Detailed information for compound 674321

Basic information

Technical information
  • TDR Targets ID: 674321
  • Name: 2-[(2-chlorophenyl)methyl-(4-chlorophenyl)sul fonylamino]-N-cyclopropylacetamide
  • MW: 413.318 | Formula: C18H18Cl2N2O3S
  • H donors: 1 H acceptors: 3 LogP: 3.72 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CN(S(=O)(=O)c1ccc(cc1)Cl)Cc1ccccc1Cl)NC1CC1
  • InChi: 1S/C18H18Cl2N2O3S/c19-14-5-9-16(10-6-14)26(24,25)22(12-18(23)21-15-7-8-15)11-13-3-1-2-4-17(13)20/h1-6,9-10,15H,7-8,11-12H2,(H,21,23)
  • InChiKey: QGCXNETYELDHDG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(2-chlorophenyl)methyl-(4-chlorophenyl)sulfonyl-amino]-N-cyclopropyl-acetamide
  • 2-[(2-chlorobenzyl)-(4-chlorophenyl)sulfonyl-amino]-N-cyclopropyl-acetamide
  • 2-[(2-chlorophenyl)methyl-(4-chlorophenyl)sulfonyl-amino]-N-cyclopropyl-ethanamide
  • STK151685
  • ZINC01093312

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.3647 0.3412
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.5856 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.2726 0.4655
Trypanosoma brucei polo-like protein kinase 0.0092 0.5856 1
Loa Loa (eye worm) hypothetical protein 0.0148 1 1
Entamoeba histolytica hypothetical protein 0.0039 0.191 0.2825
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.1331 0.2273
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.1331 0.2273
Schistosoma mansoni ap endonuclease 0.0019 0.0447 0.0577
Plasmodium falciparum thioredoxin reductase 0.0037 0.1769 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.1331 0.2273
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.3965 0.3965
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0447 0.0762
Schistosoma mansoni hypothetical protein 0.0039 0.191 0.247
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3647 0.4716
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0356 0.0608
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.084 0.1434
Echinococcus granulosus GPCR family 2 0.0031 0.1331 0.2273
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.1806 0.3083
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0359 0.0613
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0356 0.0608
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0356 0.0356
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0356 0.0608
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0447 0.0762
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0356 0.0461
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0356 0.0608
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.5238 0.8837
Brugia malayi hypothetical protein 0.0039 0.191 0.191
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.084 0.1086
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0447 0.0762
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.2726 0.4655
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0447 1
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.5856 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.5928 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.191 0.3262
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.2726 0.4655
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0356 0.0608
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0356 0.0608
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0356 0.0608
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0356 0.0608
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.2726 0.4655
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3647 0.4716
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0447 0.0762
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.084 0.084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0356 0.0608
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0447 0.0762
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.5928 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0356 0.0608
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.5856 1
Toxoplasma gondii exonuclease III APE 0.0019 0.0447 0.1292
Loa Loa (eye worm) glutathione reductase 0.0037 0.1769 0.1465
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.1769 0.3021
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0447 0.1292
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.5238 0.8837
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.3457 0.447
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0447 0.0094
Giardia lamblia GTOR 0.0018 0.0356 0.0608
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0356 0.0608
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.1806 0.3083
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.3457 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.1331 0.1331
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3647 0.4716
Entamoeba histolytica hypothetical protein 0.0039 0.191 0.2825
Trypanosoma brucei trypanothione reductase 0.0037 0.1769 0.3021
Trypanosoma brucei protein kinase, putative 0.005 0.2726 0.4655
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.2442 0.417
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.3457 1
Schistosoma mansoni hypothetical protein 0.0031 0.1331 0.1721
Entamoeba histolytica hypothetical protein 0.0024 0.084 0.0879
Trichomonas vaginalis CMGC family protein kinase 0.005 0.2726 0.4655
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.2726 0.4655
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.1331 0.1011
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.1769 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.3457 0.5903
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0356 0.0608
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0356 0.0608
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.2726 0.4655
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.5856 1
Brugia malayi MAP kinase sur-1 0.005 0.2726 0.2726
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.2726 0.4655
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0591 0.1009
Loa Loa (eye worm) RNA binding protein 0.0062 0.3647 0.3412
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0356 0.0608
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0356 0.0608
Mycobacterium tuberculosis Probable reductase 0.0084 0.5238 0.8837
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0356 0.0608
Echinococcus multilocularis GPCR, family 2 0.0031 0.1331 0.2273
Loa Loa (eye worm) hypothetical protein 0.0067 0.3965 0.3742
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.084 0.1434
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0447 1
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.3457 0.447
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.6234 0.6234
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.5238 0.8837
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0447 0.0753
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0356 0.0608
Schistosoma mansoni ap endonuclease 0.0019 0.0447 0.0577
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0356 0.0608
Echinococcus granulosus tar DNA binding protein 0.0062 0.3647 0.6228
Echinococcus granulosus serine protein kinase ATM 0.0024 0.084 0.1434
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0356 0.0608
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.191 0.3262
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0356 0.0608
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.1331 0.2273
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.3457 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0356 0.0608
Plasmodium vivax glutathione reductase, putative 0.0037 0.1769 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0356 0.0608
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.5856 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3647 0.4716
Schistosoma mansoni hypothetical protein 0.0067 0.3965 0.5127
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.6234 0.6234
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.5856 1
Trichomonas vaginalis CMGC family protein kinase 0.005 0.2726 0.4655
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0356 0.0608
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0356 0.0608
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.5238 0.8837
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0356 0.0608
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.084 0.1434
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.2726 0.2457
Plasmodium falciparum glutathione reductase 0.0037 0.1769 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0 0.5
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.1769 0.1465
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.3457 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0356 0.0608
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.5928 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0356 0.0608
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.5856 0.5856
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0356 0.0608
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0356 0.0608
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0356 0.0608
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.2726 0.4655
Loa Loa (eye worm) TAR-binding protein 0.0062 0.3647 0.3412
Brugia malayi Thioredoxin reductase 0.0037 0.1769 0.1769
Giardia lamblia Kinase, CMGC MAPK 0.005 0.2726 0.4655
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0356 0.0608
Trichomonas vaginalis CMGC family protein kinase 0.005 0.2726 0.4655
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0356 0.0608
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0356 0.0608
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0356 0.0608
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0356 0.0608
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0447 0.0762
Toxoplasma gondii FATC domain-containing protein 0.0024 0.084 0.2429
Schistosoma mansoni serine/threonine protein kinase 0.005 0.2726 0.3525
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3647 0.4716
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.084 0.1434
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0359 0.0613
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.5856 0.7573
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.5856 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.6234 0.6095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0356 0.0608
Schistosoma mansoni hypothetical protein 0.0031 0.1331 0.1721
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.5856 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.5856 1
Toxoplasma gondii thioredoxin reductase 0.0037 0.1769 0.5118
Schistosoma mansoni hypothetical protein 0.0031 0.1331 0.1721
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0356 0.0608
Schistosoma mansoni hypothetical protein 0.0031 0.1331 0.1721
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.5856 1
Echinococcus multilocularis tar DNA binding protein 0.0062 0.3647 0.6228
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.3647 0.3647
Entamoeba histolytica hypothetical protein 0.0039 0.191 0.2825
Brugia malayi TAR-binding protein 0.0062 0.3647 0.3647
Leishmania major trypanothione reductase 0.0037 0.1769 0.3021
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.2726 0.4655
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0356 0.0608
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.2442 0.417
Entamoeba histolytica hypothetical protein 0.0039 0.191 0.2825
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0447 0.2523
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.5856 1
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.191 0.247
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.5856 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0447 0.0762
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0356 0.103
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.5856 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0356 0.0608
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0356 0.0608
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0356 0.0608
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.2726 0.4655
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.5928 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0447 0.0164
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.2726 0.7886
Brugia malayi RNA binding protein 0.0062 0.3647 0.3647
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0356 0.0608
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0447 0.0447
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.5856 0.5703
Onchocerca volvulus 0.0148 1 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0356 0.0461
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0447 0.0762
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0356 0.0608
Brugia malayi Latrophilin receptor protein 2 0.0031 0.1331 0.1331
Brugia malayi glutathione reductase 0.0037 0.1769 0.1769
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.3457 0.5832
Loa Loa (eye worm) hypothetical protein 0.0097 0.6234 0.6095
Schistosoma mansoni kinase 0.0047 0.2531 0.3273
Trichomonas vaginalis CMGC family protein kinase 0.005 0.2726 0.4655
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0356 0.0608
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0356 0.0608
Loa Loa (eye worm) hypothetical protein 0.0021 0.0591 0.0243
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.3457 0.5903
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0447 0.0762
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0356 0.0356
Giardia lamblia Kinase, PLK 0.0092 0.5856 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0356 0.0608
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0356 0.0608
Loa Loa (eye worm) hypothetical protein 0.0031 0.1331 0.1011
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.5238 0.8837
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0356 0.0608
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.1769 0.2985
Echinococcus granulosus mitogen activated protein kinase 0.005 0.2726 0.4655
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0447 0.2523
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.3457 0.5903

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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