TDR Targets

Basic information

Technical information

TDR Targets ID: 673030
Name: 7-ethoxy-6-ethyl-3-(phenoxy)chromen-4-one
MW: 310.344 | Formula: C19H18O4
H donors: 0 H acceptors: 1 LogP: 4.42 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1cc2occ(c(=O)c2cc1CC)Oc1ccccc1
InChi: 1S/C19H18O4/c1-3-13-10-15-17(11-16(13)21-4-2)22-12-18(19(15)20)23-14-8-6-5-7-9-14/h5-12H,3-4H2,1-2H3
InChiKey: YQLQQFRWOHXLJK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

7-ethoxy-6-ethyl-3-(phenoxy)-4-chromenone
7-ethoxy-6-ethyl-3-(phenoxy)chromone
ZINC00189802
EU-0072698
Oprea1_154615
Oprea1_680509

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0024	0.0382	0.0382
Schistosoma mansoni	cpg binding protein	0.0032	0.0584	0.0431
Echinococcus multilocularis	zinc finger protein	0.0021	0.0308	0.0308
Brugia malayi	Bromodomain containing protein	0.0037	0.0735	0.1991
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0071	0.16	0.16
Schistosoma mansoni	tar DNA-binding protein	0.0126	0.2987	0.2873
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0056	0.1197	0.5
Entamoeba histolytica	hypothetical protein	0.0071	0.16	0.5
Brugia malayi	Muscleblind-like protein	0.0146	0.3511	1
Brugia malayi	RNA binding protein	0.0126	0.2987	0.8487
Entamoeba histolytica	hypothetical protein	0.0071	0.16	0.5
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2922	0.8323
Brugia malayi	hypothetical protein	0.0123	0.2922	0.8301
Echinococcus granulosus	zinc finger protein	0.0021	0.0308	0.0308
Schistosoma mansoni	bromodomain containing protein	0.0064	0.14	0.126
Brugia malayi	PHD-finger family protein	0.0026	0.0441	0.1144
Echinococcus granulosus	histone lysine methyltransferase setb	0.0017	0.022	0.022
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0017	0.022	0.0061
Schistosoma mansoni	tar DNA-binding protein	0.0126	0.2987	0.2873
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3511	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.022	0.0626
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0017	0.022	0.0061
Onchocerca volvulus	Huntingtin homolog	0.0123	0.2922	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.006	0.1311	0.1311
Echinococcus multilocularis	tar DNA binding protein	0.0126	0.2987	0.2987
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0126	0.2987	0.8507
Schistosoma mansoni	hypothetical protein	0.04	1	1
Echinococcus granulosus	fetal alzheimer antigen falz	0.0024	0.0382	0.0382
Echinococcus granulosus	tar DNA binding protein	0.0126	0.2987	0.2987
Echinococcus multilocularis	muscleblind protein	0.0146	0.3511	0.3511
Loa Loa (eye worm)	bromodomain containing protein	0.0017	0.0219	0.0625
Schistosoma mansoni	cpg binding protein	0.0032	0.0584	0.0431
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0496	0.1412
Echinococcus granulosus	cpg binding protein	0.0032	0.0584	0.0584
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2922	0.8323
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0496	0.13
Onchocerca volvulus	Huntingtin homolog	0.0123	0.2922	1
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3511	1
Trypanosoma brucei	ISWI complex protein	0.0015	0.016	0.5
Brugia malayi	RNA recognition motif domain containing protein	0.0126	0.2987	0.8487
Schistosoma mansoni	tar DNA-binding protein	0.0126	0.2987	0.2873
Entamoeba histolytica	hypothetical protein	0.0071	0.16	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0126	0.2987	0.2873
Brugia malayi	hypothetical protein	0.0071	0.16	0.4488
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0017	0.0204	0.0204
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0035	0.0676	0.0676
Schistosoma mansoni	tar DNA-binding protein	0.0126	0.2987	0.2873
Loa Loa (eye worm)	PHD-finger family protein	0.002	0.0294	0.0836
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.006	0.13	0.1159
Entamoeba histolytica	hypothetical protein	0.0071	0.16	0.5
Brugia malayi	TAR-binding protein	0.0126	0.2987	0.8487
Trypanosoma cruzi	ISWI complex protein	0.0015	0.016	0.5
Echinococcus multilocularis	dnaJ subfamily B	0.04	1	1
Loa Loa (eye worm)	RNA binding protein	0.0126	0.2987	0.8507
Schistosoma mansoni	cpg binding protein	0.0028	0.0496	0.0341
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0024	0.0382	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1545	0.4401
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.006	0.1311	0.1311
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0035	0.0676	0.0676
Leishmania major	hypothetical protein, conserved	0.0015	0.016	0.5
Schistosoma mansoni	transcription factor LCR-F1	0.0071	0.16	0.1464
Echinococcus granulosus	muscleblind protein	0.0146	0.3511	0.3511
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0737	0.2099
Loa Loa (eye worm)	TAR-binding protein	0.0126	0.2987	0.8507
Schistosoma mansoni	hypothetical protein	0.0071	0.16	0.1464
Trypanosoma cruzi	ISWI complex protein	0.0015	0.016	0.5
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0017	0.0204	0.0204
Loa Loa (eye worm)	hypothetical protein	0.004	0.0796	0.2267
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0017	0.022	0.022
Brugia malayi	Bromodomain containing protein	0.0075	0.1693	0.4755
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0204	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0885	0.252
Schistosoma mansoni	hypothetical protein	0.002	0.0294	0.0135
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0204	0.0045
Schistosoma mansoni	zinc finger protein	0.0021	0.0308	0.015
Echinococcus multilocularis	muscleblind protein 1	0.0146	0.3511	0.3511
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0071	0.16	0.16
Echinococcus multilocularis	cpg binding protein	0.0032	0.0584	0.0584

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 673030