Detailed information for compound 672470

Basic information

Technical information
  • TDR Targets ID: 672470
  • Name: (5E)-5-[(3-bromophenyl)methylidene]-2-(hydrox yamino)-1,3-thiazol-4-one
  • MW: 299.144 | Formula: C10H7BrN2O2S
  • H donors: 2 H acceptors: 2 LogP: 2.47 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: ONC1=NC(=O)/C(=C/c2cccc(c2)Br)/S1
  • InChi: 1S/C10H7BrN2O2S/c11-7-3-1-2-6(4-7)5-8-9(14)12-10(13-15)16-8/h1-5,15H,(H,12,13,14)/b8-5+
  • InChiKey: KIUXYBPKDVNUOZ-VMPITWQZSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (5E)-5-[(3-bromophenyl)methylene]-2-(hydroxyamino)thiazol-4-one
  • (5E)-5-[(3-bromophenyl)methylene]-2-(hydroxyamino)-4-thiazolone
  • (5E)-5-(3-bromobenzylidene)-2-(hydroxyamino)thiazol-4-one
  • STOCK3S-44910
  • ZINC04949600

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi mKIAA0176 protein 0.0011 0.027 0.0075
Schistosoma mansoni voltage-gated potassium channel 0.0256 1 1
Schistosoma mansoni edp1-related 0.0011 0.027 0.027
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0021 0.0654 0.0467
Loa Loa (eye worm) voltage-gated potassium channel 0.001 0.021 0.0008
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0021 0.0654 0.0533
Echinococcus multilocularis hyperpolarization activated cyclic 0.001 0.021 0.0083
Echinococcus granulosus transient receptor potential cation channel 0.001 0.021 0.0083
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.1208 0.1242
Echinococcus multilocularis BTB:POZ domain containing protein 0.0011 0.027 0.0145
Treponema pallidum bacterioferrin (TpF1) 0.0008 0.0151 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0654 0.0654
Schistosoma mansoni tar DNA-binding protein 0.0137 0.528 0.528
Brugia malayi RNA binding protein 0.0137 0.528 0.5186
Schistosoma mansoni ferritin 0.0008 0.0151 0.0151
Brugia malayi Transient-receptor-potential like protein 0.001 0.021 0.0013
Onchocerca volvulus 0.0011 0.027 0.061
Echinococcus multilocularis ferritin 0.0008 0.0151 0.0024
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.1208 1
Echinococcus granulosus tar DNA binding protein 0.0137 0.528 0.5219
Echinococcus multilocularis conserved hypothetical protein 0.001 0.021 0.0083
Loa Loa (eye worm) hypothetical protein 0.0035 0.1208 0.1027
Leishmania major hypothetical protein, conserved 0.0011 0.027 0.061
Loa Loa (eye worm) hypothetical protein 0.001 0.021 0.0008
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.001 0.021 0.0008
Echinococcus multilocularis short transient receptor potential channel 6 0.001 0.021 0.0083
Brugia malayi K+ channel tetramerisation domain containing protein 0.0011 0.027 0.0075
Echinococcus multilocularis transient receptor potential cation channel 0.001 0.021 0.0083
Schistosoma mansoni voltage-dependent calcium channel 0.001 0.021 0.021
Trypanosoma brucei BTB/POZ domain/Regulator of chromosome condensation (RCC1) repeat, putative 0.0011 0.027 0.061
Loa Loa (eye worm) ryanodine receptor 0.001 0.021 0.0008
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0021 0.0654 0.0533
Echinococcus multilocularis potassium voltage gated channel protein 0.0256 1 1
Echinococcus multilocularis transfer RNA-Gly 0.0021 0.0654 0.0533
Echinococcus granulosus potassium voltage gated channel protein 0.0021 0.0654 0.0533
Schistosoma mansoni voltage-gated potassium channel 0.001 0.021 0.021
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.2399 0.2399
Loa Loa (eye worm) hypothetical protein 0.001 0.021 0.0008
Onchocerca volvulus 0.0011 0.027 0.061
Loa Loa (eye worm) K+ channel tetramerisation domain-containing protein 0.0011 0.027 0.0071
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0011 0.027 0.061
Echinococcus granulosus ryanodine receptor 44f 0.001 0.021 0.0083
Echinococcus granulosus transient receptor potential cation channel 0.001 0.021 0.0083
Mycobacterium tuberculosis Conserved protein 0.0035 0.1208 0.1242
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.027 0.027
Schistosoma mansoni ryanodine receptor related 0.001 0.021 0.021
Schistosoma mansoni ferritin light chain 0.0008 0.0151 0.0151
Echinococcus multilocularis transient receptor potential cation channel 0.001 0.021 0.0083
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.001 0.021 0.0013
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.001 0.021 0.0083
Echinococcus granulosus voltage dependent calcium channel 0.001 0.021 0.0083
Loa Loa (eye worm) RNA binding protein 0.0137 0.528 0.5183
Schistosoma mansoni ferritin 0.0008 0.0151 0.0151
Echinococcus multilocularis tar DNA binding protein 0.0137 0.528 0.5219
Onchocerca volvulus 0.0035 0.1208 1
Loa Loa (eye worm) hypothetical protein 0.001 0.021 0.0008
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.001 0.021 0.0083
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.001 0.021 0.0008
Brugia malayi Voltage-gated potassium channel, Shal-family (KCND, Kv4-like) alpha-subunit. C. elegans shl-1 ortholog 0.0011 0.027 0.0075
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.027 0.027
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.001 0.021 0.0083
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.001 0.021 0.021
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0654 0.0654
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0201 0.0075
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.001 0.021 0.021
Schistosoma mansoni voltage-gated cation channel 0.001 0.021 0.021
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.001 0.021 0.0013
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.1208 0.1094
Echinococcus granulosus potassium voltage gated channel protein 0.0256 1 1
Echinococcus multilocularis transient receptor potential cation channel 0.001 0.021 0.0083
Echinococcus multilocularis two pore calcium channel protein 1 0.001 0.021 0.0083
Loa Loa (eye worm) hypothetical protein 0.0011 0.027 0.0071
Loa Loa (eye worm) hypothetical protein 0.001 0.021 0.0008
Echinococcus multilocularis BTB:POZ domain containing protein KCTD16 0.0011 0.027 0.0145
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0021 0.0654 0.0533
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.1208 0.1242
Schistosoma mansoni voltage-gated potassium channel 0.001 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.001 0.021 0.0008
Echinococcus granulosus potassium large conductance calcium activated 0.001 0.021 0.0083
Echinococcus multilocularis voltage dependent calcium channel 0.001 0.021 0.0083
Brugia malayi Cyclic-nucleotide gated cation channel 0.001 0.021 0.0013
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.027 0.061
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.001 0.021 0.0083
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.001 0.021 0.021
Echinococcus multilocularis shaker cognate 0.0021 0.0654 0.0533
Schistosoma mansoni ferritin 0.0008 0.0151 0.0151
Echinococcus multilocularis two pore calcium channel protein 2 0.001 0.021 0.0083
Echinococcus multilocularis ryanodine receptor 44f 0.001 0.021 0.0083
Loa Loa (eye worm) voltage-gated calcium channel 0.001 0.021 0.0008
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.001 0.021 0.0083
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.1208 1
Echinococcus multilocularis potassium large conductance calcium activated 0.001 0.021 0.0083
Echinococcus multilocularis sodium leak channel non selective protein 0.001 0.021 0.0083
Echinococcus multilocularis voltage gated hydrogen channel 1 0.001 0.021 0.0083
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0654 0.0654
Loa Loa (eye worm) hypothetical protein 0.0011 0.027 0.0071
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0201 0.0075
Loa Loa (eye worm) potassium channel tetramerisation domain containing 3 0.0011 0.027 0.0071
Onchocerca volvulus 0.0011 0.027 0.061
Loa Loa (eye worm) hypothetical protein 0.001 0.021 0.0008
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.001 0.021 0.0083
Trypanosoma brucei btb/poz domain containing protein, putative 0.0011 0.027 0.061
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.001 0.021 0.0013
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0011 0.027 0.5
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0021 0.0654 0.0533
Schistosoma mansoni tar DNA-binding protein 0.0137 0.528 0.528
Onchocerca volvulus 0.0031 0.1039 0.8309
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.027 0.027
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.001 0.021 0.0013
Loa Loa (eye worm) hypothetical protein 0.0035 0.1208 0.1027
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.001 0.021 0.0013
Onchocerca volvulus 0.0035 0.1208 1
Echinococcus granulosus BTB:POZ domain containing protein KCTD16 0.0011 0.027 0.0145
Echinococcus multilocularis TRP (transient receptor potential) channel 0.001 0.021 0.0083
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.1208 0.1242
Loa Loa (eye worm) hypothetical protein 0.0035 0.1208 0.1027
Mycobacterium leprae conserved hypothetical protein 0.0035 0.1208 1
Onchocerca volvulus 0.0011 0.027 0.061
Echinococcus granulosus sodium leak channel non selective protein 0.001 0.021 0.0083
Toxoplasma gondii ABC1 family protein 0.0035 0.1208 0.5214
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.001 0.021 0.0981
Brugia malayi K+ channel tetramerisation domain containing protein 0.0011 0.027 0.0075
Echinococcus granulosus cpg binding protein 0.0032 0.1108 0.0994
Loa Loa (eye worm) potassium channel tetramerisation domain containing 5 0.0011 0.027 0.0071
Schistosoma mansoni voltage-gated potassium channel 0.0256 1 1
Loa Loa (eye worm) hypothetical protein 0.001 0.021 0.0008
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.001 0.021 0.021
Trypanosoma cruzi potassium voltage-gated channel, putative 0.0011 0.027 0.061
Echinococcus multilocularis voltage gated potassium channel 0.001 0.021 0.0083
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.1208 1
Loa Loa (eye worm) hypothetical protein 0.001 0.021 0.0008
Loa Loa (eye worm) hypothetical protein 0.001 0.021 0.0008
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.001 0.021 0.0013
Brugia malayi beta-lactamase family protein 0.0035 0.1208 0.1032
Mycobacterium ulcerans lipase LipD 0.0035 0.1208 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0137 0.528 0.5183
Leishmania major potassium voltage-gated channel, putative 0.0011 0.027 0.061
Echinococcus multilocularis transient receptor potential cation channel 0.001 0.021 0.0083
Plasmodium falciparum kelch protein K13 0.0011 0.027 0.5
Echinococcus granulosus cyclic nucleotide gated cation channel 0.001 0.021 0.0083
Loa Loa (eye worm) hypothetical protein 0.0035 0.1208 0.1027
Leishmania major hypothetical protein, conserved 0.0011 0.027 0.061
Schistosoma mansoni apoferritin-2 0.0008 0.0151 0.0151
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.1208 0.1094
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.1208 1
Echinococcus granulosus short transient receptor potential channel 6 0.001 0.021 0.0083
Echinococcus granulosus hyperpolarization activated cyclic 0.001 0.021 0.0083
Trypanosoma brucei potassium voltage-gated channel, putative 0.0011 0.027 0.061
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.1208 0.1242
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0654 0.0654
Brugia malayi beta-lactamase family protein 0.0035 0.1208 0.1032
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0011 0.027 0.061
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0021 0.0654 0.0533
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.001 0.021 0.0013
Schistosoma mansoni transient receptor potential channel 4 0.001 0.021 0.021
Brugia malayi cation channel family protein 0.001 0.021 0.0013
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0127 0.0127
Echinococcus granulosus transient receptor potential gamma protein 0.001 0.021 0.0083
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0011 0.027 0.061
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.001 0.021 0.0083
Loa Loa (eye worm) hypothetical protein 0.001 0.021 0.0008
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.001 0.021 0.021
Toxoplasma gondii K+ channel tetramerisation domain-containing protein 0.0011 0.027 0.0318
Trichomonas vaginalis ferritin, putative 0.0008 0.0151 0.0457
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.001 0.021 0.0083
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.1208 1
Schistosoma mansoni ferritin light chain 0.0008 0.0151 0.0151
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.001 0.021 0.021
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.001 0.021 0.0083
Brugia malayi voltage-dependent calcium channel 0.001 0.021 0.0013
Loa Loa (eye worm) hypothetical protein 0.0011 0.027 0.0071
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.001 0.021 0.021
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.001 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0256 1 1
Loa Loa (eye worm) hypothetical protein 0.001 0.021 0.0008
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.001 0.021 0.0083
Onchocerca volvulus 0.0011 0.027 0.061
Echinococcus multilocularis transient receptor potential cation channel 0.001 0.021 0.0083
Trypanosoma brucei btb/poz domain containing protein, putative 0.0011 0.027 0.061
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.001 0.021 0.021
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.001 0.021 0.0981
Loa Loa (eye worm) TAR-binding protein 0.0137 0.528 0.5183
Echinococcus granulosus expressed protein 0.0008 0.0151 0.0024
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.1208 0.1208
Echinococcus granulosus two pore calcium channel protein 2 0.001 0.021 0.0083
Echinococcus granulosus cyclic nucleotide gated cation channel 0.001 0.021 0.0083
Loa Loa (eye worm) ion channel NompC 0.001 0.021 0.0008
Schistosoma mansoni transient receptor potential channel 0.001 0.021 0.021
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.001 0.021 0.0083
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0021 0.0654 0.0533
Trypanosoma cruzi potassium voltage-gated channel 0.0011 0.027 0.061
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.1208 0.1242
Loa Loa (eye worm) hypothetical protein 0.001 0.021 0.0008
Echinococcus multilocularis potassium voltage gated channel protein 0.001 0.021 0.0083
Trypanosoma brucei potassium voltage-gated channel, putative 0.0011 0.027 0.061
Echinococcus granulosus potassium voltage gated channel subfamily D 0.001 0.021 0.0083
Schistosoma mansoni apoferritin-2 0.0008 0.0151 0.0151
Plasmodium vivax hypothetical protein, conserved 0.0035 0.1208 1
Echinococcus granulosus sodium channel protein 0.001 0.021 0.0083
Schistosoma mansoni voltage-gated potassium channel 0.001 0.021 0.021
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.1208 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.001 0.021 0.0083
Loa Loa (eye worm) hypothetical protein 0.001 0.021 0.0008
Echinococcus granulosus potassium voltage gated channel protein 0.001 0.021 0.0083
Schistosoma mansoni tar DNA-binding protein 0.0137 0.528 0.528
Echinococcus granulosus two pore calcium channel protein 1 0.001 0.021 0.0083
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0654 0.0654
Echinococcus multilocularis short transient receptor potential channel 6 0.001 0.021 0.0083
Loa Loa (eye worm) hypothetical protein 0.001 0.021 0.0008
Schistosoma mansoni 60S ribosomal protein L21 0.001 0.021 0.021
Mycobacterium tuberculosis Conserved protein 0.0035 0.1208 0.1242
Loa Loa (eye worm) hypothetical protein 0.001 0.021 0.0008
Schistosoma mansoni voltage-gated potassium channel 0.001 0.021 0.021
Loa Loa (eye worm) voltage-gated potassium channel 0.0021 0.0654 0.0462
Trypanosoma brucei btb/poz domain containing protein, putative 0.0011 0.027 0.061
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.001 0.021 0.0013
Brugia malayi CXXC zinc finger family protein 0.0031 0.1039 0.0859
Schistosoma mansoni voltage-gated ion channel 0.001 0.021 0.021
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0654 0.0654
Echinococcus multilocularis expressed protein 0.0008 0.0151 0.0024
Brugia malayi K+ channel tetramerisation domain containing protein 0.0011 0.027 0.0075
Schistosoma mansoni cpg binding protein 0.0031 0.1039 0.1039
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.001 0.021 0.0083
Schistosoma mansoni tar DNA-binding protein 0.0137 0.528 0.528
Echinococcus multilocularis voltage dependent calcium channel 0.001 0.021 0.0083
Echinococcus granulosus calcium activated potassium channel 0.001 0.021 0.0083
Echinococcus granulosus transient receptor potential cation channel 0.001 0.021 0.0083
Schistosoma mansoni hypothetical protein 0.001 0.021 0.021
Schistosoma mansoni calcium-activated potassium channel 0.001 0.021 0.021
Echinococcus granulosus short transient receptor potential channel 6 0.001 0.021 0.0083
Echinococcus multilocularis potassium voltage gated channel protein 0.0021 0.0654 0.0533
Brugia malayi beta-lactamase 0.0035 0.1208 0.1032
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.1208 0.1027
Loa Loa (eye worm) hypothetical protein 0.0035 0.1208 0.1027
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.1208 1
Brugia malayi RNA recognition motif domain containing protein 0.0137 0.528 0.5186
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.1208 1
Echinococcus granulosus ferritin 0.0008 0.0151 0.0024
Echinococcus granulosus BTB:POZ domain containing protein 0.0011 0.027 0.0145
Schistosoma mansoni two-pore calcium channel 0.001 0.021 0.021
Loa Loa (eye worm) K+ channel tetramerisation domain-containing protein 0.0011 0.027 0.0071
Echinococcus granulosus hypothetical protein 0.001 0.021 0.0083
Schistosoma mansoni ferritin 0.0008 0.0151 0.0151
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.001 0.021 0.021
Brugia malayi olfactory channel protein osm-9 0.001 0.021 0.0013
Schistosoma mansoni transient receptor potential channel 0.001 0.021 0.021
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.001 0.021 0.0083
Echinococcus granulosus transient receptor potential cation channel 0.001 0.021 0.0083
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.001 0.021 0.021
Echinococcus granulosus voltage dependent calcium channel 0.001 0.021 0.0083
Echinococcus granulosus TRP transient receptor potential channel 0.001 0.021 0.0083
Toxoplasma gondii kelch repeat and K+ channel tetramerisation domain containing protein 0.0011 0.027 0.0318
Loa Loa (eye worm) voltage-dependent calcium channel 0.001 0.021 0.0008
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.1039 0.0855
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.1208 1
Loa Loa (eye worm) hypothetical protein 0.001 0.021 0.0008
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.1208 0.1242
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.001 0.021 0.021
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.001 0.021 0.021
Schistosoma mansoni voltage-gated potassium channel 0.001 0.021 0.021
Echinococcus granulosus transient receptor potential cation channel 0.001 0.021 0.0083
Schistosoma mansoni potassium channel tetramerization domain-containing 0.0011 0.027 0.027
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0256 1 1
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0008 0.0151 0.5
Trypanosoma brucei btb/poz domain containing protein, putative 0.0011 0.027 0.061
Loa Loa (eye worm) hypothetical protein 0.001 0.021 0.0008
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.001 0.021 0.0013
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.001 0.021 0.0013
Mycobacterium leprae Probable lipase LipE 0.0035 0.1208 1
Schistosoma mansoni inositol 145-trisphosphate receptor 0.001 0.021 0.021
Loa Loa (eye worm) Kv4.2 voltage-gated potassium channel 0.0011 0.027 0.0071
Echinococcus multilocularis transient receptor potential gamma protein 0.001 0.021 0.0083
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.1208 0.1208
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.001 0.021 0.0083
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0011 0.027 0.061
Echinococcus multilocularis voltage gated potassium channel 0.0021 0.0654 0.0533
Mycobacterium ulcerans beta-lactamase 0.0035 0.1208 1
Brugia malayi TAR-binding protein 0.0137 0.528 0.5186
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.001 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0035 0.1208 0.1027
Loa Loa (eye worm) hypothetical protein 0.001 0.021 0.0008
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.001 0.021 0.0013
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.001 0.021 0.021
Echinococcus granulosus voltage gated hydrogen channel 1 0.001 0.021 0.0083
Echinococcus granulosus potassium voltage gated channel subfamily H 0.001 0.021 0.0083
Echinococcus granulosus hyperpolarization activated cyclic 0.001 0.021 0.0083
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.001 0.021 0.0083
Echinococcus multilocularis potassium voltage gated channel protein 0.0021 0.0654 0.0533
Leishmania major hypothetical protein, conserved 0.0035 0.1208 1
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0021 0.0654 0.0467
Loa Loa (eye worm) hypothetical protein 0.001 0.021 0.0008
Mycobacterium ulcerans hypothetical protein 0.0035 0.1208 1
Schistosoma mansoni voltage-gated potassium channel 0.001 0.021 0.021
Schistosoma mansoni voltage-gated potassium channel 0.001 0.021 0.021
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0245 0.9556 0.955
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0021 0.0654 0.0533
Schistosoma mansoni cpg binding protein 0.0032 0.1108 0.1108
Echinococcus multilocularis hyperpolarization activated cyclic 0.001 0.021 0.0083
Schistosoma mansoni transient receptor potential channel 0.001 0.021 0.021
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.2124 1
Schistosoma mansoni cpg binding protein 0.0032 0.1108 0.1108
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.001 0.021 0.0008
Mycobacterium tuberculosis Conserved protein 0.0035 0.1208 0.1242
Echinococcus multilocularis cpg binding protein 0.0032 0.1108 0.0994
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0011 0.027 0.061
Loa Loa (eye worm) calcium channel 0.001 0.021 0.0008
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.8654 1
Echinococcus granulosus transient receptor potential cation channel 0.001 0.021 0.0083
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.1208 0.1032
Echinococcus granulosus potassium voltage gated channel subfamily H 0.001 0.021 0.0083
Schistosoma mansoni voltage-gated potassium channel 0.001 0.021 0.021
Echinococcus granulosus voltage gated potassium channel 0.001 0.021 0.0083
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.001 0.021 0.0083
Echinococcus granulosus shaker cognate 0.0021 0.0654 0.0533
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.001 0.021 0.0083
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.1208 0.1242
Schistosoma mansoni voltage-gated potassium channel 0.001 0.021 0.021
Echinococcus multilocularis sodium channel protein 0.001 0.021 0.0083
Brugia malayi ion channel NompC 0.001 0.021 0.0013
Echinococcus granulosus voltage gated potassium channel 0.0021 0.0654 0.0533
Brugia malayi cation channel family protein 0.001 0.021 0.0013
Loa Loa (eye worm) beta-lactamase 0.0035 0.1208 0.1027
Echinococcus multilocularis calcium activated potassium channel 0.001 0.021 0.0083
Loa Loa (eye worm) hypothetical protein 0.0021 0.0654 0.0462
Brugia malayi K+ channel tetramerisation domain containing protein 0.0011 0.027 0.0075
Echinococcus multilocularis transient receptor potential cation channel 0.001 0.021 0.0083
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.1208 1
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.001 0.021 0.0013
Onchocerca volvulus 0.0035 0.1208 1
Schistosoma mansoni vesicular amine transporter 0.0021 0.0654 0.0654
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0011 0.027 0.061
Echinococcus granulosus potassium voltage gated channel protein 0.0021 0.0654 0.0533
Echinococcus granulosus potassium voltage gated channel protein 0.001 0.021 0.0083
Schistosoma mansoni tar DNA-binding protein 0.0137 0.528 0.528
Leishmania major hypothetical protein, conserved 0.0011 0.027 0.061
Brugia malayi hypothetical protein 0.001 0.021 0.0013
Loa Loa (eye worm) K+ channel tetramerisation domain-containing protein 0.0011 0.027 0.0071
Trichomonas vaginalis esterase, putative 0.0035 0.1208 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.001 0.021 0.0008
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.001 0.021 0.021
Schistosoma mansoni voltage-gated potassium channel 0.001 0.021 0.021

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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