Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.0232 | 0.0232 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0064 | 0.2084 | 1 |
Echinococcus multilocularis | lamin | 0.0028 | 0.0564 | 0.034 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0051 | 0.1522 | 0.1522 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0077 | 0.2658 | 0.2484 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0064 | 0.2084 | 0.2745 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0542 | 0.0542 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0232 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.0564 | 0.034 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.0232 | 0.5 |
Schistosoma mansoni | lamin | 0.0028 | 0.0564 | 0.0492 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0064 | 0.2084 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0051 | 0.1522 | 0.1911 |
Echinococcus granulosus | lamin | 0.0028 | 0.0564 | 0.034 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.0564 | 0.0564 |
Entamoeba histolytica | hypothetical protein | 0.0077 | 0.2658 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0248 | 1 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0232 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.2084 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0064 | 0.2084 | 0.1896 |
Onchocerca volvulus | 0.0051 | 0.1522 | 1 | |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0064 | 0.2084 | 0.1896 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.2084 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.2084 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0232 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0232 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0564 | 0.0564 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 0.0232 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.0564 | 0.034 |
Entamoeba histolytica | hypothetical protein | 0.0077 | 0.2658 | 1 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.0564 | 0.0564 |
Echinococcus multilocularis | musashi | 0.0028 | 0.0564 | 0.034 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.0232 | 0.0232 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0077 | 0.2658 | 0.2484 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.1522 | 0.1911 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0248 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0077 | 0.2658 | 0.2658 |
Entamoeba histolytica | hypothetical protein | 0.0077 | 0.2658 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0064 | 0.2084 | 0.2745 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.0564 | 0.0564 |
Entamoeba histolytica | hypothetical protein | 0.0077 | 0.2658 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0248 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.0232 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.0564 | 0.0564 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0232 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0077 | 0.2658 | 0.3594 |
Echinococcus multilocularis | geminin | 0.0178 | 0.6981 | 0.691 |
Echinococcus granulosus | geminin | 0.0178 | 0.6981 | 0.691 |
Schistosoma mansoni | lamin | 0.0028 | 0.0564 | 0.0492 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 0.6981 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0232 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0077 | 0.2658 | 0.3594 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0064 | 0.2084 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.0232 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.0564 | 0.034 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 0.0564 | 0.0492 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 0.6981 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.