Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.059 | 0.9561 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0168 | 0.0168 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.059 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.059 | 0.9561 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.059 | 0.9561 |
Trypanosoma brucei | glucosidase, putative | 0.0036 | 0.0612 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.059 | 0.059 |
Onchocerca volvulus | 0.0035 | 0.059 | 0.265 | |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.059 | 0.059 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0161 | 0.3372 | 0.3372 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0036 | 0.0612 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0161 | 0.3372 | 0.3372 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0036 | 0.0612 | 0.0612 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.2393 | 0.2393 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0168 | 0.0168 |
Onchocerca volvulus | 0.0028 | 0.045 | 0.1863 | |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.1147 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0462 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0612 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.045 | 0.0516 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0036 | 0.0612 | 1 |
Brugia malayi | TAR-binding protein | 0.0125 | 0.2567 | 0.2567 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0168 | 0.0168 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.059 | 0.0676 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.059 | 0.059 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0168 | 0.0168 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.059 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.1147 | 0.1314 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0168 | 0.0168 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.1147 | 0.1349 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0608 | 0.0608 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.059 | 0.059 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0018 | 0.0018 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 0.2393 | 0.2393 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.091 | 0.091 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0486 | 0.0557 |
Schistosoma mansoni | hypothetical protein | 0.0405 | 0.873 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.059 | 0.0676 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0125 | 0.2567 | 0.2567 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0168 | 0.0168 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0168 | 0.0193 |
Loa Loa (eye worm) | TAR-binding protein | 0.0125 | 0.2567 | 0.2567 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.1147 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0125 | 0.2567 | 0.2567 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0168 | 0.0168 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.0486 | 0.0486 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.2567 | 0.294 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.059 | 0.059 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.059 | 0.059 |
Echinococcus multilocularis | tar DNA binding protein | 0.0125 | 0.2567 | 0.2567 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.1147 | 0.1147 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.091 | 0.091 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.091 | 0.091 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0168 | 0.0168 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0168 | 0.0168 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.059 | 0.9561 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.045 | 0.045 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0036 | 0.0612 | 0.0612 |
Echinococcus granulosus | geminin | 0.0168 | 0.3514 | 0.3514 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.2567 | 0.294 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0608 | 0.9923 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0168 | 0.0193 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0612 | 0.0389 |
Brugia malayi | beta-lactamase | 0.0035 | 0.059 | 0.059 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.006 | 0.1151 | 0.1319 |
Onchocerca volvulus | 0.0093 | 0.1876 | 0.9866 | |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.059 | 0.059 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.059 | 0.9561 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0612 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0036 | 0.0612 | 0.0612 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.1147 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0608 | 0.9923 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.059 | 0.459 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.0486 | 0.0486 |
Onchocerca volvulus | 0.0035 | 0.059 | 0.265 | |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0462 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0168 | 0.0193 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0125 | 0.2567 | 0.2567 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.2567 | 0.294 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0612 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.059 | 0.059 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0608 | 0.0608 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0036 | 0.0612 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.059 | 0.9561 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0168 | 0.0168 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.0016 | 0.0016 |
Schistosoma mansoni | alpha-glucosidase | 0.0139 | 0.2878 | 0.3297 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.059 | 0.059 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0567 | 0.0567 |
Onchocerca volvulus | 0.0094 | 0.19 | 1 | |
Schistosoma mansoni | alpha-glucosidase | 0.0139 | 0.2878 | 0.3297 |
Schistosoma mansoni | alpha glucosidase | 0.0036 | 0.0612 | 0.0701 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.059 | 0.059 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0612 | 1 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0018 | 0.0018 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0222 | 0.4715 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0612 | 1 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0036 | 0.0612 | 0.0612 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.059 | 0.059 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0486 | 0.0557 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0168 | 0.0193 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0161 | 0.3372 | 0.3372 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.059 | 0.059 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.059 | 0.9561 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0036 | 0.0612 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.059 | 0.059 |
Echinococcus granulosus | dnaJ subfamily B | 0.0405 | 0.873 | 0.873 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0458 | 0.9892 | 0.9892 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0458 | 0.9892 | 0.9892 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0458 | 0.9892 | 0.9892 |
Echinococcus multilocularis | geminin | 0.0168 | 0.3514 | 0.3514 |
Schistosoma mansoni | hypothetical protein | 0.0094 | 0.19 | 0.2177 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0013 | 0.0118 | 0.0118 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.059 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0608 | 0.9923 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.045 | 0.045 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.1147 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0612 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0612 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0612 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.1147 | 0.1147 |
Onchocerca volvulus | 0.0035 | 0.059 | 0.265 | |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0161 | 0.3372 | 0.3372 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.091 | 0.091 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0608 | 0.0697 |
Echinococcus granulosus | tar DNA binding protein | 0.0125 | 0.2567 | 0.2567 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.2567 | 0.294 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0094 | 0.19 | 0.19 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0608 | 0.0608 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.3514 | 0.4025 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0567 | 0.0649 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.059 | 0.9561 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.3514 | 0.4025 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0118 | 0.0118 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0161 | 0.3372 | 0.3372 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0567 | 0.0567 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0612 | 1 |
Brugia malayi | RNA binding protein | 0.0125 | 0.2567 | 0.2567 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0608 | 0.9923 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0608 | 0.0697 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0018 | 0.0018 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0462 | 1 | 1 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0036 | 0.0612 | 0.4801 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.2567 | 0.294 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0405 | 0.873 | 0.873 |
Schistosoma mansoni | survival motor neuron protein | 0.0094 | 0.19 | 0.2177 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.059 | 0.9561 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.1147 | 1 |
Echinococcus granulosus | neuropeptide s receptor | 0.0458 | 0.9892 | 0.9892 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.1147 | 0.1314 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0054 | 0.101 | 0.7531 |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.2393 | 0.2393 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Analgesic efficacy (functional) | = 38 % | Analagesic activity as percentage analgesic efficacy on male albino swiss-webster mice with the hot-plate test | ChEMBL. | 8201605 |
ED50 (functional) | = 18 mg kg-1 | Analagesic activity after subcutaneous administration in male albino swiss-webster mice with the hot-plate test | ChEMBL. | 8201605 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.