Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0136 | 0.0465 | 0.0465 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0295 | 0.1244 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0136 | 0.0465 | 0.0465 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0077 | 0.0178 | 0.0178 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0117 | 0.0371 | 0.2049 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0077 | 0.0178 | 0.0178 |
Loa Loa (eye worm) | RNA binding protein | 0.0136 | 0.0465 | 0.4822 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0117 | 0.0371 | 0.5059 |
Brugia malayi | hypothetical protein | 0.0172 | 0.0644 | 0.6686 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0117 | 0.0371 | 0.2049 |
Onchocerca volvulus | 0.0077 | 0.0178 | 0.1593 | |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.005 | 0.0046 | 0.0358 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0155 | 0.056 | 0.186 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0078 | 0.0182 | 0.0182 |
Toxoplasma gondii | ABC1 family protein | 0.0077 | 0.0178 | 0.4329 |
Schistosoma mansoni | inositol monophosphatase | 0.0117 | 0.0371 | 0.0371 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0139 | 0.0482 | 0.3871 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0117 | 0.0371 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.0117 | 0.0371 | 0.3851 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0136 | 0.0465 | 0.4822 |
Brugia malayi | Pre-SET motif family protein | 0.0237 | 0.0959 | 0.9952 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0077 | 0.0178 | 0.1425 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0178 | 0.185 |
Schistosoma mansoni | inositol monophosphatase | 0.0117 | 0.0371 | 0.0371 |
Brugia malayi | TAR-binding protein | 0.0136 | 0.0465 | 0.4822 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0139 | 0.0482 | 0.2852 |
Onchocerca volvulus | 0.0269 | 0.112 | 1 | |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0105 | 0.0311 | 1 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0295 | 0.1244 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0077 | 0.0178 | 0.0178 |
Mycobacterium ulcerans | hypothetical protein | 0.0155 | 0.056 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0295 | 0.1244 | 1 |
Schistosoma mansoni | gabp alpha | 0.0078 | 0.0182 | 0.0182 |
Onchocerca volvulus | 0.0077 | 0.0178 | 0.1593 | |
Trichomonas vaginalis | set domain proteins, putative | 0.0269 | 0.112 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0178 | 0.185 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.013 | 0.0434 | 0.4506 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0117 | 0.0371 | 0.2977 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.013 | 0.0434 | 0.4506 |
Echinococcus granulosus | tar DNA binding protein | 0.0136 | 0.0465 | 0.0465 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0495 | 0.2228 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0139 | 0.0482 | 0.3871 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0178 | 0.185 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0804 | 0.3746 | 0.3746 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0117 | 0.0371 | 0.2049 |
Echinococcus multilocularis | tar DNA binding protein | 0.0136 | 0.0465 | 0.0465 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0078 | 0.0182 | 0.1888 |
Plasmodium vivax | hypothetical protein, conserved | 0.0077 | 0.0178 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0554 | 0.2517 | 0.2517 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.2078 | 1 | 1 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0117 | 0.0371 | 0.0371 |
Brugia malayi | MH2 domain containing protein | 0.013 | 0.0434 | 0.4506 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0117 | 0.0371 | 0.181 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0136 | 0.0465 | 0.4822 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0117 | 0.0371 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0136 | 0.0465 | 0.4822 |
Onchocerca volvulus | 0.0172 | 0.0644 | 0.5756 | |
Brugia malayi | Ets-domain containing protein | 0.0078 | 0.0182 | 0.1888 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0077 | 0.0178 | 0.185 |
Brugia malayi | beta-lactamase family protein | 0.0077 | 0.0178 | 0.185 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0126 | 0.131 |
Brugia malayi | beta-lactamase | 0.0077 | 0.0178 | 0.185 |
Brugia malayi | Ets-domain containing protein | 0.0078 | 0.0182 | 0.1888 |
Brugia malayi | Fli-1 protein | 0.0237 | 0.0964 | 1 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0105 | 0.0311 | 0.0648 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0078 | 0.0182 | 0.0182 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0237 | 0.0959 | 0.9952 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.0644 | 0.6686 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0117 | 0.0371 | 0.0371 |
Schistosoma mansoni | ets-related | 0.0237 | 0.0964 | 0.0964 |
Schistosoma mansoni | tar DNA-binding protein | 0.0136 | 0.0465 | 0.0465 |
Brugia malayi | RNA binding protein | 0.0136 | 0.0465 | 0.4822 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0178 | 0.185 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0178 | 0.185 |
Schistosoma mansoni | microtubule-associated protein tau | 0.2078 | 1 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0077 | 0.0178 | 0.0178 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0077 | 0.0178 | 0.185 |
Loa Loa (eye worm) | beta-lactamase | 0.0077 | 0.0178 | 0.185 |
Schistosoma mansoni | tar DNA-binding protein | 0.0136 | 0.0465 | 0.0465 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0117 | 0.0371 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0295 | 0.1244 | 1 |
Brugia malayi | Inositol-1 | 0.0117 | 0.0371 | 0.3851 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0117 | 0.0371 | 0.2977 |
Onchocerca volvulus | 0.0077 | 0.0178 | 0.1593 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0077 | 0.0178 | 0.1425 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0178 | 0.185 |
Loa Loa (eye worm) | fli-1 protein | 0.0237 | 0.0964 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0136 | 0.0465 | 0.0465 |
Brugia malayi | beta-lactamase family protein | 0.0077 | 0.0178 | 0.185 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0077 | 0.0178 | 0.1425 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0117 | 0.0371 | 0.2977 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0554 | 0.2517 | 0.2517 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0513 | 0.2315 | 0.2315 |
Schistosoma mansoni | hypothetical protein | 0.0513 | 0.2315 | 0.2315 |
Schistosoma mansoni | thyroid hormone receptor | 0.0554 | 0.2517 | 0.2517 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0513 | 0.2315 | 0.2315 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.