (eye worm) hypothetical protein 0.00744451 0.00487001 0.00469106
Toxoplasma gondii aspartyl protease ASP1 0.00350718 0.00113585 0.024032
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.173024 0.161905 0.226795
Toxoplasma gondii subtilisin SUB8 0.0234387 0.0200388 0.464115
Chlamydia trachomatis protoporphyrinogen oxidase 0.00695071 0.00440169 0.0195782
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0234387 0.0200388 0.0462385
Loa Loa (eye worm) hypothetical protein 0.0310462 0.0272538 0.0270788
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0062035 0.00369303 0.152733
Brugia malayi hypothetical protein 0.0343197 0.0303583 0.0301097
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.173024 0.161905 0.379364
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0069166 0.00436933 0.00944383
Schistosoma mansoni hypothetical protein 0.00267599 0.000347556 0.000486852
Brugia malayi Integrin beta pat-3 precursor 1.05672 1 1
Onchocerca volvulus 0.00564909 0.00316724 0.0684723
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0234387 0.0200388 0.879021
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.00428655 0.00187501 0.071953
Schistosoma mansoni memapsin-2 (A01 family) 0.00350718 0.00113585 0.00159109
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0625717 0.0571526 0.0769688
Echinococcus granulosus integrin alpha ps 0.155984 0.145745 0.196816
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0069166 0.00436933 0.00944383
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.00267599 0.000347556 0.00408426
Onchocerca volvulus 0.0090561 0.00639844 0.144479
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.0327452 0.0288651 0.6696
Schistosoma mansoni protein kinase 0.014588 0.0116449 0.016312
Plasmodium vivax aspartyl protease, putative 0.00350718 0.00113585 0.0171237
Schistosoma mansoni furin-1 (S08 family) 0.326764 0.307712 0.431039
Loa Loa (eye worm) hypothetical protein 0.00257982 0.000256346 0.0000765613
Loa Loa (eye worm) hypothetical protein 0.00667249 0.00413783 0.00395874
Trichomonas vaginalis conserved hypothetical protein 0.0234387 0.0200388 0.0462385
Mycobacterium leprae conserved hypothetical protein 0.00643561 0.00391317 0.15908
Brugia malayi EGF-like domain containing protein 0.0310462 0.0272538 0.0270043
Schistosoma mansoni amine oxidase 0.00695071 0.00440169 0.00616583
Toxoplasma gondii hypothetical protein 0.0310462 0.0272538 0.632087
Plasmodium falciparum plasmepsin IX 0.00350718 0.00113585 0.0171237
Brugia malayi Protein kinase domain containing protein 0.00267599 0.000347556 0.0000912328
Toxoplasma gondii subtilisin SUB6 0.0234387 0.0200388 0.464115
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0234387 0.0200388 0.0267616
Echinococcus granulosus protein will die slowly 0.0090561 0.00639844 0.00830897
Trichomonas vaginalis conserved hypothetical protein 0.0234387 0.0200388 0.0462385
Schistosoma mansoni cathepsin D (A01 family) 0.00350718 0.00113585 0.00159109
Toxoplasma gondii subtilisin SUB11 0.0234387 0.0200388 0.464115
Loa Loa (eye worm) hypothetical protein 0.755035 0.713884 0.713832
Onchocerca volvulus 0.00267599 0.000347556 0.0021455
Echinococcus granulosus disintegrin and metalloproteinase 0.0100087 0.00730191 0.00953119
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.00695071 0.00440169 0.00616583
Echinococcus granulosus integrin alpha 3 0.256498 0.241072 0.325773
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.00325616 0.000897783 0.000867731
Mycobacterium ulcerans polyketide synthase 0.00407515 0.00167452 0.0533096
Brugia malayi metalloprotease 0.00667249 0.00413783 0.00388247
Schistosoma mansoni serine protease inhibitors serpins 0.00257982 0.000256346 0.000359087
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0234387 0.0200388 0.0462385
Brugia malayi Kringle domain containing protein 0.00463395 0.00220448 0.00194863
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.00350718 0.00113585 0.00159109
Brugia malayi Glutamate receptor 1 precursor 0.00325616 0.000897783 0.000641601
Brugia malayi angiogenesis inhibito 0.014117 0.0111982 0.0109446
Mycobacterium ulcerans Type I modular polyketide synthase 0.00407515 0.00167452 0.0533096
Toxoplasma gondii aspartyl protease ASP5 0.0477091 0.0430568 1
Echinococcus granulosus furin 0.755035 0.713884 0.96539
Echinococcus granulosus discoidin domain receptor 0.00267599 0.000347556 0.000123387
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.00325616 0.000897783 0.000867731
Loa Loa (eye worm) integrin alpha pat-2 0.477283 0.450464 0.450365
Onchocerca volvulus 0.0310462 0.0272538 0.635054
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.00334497 0.000982014 0.0283063
Toxoplasma gondii type I fatty acid synthase, putative 0.00262996 0.000303895 0.00466305
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.00357154 0.00119689 0.0418224
Loa Loa (eye worm) glutamate receptor 2 0.00325616 0.000897783 0.000718114
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0248645 0.0213911 0.589606
Trichomonas vaginalis conserved hypothetical protein 0.149585 0.139676 0.327167
Giardia lamblia Tenascin precursor 0.0310462 0.0272538 0.103099
Trichomonas vaginalis conserved hypothetical protein 0.149585 0.139676 0.327167
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.00325616 0.000897783 0.000867731
Trypanosoma cruzi UDP-galactopyranose mutase 0.00695071 0.00440169 0.0675202
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0268751 0.023298 0.0311705
Mycobacterium leprae Polyketide synthase Pks13 0.0062035 0.00369303 0.149258
Echinococcus granulosus glutamate NMDA receptor subunit 0.00325616 0.000897783 0.000867731
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0237421 0.0203266 0.0271509
Echinococcus granulosus glutamate receptor 2 0.00325616 0.000897783 0.000867731
Mycobacterium tuberculosis Polyketide synthase Pks12 0.00428655 0.00187501 0.071953
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0069166 0.00436933 0.119253
Echinococcus granulosus adam 0.0653658 0.0598025 0.0805535
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0069166 0.00436933 0.00944383
Echinococcus multilocularis 0.60545 0.572018 0.773474
Mycobacterium ulcerans Sir2-like regulatory protein 0.0069166 0.00436933 0.174292
Mycobacterium tuberculosis Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) 0.0094962 0.00681583 0.291487
Onchocerca volvulus 0.0474049 0.0427683 1
Brugia malayi Integrin alpha pat-2 precursor 0.332939 0.313568 0.313392
Echinococcus multilocularis protoporphyrinogen oxidase 0.00695071 0.00440169 0.00560779
Echinococcus multilocularis adam 0.0653658 0.0598025 0.0805535
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0234387 0.0200388 0.0462385
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0069166 0.00436933 0.0157069
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.00695071 0.00440169 0.0880653
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.0327452 0.0288651 0.806403
Loa Loa (eye worm) hypothetical protein 0.0474049 0.0427683 0.0425962
Brugia malayi Kelch motif family protein 0.162461 0.151888 0.15167
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0234387 0.0200388 0.0462385
Mycobacterium ulcerans Type I modular polyketide synthase 0.00407515 0.00167452 0.0533096
Echinococcus granulosus lysine specific histone demethylase 1A 0.0433008 0.038876 0.0522444
Giardia lamblia Tenascin-like 0.0310462 0.0272538 0.103099
Echinococcus multilocularis 0.00695071 0.00440169 0.00560779
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.0327452 0.0288651 0.0404339
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.014588 0.0116449 0.0154063
Mycobacterium ulcerans dehydrogenase 0.00695071 0.00440169 0.175744
Plasmodium falciparum subtilisin-like protease 3 0.0234387 0.0200388 0.427741
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.00267599 0.000347556 0.000123387
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0234387 0.0200388 0.879021
Loa Loa (eye worm) reprolysin 0.0268751 0.023298 0.0231223
Mycobacterium leprae Possible secreted protease 0.0234387 0.0200388 0.878525
Plasmodium vivax subtilisin-like protease 2, putative 0.0234387 0.0200388 0.427741
Echinococcus granulosus fibrillin 1 0.0311413 0.027344 0.036644
Mycobacterium tuberculosis Possible oxidoreductase 0.00695071 0.00440169 0.18422
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.0327452 0.0288651 0.619469
Brugia malayi hypothetical protein 0.00695071 0.00440169 0.0041464
Loa Loa (eye worm) hypothetical protein 0.00276614 0.000433053 0.0002533
Loa Loa (eye worm) hypothetical protein 0.00257982 0.000256346 0.0000765613
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.038946 0.0347459 0.0466572
Loa Loa (eye worm) hypothetical protein 0.0100087 0.00730191 0.0071234
Echinococcus granulosus c-Jun N-terminal kinases 0.0237421 0.0203266 0.0271509
Brugia malayi SWIRM domain containing protein 0.0474049 0.0427683 0.0425229
Loa Loa (eye worm) bone morphogenetic protein 1b 0.00271618 0.000385671 0.00020591
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.00350718 0.00113585 0.024032
Toxoplasma gondii subtilisin SUB9 0.0234387 0.0200388 0.464115
Schistosoma mansoni glutamate receptor kainate 0.00325616 0.000897783 0.0012576
Brugia malayi proprotein convertase 2 0.476349 0.449578 0.449437
Loa Loa (eye worm) hypothetical protein 0.262565 0.246825 0.24669
Schistosoma mansoni hypothetical protein 0.0703744 0.0645526 0.0904246
Echinococcus granulosus protein kinase c epsilon type 0.00860698 0.00597249 0.00773276
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.00804959 0.00544386 0.0995464
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0033804 0.00101561 0.0298053
Onchocerca volvulus 0.00463395 0.00220448 0.0458256
Giardia lamblia Tenascin-X 0.0310462 0.0272538 0.103099
Brugia malayi Glutamate receptor 2 precursor 0.00325616 0.000897783 0.000641601
Loa Loa (eye worm) serpin 0.00257982 0.000256346 0.0000765613
Loa Loa (eye worm) hypothetical protein 0.223887 0.210143 0.210001
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0127536 0.00990514 0.00972709
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.00688979 0.00434391 0.0060849
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.149585 0.139676 0.327167
Echinococcus multilocularis discoidin domain containing receptor 2 0.00267599 0.000347556 0.000123387
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.00407515 0.00167452 0.0592022
Schistosoma mansoni cathepsin D (A01 family) 0.00350718 0.00113585 0.00159109
Loa Loa (eye worm) aspartic protease BmAsp-2 0.00350718 0.00113585 0.000956227
Trypanosoma brucei subtilisin peptidase 0.0234387 0.0200388 0.515841
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0069166 0.00436933 0.00944383
Giardia lamblia Neurogenic locus Notch protein precursor 0.0310462 0.0272538 0.103099
Loa Loa (eye worm) hypothetical protein 0.0234387 0.0200388 0.0198626
Loa Loa (eye worm) hypothetical protein 0.0433008 0.038876 0.0387032
Plasmodium falciparum plasmepsin I 0.00350718 0.00113585 0.0171237
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.00428655 0.00187501 0.0623105
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0234387 0.0200388 0.877764
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.0263095 0.0227616 1
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.00667249 0.00413783 0.00579622
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0310462 0.0272538 0.0631804
Schistosoma mansoni serpin 0.00257982 0.000256346 0.000359087
Brugia malayi endoprotease bli-4 precursor 0.755035 0.713884 0.713811
Plasmodium vivax aspartyl proteinase, putative 0.00350718 0.00113585 0.0171237
Echinococcus granulosus integrin beta 2 0.782012 0.739468 1
Brugia malayi Subtilase family protein 0.0234387 0.0200388 0.0197876
Loa Loa (eye worm) AMP-binding enzyme family protein 0.00370439 0.00132288 0.00114329
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.00350718 0.00113585 0.00118979
Echinococcus granulosus Furin 1 0.173024 0.161905 0.218677
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.00407515 0.00167452 0.0592022
Mycobacterium ulcerans polyketide synthase 0.00428655 0.00187501 0.0623105
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.0327452 0.0288651 0.5
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0069166 0.00436933 0.00556402
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0069166 0.00436933 0.00944383
Trichomonas vaginalis conserved hypothetical protein 0.149585 0.139676 0.327167
Schistosoma mansoni SWI/SNF complex-related 0.00410407 0.00170194 0.00238405
Giardia lamblia Transcriptional regulator, Sir2 family 0.0069166 0.00436933 0.0157069
Giardia lamblia Furin precursor putative serine protease 0.149585 0.139676 0.532422
Brugia malayi Pepsin A precursor 0.00350718 0.00113585 0.000879733
Mycobacterium ulcerans transcriptional regulator NrdR 0.00643561 0.00391317 0.153813
Loa Loa (eye worm) hypothetical protein 0.00695071 0.00440169 0.00422265
Trypanosoma brucei Silent information regulator 2 related protein 1 0.038946 0.0347459 1
Echinococcus multilocularis protein kinase c epsilon type 0.00860698 0.00597249 0.00773276
Schistosoma mansoni integrin alpha 0.332939 0.313568 0.439243
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.0327452 0.0288651 0.819282
Mycobacterium tuberculosis Polyketide synthase Pks2 0.00357154 0.00119689 0.0418224
Schistosoma mansoni integrin alpha-ps 0.146816 0.137049 0.191977
Schistosoma mansoni site-1 peptidase (S08 family) 0.0234387 0.0200388 0.0280702
Loa Loa (eye worm) hypothetical protein 0.303325 0.285483 0.285354
Loa Loa (eye worm) hypothetical protein 0.00257982 0.000256346 0.0000765613
Entamoeba histolytica hypothetical protein, conserved 0.0069166 0.00436933 0.119253
Loa Loa (eye worm) hypothetical protein 0.0069166 0.00436933 0.00419029
Plasmodium falciparum protoporphyrinogen oxidase 0.00695071 0.00440169 0.0880653
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.00325616 0.000897783 0.000867731
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.00407515 0.00167452 0.00141853
Schistosoma mansoni serpin 0.00257982 0.000256346 0.000359087

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) = 116 ug ml-1 Cytotoxicity against human MT4 cells by MTT assay ChEMBL. 17583388
IC50 (functional) > 10 ug ml-1 Concentration required for inhibition of growth of Mycobacterium tuberculosis in level 2 assay ChEMBL. 11425542
IC50 (functional) > 10 ug ml-1 Concentration required for inhibition of growth of Mycobacterium tuberculosis in level 2 assay ChEMBL. 11425542
Inhibition (functional) = 94 % Percent reduction of mycobacterial growth using Mycobacterium tuberculosis H37Rv at a concentration of 12.5 microg/mL ChEMBL. 11425542
Inhibition (functional) = 94 % Percent reduction of mycobacterial growth using Mycobacterium tuberculosis H37Rv at a concentration of 12.5 microg/mL ChEMBL. 11425542
MCC (ADMET) = 80 ug ml-1 Cytotoxicity against human E6SM cells ChEMBL. 17583388
MCC (ADMET) = 80 ug ml-1 Cytotoxicity against human HEL cells assessed as alteration of cell morphology ChEMBL. 17583388
MCC (ADMET) = 400 ug ml-1 Cytotoxicity against human HeLa cells ChEMBL. 17583388
MIC (functional) = 6.25 ug ml-1 Compound was evaluated for antituberculosis activity against Mycobacterium tuberculosis in level 2 assay (performed using BACTEC in which MIC of RMP was found as 0.125 mg/mL) ChEMBL. 11425542
MIC (functional) = 6.25 ug ml-1 Compound was evaluated for antituberculosis activity against Mycobacterium tuberculosis in level 2 assay (performed using BACTEC in which MIC of RMP was found as 0.125 mg/mL) ChEMBL. 11425542
MIC (functional) < 12.5 ug ml-1 In vitro antituberculosis activity against Mycobacterium tuberculosis H37Rv using the BACTEC 12B medium using a micro dilution assay( MABA) ChEMBL. 11425542
MIC (functional) < 12.5 ug ml-1 In vitro antituberculosis activity against Mycobacterium tuberculosis H37Rv using the BACTEC 12B medium using a micro dilution assay( MABA) ChEMBL. 11425542
MIC (functional) > 128 ug ml-1 In vitro anti-mycobacterial activity expressed as minimum inhibitory concentration against Mycobacterium fortuitum ATCC6841 ChEMBL. 11425542
Ratio (functional) > 1.6 Selectivity index (IC50/MIC) of the compound was determined ChEMBL. 11425542

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mycobacterium tuberculosis ChEMBL23 11425542

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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