Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0042 | 0.0769 | 0.0481 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0042 | 0.0769 | 0.1505 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0042 | 0.0769 | 0.0481 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0042 | 0.0769 | 0.0099 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0769 | 0.0481 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.0303 | 0.0055 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0029 | 0.0344 | 0.0043 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0329 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0699 | 0.0996 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0042 | 0.0769 | 0.0805 |
Trichomonas vaginalis | set domain proteins, putative | 0.0258 | 0.7714 | 1 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0303 | 0.0083 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0042 | 0.0769 | 0.1483 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0026 | 0.0249 | 0.0433 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0042 | 0.0769 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0329 | 1 | 1 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.004 | 0.0699 | 0.0586 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0056 | 0.1217 | 0.0943 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0184 | 0.5336 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0029 | 0.0344 | 0.0043 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0046 | 0.0891 | 0.0607 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.0303 | 0.6471 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0769 | 0.0481 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0042 | 0.0769 | 0.0728 |
Giardia lamblia | DINP protein human, muc B family | 0.0042 | 0.0769 | 1 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.004 | 0.0699 | 0.0409 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0156 | 0.4417 | 0.4243 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.004 | 0.0699 | 0.0409 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0769 | 0.0481 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0156 | 0.4417 | 0.4275 |
Leishmania major | DNA polymerase eta, putative | 0.0069 | 0.163 | 0.1417 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.004 | 0.0699 | 0.0512 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0026 | 0.0249 | 0.0433 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.002 | 0.0035 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0173 | 0.4984 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0042 | 0.0769 | 0.0481 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0156 | 0.4417 | 0.4243 |
Echinococcus multilocularis | dna polymerase kappa | 0.0042 | 0.0769 | 0.0654 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0069 | 0.163 | 0.1369 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0042 | 0.0769 | 0.0481 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0249 | 0.0433 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0597 | 0.0698 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.004 | 0.0699 | 0.0512 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0042 | 0.0769 | 0.1505 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0046 | 0.0891 | 0.0607 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0249 | 0.0321 |
Echinococcus multilocularis | dna polymerase eta | 0.0099 | 0.2574 | 0.4348 |
Leishmania major | DNA polymerase kappa, putative | 0.0042 | 0.0769 | 0.0533 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.1151 | 0.1396 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0769 | 0.0481 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.004 | 0.0699 | 0.0586 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0769 | 0.0481 |
Trypanosoma brucei | unspecified product | 0.0029 | 0.0344 | 0.0043 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0249 | 0.0433 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0069 | 0.163 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0769 | 0.0481 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0769 | 0.0481 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0099 | 0.2574 | 0.2342 |
Trypanosoma brucei | unspecified product | 0.0042 | 0.0769 | 0.0481 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0042 | 0.0769 | 0.11 |
Echinococcus granulosus | dna polymerase kappa | 0.0042 | 0.0769 | 0.0728 |
Plasmodium vivax | SET domain protein, putative | 0.0033 | 0.0449 | 1 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.004 | 0.0699 | 0.0586 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0046 | 0.0891 | 0.0607 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0173 | 0.4984 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0053 | 0.1111 | 0.6084 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.6532 | 0.9741 |
Onchocerca volvulus | 0.0258 | 0.7714 | 1 | |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0026 | 0.0249 | 0.0433 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0222 | 0.6532 | 0.9733 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0227 | 0.6705 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0227 | 0.6705 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0042 | 0.0769 | 0.0481 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0026 | 0.0249 | 0.5 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.004 | 0.0699 | 0.8658 |
Brugia malayi | Pre-SET motif family protein | 0.0033 | 0.0449 | 0.0309 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0042 | 0.0769 | 0.0654 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0026 | 0.0249 | 0.5 |
Schistosoma mansoni | DNA polymerase eta | 0.0099 | 0.2574 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0597 | 0.0843 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0029 | 0.0344 | 0.0043 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.004 | 0.0699 | 0.0697 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.004 | 0.0699 | 0.0512 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0303 | 0.0402 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0769 | 0.0481 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0042 | 0.0769 | 0.0533 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0042 | 0.0769 | 0.0099 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0184 | 0.5336 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0046 | 0.0891 | 0.0607 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0033 | 0.0449 | 0.0078 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0249 | 0.0321 |
Onchocerca volvulus | 0.0033 | 0.0449 | 0.0267 | |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0026 | 0.0249 | 0.05 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.004 | 0.0699 | 0.1177 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0329 | 1 | 1 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.004 | 0.0699 | 0.0409 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.004 | 0.0699 | 0.0461 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0042 | 0.0769 | 0.1483 |
Mycobacterium ulcerans | hypothetical protein | 0.0026 | 0.0249 | 0.0433 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0042 | 0.0769 | 0.1542 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0042 | 0.0769 | 0.0481 |
Echinococcus granulosus | dna polymerase eta | 0.0099 | 0.2574 | 0.4392 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.002 | 0.0035 | 0.0069 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.2574 | 0.3806 |
Leishmania major | DNA polymerase eta, putative | 0.0099 | 0.2574 | 0.2384 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0769 | 0.0481 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0042 | 0.0769 | 0.0481 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0249 | 0.0433 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0099 | 0.2574 | 0.2342 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0769 | 0.0481 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0303 | 1 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.004 | 0.0699 | 0.1177 |
Trypanosoma brucei | unspecified product | 0.0029 | 0.0344 | 0.0043 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0449 | 0.0621 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0026 | 0.0249 | 0.05 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.0597 | 0.0539 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0033 | 0.0449 | 0.11 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0026 | 0.0249 | 0.0433 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0249 | 0.0321 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0042 | 0.0769 | 0.1542 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0303 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0099 | 0.2574 | 0.3601 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.1151 | 0.1673 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.