TDR Targets

Basic information

Technical information

TDR Targets ID: 674184
Name: 2-cyclohexyl-N-(2,5-dimethoxyphenyl)acetamide
MW: 277.359 | Formula: C16H23NO3
H donors: 1 H acceptors: 1 LogP: 3.71 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1NC(=O)CC1CCCCC1)OC
InChi: 1S/C16H23NO3/c1-19-13-8-9-15(20-2)14(11-13)17-16(18)10-12-6-4-3-5-7-12/h8-9,11-12H,3-7,10H2,1-2H3,(H,17,18)
InChiKey: VDADZISSPILABT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-cyclohexyl-N-(2,5-dimethoxyphenyl)ethanamide
Oprea1_650634
ZINC00317957
STK161577

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	netrin 1	0.0021	0.0624	0.0624
Onchocerca volvulus		0.0035	0.1277	0.7108
Echinococcus multilocularis	netrin 1	0.0021	0.0624	0.0624
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0092	0.3826	0.3826
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.1277	0.1302
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.1277	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0736	0.5766
Mycobacterium ulcerans	epoxide hydrolase EphA	0.0159	0.6805	1
Echinococcus multilocularis	smoothened	0.0007	0.0015	0.0015
Schistosoma mansoni	hypothetical protein	0.0047	0.1796	0.4695
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0736	0.0736
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.1277	1
Entamoeba histolytica	hypothetical protein	0.0035	0.1275	1
Echinococcus multilocularis	secreted frizzled protein 5	0.0007	0.0015	0.0015
Brugia malayi	beta-lactamase family protein	0.0035	0.1277	0.1277
Schistosoma mansoni	frizzled	0.0007	0.0015	0.0039
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.0736	0.5772
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.1277	1
Brugia malayi	beta-lactamase family protein	0.0035	0.1277	0.1277
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0736	0.0736
Mycobacterium leprae	Probable lipase LipE	0.0035	0.1277	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1277	0.1277
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.3121	0.8158
Schistosoma mansoni	wnt inhibitor frzb2	0.0007	0.0015	0.0039
Echinococcus granulosus	smoothened	0.0007	0.0015	0.0015
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.043	0.0439
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.1275	0.3334
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.3121	0.3121
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0092	0.3826	0.3826
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.1277	0.1277
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.1277	0.1277
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0473	0.0473
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0015	0.0015
Entamoeba histolytica	hypothetical protein	0.0035	0.1275	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0736	0.0736
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.1277	0.3337
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0736	0.1082
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.3121	0.8158
Schistosoma mansoni	survival motor neuron protein	0.0047	0.1796	0.4695
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0092	0.3826	0.3826
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0736	0.5766
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.1277	1
Brugia malayi	Frizzled/Smoothened family membrane region containing protein	0.0007	0.0015	0.0015
Loa Loa (eye worm)	beta-lactamase	0.0035	0.1277	0.1277
Loa Loa (eye worm)	frizzled/Smoothened family membrane region containing protein	0.0007	0.0015	0.0015
Loa Loa (eye worm)	frizzled/Smoothened family membrane region containing protein	0.0007	0.0015	0.0015
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0736	0.1082
Loa Loa (eye worm)	sfrp2	0.0007	0.0015	0.0015
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0736	0.1082
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.043	0.0439
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.3121	0.8158
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.3121	0.8158
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.1277	0.1302
Brugia malayi	Frizzled/Smoothened family membrane region containing protein	0.0007	0.0015	0.0015
Echinococcus multilocularis	survival motor neuron protein 1	0.023	1	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1277	0.1277
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0736	0.5766
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0736	0.1082
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0736	0.0736
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0624	0.0624
Loa Loa (eye worm)	hypothetical protein	0.023	1	1
Mycobacterium ulcerans	lipase LipD	0.0035	0.1277	0.1876
Schistosoma mansoni	frizzled-like receptor	0.0007	0.0015	0.0039
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.0473	0.0482
Echinococcus granulosus	survival motor neuron protein 1	0.023	1	1
Schistosoma mansoni	netrin	0.0021	0.0624	0.1632
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0736	0.5766
Brugia malayi	TAR-binding protein	0.0076	0.3121	0.3121
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0736	0.0736
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1277	0.1277
Echinococcus multilocularis	frizzled	0.0007	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0473	0.0473
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.1277	0.1277
Echinococcus multilocularis	secreted frizzled protein	0.0007	0.0015	0.0015
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.1277	0.1302
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0473	0.0473
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.3826	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.3826	1
Mycobacterium tuberculosis	Conserved protein	0.0035	0.1277	0.1302
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.1277	1
Onchocerca volvulus		0.0035	0.1277	0.7108
Onchocerca volvulus		0.0023	0.0736	0.4099
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1277	0.1277
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0736	0.1082
Loa Loa (eye worm)	RNA binding protein	0.0076	0.3121	0.3121
Onchocerca volvulus		0.0028	0.0945	0.5262
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0736	0.1082
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0017	0.0473	0.5
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.3121	0.3121
Onchocerca volvulus		0.0035	0.1277	0.7108
Echinococcus multilocularis	secreted frizzled protein	0.0007	0.0015	0.0015
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.1277	0.1302
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0017	0.0473	0.0695
Entamoeba histolytica	hypothetical protein	0.0035	0.1275	1
Toxoplasma gondii	ABC1 family protein	0.0035	0.1277	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.1275	0.1275
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.043	0.0439
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0092	0.3826	0.3826
Brugia malayi	Fz domain containing protein	0.0007	0.0015	0.0015
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0736	0.5772
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.1277	0.1302
Brugia malayi	Fz domain containing protein	0.0007	0.0015	0.0015
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.1277	1
Onchocerca volvulus		0.0047	0.1796	1
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.3121	0.3121
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0473	0.0473
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.1277	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.1277	0.3337
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.3826	1
Echinococcus granulosus	frizzled	0.0007	0.0015	0.0015
Schistosoma mansoni	secreted frizzled-related protein	0.0007	0.0015	0.0039
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0226	0.9806	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.1277	1
Brugia malayi	beta-lactamase	0.0035	0.1277	0.1277
Echinococcus granulosus	frizzled 4	0.0007	0.0015	0.0015
Leishmania major	hypothetical protein, conserved	0.0035	0.1277	1
Echinococcus multilocularis	frizzled 4	0.0007	0.0015	0.0015
Mycobacterium ulcerans	hypothetical protein	0.0035	0.1277	0.1876
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.1277	0.1302
Echinococcus granulosus	secreted frizzled protein	0.0007	0.0015	0.0015
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.1277	0.1876
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1277	0.1277
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0736	0.1082
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0473	0.0473
Echinococcus multilocularis	frizzled 5	0.0007	0.0015	0.0015
Entamoeba histolytica	hypothetical protein	0.0035	0.1275	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0092	0.3826	0.3826
Echinococcus granulosus	frizzled	0.0007	0.0015	0.0015
Brugia malayi	Unc-6 protein precursor	0.0021	0.0624	0.0624
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.3121	0.3121
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.1277	0.1277
Echinococcus multilocularis	frizzled 10	0.0007	0.0015	0.0015
Echinococcus granulosus	frizzled 5	0.0007	0.0015	0.0015
Echinococcus granulosus	frizzled	0.0007	0.0015	0.0015
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.1275	0.1275
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.1277	0.1876
Schistosoma mansoni	hypothetical protein	0.0035	0.1275	0.3334
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0736	0.0751
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.3121	0.8158
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1277	0.1277
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0736	0.1082
Brugia malayi	RNA binding protein	0.0076	0.3121	0.3121
Mycobacterium tuberculosis	Conserved protein	0.0035	0.1277	0.1302
Plasmodium vivax	acyl-CoA synthetase, putative	0.0017	0.0473	0.3703
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.1277	0.1302
Brugia malayi	hypothetical protein	0.0035	0.1275	0.1275
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0092	0.3826	0.3826
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.1796	0.1796
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.1277	1
Plasmodium falciparum	acyl-CoA synthetase	0.0017	0.0473	1
Echinococcus granulosus	tar DNA binding protein	0.0076	0.3121	0.3121
Echinococcus multilocularis	frizzled	0.0007	0.0015	0.0015
Mycobacterium tuberculosis	Conserved protein	0.0035	0.1277	0.1302
Schistosoma mansoni	frizzled-like receptor	0.0007	0.0015	0.0039
Mycobacterium tuberculosis	Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase)	0.0159	0.6805	0.694
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0736	0.0751
Schistosoma mansoni	netrin	0.0021	0.0624	0.1632
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0015	0.0015
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.1277	1
Mycobacterium ulcerans	beta-lactamase	0.0035	0.1277	0.1876
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.043	0.0439
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0736	0.5772
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0736	0.0736
Echinococcus granulosus	secreted frizzled protein 5	0.0007	0.0015	0.0015
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0736	0.5766
Trichomonas vaginalis	esterase, putative	0.0035	0.1277	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 674184