Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.002 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 0.3052 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.3052 | 0.3052 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 0.3052 | 0.3052 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.002 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.002 | 0 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0 | 0.5 |
Brugia malayi | RNA binding protein | 0.0065 | 0.3052 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0 | 0.5 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0061 | 0.2738 | 0.2738 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0061 | 0.2738 | 0.2738 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.3052 | 0.3052 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0061 | 0.2738 | 0.2738 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.3052 | 0.3052 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 0.3052 | 0.3052 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 1 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0061 | 0.2738 | 0.2738 |
Leishmania major | DNA polymerase eta, putative | 0.002 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0169 | 1 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.002 | 0 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.002 | 0 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0061 | 0.2738 | 0.8971 |
Giardia lamblia | DINP protein human, muc B family | 0.002 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 0.3052 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0061 | 0.2738 | 0.2738 |
Trypanosoma brucei | unspecified product | 0.002 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0065 | 0.3052 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0061 | 0.2738 | 0.8971 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 0.3052 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0061 | 0.2738 | 0.8971 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0 | 0.5 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.002 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.002 | 0 | 0.5 |
Leishmania major | DNA polymerase kappa, putative | 0.002 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 0.3052 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0 | 0.5 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0061 | 0.2738 | 0.2738 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.3052 | 0.3052 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.002 | 0 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.002 | 0 | 0.5 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0061 | 0.2738 | 0.2738 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.3052 | 0.3052 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.002 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.