Detailed information for compound 671075

Basic information

Technical information
  • TDR Targets ID: 671075
  • Name: N-(2-chloro-4-nitrophenyl)-2-(4-methoxyphenyl )acetamide
  • MW: 320.728 | Formula: C15H13ClN2O4
  • H donors: 1 H acceptors: 3 LogP: 3.12 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)CC(=O)Nc1ccc(cc1Cl)[N+](=O)[O-]
  • InChi: 1S/C15H13ClN2O4/c1-22-12-5-2-10(3-6-12)8-15(19)17-14-7-4-11(18(20)21)9-13(14)16/h2-7,9H,8H2,1H3,(H,17,19)
  • InChiKey: ZRXFTDBTLUPDIR-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2-chloro-4-nitro-phenyl)-2-(4-methoxyphenyl)acetamide
  • N-(2-chloro-4-nitro-phenyl)-2-(4-methoxyphenyl)ethanamide
  • ZINC04893741
  • IVK/8191452

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus multilocularis BC026374 protein (S09 family) 0.0017 0.0394 0.0394
Brugia malayi intermediate filament protein 0.0027 0.1507 0.1507
Trypanosoma cruzi DNA polymerase eta, putative 0.0052 0.4305 1
Schistosoma mansoni DNA polymerase eta 0.0052 0.4305 0.4305
Loa Loa (eye worm) hypothetical protein 0.0017 0.0394 0.0394
Echinococcus granulosus BC026374 protein S09 family 0.0017 0.0394 0.0394
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0969 0.225
Echinococcus granulosus para nitrobenzyl esterase 0.0017 0.0394 0.0394
Mycobacterium leprae Conserved hypothetical protein 0.0014 0 0.5
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.2562 1
Echinococcus granulosus acetylcholinesterase 0.0103 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0965 0.0965
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0017 0.0394 0.407
Echinococcus multilocularis para nitrobenzyl esterase 0.0017 0.0394 0.0394
Mycobacterium ulcerans carboxylesterase, LipT 0.0017 0.0394 0.407
Loa Loa (eye worm) hypothetical protein 0.0103 1 1
Loa Loa (eye worm) intermediate filament protein 0.0027 0.1507 0.1507
Loa Loa (eye worm) hypothetical protein 0.0017 0.0394 0.0394
Echinococcus granulosus dna polymerase eta 0.0052 0.4305 0.4305
Onchocerca volvulus 0.0027 0.1507 1
Brugia malayi Carboxylesterase family protein 0.0017 0.0394 0.0394
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0969 0.225
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.356 0.356
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0969 0.225
Brugia malayi ImpB/MucB/SamB family protein 0.0052 0.4305 0.4305
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0969 0.0969
Brugia malayi Cytochrome P450 family protein 0.0033 0.2101 0.2101
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.356 0.356
Echinococcus multilocularis dna polymerase eta 0.0052 0.4305 0.4305
Loa Loa (eye worm) hypothetical protein 0.0017 0.0394 0.0394
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0083 0.0083
Schistosoma mansoni neuroligin 3 (S09 family) 0.0017 0.0394 0.0394
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0969 0.225
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0184 0.0428
Loa Loa (eye worm) carboxylesterase 0.0103 1 1
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0017 0.0394 0.0394
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0969 0.225
Trypanosoma brucei unspecified product 0.0016 0.0184 0.0428
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.356 0.356
Leishmania major DNA polymerase eta, putative 0.0052 0.4305 1
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0969 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0965 0.9962
Mycobacterium leprae putative cytochrome p450 0.0014 0 0.5
Brugia malayi Cytochrome P450 family protein 0.0023 0.0965 0.0965
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.356 0.356
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.356 0.356
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.356 0.356
Loa Loa (eye worm) hypothetical protein 0.0027 0.1507 0.1507
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0017 0.0394 0.407
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0103 1 1
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.1507 0.1507
Mycobacterium tuberculosis Carboxylesterase LipT 0.0017 0.0394 0.407
Echinococcus granulosus neuroligin 0.0017 0.0394 0.0394
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0969 0.225
Trypanosoma brucei unspecified product 0.0016 0.0184 0.0428
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0969 0.225
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.1507 0.1507
Brugia malayi Carboxylesterase family protein 0.0017 0.0394 0.0394
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0969 1
Echinococcus granulosus lamin 0.0027 0.1507 0.1507
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0969 0.5
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0969 1
Echinococcus multilocularis carboxylesterase 5A 0.0103 1 1
Echinococcus granulosus intermediate filament protein 0.0027 0.1507 0.1507
Brugia malayi Carboxylesterase family protein 0.0017 0.0394 0.0394
Loa Loa (eye worm) carboxylesterase 0.0017 0.0394 0.0394
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0969 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.2562 0.5951
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0965 0.0965
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0969 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0969 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0969 0.225
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0965 0.2241
Schistosoma mansoni lamin 0.0027 0.1507 0.1507
Schistosoma mansoni lamin 0.0027 0.1507 0.1507
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0969 0.0969
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0969 0.225
Leishmania major DNA polymerase eta, putative 0.0037 0.2562 0.5951
Echinococcus multilocularis lamin dm0 0.0027 0.1507 0.1507
Echinococcus multilocularis acetylcholinesterase 0.0103 1 1
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0965 0.2241
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0184 0.0428
Echinococcus multilocularis acetylcholinesterase 0.0103 1 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0969 0.0969
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0017 0.0394 0.0394
Brugia malayi Carboxylesterase family protein 0.0017 0.0394 0.0394
Echinococcus multilocularis musashi 0.0027 0.1507 0.1507
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0969 0.225
Echinococcus granulosus dna polymerase kappa 0.0023 0.0969 0.0969
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0969 0.225
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0969 0.225
Echinococcus granulosus lamin dm0 0.0027 0.1507 0.1507
Brugia malayi hypothetical protein 0.0017 0.0394 0.0394
Echinococcus multilocularis lamin 0.0027 0.1507 0.1507
Schistosoma mansoni gliotactin 0.0017 0.0394 0.0394
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0969 0.0969
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0017 0.0394 0.0394
Loa Loa (eye worm) hypothetical protein 0.0017 0.0394 0.0394
Schistosoma mansoni acetylcholinesterase 0.0017 0.0394 0.0394
Giardia lamblia DINP protein human, muc B family 0.0023 0.0969 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0969 0.225
Echinococcus multilocularis neuroligin 0.0017 0.0394 0.0394
Leishmania major DNA polymerase kappa, putative 0.0023 0.0969 0.225
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.2101 0.2101
Schistosoma mansoni intermediate filament proteins 0.0027 0.1507 0.1507
Loa Loa (eye worm) hypothetical protein 0.0027 0.1451 0.1451
Loa Loa (eye worm) hypothetical protein 0.0052 0.4305 0.4305
Loa Loa (eye worm) hypothetical protein 0.0103 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0969 0.225
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.356 0.356
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0017 0.0394 0.0394
Loa Loa (eye worm) hypothetical protein 0.0017 0.0394 0.0394
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0017 0.0394 0.0394
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0965 0.2241
Trypanosoma brucei unspecified product 0.0023 0.0969 0.225
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0184 0.0428
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0969 0.0969
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0969 0.0969
Trypanosoma brucei DNA polymerase eta, putative 0.0052 0.4305 1
Brugia malayi Carboxylesterase family protein 0.0103 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.356 0.356
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0017 0.0394 0.0394
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0969 0.225
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0969 0.225
Echinococcus granulosus acetylcholinesterase 0.0103 1 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0394 0.0394
Loa Loa (eye worm) acetylcholinesterase 1 0.0103 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0969 0.225
Schistosoma mansoni BC026374 protein (S09 family) 0.0017 0.0394 0.0394
Loa Loa (eye worm) carboxylesterase 0.0017 0.0394 0.0394
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0969 0.0969
Brugia malayi Cytochrome P450 family protein 0.0023 0.0965 0.0965
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0969 0.225
Echinococcus granulosus carboxylesterase 5A 0.0103 1 1
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0965 0.0965
Onchocerca volvulus 0.0027 0.1507 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.356 0.356
Leishmania major cytochrome p450-like protein 0.0023 0.0965 0.2241

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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