Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | jmjC domain-containing protein | 0.006 | 0.0864 | 0.0864 |
Echinococcus granulosus | thymidylate synthase | 0.0389 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0389 | 1 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.003 | 0.0019 | 0.0019 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0035 | 0.0171 | 0.0171 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.003 | 0.0019 | 0.0019 |
Brugia malayi | Pre-SET motif family protein | 0.003 | 0.0019 | 0.0019 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0389 | 1 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0237 | 0.5779 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0035 | 0.0171 | 0.0171 |
Brugia malayi | jmjC domain containing protein | 0.0096 | 0.1845 | 0.1845 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0389 | 1 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0389 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0389 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0389 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0389 | 1 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0389 | 1 | 1 |
Onchocerca volvulus | 0.003 | 0.0019 | 0.0019 | |
Loa Loa (eye worm) | thymidylate synthase | 0.0389 | 1 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.003 | 0.0019 | 0.0019 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0389 | 1 | 1 |
Onchocerca volvulus | 0.0389 | 1 | 1 | |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0019 | 0.0019 |
Echinococcus granulosus | geminin | 0.017 | 0.3903 | 0.3903 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0035 | 0.0171 | 0.0171 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0019 | 0.0019 |
Schistosoma mansoni | hypothetical protein | 0.017 | 0.3903 | 0.3903 |
Giardia lamblia | PHD finger protein 15 | 0.0029 | 0 | 0.5 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.0019 | 0.0019 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0389 | 1 | 0.5 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0096 | 0.1845 | 0.1845 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0035 | 0.0171 | 0.0171 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0041 | 0.0318 | 0.0318 |
Echinococcus granulosus | jumonji domain containing protein | 0.0041 | 0.0318 | 0.0318 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0389 | 1 | 1 |
Onchocerca volvulus | 0.0237 | 0.5779 | 0.5779 | |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.003 | 0.0019 | 0.0019 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0035 | 0.0171 | 0.0171 |
Schistosoma mansoni | jumonji domain containing protein | 0.0076 | 0.1299 | 0.1299 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0019 | 0.0019 |
Plasmodium vivax | SET domain protein, putative | 0.003 | 0.0019 | 0.0019 |
Schistosoma mansoni | hypothetical protein | 0.017 | 0.3903 | 0.3903 |
Brugia malayi | Pre-SET motif family protein | 0.0208 | 0.4979 | 0.4979 |
Brugia malayi | hypothetical protein | 0.0185 | 0.4332 | 0.4332 |
Echinococcus multilocularis | geminin | 0.017 | 0.3903 | 0.3903 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0035 | 0.0171 | 0.0171 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0579 | 0.0579 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0208 | 0.4979 | 0.4979 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0096 | 0.1845 | 0.1845 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0019 | 0.0019 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
k cat (binding) | = 0.065 s-1 | Rate constant (Kcat) of the compound was determined | ChEMBL. | 3746818 |
K inact (binding) | = 0.065 s-1 | Kinetic constant for inactivation of L. casei thymidylate synthase from double reciprocal plots | ChEMBL. | 3027341 |
k2 (binding) | = 32000 M-1 s-1 | The rate constant of the compound in Acetonitrile and buffered aqueous acetonitrile solution, at 30 degrees C and pH 6.8 | ChEMBL. | 3746818 |
Ki (binding) | = 2 uM | Ability to inhibit the thymidylate synthase from L. casei was determined and expressed as inhibition constant(Ki) | ChEMBL. | 3027341 |
Ki (binding) | = 2 uM | Binding affinity of the compound against thymidylateSynthase | ChEMBL. | 3746818 |
Km (binding) | = 7.6 uM | Ability to inhibit the thymidylate synthase from L. casei was determined and expressed as inhibition constant(Km) | ChEMBL. | 3027341 |
Ratio (binding) | = 3.2 | Apparent second order rate constant determined as the ratio of kinact/Ki | ChEMBL. | 3027341 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.