Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0769 | 0.0481 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.004 | 0.0699 | 0.0409 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0154 | 0.4417 | 0.4243 |
Mycobacterium ulcerans | hypothetical protein | 0.0171 | 0.4984 | 1 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.004 | 0.0699 | 0.0512 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0026 | 0.0249 | 0.0433 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0019 | 0.0035 | 0.5 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0154 | 0.4417 | 0.4275 |
Leishmania major | DNA polymerase eta, putative | 0.0068 | 0.1631 | 0.1417 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0182 | 0.5336 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0029 | 0.0344 | 0.0043 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0056 | 0.1217 | 0.0943 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.004 | 0.0699 | 0.0586 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0325 | 1 | 1 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.004 | 0.0699 | 0.0409 |
Giardia lamblia | DINP protein human, muc B family | 0.0042 | 0.0769 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0769 | 0.0481 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0042 | 0.0769 | 0.0728 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0046 | 0.0891 | 0.0607 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.0303 | 0.6472 |
Trichomonas vaginalis | set domain proteins, putative | 0.0255 | 0.7714 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0042 | 0.0769 | 0.0805 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0699 | 0.0996 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0042 | 0.0769 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0026 | 0.0249 | 0.0433 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0303 | 0.0083 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0042 | 0.0769 | 0.1483 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0042 | 0.0769 | 0.1505 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0042 | 0.0769 | 0.0481 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0325 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0029 | 0.0344 | 0.0043 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.0303 | 0.0055 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0769 | 0.0481 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0042 | 0.0769 | 0.0099 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0042 | 0.0769 | 0.0481 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.004 | 0.0699 | 0.0586 |
Plasmodium vivax | SET domain protein, putative | 0.0032 | 0.0449 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.0042 | 0.0769 | 0.0728 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0042 | 0.0769 | 0.11 |
Toxoplasma gondii | hypothetical protein | 0.0052 | 0.111 | 0.6084 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0171 | 0.4984 | 1 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0046 | 0.0891 | 0.0607 |
Trypanosoma brucei | unspecified product | 0.0042 | 0.0769 | 0.0481 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0097 | 0.2574 | 0.2342 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0769 | 0.0481 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.115 | 0.1396 |
Echinococcus multilocularis | dna polymerase eta | 0.0097 | 0.2574 | 0.4348 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0042 | 0.0769 | 0.1505 |
Leishmania major | DNA polymerase kappa, putative | 0.0042 | 0.0769 | 0.0533 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0046 | 0.0891 | 0.0607 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.004 | 0.0699 | 0.0512 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0249 | 0.0321 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0769 | 0.0481 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0769 | 0.0481 |
Trypanosoma brucei | unspecified product | 0.0029 | 0.0344 | 0.0043 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0769 | 0.0481 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0068 | 0.1631 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0249 | 0.0433 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.004 | 0.0699 | 0.0586 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0154 | 0.4417 | 0.4243 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0042 | 0.0769 | 0.0481 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0597 | 0.0698 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0249 | 0.0433 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0042 | 0.0769 | 0.0481 |
Echinococcus multilocularis | dna polymerase kappa | 0.0042 | 0.0769 | 0.0654 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0068 | 0.1631 | 0.1369 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0026 | 0.0249 | 0.05 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0249 | 0.0321 |
Onchocerca volvulus | 0.0032 | 0.0449 | 0.0267 | |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0046 | 0.0891 | 0.0607 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0032 | 0.0449 | 0.0078 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.004 | 0.0699 | 0.1177 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0303 | 0.0402 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.004 | 0.0699 | 0.0512 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.004 | 0.0699 | 0.0697 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0597 | 0.0843 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0029 | 0.0344 | 0.0043 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0042 | 0.0769 | 0.0099 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0182 | 0.5336 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0769 | 0.0481 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0042 | 0.0769 | 0.0533 |
Brugia malayi | Pre-SET motif family protein | 0.0032 | 0.0449 | 0.0309 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.004 | 0.0699 | 0.8658 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0026 | 0.0249 | 0.5 |
Schistosoma mansoni | DNA polymerase eta | 0.0097 | 0.2574 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0026 | 0.0249 | 0.5 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0042 | 0.0769 | 0.0654 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0224 | 0.6705 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0224 | 0.6705 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0219 | 0.6532 | 0.9733 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0026 | 0.0249 | 0.0433 |
Onchocerca volvulus | 0.0255 | 0.7714 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0219 | 0.6532 | 0.9741 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0042 | 0.0769 | 0.0481 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0303 | 1 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0042 | 0.0769 | 0.1542 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.115 | 0.1673 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0097 | 0.2574 | 0.3601 |
Trypanosoma brucei | unspecified product | 0.0029 | 0.0344 | 0.0043 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.004 | 0.0699 | 0.1177 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0303 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0249 | 0.0321 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0026 | 0.0249 | 0.0433 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.0597 | 0.0539 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0032 | 0.0449 | 0.11 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0026 | 0.0249 | 0.05 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0449 | 0.0621 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0769 | 0.0481 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.2574 | 0.3806 |
Leishmania major | DNA polymerase eta, putative | 0.0097 | 0.2574 | 0.2384 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0769 | 0.0481 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0097 | 0.2574 | 0.2342 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0249 | 0.0433 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0042 | 0.0769 | 0.0481 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.004 | 0.0699 | 0.0461 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.004 | 0.0699 | 0.0409 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0325 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0042 | 0.0769 | 0.1542 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0042 | 0.0769 | 0.0481 |
Echinococcus granulosus | dna polymerase eta | 0.0097 | 0.2574 | 0.4392 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0019 | 0.0035 | 0.0069 |
Mycobacterium ulcerans | hypothetical protein | 0.0026 | 0.0249 | 0.0433 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0042 | 0.0769 | 0.1483 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.