TDR Targets

Basic information

Technical information

TDR Targets ID: 671075
Name: N-(2-chloro-4-nitrophenyl)-2-(4-methoxyphenyl )acetamide
MW: 320.728 | Formula: C15H13ClN2O4
H donors: 1 H acceptors: 3 LogP: 3.12 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)CC(=O)Nc1ccc(cc1Cl)[N+](=O)[O-]
InChi: 1S/C15H13ClN2O4/c1-22-12-5-2-10(3-6-12)8-15(19)17-14-7-4-11(18(20)21)9-13(14)16/h2-7,9H,8H2,1H3,(H,17,19)
InChiKey: ZRXFTDBTLUPDIR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(2-chloro-4-nitro-phenyl)-2-(4-methoxyphenyl)acetamide
N-(2-chloro-4-nitro-phenyl)-2-(4-methoxyphenyl)ethanamide
ZINC04893741
IVK/8191452

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	dna polymerase kappa	0.0023	0.0969	0.0969
Schistosoma mansoni	BC026374 protein (S09 family)	0.0017	0.0394	0.0394
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0969	0.225
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0969	0.225
Loa Loa (eye worm)	acetylcholinesterase 1	0.0103	1	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0394	0.0394
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0969	0.225
Echinococcus multilocularis	lamin	0.0027	0.1507	0.1507
Schistosoma mansoni	DNA polymerase eta	0.0052	0.4305	0.4305
Trichomonas vaginalis	DNA polymerase eta, putative	0.0023	0.0969	1
Trypanosoma brucei	cytochrome P450, putative	0.0023	0.0965	0.2241
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0969	0.225
Echinococcus granulosus	neuroligin	0.0017	0.0394	0.0394
Trypanosoma cruzi	cytochrome P450, putative	0.0023	0.0965	0.2241
Brugia malayi	Carboxylesterase family protein	0.0017	0.0394	0.0394
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0394	0.0394
Loa Loa (eye worm)	carboxylesterase	0.0017	0.0394	0.0394
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.356	0.356
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0017	0.0394	0.0394
Echinococcus multilocularis	acetylcholinesterase	0.0103	1	1
Brugia malayi	ImpB/MucB/SamB family protein	0.0052	0.4305	0.4305
Onchocerca volvulus		0.0027	0.1507	1
Brugia malayi	hypothetical protein	0.0017	0.0394	0.0394
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.1507	0.1507
Loa Loa (eye worm)	cytochrome P450 family protein	0.0033	0.2101	0.2101
Loa Loa (eye worm)	hypothetical protein	0.0103	1	1
Echinococcus multilocularis	dna polymerase kappa	0.0023	0.0969	0.0969
Leishmania major	DNA polymerase eta, putative	0.0037	0.2562	0.5951
Giardia lamblia	DINP protein human, muc B family	0.0023	0.0969	0.5
Brugia malayi	ImpB/MucB/SamB family protein	0.0023	0.0969	0.0969
Schistosoma mansoni	gliotactin	0.0017	0.0394	0.0394
Leishmania major	DNA polymerase eta, putative	0.0052	0.4305	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.1507	0.1507
Loa Loa (eye worm)	cytochrome P450 family protein	0.0023	0.0965	0.0965
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0969	0.225
Echinococcus granulosus	acetylcholinesterase	0.0103	1	1
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0023	0.0969	0.0969
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.356	0.356
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.356	0.356
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.356	0.356
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0103	1	1
Brugia malayi	Carboxylesterase family protein	0.0017	0.0394	0.0394
Leishmania major	cytochrome p450-like protein	0.0023	0.0965	0.2241
Echinococcus multilocularis	acetylcholinesterase	0.0103	1	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0394	0.0394
Brugia malayi	Carboxylesterase family protein	0.0017	0.0394	0.0394
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.1507	0.1507
Loa Loa (eye worm)	hypothetical protein	0.0052	0.4305	0.4305
Loa Loa (eye worm)	carboxylesterase	0.0017	0.0394	0.0394
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0184	0.0428
Schistosoma mansoni	intermediate filament proteins	0.0027	0.1507	0.1507
Mycobacterium ulcerans	carboxylesterase, LipT	0.0017	0.0394	0.407
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0017	0.0394	0.407
Mycobacterium leprae	Conserved hypothetical protein	0.0014	0	0.5
Trypanosoma cruzi	DNA polymerase eta, putative	0.0037	0.2562	0.5951
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0184	0.0428
Loa Loa (eye worm)	hypothetical protein	0.0027	0.1507	0.1507
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0394	0.0394
Echinococcus multilocularis	neuroligin	0.0017	0.0394	0.0394
Trypanosoma brucei	DNA polymerase eta, putative	0.0052	0.4305	1
Trypanosoma brucei	unspecified product	0.0016	0.0184	0.0428
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0083	0.0083
Trypanosoma brucei	unspecified product	0.0016	0.0184	0.0428
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0023	0.0969	0.0969
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0969	0.225
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0969	0.225
Schistosoma mansoni	acetylcholinesterase	0.0017	0.0394	0.0394
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0017	0.0394	0.0394
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0017	0.0394	0.0394
Brugia malayi	Cytochrome P450 family protein	0.0033	0.2101	0.2101
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0969	0.225
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0023	0.0969	0.0969
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.356	0.356
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0017	0.0394	0.0394
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0969	0.225
Echinococcus multilocularis	musashi	0.0027	0.1507	0.1507
Loa Loa (eye worm)	cytochrome P450 family protein	0.0023	0.0965	0.0965
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0969	0.225
Echinococcus granulosus	acetylcholinesterase	0.0103	1	1
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0017	0.0394	0.0394
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.356	0.356
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0023	0.0969	1
Echinococcus granulosus	para nitrobenzyl esterase	0.0017	0.0394	0.0394
Echinococcus granulosus	dna polymerase eta	0.0052	0.4305	0.4305
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0184	0.0428
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0023	0.0969	0.225
Echinococcus granulosus	lamin dm0	0.0027	0.1507	0.1507
Brugia malayi	Carboxylesterase family protein	0.0017	0.0394	0.0394
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.356	0.356
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.356	0.356
Echinococcus multilocularis	dna polymerase eta	0.0052	0.4305	0.4305
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0023	0.0965	0.9962
Brugia malayi	Cytochrome P450 family protein	0.0023	0.0965	0.0965
Echinococcus multilocularis	lamin dm0	0.0027	0.1507	0.1507
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0969	0.225
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0083	0.0083
Trypanosoma cruzi	DNA polymerase eta, putative	0.0052	0.4305	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0017	0.0394	0.0394
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0969	0.225
Loa Loa (eye worm)	carboxylesterase	0.0103	1	1
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0023	0.0969	1
Onchocerca volvulus		0.0027	0.1507	1
Leishmania major	DNA polymerase kappa, putative	0.0023	0.0969	0.225
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.356	0.356
Echinococcus granulosus	carboxylesterase 5A	0.0103	1	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0394	0.0394
Trypanosoma cruzi	cytochrome P450, putative	0.0023	0.0965	0.2241
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0969	0.225
Loa Loa (eye worm)	CYP4Cod1	0.0023	0.0965	0.0965
Mycobacterium ulcerans	DNA polymerase IV	0.0023	0.0969	1
Schistosoma mansoni	lamin	0.0027	0.1507	0.1507
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0394	0.0394
Echinococcus granulosus	lamin	0.0027	0.1507	0.1507
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0023	0.0969	0.0969
Echinococcus multilocularis	para nitrobenzyl esterase	0.0017	0.0394	0.0394
Brugia malayi	Cytochrome P450 family protein	0.0023	0.0965	0.0965
Trypanosoma brucei	unspecified product	0.0023	0.0969	0.225
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0017	0.0394	0.407
Echinococcus granulosus	BC026374 protein S09 family	0.0017	0.0394	0.0394
Mycobacterium ulcerans	DNA polymerase IV	0.0023	0.0969	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0017	0.0394	0.0394
Mycobacterium leprae	putative cytochrome p450	0.0014	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0394	0.0394
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0037	0.2562	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0969	0.225
Echinococcus multilocularis	carboxylesterase 5A	0.0103	1	1
Brugia malayi	intermediate filament protein	0.0027	0.1507	0.1507
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0969	0.225
Brugia malayi	Carboxylesterase family protein	0.0103	1	1
Schistosoma mansoni	lamin	0.0027	0.1507	0.1507
Loa Loa (eye worm)	hypothetical protein	0.0103	1	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0969	0.225
Echinococcus granulosus	intermediate filament protein	0.0027	0.1507	0.1507
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0017	0.0394	0.407
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0023	0.0969	0.5
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0023	0.0969	0.0969
Loa Loa (eye worm)	hypothetical protein	0.0027	0.1451	0.1451
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0969	0.225
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0023	0.0969	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 671075