TDR Targets

Basic information

Technical information

TDR Targets ID: 671697
Name: N-(2,4-difluorophenyl)-2-[(4-nitrophenyl)-phe nylsulfonylamino]acetamide
MW: 447.412 | Formula: C20H15F2N3O5S
H donors: 1 H acceptors: 5 LogP: 3.56 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=C(CN(S(=O)(=O)c1ccccc1)c1ccc(cc1)[N+](=O)[O-])Nc1ccc(cc1F)F
InChi: 1S/C20H15F2N3O5S/c21-14-6-11-19(18(22)12-14)23-20(26)13-24(15-7-9-16(10-8-15)25(27)28)31(29,30)17-4-2-1-3-5-17/h1-12H,13H2,(H,23,26)
InChiKey: DRWKQSWHOKTEDM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(2,4-difluorophenyl)-2-[(4-nitrophenyl)-phenylsulfonyl-amino]acetamide
N-(2,4-difluorophenyl)-2-[(4-nitrophenyl)-phenylsulfonyl-amino]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0034	0.058	0.1549
Mycobacterium tuberculosis	Probable dehydrogenase	0.0225	0.6483	0.8898
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0225	0.6483	0.7034
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0098	0.2574	0.3349
Onchocerca volvulus		0.0274	0.8014	1
Loa Loa (eye worm)	hypothetical protein	0.0142	0.3915	0.5466
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0241	0.6983	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0338	1	1
Brugia malayi	glutathione reductase	0.0098	0.2574	0.3485
Loa Loa (eye worm)	glutathione reductase	0.0098	0.2574	0.3485
Onchocerca volvulus	Huntingtin homolog	0.0142	0.3915	0.4476
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0593	0.0418
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0035	0.0593	0.1591
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0034	0.058	0.1549
Trichomonas vaginalis	glutathione reductase, putative	0.0034	0.058	0.0373
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.058	0.1549
Trichomonas vaginalis	set domain proteins, putative	0.0274	0.8014	0.7971
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.025	0.7259	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0034	0.058	0.5
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0225	0.6483	0.8898
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0215	0.0834
Plasmodium vivax	thioredoxin reductase, putative	0.0098	0.2574	1
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0034	0.058	0.1537
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0338	1	1
Giardia lamblia	Fructose-bisphosphate aldolase	0.0338	1	1
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0034	0.058	0.1549
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0034	0.058	0.0519
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0034	0.058	0.1537
Brugia malayi	Thioredoxin reductase	0.0098	0.2574	0.3485
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0035	0.0593	0.0064
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0215	0.0834
Trypanosoma brucei	DNA polymerase eta, putative	0.0022	0.0215	0.0834
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.058	0.1549
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0338	1	1
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0034	0.058	0.1549
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0225	0.6483	0.8898
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0215	0.0834
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0338	1	1
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0165	0.4641	0.6283
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0225	0.6483	0.8898
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0035	0.0593	0.1591
Mycobacterium tuberculosis	Probable reductase	0.0225	0.6483	0.8898
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0338	1	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.058	0.1549
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0034	0.058	0.1549
Trypanosoma cruzi	trypanothione reductase, putative	0.0034	0.058	0.1549
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0593	0.0559
Echinococcus granulosus	histone lysine methyltransferase setb	0.0035	0.0593	0.1591
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0593	0.0418
Brugia malayi	Pre-SET motif family protein	0.0035	0.0593	0.0559
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0338	1	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.025	0.7259	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.025	0.7259	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0215	0.0834
Trichomonas vaginalis	mercuric reductase, putative	0.0034	0.058	0.0373
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0025	0.03	0.0125
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.0215	0.0834
Loa Loa (eye worm)	thioredoxin reductase	0.0098	0.2574	0.3485
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0033	0.0554	0.1426
Onchocerca volvulus	Huntingtin homolog	0.0142	0.3915	0.4476
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0034	0.058	0.2254
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.025	0.7259	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0215	0.0834
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0225	0.6483	0.8898
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0034	0.058	0.2254
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0215	0.0834
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0215	0.0834
Trypanosoma brucei	trypanothione reductase	0.0098	0.2574	1
Brugia malayi	hypothetical protein	0.0142	0.3915	0.5466
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0034	0.058	0.0826
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0034	0.058	0.054
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0215	0.0834
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0099	0.2592	1
Toxoplasma gondii	thioredoxin reductase	0.0098	0.2574	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0215	0.0834
Plasmodium vivax	glutathione reductase, putative	0.0098	0.2574	1
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0034	0.058	0.2254
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0593	0.0418
Brugia malayi	Pre-SET motif family protein	0.0241	0.6983	1
Plasmodium falciparum	glutathione reductase	0.0098	0.2574	1
Plasmodium vivax	SET domain protein, putative	0.0035	0.0593	0.0064
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0338	1	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.058	0.1549
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0215	0.0834
Trypanosoma brucei	unspecified product	0.0022	0.0215	0.0834
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.0215	0.0834
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0034	0.058	0.5
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0165	0.4641	1
Plasmodium falciparum	thioredoxin reductase	0.0098	0.2574	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0034	0.058	0.5
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0034	0.058	0.2254
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.0215	0.0834
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.058	0.1549
Trypanosoma cruzi	trypanothione reductase, putative	0.0098	0.2574	1
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0034	0.058	0.0373
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.058	0.1549
Leishmania major	trypanothione reductase	0.0098	0.2574	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0338	1	1
Treponema pallidum	fructose-bisphosphate aldolase	0.0338	1	1
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0034	0.058	0.0404
Echinococcus granulosus	thioredoxin glutathione reductase	0.0099	0.2592	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0035	0.0593	0.0418
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0338	1	1
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0025	0.03	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0142	0.3915	0.5466
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0034	0.058	0.0826
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0034	0.058	0.1549
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0034	0.058	0.0826

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 671697