Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | nuclear receptor NHR-88 | 0.0021 | 0.7534 | 0.7534 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0021 | 0.7534 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0021 | 0.7534 | 0.7534 |
Brugia malayi | nuclear hormone receptor | 0.0021 | 0.7534 | 0.7534 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0021 | 0.7534 | 0.7534 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.5771 | 0.5771 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0021 | 0.7534 | 0.7534 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.7534 | 0.7534 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0021 | 0.7534 | 0.7534 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.7534 | 0.7534 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0021 | 0.7534 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0021 | 0.7534 | 0.7534 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0807 | 0.0807 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0021 | 0.7534 | 0.7534 |
Schistosoma mansoni | thyroid hormone receptor | 0.0021 | 0.7534 | 1 |
Onchocerca volvulus | 0.0021 | 0.7534 | 0.7534 | |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.5771 | 0.5771 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0021 | 0.7534 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0021 | 0.7534 | 0.7534 |
Mycobacterium ulcerans | hypothetical protein | 0.0025 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0021 | 0.7534 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0021 | 0.7534 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0021 | 0.7534 | 0.7534 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 1 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0011 | 0.0807 | 0.1071 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0019 | 0.5771 | 0.5 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0011 | 0.0807 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0021 | 0.7534 | 0.7534 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0025 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0021 | 0.7534 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0021 | 0.7534 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.7534 | 0.7534 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0025 | 1 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0025 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0021 | 0.7534 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0021 | 0.7534 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0021 | 0.7534 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.6542 | 0.6542 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0025 | 1 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0019 | 0.5771 | 0.139 |
Echinococcus granulosus | FTZ F1 alpha | 0.0021 | 0.7534 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0025 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0807 | 0.0807 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0021 | 0.7534 | 0.7534 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0807 | 0.0807 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0021 | 0.7534 | 0.7534 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.6542 | 0.8683 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0021 | 0.7534 | 0.7534 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0011 | 0.0807 | 0.1071 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0011 | 0.0807 | 0.0807 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0025 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.6542 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0021 | 0.7534 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.6542 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0021 | 0.7534 | 0.7534 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0025 | 1 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0025 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 1 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0025 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0021 | 0.7534 | 0.7534 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0021 | 0.7534 | 0.7534 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0021 | 0.7534 | 0.7534 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.6542 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0021 | 0.7534 | 0.7534 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0021 | 0.7534 | 0.7534 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.6542 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.5771 | 0.5771 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0021 | 0.7534 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0021 | 0.7534 | 0.7534 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0021 | 0.7534 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0021 | 0.7534 | 0.7534 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.5771 | 0.5771 |
Brugia malayi | hypothetical protein | 0.0011 | 0.0807 | 0.0807 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0021 | 0.7534 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0011 | 0.0807 | 0.0807 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.7534 | 0.7534 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0025 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0021 | 0.7534 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0021 | 0.7534 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0021 | 0.7534 | 0.7534 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0011 | 0.0807 | 0.0807 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.6542 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0021 | 0.7534 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0021 | 0.7534 | 0.7534 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.6542 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0021 | 0.7534 | 0.7534 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0021 | 0.7534 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.6542 | 0.5 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0011 | 0.0807 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.7534 | 0.7534 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0807 | 0.0807 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0021 | 0.7534 | 0.7534 |
Brugia malayi | steroid hormone receptor | 0.0021 | 0.7534 | 0.7534 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0021 | 0.7534 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.6542 | 0.8683 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0021 | 0.7534 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.6542 | 0.1822 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0021 | 0.7534 | 0.7534 |
Onchocerca volvulus | 0.0025 | 1 | 1 | |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0021 | 0.7534 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0807 | 0.0807 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0021 | 0.7534 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0021 | 0.7534 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0021 | 0.7534 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0021 | 0.7534 | 0.7534 |
Brugia malayi | hypothetical protein | 0.0011 | 0.0807 | 0.0807 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0025 | 1 | 0.5 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.6542 | 0.6542 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.6542 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0021 | 0.7534 | 0.7534 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0021 | 0.7534 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.6542 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0021 | 0.7534 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.6542 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.6542 | 0.8683 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.7534 | 0.7534 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.7534 | 0.7534 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0011 | 0.0807 | 0.0807 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.5771 | 0.5771 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.6542 | 0.8683 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.7534 | 0.7534 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0021 | 0.7534 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.6542 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0021 | 0.7534 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0021 | 0.7534 | 0.7534 |
Schistosoma mansoni | thyroid hormone receptor | 0.0021 | 0.7534 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.6542 | 0.2958 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.