TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 287.787 | Formula: C16H18ClN3
H donors: 0 H acceptors: 1 LogP: 3.24 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Clc1cccnc1N1CCN(CC1)Cc1ccccc1
InChi: 1S/C16H18ClN3/c17-15-7-4-8-18-16(15)20-11-9-19(10-12-20)13-14-5-2-1-3-6-14/h1-8H,9-13H2
InChiKey: DXBCZLBBXQSAMW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Bos taurus	Alpha-1a adrenergic receptor	Starlite/ChEMBL	References
Rattus norvegicus	Adrenergic receptor alpha-2	Starlite/ChEMBL	References
Bos taurus	Alpha-2a adrenergic receptor	Starlite/ChEMBL	References
Rattus norvegicus	Adrenergic receptor alpha-1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus multilocularis	serotonin receptor	Alpha-2a adrenergic receptor	452 aa	421 aa	33.0 %
Echinococcus multilocularis	alpha 1A adrenergic receptor	Alpha-2a adrenergic receptor	452 aa	452 aa	20.6 %
Schistosoma japonicum	ko:K04136 adrenergic receptor, alpha 1b, putative	Alpha-1a adrenergic receptor	466 aa	447 aa	29.3 %
Loa Loa (eye worm)	TYRA-2 protein	Alpha-2a adrenergic receptor	452 aa	491 aa	24.4 %
Echinococcus granulosus	rhodopsin orphan GPCR	Alpha-1a adrenergic receptor	466 aa	418 aa	20.3 %
Onchocerca volvulus		Alpha-2a adrenergic receptor	452 aa	426 aa	18.3 %
Echinococcus granulosus	g protein coupled receptor	Alpha-1a adrenergic receptor	466 aa	414 aa	20.5 %
Schistosoma mansoni	biogenic amine (5HT) receptor	Adrenergic receptor alpha-2	450 aa	433 aa	27.9 %
Echinococcus multilocularis	g protein coupled receptor	Alpha-1a adrenergic receptor	466 aa	396 aa	21.7 %
Schistosoma japonicum	ko:K04145 dopamine receptor D2, putative	Adrenergic receptor alpha-2	450 aa	473 aa	24.1 %
Echinococcus granulosus	g protein coupled receptor	Alpha-1a adrenergic receptor	466 aa	396 aa	21.7 %
Onchocerca volvulus		Alpha-2a adrenergic receptor	452 aa	471 aa	27.4 %
Echinococcus multilocularis	g protein coupled receptor	Alpha-1a adrenergic receptor	466 aa	414 aa	20.8 %
Schistosoma japonicum	ko:K04207 neuropeptide Y receptor Y5, putative	Alpha-2a adrenergic receptor	452 aa	381 aa	21.8 %
Schistosoma mansoni	amine GPCR	Alpha-2a adrenergic receptor	452 aa	440 aa	29.1 %
Echinococcus multilocularis	fmrfamide receptor	Alpha-2a adrenergic receptor	452 aa	453 aa	19.2 %
Echinococcus granulosus	alpha 1A adrenergic receptor	Alpha-2a adrenergic receptor	452 aa	456 aa	21.1 %
Echinococcus granulosus	biogenic amine 5HT receptor	Alpha-1a adrenergic receptor	466 aa	408 aa	32.6 %
Echinococcus multilocularis	fmrfamide receptor	Adrenergic receptor alpha-2	450 aa	366 aa	19.9 %
Echinococcus multilocularis	neuropeptides capa receptor	Adrenergic receptor alpha-2	450 aa	486 aa	20.6 %
Schistosoma japonicum	ko:K04135 adrenergic receptor, alpha 1a, putative	Alpha-1a adrenergic receptor	466 aa	446 aa	31.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0009	0.0281
Mycobacterium ulcerans	phospho-N-acetylmuramoyl-pentapeptide-transferase	0.0808	0.133	0.1321
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0117	0.0152	0.0133
Chlamydia trachomatis	UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase	0.0186	0.027	0.535
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0066	0.0064	0.2772
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.0007	0.0304
Plasmodium falciparum	cysteine--tRNA ligase	0.0086	0.0098	0.4223
Onchocerca volvulus		0.0258	0.0391	1
Plasmodium vivax	thioredoxin reductase, putative	0.0051	0.0039	0.1696
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0165	0.0232	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.013	0.0174	0.0156
Echinococcus multilocularis	UDP N acetylglucosamine dolichyl phosphate	0.0034	0.0009	0.0409
Trypanosoma brucei	cysteinyl-tRNA synthetase, putative	0.0086	0.0098	0.4223
Mycobacterium tuberculosis	Probable oxidoreductase	0.013	0.0174	0.0156
Entamoeba histolytica	cysteinyl-tRNA synthetase, putative	0.0086	0.0098	1
Mycobacterium ulcerans	glycosyltransferase	0.0039	0.0019	0.001
Trypanosoma brucei	UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative	0.0034	0.0009	0.0408
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0117	0.0151	0.0132
Giardia lamblia	UDP-N-acetylglucosamine-dolichyl-phosphateN-acetylglucosaminephosphotransferase	0.0034	0.0009	0.0967
Entamoeba histolytica	UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative	0.0034	0.0009	0.0967
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.0064	0.0055
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0164	0.0232	1
Echinococcus multilocularis	thymidylate synthase	0.0117	0.0151	0.6508
Schistosoma mansoni	dihydrofolate reductase	0.0048	0.0033	0.1151
Echinococcus granulosus	cysteinyl tRNA synthetase	0.0086	0.0098	0.4228
Schistosoma mansoni	cysteinyl-tRNA synthetase	0.0086	0.0098	0.4046
Trypanosoma cruzi	cysteinyl-tRNA synthetase, putative	0.0086	0.0098	0.4223
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0164	0.0232	0.687
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0165	0.0232	1
Plasmodium vivax	N-acetylglucosamine-1-phosphate transferase, putative	0.0034	0.0009	0.0408
Trichomonas vaginalis	cysteinyl-tRNA synthetase, putative	0.0086	0.0098	0.2508
Trypanosoma cruzi	UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative	0.0034	0.0009	0.0408
Mycobacterium tuberculosis	Probable UPD-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol-N-acetylglucosamine transferase MurG	0.0137	0.0185	0.0166
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0066	0.0064	0.2772
Trypanosoma brucei	trypanothione reductase	0.0051	0.0039	0.1696
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0165	0.0232	1
Toxoplasma gondii	glycosyl transferase, group 4 family protein	0.0034	0.0009	0.0408
Brugia malayi	hypothetical protein	0.0056	0.0047	0.1377
Echinococcus multilocularis	serotonin transporter	0.0164	0.0232	1
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0051	0.0039	0.1698
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.0005	0.0217
Toxoplasma gondii	cysteine-tRNA synthetase (CysRS)	0.0086	0.0098	0.4223
Mycobacterium tuberculosis	Hypothetical protein	0.0056	0.0047	0.0028
Trypanosoma cruzi	trypanothione reductase, putative	0.0051	0.0039	0.1696
Echinococcus granulosus	serotonin transporter	0.0164	0.0232	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0032	0.0007	0.0305
Onchocerca volvulus		0.0034	0.0009	0.0063
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0117	0.0152	0.0133
Schistosoma mansoni	UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase	0.0034	0.0009	0.0108
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0117	0.0151	0.0132
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0165	0.0232	1
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0117	0.0152	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0098	0.2904
Chlamydia trachomatis	cysteine--tRNA ligase	0.0086	0.0098	0.1473
Schistosoma mansoni	sodium/chloride dependent transporter	0.0164	0.0232	1
Treponema pallidum	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase	0.0186	0.027	0.4547
Echinococcus granulosus	thymidylate synthase	0.0117	0.0151	0.6508
Loa Loa (eye worm)	glutathione reductase	0.0051	0.0039	0.1167
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.0007	0.0305
Loa Loa (eye worm)	dihydrofolate reductase	0.0048	0.0033	0.0976
Leishmania major	UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative	0.0034	0.0009	0.0408
Schistosoma mansoni	aldehyde dehydrogenase	0.0066	0.0064	0.2545
Loa Loa (eye worm)	norepinephrine transporter	0.0164	0.0232	0.687
Loa Loa (eye worm)	thioredoxin reductase	0.0051	0.0039	0.1167
Onchocerca volvulus		0.0086	0.0098	0.237
Brugia malayi	Pre-SET motif family protein	0.0226	0.0338	1
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.0048	0.0033	0.0024
Brugia malayi	Thioredoxin reductase	0.0051	0.0039	0.1167
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0007	0.0305
Echinococcus granulosus	thioredoxin glutathione reductase	0.0051	0.0039	0.1698
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.0048	0.0033	0.0014
Trichomonas vaginalis	glucosaminephosphotransferase, putative	0.0034	0.0009	0.0243
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0047	0.1189
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0232	0.687
Brugia malayi	Pre-SET motif family protein	0.0032	0.0007	0.0209
Mycobacterium tuberculosis	Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX	0.0808	0.133	0.1313
Schistosoma mansoni	aldehyde dehydrogenase	0.0066	0.0064	0.2545
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0165	0.0232	1
Wolbachia endosymbiont of Brugia malayi	UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase	0.0186	0.027	0.1393
Loa Loa (eye worm)	serotonin transporter b	0.0164	0.0232	0.687
Plasmodium vivax	cysteine--tRNA ligase, putative	0.0086	0.0098	0.4223
Mycobacterium ulcerans	thymidylate synthase	0.0117	0.0151	0.0142
Plasmodium vivax	glutathione reductase, putative	0.0051	0.0039	0.1696
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0117	0.0152	0.0133
Mycobacterium leprae	ProbableUPD-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol-N-acetylglucosamine transferase MurG	0.0137	0.0185	0.0166
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.013	0.0174	0.0156
Mycobacterium ulcerans	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase	0.0186	0.027	0.026
Plasmodium falciparum	UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative	0.0034	0.0009	0.0408
Echinococcus multilocularis	dihydrofolate reductase	0.0048	0.0033	0.1421
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0066	0.0064	0.2769
Schistosoma mansoni	cysteinyl-tRNA synthetase	0.0086	0.0098	0.4046
Plasmodium falciparum	glutathione reductase	0.0051	0.0039	0.1696
Wolbachia endosymbiont of Brugia malayi	phospho-N-acetylmuramoyl-pentapeptide-transferase	0.0808	0.133	1
Giardia lamblia	Cysteinyl-tRNA synthetase	0.0086	0.0098	1
Treponema pallidum	phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY)	0.0307	0.0475	1
Plasmodium falciparum	thioredoxin reductase	0.0051	0.0039	0.1696
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0007	0.0209
Onchocerca volvulus		0.0117	0.0151	0.3748
Mycobacterium leprae	Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX	0.0808	0.133	0.1313
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0056	0.0047	0.2002
Toxoplasma gondii	aldehyde dehydrogenase	0.0066	0.0064	0.2769
Plasmodium falciparum	cysteine--tRNA ligase	0.0086	0.0098	0.4223
Mycobacterium tuberculosis	Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC	0.5889	1	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.013	0.0174	0.0156
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0117	0.0151	0.6399
Echinococcus multilocularis	cysteinyl tRNA synthetase	0.0086	0.0098	0.4228
Brugia malayi	UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase	0.0034	0.0009	0.0281
Leishmania major	cysteinyl-tRNA synthetase, putative	0.0086	0.0098	0.4223
Leishmania major	trypanothione reductase	0.0051	0.0039	0.1696
Brugia malayi	dihydrofolate reductase family protein	0.0048	0.0033	0.0976
Brugia malayi	cysteinyl tRNA synthetase protein 1	0.0086	0.0098	0.2904
Mycobacterium tuberculosis	Probable dehydrogenase	0.0117	0.0152	0.0133
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0164	0.0232	0.687
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0066	0.0064	0.0045
Onchocerca volvulus		0.0164	0.0232	0.5858
Brugia malayi	Dihydrofolate reductase	0.0048	0.0033	0.0976
Loa Loa (eye worm)	cysteinyl tRNA synthetase 1	0.0086	0.0098	0.2904
Trypanosoma cruzi	cysteinyl-tRNA synthetase, putative	0.0086	0.0098	0.4223
Mycobacterium ulcerans	cysteinyl-tRNA synthetase	0.5889	1	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.0064	0.0055
Loa Loa (eye worm)	thymidylate synthase	0.0117	0.0151	0.4471
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.0048	0.0033	0.0014
Mycobacterium tuberculosis	Probable reductase	0.0117	0.0152	0.0133
Echinococcus granulosus	leucyl tRNA synthetase	0.0086	0.0098	0.4228
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0232	0.687
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0117	0.0152	0.0133
Chlamydia trachomatis	phospho-N-acetylmuramoyl-pentapeptide-transferase	0.0307	0.0475	1
Plasmodium vivax	SET domain protein, putative	0.0032	0.0007	0.0304
Toxoplasma gondii	thioredoxin reductase	0.0051	0.0039	0.1696
Trichomonas vaginalis	set domain proteins, putative	0.0258	0.0391	1
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0232	0.687
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0165	0.0232	1
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0051	0.0039	0.002
Brugia malayi	thymidylate synthase	0.0117	0.0151	0.4471
Mycobacterium ulcerans	cysteinyl-tRNA synthetase	0.0086	0.0098	0.0089
Echinococcus granulosus	dihydrofolate reductase	0.0048	0.0033	0.1421
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0226	0.0338	1
Schistosoma mansoni	UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase	0.0034	0.0009	0.0108
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.0064	0.0055
Echinococcus granulosus	UDP N acetylglucosamine dolichyl phosphate	0.0034	0.0009	0.0409
Trypanosoma cruzi	UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative	0.0034	0.0009	0.0408
Treponema pallidum	sodium- and chloride- dependent transporter	0.0164	0.0232	0.3554
Brugia malayi	glutathione reductase	0.0051	0.0039	0.1167

Activities

Activity type	Activity value	Assay description	Source	Reference
AD50 (functional)	> 3 mg kg-1	Antagonistic activity against central alpha-2 adrenergic receptor, in anesthetized rats (reversal of clonidine-induced mydriasis)	ChEMBL.	6139479
AD50 (functional)	> 3 mg kg-1	Antagonistic activity against central alpha-2 adrenergic receptor, in anesthetized rats (reversal of clonidine-induced mydriasis)	ChEMBL.	6139479
Kd (functional)	= 6.5	Presynaptic antagonistic activity against alpha-2 adrenergic receptor from rat, isolated, field-stimulated vas deferens, using clonidine as the agonist	ChEMBL.	6139479
Kd (functional)	= 7	Presynaptic antagonistic activity against alpha-1 adrenergic receptor from rat, isolated, field-stimulated vas deferens, using methoxamine as the agonist	ChEMBL.	6139479
Ki (binding)	= 120 nM	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]-clonidine as the radioligand	ChEMBL.	6139479
Ki (binding)	= 120 nM	Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]-clonidine as the radioligand	ChEMBL.	6139479
Ki (binding)	= 700 nM	Binding activity against alpha-1 adrenergic receptor from calf cerebral cortex, using [3H]-prazosin as the radioligand	ChEMBL.	6139479
Ki (binding)	= 700 nM	Binding activity against alpha-1 adrenergic receptor from calf cerebral cortex, using [3H]-prazosin as the radioligand	ChEMBL.	6139479
pA2 (functional)	= 6.5	Presynaptic antagonistic activity against alpha-2 adrenergic receptor from rat, isolated, field-stimulated vas deferens, using clonidine as the agonist	ChEMBL.	6139479
pA2 (functional)	= 7	Presynaptic antagonistic activity against alpha-1 adrenergic receptor from rat, isolated, field-stimulated vas deferens, using methoxamine as the agonist	ChEMBL.	6139479
Selectivity ratio (binding)	= 0.3	Selectivity ratio for alpha2 adrenoceptor over alpha1 adrenoceptor of rat vas deferens	ChEMBL.	6139479
Selectivity ratio (binding)	= 5.8	Selectivity ratio of compound towards alpha2 adrenoceptor over alpha1 adrenoceptor of calf cerebral cortex	ChEMBL.	6139479
Selectivity ratio (binding)	= 0.3	Selectivity ratio for alpha2 adrenoceptor over alpha1 adrenoceptor of rat vas deferens	ChEMBL.	6139479
Selectivity ratio (binding)	= 5.8	Selectivity ratio of compound towards alpha2 adrenoceptor over alpha1 adrenoceptor of calf cerebral cortex	ChEMBL.	6139479

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL47471

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 67178