TDR Targets

Basic information

Technical information

TDR Targets ID: 673658
Name: N-[(3,4-dichlorophenyl)methyl]-4-methoxybenza mide
MW: 310.175 | Formula: C15H13Cl2NO2
H donors: 1 H acceptors: 1 LogP: 3.92 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)C(=O)NCc1ccc(c(c1)Cl)Cl
InChi: 1S/C15H13Cl2NO2/c1-20-12-5-3-11(4-6-12)15(19)18-9-10-2-7-13(16)14(17)8-10/h2-8H,9H2,1H3,(H,18,19)
InChiKey: BXDYTSXDKHSFRK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[(3,4-dichlorophenyl)methyl]-4-methoxy-benzamide
N-(3,4-dichlorobenzyl)-4-methoxy-benzamide
AK-968/41927081
ZINC00376274
IVK/9621717
Oprea1_613685

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0301	0.0256
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0082	0.0842	0.0766
Echinococcus multilocularis	inositol monophosphatase 1	0.0036	0.0189	0.01
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0204	0.2596	0.3049
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0156	0.1911	0.1911
Brugia malayi	MH2 domain containing protein	0.0252	0.3277	0.3878
Toxoplasma gondii	hypothetical protein	0.0048	0.0357	0.2467
Echinococcus multilocularis	microtubule associated protein 2	0.0713	0.9884	1
Brugia malayi	ImpB/MucB/SamB family protein	0.0044	0.0301	0.0256
Loa Loa (eye worm)	transcription factor SMAD2	0.0252	0.3277	0.3878
Schistosoma mansoni	tar DNA-binding protein	0.0204	0.2596	0.2558
Toxoplasma gondii	aldehyde dehydrogenase	0.0124	0.1446	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0842	0.0914
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0189	0.0198
Echinococcus multilocularis	dna polymerase eta	0.0044	0.0301	0.0215
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0036	0.0189	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0371	0.034
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0371	0.034
Brugia malayi	RNA recognition motif domain containing protein	0.0204	0.2596	0.3049
Loa Loa (eye worm)	hypothetical protein	0.0113	0.1287	0.1456
Brugia malayi	beta-lactamase family protein	0.0113	0.1287	0.1456
Echinococcus granulosus	beta LACTamase domain containing family member	0.0113	0.1287	0.1235
Schistosoma mansoni	tar DNA-binding protein	0.0204	0.2596	0.2558
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0189	0.01
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0036	0.0189	0.099
Brugia malayi	Inositol-1	0.0036	0.0189	0.0119
Onchocerca volvulus		0.0113	0.1287	0.4103
Trichomonas vaginalis	penicillin-binding protein, putative	0.0113	0.1287	0.3897
Loa Loa (eye worm)	beta-lactamase	0.0113	0.1287	0.1456
Onchocerca volvulus		0.0082	0.0842	0.2574
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0371	0.034
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0032	0.0135	0.1048
Trichomonas vaginalis	D-aminoacylase, putative	0.0113	0.1287	0.3897
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.0269	0.0407
Trypanosoma cruzi	hypothetical protein, conserved	0.0113	0.1287	0.308
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0113	0.1287	0.1456
Plasmodium vivax	hypothetical protein, conserved	0.0113	0.1287	1
Schistosoma mansoni	tar DNA-binding protein	0.0204	0.2596	0.2558
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0189	0.0482
Echinococcus granulosus	dna polymerase eta	0.0044	0.0301	0.023
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0042	0.0269	0.0685
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0149	0.0071
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0297	0.3925	1
Echinococcus granulosus	tar DNA binding protein	0.0204	0.2596	0.2569
Echinococcus granulosus	tumor protein p63	0.0692	0.958	0.969
Schistosoma mansoni	hypothetical protein	0.0298	0.3935	0.3925
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0141	0.1684	0.412
Loa Loa (eye worm)	TAR-binding protein	0.0204	0.2596	0.3049
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.0269	0.0407
Echinococcus granulosus	L aminoadipate semialdehyde	0.0082	0.0842	0.0781
Trichomonas vaginalis	esterase, putative	0.0113	0.1287	0.3897
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1121	0.1254
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0113	0.1287	0.1222
Mycobacterium ulcerans	esterase/lipase LipP	0.0113	0.1287	0.6736
Loa Loa (eye worm)	hypothetical protein	0.0113	0.1287	0.1456
Loa Loa (eye worm)	hypothetical protein	0.0113	0.1287	0.1456
Schistosoma mansoni	microtubule-associated protein tau	0.0713	0.9884	1
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0189	0.0482
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0141	0.1684	0.4291
Leishmania major	mitochondrial DNA polymerase beta	0.0297	0.3925	1
Echinococcus multilocularis	X box binding protein 1	0.0298	0.3935	0.3925
Plasmodium vivax	SET domain protein, putative	0.0029	0.0091	0.0708
Trypanosoma cruzi	hypothetical protein, conserved	0.0113	0.1287	0.308
Loa Loa (eye worm)	hypothetical protein	0.0603	0.8306	1
Loa Loa (eye worm)	hypothetical protein	0.0113	0.1287	0.1456
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0189	0.0198
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0124	0.1446	0.7567
Mycobacterium ulcerans	lipase LipD	0.0113	0.1287	0.6736
Onchocerca volvulus		0.0233	0.3007	1
Brugia malayi	Pre-SET motif family protein	0.0205	0.2602	0.3056
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0082	0.0842	0.0766
Trichomonas vaginalis	D-aminoacylase, putative	0.0113	0.1287	0.3897
Brugia malayi	RNA binding protein	0.0204	0.2596	0.3049
Echinococcus granulosus	muscleblind protein	0.0603	0.8306	0.8392
Leishmania major	DNA polymerase eta, putative	0.0031	0.0114	0.029
Schistosoma mansoni	tar DNA-binding protein	0.0204	0.2596	0.2558
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0113	0.1287	0.1287
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0051	0.04	0.075
Brugia malayi	beta-lactamase	0.0113	0.1287	0.1456
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0371	0.034
Onchocerca volvulus		0.0113	0.1287	0.4103
Mycobacterium leprae	conserved hypothetical protein	0.0113	0.1287	1
Trypanosoma brucei	DNA polymerase eta, putative	0.0044	0.0301	0.0768
Schistosoma mansoni	cellular tumor antigen P53	0.0101	0.1121	0.1052
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0149	0.0071
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0036	0.0189	0.1308
Loa Loa (eye worm)	hypothetical protein	0.0113	0.1287	0.1456
Mycobacterium tuberculosis	Probable lipase LipE	0.0113	0.1287	0.1287
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0091	0.063
Onchocerca volvulus		0.0101	0.1121	0.3532
Mycobacterium leprae	Probable lipase LipE	0.0113	0.1287	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0124	0.1446	0.7567
Mycobacterium tuberculosis	Probable esterase LipL	0.0113	0.1287	0.1287
Mycobacterium ulcerans	hypothetical protein	0.0156	0.1911	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0042	0.0269	0.0407
Echinococcus granulosus	inositol monophosphatase 1	0.0036	0.0189	0.0116
Mycobacterium ulcerans	hypothetical protein	0.0113	0.1287	0.6736
Toxoplasma gondii	ABC1 family protein	0.0113	0.1287	0.8902
Loa Loa (eye worm)	RNA binding protein	0.0204	0.2596	0.3049
Brugia malayi	Muscleblind-like protein	0.0603	0.8306	1
Echinococcus multilocularis	tumor protein p63	0.0692	0.958	0.969
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0124	0.1446	0.1384
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0113	0.1287	0.1456
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0113	0.1287	0.1287
Mycobacterium tuberculosis	Probable lipase LipD	0.0113	0.1287	0.1287
Mycobacterium tuberculosis	Conserved protein	0.0113	0.1287	0.1287
Mycobacterium tuberculosis	Probable hydrolase	0.0113	0.1287	0.1287
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0124	0.1446	0.3685
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0113	0.1287	0.1222
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0141	0.1684	0.4291
Onchocerca volvulus		0.0113	0.1287	0.4103
Schistosoma mansoni	hypothetical protein	0.0033	0.0149	0.0059
Trypanosoma brucei	hypothetical protein, conserved	0.0113	0.1287	0.328
Loa Loa (eye worm)	hypothetical protein	0.0603	0.8306	1
Leishmania major	DNA polymerase eta, putative	0.0044	0.0301	0.0768
Chlamydia trachomatis	holo [acyl-carrier protein] synthase	0.0023	0	0.5
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0091	0.0016
Schistosoma mansoni	tar DNA-binding protein	0.0204	0.2596	0.2558
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0124	0.1446	0.1446
Treponema pallidum	4'-phosphopantetheinyl transferase	0.0023	0	0.5
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0124	0.1446	0.7567
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0124	0.1446	0.1397
Schistosoma mansoni	DNA polymerase eta	0.0044	0.0301	0.0215
Brugia malayi	TAR-binding protein	0.0204	0.2596	0.3049
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0205	0.2602	0.3056
Echinococcus multilocularis	tar DNA binding protein	0.0204	0.2596	0.2558
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0113	0.1287	0.6736
Loa Loa (eye worm)	hypothetical protein	0.0113	0.1287	0.1456
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0113	0.1287	0.1222
Echinococcus multilocularis	muscleblind protein 1	0.0603	0.8306	0.8389
Trichomonas vaginalis	set domain proteins, putative	0.0233	0.3007	1
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0113	0.1287	0.1287
Trypanosoma cruzi	DNA polymerase eta, putative	0.0044	0.0301	0.0492
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0082	0.0842	0.0914
Echinococcus granulosus	X box binding protein 1	0.0298	0.3935	0.3934
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0036	0.0189	1
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0023	0	0.5
Trichomonas vaginalis	D-aminoacylase, putative	0.0113	0.1287	0.3897
Echinococcus granulosus	microtubule associated protein 2	0.0713	0.9884	1
Leishmania major	hypothetical protein, conserved	0.0113	0.1287	0.328
Schistosoma mansoni	aldehyde dehydrogenase	0.0124	0.1446	0.1384
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0031	0.0114	0.0787
Mycobacterium tuberculosis	Conserved protein	0.0113	0.1287	0.1287
Loa Loa (eye worm)	MH2 domain-containing protein	0.0252	0.3277	0.3878
Echinococcus multilocularis	muscleblind protein	0.0603	0.8306	0.8389
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0297	0.3925	1
Brugia malayi	beta-lactamase family protein	0.0113	0.1287	0.1456
Mycobacterium ulcerans	beta-lactamase	0.0113	0.1287	0.6736
Schistosoma mansoni	aldehyde dehydrogenase	0.0124	0.1446	0.1384
Trichomonas vaginalis	penicillin-binding protein, putative	0.0113	0.1287	0.3897
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0032	0.0135	0.0135
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0189	0.01
Mycobacterium tuberculosis	Conserved protein	0.0113	0.1287	0.1287
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0297	0.3925	1
Loa Loa (eye worm)	inositol-1	0.0036	0.0189	0.0119

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 673658