TDR Targets

Basic information

Technical information

TDR Targets ID: 673626
Name: 1-[2-(3-chlorophenyl)ethyl]-3-(3,4-dichloroph enyl)urea
MW: 343.636 | Formula: C15H13Cl3N2O
H donors: 2 H acceptors: 1 LogP: 4.77 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1ccc(c(c1)Cl)Cl)NCCc1cccc(c1)Cl
InChi: 1S/C15H13Cl3N2O/c16-11-3-1-2-10(8-11)6-7-19-15(21)20-12-4-5-13(17)14(18)9-12/h1-5,8-9H,6-7H2,(H2,19,20,21)
InChiKey: YLMCNRLJTYSPOX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

Oprea1_362366
IVK/8165366
ZINC00474498

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0032	0.0115	0.0788
Trichomonas vaginalis	esterase, putative	0.0115	0.1258	0.3789
Brugia malayi	TAR-binding protein	0.0206	0.2523	0.2944
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0214	0.2635	0.3079
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0147	0.1705	0.4291
Plasmodium vivax	SET domain protein, putative	0.0031	0.0092	0.0733
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0311	0.3975	1
Onchocerca volvulus		0.0086	0.0852	0.2574
Trypanosoma cruzi	hypothetical protein, conserved	0.0115	0.1258	0.2962
Schistosoma mansoni	hypothetical protein	0.0034	0.0134	0.0042
Trichomonas vaginalis	set domain proteins, putative	0.0244	0.3045	1
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0852	0.0921
Mycobacterium leprae	Probable lipase LipE	0.0115	0.1258	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0115	0.1258	0.3789
Echinococcus granulosus	tumor protein p63	0.0745	0.9999	0.9999
Mycobacterium tuberculosis	Conserved protein	0.0115	0.1258	0.1279
Echinococcus multilocularis	inositol monophosphatase 1	0.0036	0.0168	0.0076
Loa Loa (eye worm)	transcription factor SMAD2	0.0255	0.3202	0.3766
Loa Loa (eye worm)	hypothetical protein	0.0109	0.1179	0.1316
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0168	0.0076
Echinococcus multilocularis	microtubule associated protein 2	0.0745	1	1
Toxoplasma gondii	ABC1 family protein	0.0115	0.1258	0.8604
Leishmania major	DNA polymerase eta, putative	0.0046	0.0305	0.0768
Trichomonas vaginalis	D-aminoacylase, putative	0.0115	0.1258	0.3789
Echinococcus multilocularis	tumor protein p63	0.0745	0.9999	0.9999
Trypanosoma brucei	DNA polymerase eta, putative	0.0046	0.0305	0.0768
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0115	0.1258	0.1279
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0044	0.0272	0.0407
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0036	0.0168	0.1148
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0036	0.0168	1
Plasmodium vivax	hypothetical protein, conserved	0.0115	0.1258	1
Onchocerca volvulus		0.0115	0.1258	0.3948
Echinococcus multilocularis	tar DNA binding protein	0.0206	0.2523	0.2454
Brugia malayi	beta-lactamase	0.0115	0.1258	0.1412
Echinococcus multilocularis	muscleblind protein 1	0.0626	0.835	0.8335
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0311	0.3975	1
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0086	0.0852	0.0767
Brugia malayi	MH2 domain containing protein	0.0255	0.3202	0.3766
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0044	0.0272	0.0685
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0134	0.005
Mycobacterium tuberculosis	Probable esterase LipL	0.0115	0.1258	0.1279
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.035	0.0312
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0733	0.9836	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.035	0.0312
Echinococcus multilocularis	dna polymerase eta	0.0046	0.0305	0.0215
Toxoplasma gondii	aldehyde dehydrogenase	0.0129	0.1462	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0115	0.1258	0.1177
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0129	0.1462	0.7555
Echinococcus multilocularis	X box binding protein 1	0.0311	0.3981	0.3925
Mycobacterium ulcerans	esterase/lipase LipP	0.0115	0.1258	0.65
Brugia malayi	Inositol-1	0.0036	0.0168	0.0092
Trichomonas vaginalis	D-aminoacylase, putative	0.0115	0.1258	0.3789
Schistosoma mansoni	tar DNA-binding protein	0.0206	0.2523	0.2454
Treponema pallidum	4'-phosphopantetheinyl transferase	0.0024	0	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0206	0.2523	0.2454
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0115	0.1258	0.1279
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0168	0.0423
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.0092	0.0631
Echinococcus granulosus	X box binding protein 1	0.0311	0.3981	0.3934
Loa Loa (eye worm)	hypothetical protein	0.0115	0.1258	0.1412
Trichomonas vaginalis	D-aminoacylase, putative	0.0115	0.1258	0.3789
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.035	0.0312
Mycobacterium tuberculosis	Probable lipase LipD	0.0115	0.1258	0.1279
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0086	0.0852	0.0767
Loa Loa (eye worm)	beta-lactamase	0.0115	0.1258	0.1412
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0044	0.0272	0.0407
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0129	0.1462	0.1383
Mycobacterium ulcerans	lipase LipD	0.0115	0.1258	0.65
Mycobacterium ulcerans	beta-lactamase	0.0115	0.1258	0.65
Toxoplasma gondii	hypothetical protein	0.005	0.0361	0.2471
Echinococcus granulosus	beta LACTamase domain containing family member	0.0115	0.1258	0.1191
Schistosoma mansoni	tar DNA-binding protein	0.0206	0.2523	0.2454
Schistosoma mansoni	hypothetical protein	0.0311	0.3981	0.3925
Mycobacterium ulcerans	hypothetical protein	0.0115	0.1258	0.65
Loa Loa (eye worm)	hypothetical protein	0.0626	0.835	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0115	0.1258	0.1177
Mycobacterium tuberculosis	Conserved protein	0.0115	0.1258	0.1279
Loa Loa (eye worm)	inositol-1	0.0036	0.0168	0.0092
Mycobacterium tuberculosis	Probable lipase LipE	0.0115	0.1258	0.1279
Loa Loa (eye worm)	MH2 domain-containing protein	0.0255	0.3202	0.3766
Onchocerca volvulus		0.0109	0.1179	0.3679
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0134	0.005
Schistosoma mansoni	tar DNA-binding protein	0.0206	0.2523	0.2454
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0311	0.3975	1
Schistosoma mansoni	DNA polymerase eta	0.0046	0.0305	0.0215
Mycobacterium ulcerans	hypothetical protein	0.0164	0.1936	1
Loa Loa (eye worm)	hypothetical protein	0.0626	0.835	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0115	0.1258	0.1412
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0168	0.0423
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0129	0.1462	0.1487
Brugia malayi	RNA binding protein	0.0206	0.2523	0.2944
Loa Loa (eye worm)	hypothetical protein	0.0115	0.1258	0.1412
Trypanosoma cruzi	DNA polymerase eta, putative	0.0046	0.0305	0.0492
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0206	0.2523	0.2944
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0086	0.0852	0.0921
Onchocerca volvulus		0.0115	0.1258	0.3948
Loa Loa (eye worm)	RNA binding protein	0.0206	0.2523	0.2944
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0036	0.0168	0.0868
Brugia malayi	Muscleblind-like protein	0.0626	0.835	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0115	0.1258	0.2962
Echinococcus granulosus	L aminoadipate semialdehyde	0.0086	0.0852	0.0782
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0168	0.0076
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0147	0.1705	0.4291
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0053	0.0405	0.075
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0115	0.1258	0.1177
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0036	0.0168	1
Mycobacterium leprae	conserved hypothetical protein	0.0115	0.1258	1
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0129	0.1462	0.3679
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0164	0.1936	0.1968
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0305	0.0258
Loa Loa (eye worm)	hypothetical protein	0.0115	0.1258	0.1412
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0115	0.1258	0.1412
Chlamydia trachomatis	holo [acyl-carrier protein] synthase	0.0024	0	0.5
Brugia malayi	RNA recognition motif domain containing protein	0.0206	0.2523	0.2944
Schistosoma mansoni	cellular tumor antigen P53	0.0109	0.1179	0.1097
Brugia malayi	ImpB/MucB/SamB family protein	0.0046	0.0305	0.0258
Brugia malayi	beta-lactamase family protein	0.0115	0.1258	0.1412
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0168	0.0137
Echinococcus granulosus	dna polymerase eta	0.0046	0.0305	0.023
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0147	0.1705	0.412
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0129	0.1462	0.7555
Trypanosoma brucei	hypothetical protein, conserved	0.0115	0.1258	0.3166
Onchocerca volvulus		0.0115	0.1258	0.3948
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0115	0.1258	0.1279
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0129	0.1462	0.1396
Brugia malayi	Pre-SET motif family protein	0.0214	0.2635	0.3079
Mycobacterium tuberculosis	Conserved protein	0.0115	0.1258	0.1279
Echinococcus granulosus	inositol monophosphatase 1	0.0036	0.0168	0.0092
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0032	0.0115	0.0917
Schistosoma mansoni	aldehyde dehydrogenase	0.0129	0.1462	0.1383
Loa Loa (eye worm)	hypothetical protein	0.0049	0.035	0.0312
Leishmania major	mitochondrial DNA polymerase beta	0.0311	0.3975	1
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0024	0	0.5
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0092	0.0016
Echinococcus granulosus	muscleblind protein	0.0626	0.835	0.8337
Loa Loa (eye worm)	hypothetical protein	0.0115	0.1258	0.1412
Loa Loa (eye worm)	hypothetical protein	0.0115	0.1258	0.1412
Schistosoma mansoni	microtubule-associated protein tau	0.0745	1	1
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0044	0.0272	0.0407
Onchocerca volvulus		0.0244	0.3045	1
Loa Loa (eye worm)	TAR-binding protein	0.0206	0.2523	0.2944
Loa Loa (eye worm)	hypothetical protein	0.0115	0.1258	0.1412
Brugia malayi	beta-lactamase family protein	0.0115	0.1258	0.1412
Echinococcus granulosus	tar DNA binding protein	0.0206	0.2523	0.2466
Mycobacterium tuberculosis	Probable hydrolase	0.0115	0.1258	0.1279
Trichomonas vaginalis	penicillin-binding protein, putative	0.0115	0.1258	0.3789
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0032	0.0115	0.0117
Leishmania major	DNA polymerase eta, putative	0.0032	0.0115	0.029
Echinococcus multilocularis	muscleblind protein	0.0626	0.835	0.8335
Schistosoma mansoni	tar DNA-binding protein	0.0206	0.2523	0.2454
Leishmania major	hypothetical protein, conserved	0.0115	0.1258	0.3166
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0168	0.0137
Schistosoma mansoni	aldehyde dehydrogenase	0.0129	0.1462	0.1383
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0115	0.1258	0.65
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0129	0.1462	0.7555

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 673626