Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | beta-lactamase | 0.0076 | 0.0754 | 0.1758 |
Echinococcus granulosus | muscleblind protein | 0.0297 | 0.3872 | 0.3826 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0076 | 0.0754 | 0.0672 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0076 | 0.0754 | 0.1799 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0076 | 0.0754 | 0.1799 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0296 | 0.3859 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0076 | 0.0754 | 0.4014 |
Leishmania major | DNA polymerase eta, putative | 0.0044 | 0.0296 | 0.0768 |
Echinococcus multilocularis | muscleblind protein | 0.0297 | 0.3872 | 0.3816 |
Echinococcus multilocularis | tar DNA binding protein | 0.0264 | 0.3415 | 0.3356 |
Loa Loa (eye worm) | RNA binding protein | 0.0264 | 0.3415 | 0.8792 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0264 | 0.3415 | 0.8792 |
Onchocerca volvulus | 0.0232 | 0.2957 | 1 | |
Schistosoma mansoni | DNA polymerase eta | 0.0044 | 0.0296 | 0.0209 |
Mycobacterium tuberculosis | Conserved protein | 0.0076 | 0.0754 | 0.1149 |
Mycobacterium leprae | Probable lipase LipE | 0.0076 | 0.0754 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0263 | 0.3404 | 0.8762 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0042 | 0.0271 | 0.0198 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0042 | 0.0264 | 0.0407 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0042 | 0.0271 | 0.3594 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0042 | 0.0271 | 0.0425 |
Mycobacterium tuberculosis | Conserved protein | 0.0076 | 0.0754 | 0.1149 |
Toxoplasma gondii | ABC1 family protein | 0.0076 | 0.0754 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0076 | 0.0754 | 0.1149 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0076 | 0.0754 | 0.1758 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0076 | 0.0754 | 0.1758 |
Trichomonas vaginalis | set domain proteins, putative | 0.0232 | 0.2957 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0296 | 0.3859 | 1 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0042 | 0.0264 | 0.0407 |
Onchocerca volvulus | 0.0107 | 0.1187 | 0.3828 | |
Mycobacterium ulcerans | hypothetical protein | 0.0156 | 0.188 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0264 | 0.3415 | 0.3363 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0487 | 0.6565 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0044 | 0.0296 | 0.0224 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0076 | 0.0754 | 0.0671 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0728 | 0.9979 | 0.9979 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0038 | 0.0209 | 0.2768 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0754 | 0.1758 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0076 | 0.0754 | 0.1799 |
Echinococcus multilocularis | dna polymerase eta | 0.0044 | 0.0296 | 0.0209 |
Mycobacterium tuberculosis | Conserved protein | 0.0076 | 0.0754 | 0.1149 |
Echinococcus granulosus | tar DNA binding protein | 0.0264 | 0.3415 | 0.3366 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0107 | 0.1187 | 0.111 |
Brugia malayi | Pre-SET motif family protein | 0.0204 | 0.2559 | 0.6528 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0042 | 0.0271 | 0.0183 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0427 | 0.0893 |
Brugia malayi | TAR-binding protein | 0.0264 | 0.3415 | 0.8792 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0076 | 0.0754 | 0.1149 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0754 | 0.1758 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0754 | 0.1758 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0076 | 0.0754 | 0.1149 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0076 | 0.0754 | 0.4014 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.019 | 0.0101 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0031 | 0.0112 | 0.1483 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.019 | 0.0264 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0042 | 0.0271 | 0.0425 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0044 | 0.0296 | 0.0546 |
Schistosoma mansoni | tar DNA-binding protein | 0.0264 | 0.3415 | 0.3363 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0044 | 0.0296 | 0.0492 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0042 | 0.0271 | 0.1443 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.014 | 0.1656 | 0.4291 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0263 | 0.3404 | 0.8762 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0038 | 0.0209 | 0.0318 |
Brugia malayi | RNA binding protein | 0.0264 | 0.3415 | 0.8792 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0156 | 0.188 | 0.2863 |
Echinococcus multilocularis | tumor protein p63 | 0.073 | 1 | 1 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0042 | 0.0264 | 0.0685 |
Brugia malayi | Inositol-1 | 0.0042 | 0.0271 | 0.048 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.009 | 0.1187 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0042 | 0.0271 | 0.0703 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0081 | 0.0828 | 0.0745 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0296 | 0.0546 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0042 | 0.0271 | 0.0703 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.019 | 0.0264 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0081 | 0.0828 | 0.0759 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0076 | 0.0754 | 0.0685 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0076 | 0.0754 | 0.1149 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0728 | 0.9979 | 0.9979 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.3872 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0264 | 0.3415 | 0.3363 |
Onchocerca volvulus | 0.0076 | 0.0754 | 0.2319 | |
Trichomonas vaginalis | esterase, putative | 0.0076 | 0.0754 | 0.1799 |
Plasmodium vivax | hypothetical protein, conserved | 0.0076 | 0.0754 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0264 | 0.3415 | 0.8792 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0296 | 0.3859 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.0427 | 0.0893 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.009 | 0.0015 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0754 | 0.1758 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0081 | 0.0828 | 0.1951 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0828 | 0.1951 |
Schistosoma mansoni | inositol monophosphatase | 0.0042 | 0.0271 | 0.0184 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0076 | 0.0754 | 0.1799 |
Schistosoma mansoni | tar DNA-binding protein | 0.0264 | 0.3415 | 0.3363 |
Schistosoma mansoni | tar DNA-binding protein | 0.0264 | 0.3415 | 0.3363 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0297 | 0.3872 | 0.3816 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0076 | 0.0754 | 0.1149 |
Mycobacterium ulcerans | lipase LipD | 0.0076 | 0.0754 | 0.4014 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.014 | 0.1656 | 0.4291 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0754 | 0.1758 |
Leishmania major | DNA polymerase eta, putative | 0.0031 | 0.0112 | 0.029 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0296 | 0.3859 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0076 | 0.0754 | 0.1758 |
Loa Loa (eye worm) | inositol-1 | 0.0042 | 0.0271 | 0.048 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0264 | 0.3415 | 0.8792 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0044 | 0.0296 | 0.0768 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0728 | 0.9979 | 1 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0081 | 0.0828 | 0.0746 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.3872 | 1 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0076 | 0.0754 | 0.1149 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0076 | 0.0754 | 0.1955 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0076 | 0.0754 | 0.4014 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.1187 | 0.2902 |
Mycobacterium leprae | conserved hypothetical protein | 0.0076 | 0.0754 | 1 |
Brugia malayi | beta-lactamase | 0.0076 | 0.0754 | 0.1758 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.0427 | 0.0893 |
Onchocerca volvulus | 0.0081 | 0.0828 | 0.2574 | |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0754 | 0.1758 |
Onchocerca volvulus | 0.0076 | 0.0754 | 0.2319 | |
Brugia malayi | Muscleblind-like protein | 0.0297 | 0.3872 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0076 | 0.0754 | 0.1149 |
Brugia malayi | MH2 domain containing protein | 0.0263 | 0.3404 | 0.8762 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0042 | 0.0271 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0076 | 0.0754 | 0.4014 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0076 | 0.0754 | 0.0672 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0042 | 0.0264 | 0.0407 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.009 | 0.1187 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.0427 | 0.0893 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0076 | 0.0754 | 0.1715 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0042 | 0.0271 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0048 | 0.0351 | 0.465 |
Onchocerca volvulus | 0.0076 | 0.0754 | 0.2319 | |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0076 | 0.0754 | 0.1799 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0076 | 0.0754 | 0.1715 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0051 | 0.0393 | 0.075 |
Brugia malayi | beta-lactamase family protein | 0.0076 | 0.0754 | 0.1758 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0204 | 0.2559 | 0.6528 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.014 | 0.1656 | 0.412 |
Schistosoma mansoni | inositol monophosphatase | 0.0042 | 0.0271 | 0.0184 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0023 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0076 | 0.0754 | 0.1955 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.