Detailed information for compound 672658

Basic information

Technical information
  • TDR Targets ID: 672658
  • Name: N-[(5Z)-5-[[3-chloro-4-[(4-fluorophenyl)metho xy]phenyl]methylidene]-4-oxo-1,3-thiazol-2-yl ]acetamide
  • MW: 404.842 | Formula: C19H14ClFN2O3S
  • H donors: 1 H acceptors: 2 LogP: 4.25 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)NC1=NC(=O)C(=Cc2ccc(c(c2)Cl)OCc2ccc(cc2)F)S1
  • InChi: 1S/C19H14ClFN2O3S/c1-11(24)22-19-23-18(25)17(27-19)9-13-4-7-16(15(20)8-13)26-10-12-2-5-14(21)6-3-12/h2-9H,10H2,1H3,(H,22,23,24,25)/b17-9-
  • InChiKey: CUNRJVWTHQERGK-MFOYZWKCSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[(5Z)-5-[[3-chloro-4-[(4-fluorophenyl)methoxy]phenyl]methylene]-4-oxo-thiazol-2-yl]acetamide
  • N-[(5Z)-5-[[3-chloro-4-[(4-fluorophenyl)methoxy]phenyl]methylene]-4-oxo-2-thiazolyl]acetamide
  • N-[(5Z)-5-[3-chloro-4-(4-fluorobenzyl)oxy-benzylidene]-4-keto-thiazol-2-yl]acetamide
  • N-[(5Z)-5-[[3-chloro-4-[(4-fluorophenyl)methoxy]phenyl]methylidene]-4-oxo-1,3-thiazol-2-yl]ethanamide
  • STK189402
  • ZINC01146586

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.4018 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0154 0.1942 0.1632
Echinococcus multilocularis Niemann Pick C1 protein 0.0108 0.1265 0.1787
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0306 0.0078
Echinococcus multilocularis cpg binding protein 0.006 0.0566 0.0799
Trypanosoma brucei unspecified product 0.0148 0.1848 0.4199
Echinococcus granulosus histone lysine methyltransferase setb 0.009 0.1012 0.143
Leishmania major mitochondrial DNA polymerase beta 0.0297 0.4018 1
Loa Loa (eye worm) glutaminase 2 0.0268 0.3608 0.4123
Mycobacterium ulcerans DNA polymerase IV 0.0154 0.1942 0.4998
Onchocerca volvulus 0.0071 0.0732 0.0375
Schistosoma mansoni hypothetical protein 0.0507 0.708 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0128 0.1562 0.1488
Brugia malayi ImpB/MucB/SamB family protein 0.0203 0.2652 0.3011
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0372 0.0525
Brugia malayi polk-prov protein 0.0066 0.0657 0.0725
Mycobacterium ulcerans glutaminase 0.0268 0.3608 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0732 0.0837
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.009 0.1012 0.6746
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.4077 0.3849
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0109 0.1289 0.1488
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.4077 0.3849
Echinococcus multilocularis dna polymerase kappa 0.0154 0.1942 0.2743
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0465 0.0656
Loa Loa (eye worm) hypothetical protein 0.0146 0.1831 0.2092
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.1743 0.3919
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0732 0.0837
Loa Loa (eye worm) hypothetical protein 0.0057 0.0522 0.0596
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0657 0.1017
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.1012 0.1081
Echinococcus granulosus dna polymerase eta 0.0203 0.2652 0.3746
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0186 0.2406 0.3398
Loa Loa (eye worm) MBCTL1 0.0053 0.0465 0.0531
Plasmodium falciparum DNA repair protein REV1, putative 0.004 0.0277 0.5
Brugia malayi CHE-14 protein 0.0046 0.0371 0.0397
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0128 0.1562 0.1784
Trypanosoma brucei DNA polymerase kappa, putative 0.0095 0.1078 0.2141
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0186 0.2406 0.3398
Brugia malayi ImpB/MucB/SamB family protein 0.0128 0.1562 0.1762
Loa Loa (eye worm) hypothetical protein 0.0071 0.0732 0.0837
Trypanosoma brucei DNA polymerase kappa, putative 0.0095 0.1078 0.2141
Mycobacterium ulcerans hypothetical protein 0.0071 0.0732 0.1368
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0134 0.1656 0.1657
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0732 0.0376
Echinococcus granulosus geminin 0.0507 0.708 1
Mycobacterium ulcerans lipase LipD 0.0071 0.0732 0.1368
Schistosoma mansoni hypothetical protein 0.0044 0.0346 0.0103
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.4077 0.3849
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0732 0.1034
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.009 0.1012 0.143
Trypanosoma brucei DNA polymerase IV, putative 0.0154 0.1942 0.4451
Loa Loa (eye worm) hypothetical protein 0.0071 0.0732 0.0837
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.0371 0.0424
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0465 0.0277
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.4018 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.011 0.1301 0.9394
Trypanosoma brucei DNA polymerase kappa, putative 0.0154 0.1942 0.4451
Trypanosoma brucei DNA polymerase kappa, putative 0.0154 0.1942 0.4451
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0465 0.0505
Leishmania major DNA polymerase eta, putative 0.0115 0.1367 0.2914
Onchocerca volvulus 0.0071 0.0732 0.0375
Echinococcus granulosus dna polymerase kappa 0.0154 0.1942 0.2743
Loa Loa (eye worm) hypothetical protein 0.009 0.1012 0.1157
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.1743 0.3919
Echinococcus multilocularis dna polymerase eta 0.0203 0.2652 0.3746
Brugia malayi Niemann-Pick C1 protein precursor 0.0108 0.1265 0.1422
Trypanosoma brucei unspecified product 0.0088 0.0983 0.1889
Schistosoma mansoni hypothetical protein 0.0285 0.3846 0.5246
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.1743 0.3919
Trypanosoma brucei DNA polymerase kappa, putative 0.0154 0.1942 0.4451
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0732 0.067
Entamoeba histolytica deoxycytidyl transferase, putative 0.0128 0.1562 0.1055
Echinococcus multilocularis Niemann Pick C1 protein 0.0154 0.1937 0.2736
Mycobacterium ulcerans hypothetical protein 0.0156 0.1974 0.5094
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0372 0.014
Loa Loa (eye worm) hypothetical protein 0.0066 0.0657 0.0751
Trypanosoma cruzi DNA polymerase kappa, putative 0.0154 0.1942 0.4451
Loa Loa (eye worm) hypothetical protein 0.0203 0.2652 0.303
Loa Loa (eye worm) hypothetical protein 0.0046 0.0371 0.0424
Echinococcus granulosus dnaJ subfamily B 0.0402 0.5549 0.7837
Toxoplasma gondii ABC1 family protein 0.0071 0.0732 0.4179
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0115 0.1367 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0732 0.0837
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0657 0.1017
Trypanosoma brucei DNA polymerase kappa, putative 0.0154 0.1942 0.4451
Trypanosoma cruzi DNA polymerase kappa, putative 0.0154 0.1942 0.4451
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0732 0.0812
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0147 0.1837 0.4685
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0439 0.0433
Trypanosoma cruzi DNA polymerase eta, putative 0.0203 0.2652 0.6349
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.4077 0.3849
Trypanosoma brucei unspecified product 0.0088 0.0983 0.1889
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0147 0.1837 0.1983
Brugia malayi glutaminase DH11.1 0.0268 0.3608 0.4107
Brugia malayi CXXC zinc finger family protein 0.0056 0.0519 0.0567
Echinococcus granulosus muscleblind protein 0.0146 0.1831 0.2586
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0147 0.1837 1
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0732 0.1218
Echinococcus multilocularis geminin 0.0507 0.708 1
Brugia malayi beta-lactamase 0.0071 0.0732 0.0812
Echinococcus granulosus Protein patched homolog 1 0.0046 0.0371 0.0524
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0732 0.0376
Brugia malayi mbt repeat family protein 0.0046 0.0372 0.0398
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0454 0.6305 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0465 0.0531
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0732 0.1368
Treponema pallidum fructose-bisphosphate aldolase 0.0301 0.4077 0.5
Schistosoma mansoni hypothetical protein 0.0044 0.0346 0.0103
Loa Loa (eye worm) hypothetical protein 0.0108 0.1265 0.1445
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0306 0.0078
Loa Loa (eye worm) beta-lactamase 0.0071 0.0732 0.0837
Trypanosoma cruzi DNA polymerase eta, putative 0.0115 0.1367 0.2914
Echinococcus multilocularis protein dispatched 1 0.0053 0.0466 0.0658
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0732 0.1218
Trypanosoma brucei DNA polymerase IV, putative 0.0154 0.1942 0.4451
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0622 0.8752 1
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0372 0.0525
Schistosoma mansoni terminal deoxycytidyl transferase 0.0128 0.1562 0.1889
Echinococcus granulosus Niemann Pick C1 protein 0.0108 0.1265 0.1787
Trypanosoma brucei DNA polymerase kappa, putative 0.0134 0.1656 0.3686
Brugia malayi beta-lactamase family protein 0.0071 0.0732 0.0812
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.4077 0.3849
Schistosoma mansoni cpg binding protein 0.0056 0.0519 0.0356
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0732 0.6195
Leishmania major DNA polymerase eta, putative 0.0203 0.2652 0.6349
Toxoplasma gondii hypothetical protein 0.0048 0.0395 0.1086
Schistosoma mansoni patched 1 0.0046 0.0371 0.0138
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.4077 0.3849
Echinococcus granulosus expressed conserved protein 0.0101 0.117 0.1653
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.0371 0.0524
Trichomonas vaginalis glutaminase, putative 0.0268 0.3608 0.3362
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0297 0.4018 1
Brugia malayi beta-lactamase family protein 0.0071 0.0732 0.0812
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0024 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0154 0.1942 0.4451
Schistosoma mansoni cpg binding protein 0.006 0.0566 0.0425
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0306 0.0078
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0372 0.014
Schistosoma mansoni hypothetical protein 0.0044 0.0346 0.0103
Brugia malayi mbt repeat family protein 0.0046 0.0372 0.0398
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0732 0.1368
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0372 0.0525
Trypanosoma brucei DNA polymerase kappa, putative 0.0154 0.1942 0.4451
Trichomonas vaginalis esterase, putative 0.0071 0.0732 0.0376
Echinococcus multilocularis expressed conserved protein 0.0101 0.117 0.1653
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0301 0.4077 1
Giardia lamblia DINP protein human, muc B family 0.0134 0.1656 0.3629
Trypanosoma brucei DNA polymerase eta, putative 0.0203 0.2652 0.6349
Echinococcus multilocularis dnaJ subfamily B 0.0402 0.5549 0.7837
Giardia lamblia Fructose-bisphosphate aldolase 0.0301 0.4077 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0732 0.0837
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0372 0.0525
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0732 0.0376
Trichomonas vaginalis DNA polymerase eta, putative 0.0154 0.1942 0.1632
Leishmania major DNA polymerase kappa, putative 0.0134 0.1656 0.3686
Loa Loa (eye worm) hypothetical protein 0.0071 0.0732 0.0837
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0732 0.1034
Brugia malayi Pre-SET motif family protein 0.0622 0.8752 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.1012 0.1081
Trypanosoma brucei DNA polymerase kappa, putative 0.0154 0.1942 0.4451
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0372 0.014
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0128 0.1562 0.2206
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0123 0.1487 0.1779
Brugia malayi Pre-SET motif family protein 0.009 0.1012 0.1132
Trichomonas vaginalis set domain proteins, putative 0.0707 1 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0519 0.0593
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0465 0.0656
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0732 0.0376
Loa Loa (eye worm) glutaminase 0.0268 0.3608 0.4123
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0128 0.1562 0.1889
Loa Loa (eye worm) hypothetical protein 0.0046 0.0372 0.0425
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0465 0.0656
Leishmania major hypothetical protein, conserved 0.0071 0.0732 0.1218
Onchocerca volvulus 0.0071 0.0732 0.0375
Echinococcus multilocularis muscleblind protein 0.0146 0.1831 0.2586
Echinococcus granulosus cpg binding protein 0.006 0.0566 0.0799
Schistosoma mansoni DNA polymerase eta 0.0203 0.2652 0.3492
Trypanosoma brucei DNA polymerase kappa, putative 0.0154 0.1942 0.4451
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.4077 0.3849
Mycobacterium ulcerans DNA polymerase IV 0.0154 0.1942 0.4998
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0134 0.1656 0.3686
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.1974 0.2228
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.009 0.1012 0.1081
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.1012 0.1081
Schistosoma mansoni hypothetical protein 0.0507 0.708 1
Onchocerca volvulus 0.0056 0.0519 0.0153
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0046 0.0371 0.0865
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.009 0.1012 0.143
Schistosoma mansoni cpg binding protein 0.006 0.0566 0.0425
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0306 0.0078
Schistosoma mansoni hypothetical protein 0.0402 0.5549 0.7749
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0301 0.4077 1
Schistosoma mansoni hypothetical protein 0.0044 0.0346 0.0103
Trypanosoma brucei DNA polymerase IV, putative 0.0148 0.1848 0.4199
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0372 0.0425
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0128 0.1562 0.2206
Trypanosoma cruzi DNA polymerase kappa, putative 0.0154 0.1942 0.4451
Onchocerca volvulus 0.009 0.1012 0.0665
Schistosoma mansoni glutaminase 0.0268 0.3608 0.4897
Echinococcus multilocularis protein patched 0.0046 0.0371 0.0524
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0086 0.0947 0.1337
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0732 0.1218
Trypanosoma cruzi DNA polymerase kappa, putative 0.0154 0.1942 0.4451
Echinococcus granulosus Niemann Pick C1 protein 0.0154 0.1937 0.2736
Trypanosoma brucei DNA polymerase kappa, putative 0.0095 0.1078 0.2141
Brugia malayi Muscleblind-like protein 0.0146 0.1831 0.207
Echinococcus multilocularis muscleblind protein 1 0.0146 0.1831 0.2586
Plasmodium vivax SET domain protein, putative 0.009 0.1012 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0732 0.067
Mycobacterium ulcerans beta-lactamase 0.0071 0.0732 0.1368
Trypanosoma brucei DNA polymerase kappa, putative 0.0154 0.1942 0.4451
Loa Loa (eye worm) hypothetical protein 0.0146 0.1831 0.2092
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0732 0.0376
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0465 0.0656
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.4077 0.3849
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.0371 0.0524

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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