TDR Targets

Basic information

Technical information

TDR Targets ID: 673540
Name: N-(3-acetylphenyl)-2-(3-chlorophenoxy)propana mide
MW: 317.767 | Formula: C17H16ClNO3
H donors: 1 H acceptors: 2 LogP: 3.51 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(C(Oc1cccc(c1)Cl)C)Nc1cccc(c1)C(=O)C
InChi: 1S/C17H16ClNO3/c1-11(20)13-5-3-7-15(9-13)19-17(21)12(2)22-16-8-4-6-14(18)10-16/h3-10,12H,1-2H3,(H,19,21)
InChiKey: PBCIZQNIWDKCKR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(3-acetylphenyl)-2-(3-chlorophenoxy)propionamide
2-(3-chlorophenoxy)-N-(3-ethanoylphenyl)propanamide
AN-652/12515973
IVK/8133352

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0732	0.1771
Mycobacterium ulcerans	lipase LipD	0.0077	0.0732	0.4041
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.014	0.1597	0.4291
Loa Loa (eye worm)	hypothetical protein	0.0297	0.3734	1
Mycobacterium tuberculosis	Probable hydrolase	0.0077	0.0732	0.1151
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0044	0.0288	0.0498
Brugia malayi	ImpB/MucB/SamB family protein	0.0044	0.0286	0.0546
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0077	0.0732	0.1771
Brugia malayi	RNA recognition motif domain containing protein	0.0267	0.3336	0.8911
Leishmania major	DNA polymerase eta, putative	0.0031	0.0108	0.029
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0296	0.3721	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0077	0.0732	0.1733
Schistosoma mansoni	inositol monophosphatase	0.0044	0.0288	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0798	0.1951
Schistosoma mansoni	tar DNA-binding protein	0.0267	0.3336	0.3278
Schistosoma mansoni	tar DNA-binding protein	0.0267	0.3336	0.3278
Loa Loa (eye worm)	TAR-binding protein	0.0267	0.3336	0.8911
Mycobacterium leprae	Probable lipase LipE	0.0077	0.0732	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0077	0.0732	0.0665
Chlamydia trachomatis	holo [acyl-carrier protein] synthase	0.0023	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0732	0.1771
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0081	0.0798	0.1951
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0086	0.118
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0053	0.0412	0.0893
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0296	0.3721	1
Mycobacterium tuberculosis	Probable esterase LipL	0.0077	0.0732	0.1151
Schistosoma mansoni	microtubule-associated protein tau	0.0756	1	1
Trichomonas vaginalis	esterase, putative	0.0077	0.0732	0.1733
Echinococcus granulosus	L aminoadipate semialdehyde	0.0081	0.0798	0.0732
Onchocerca volvulus		0.0077	0.0732	0.2336
Brugia malayi	Muscleblind-like protein	0.0297	0.3734	1
Schistosoma mansoni	tar DNA-binding protein	0.0267	0.3336	0.3278
Trypanosoma cruzi	hypothetical protein, conserved	0.0077	0.0732	0.1728
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0051	0.0379	0.075
Trichomonas vaginalis	D-aminoacylase, putative	0.0077	0.0732	0.1733
Onchocerca volvulus		0.0077	0.0732	0.2336
Toxoplasma gondii	ABC1 family protein	0.0077	0.0732	1
Treponema pallidum	4'-phosphopantetheinyl transferase	0.0023	0	0.5
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.014	0.1597	0.412
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0042	0.0255	0.0685
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0204	0.2467	0.6528
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0077	0.0732	0.0652
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0044	0.0288	0.0774
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0077	0.0732	0.0652
Mycobacterium ulcerans	beta-lactamase	0.0077	0.0732	0.4041
Toxoplasma gondii	hypothetical protein	0.0048	0.0338	0.4619
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0044	0.0288	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0412	0.0893
Leishmania major	hypothetical protein, conserved	0.0077	0.0732	0.1968
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0086	0.0015
Brugia malayi	MH2 domain containing protein	0.0262	0.3265	0.8715
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0286	0.0546
Echinococcus multilocularis	muscleblind protein 1	0.0297	0.3734	0.3679
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0077	0.0732	0.1151
Onchocerca volvulus		0.0077	0.0732	0.2336
Mycobacterium tuberculosis	Conserved protein	0.0077	0.0732	0.1151
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0081	0.0798	0.0718
Echinococcus granulosus	tumor protein p63	0.0726	0.9594	0.9591
Echinococcus multilocularis	muscleblind protein	0.0297	0.3734	0.3679
Onchocerca volvulus		0.0081	0.0798	0.2574
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0732	0.1771
Trypanosoma cruzi	hypothetical protein, conserved	0.0077	0.0732	0.1728
Brugia malayi	beta-lactamase	0.0077	0.0732	0.1771
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0053	0.0412	0.0893
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0077	0.0732	0.4041
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1138	0.2882
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0077	0.0732	0.1151
Trichomonas vaginalis	penicillin-binding protein, putative	0.0077	0.0732	0.1733
Trypanosoma brucei	hypothetical protein, conserved	0.0077	0.0732	0.1968
Trypanosoma cruzi	DNA polymerase eta, putative	0.0044	0.0286	0.0492
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0039	0.0225	0.3074
Echinococcus multilocularis	tumor protein p63	0.0726	0.9594	0.9591
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0732	0.1771
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0077	0.0732	0.0652
Schistosoma mansoni	cellular tumor antigen P53	0.0106	0.1138	0.106
Echinococcus granulosus	tar DNA binding protein	0.0267	0.3336	0.3288
Brugia malayi	beta-lactamase family protein	0.0077	0.0732	0.1771
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0077	0.0732	0.1771
Mycobacterium leprae	conserved hypothetical protein	0.0077	0.0732	1
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.0255	0.0407
Mycobacterium tuberculosis	Conserved protein	0.0077	0.0732	0.1151
Schistosoma mansoni	inositol monophosphatase	0.0044	0.0288	0.0203
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0042	0.0255	0.0407
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.0255	0.0407
Loa Loa (eye worm)	MH2 domain-containing protein	0.0262	0.3265	0.8715
Echinococcus multilocularis	inositol monophosphatase 1	0.0044	0.0288	0.0203
Trichomonas vaginalis	set domain proteins, putative	0.0232	0.2851	1
Onchocerca volvulus		0.0106	0.1138	0.3802
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0296	0.3721	1
Loa Loa (eye worm)	inositol-1	0.0044	0.0288	0.0553
Mycobacterium ulcerans	hypothetical protein	0.0156	0.1812	1
Schistosoma mansoni	tar DNA-binding protein	0.0267	0.3336	0.3278
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0489	0.6362	1
Mycobacterium tuberculosis	Probable lipase LipE	0.0077	0.0732	0.1151
Onchocerca volvulus		0.0232	0.2851	1
Brugia malayi	beta-lactamase family protein	0.0077	0.0732	0.1771
Leishmania major	DNA polymerase eta, putative	0.0044	0.0286	0.0768
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0077	0.0732	0.1151
Leishmania major	mitochondrial DNA polymerase beta	0.0296	0.3721	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0077	0.0732	0.1733
Trichomonas vaginalis	D-aminoacylase, putative	0.0077	0.0732	0.1733
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0023	0	0.5
Loa Loa (eye worm)	beta-lactamase	0.0077	0.0732	0.1771
Loa Loa (eye worm)	hypothetical protein	0.0297	0.3734	1
Plasmodium vivax	hypothetical protein, conserved	0.0077	0.0732	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0267	0.3336	0.8911
Loa Loa (eye worm)	RNA binding protein	0.0267	0.3336	0.8911
Echinococcus granulosus	muscleblind protein	0.0297	0.3734	0.3688
Echinococcus multilocularis	tar DNA binding protein	0.0267	0.3336	0.3278
Mycobacterium ulcerans	hypothetical protein	0.0077	0.0732	0.4041
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0044	0.0288	0.0498
Echinococcus granulosus	dna polymerase eta	0.0044	0.0286	0.0215
Schistosoma mansoni	DNA polymerase eta	0.0044	0.0286	0.0201
Echinococcus multilocularis	microtubule associated protein 2	0.0756	1	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0156	0.1812	0.2849
Brugia malayi	RNA binding protein	0.0267	0.3336	0.8911
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.0183	0.0264
Brugia malayi	Inositol-1	0.0044	0.0288	0.0553
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0081	0.0798	0.0718
Trypanosoma brucei	DNA polymerase eta, putative	0.0044	0.0286	0.0768
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0044	0.0288	0.0774
Plasmodium vivax	SET domain protein, putative	0.0029	0.0086	0.118
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.014	0.1597	0.4291
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0039	0.0225	0.0354
Loa Loa (eye worm)	transcription factor SMAD2	0.0262	0.3265	0.8715
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0044	0.0288	0.1589
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0044	0.0288	0.3933
Schistosoma mansoni	tar DNA-binding protein	0.0267	0.3336	0.3278
Schistosoma mansoni	hypothetical protein	0.0036	0.0183	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0183	0.0264
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0031	0.0108	0.1474
Mycobacterium tuberculosis	Probable lipase LipD	0.0077	0.0732	0.1151
Mycobacterium ulcerans	esterase/lipase LipP	0.0077	0.0732	0.4041
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0732	0.1771
Echinococcus multilocularis	dna polymerase eta	0.0044	0.0286	0.0201
Echinococcus granulosus	inositol monophosphatase 1	0.0044	0.0288	0.0218
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0044	0.0288	1
Brugia malayi	Pre-SET motif family protein	0.0204	0.2467	0.6528
Mycobacterium tuberculosis	Conserved protein	0.0077	0.0732	0.1151
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0732	0.1771
Brugia malayi	TAR-binding protein	0.0267	0.3336	0.8911
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0053	0.0412	0.0893

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 673540