Detailed information for compound 674322

Basic information

Technical information
  • TDR Targets ID: 674322
  • Name: EU-0045651
  • MW: 422.54 | Formula: C24H26N2O3S
  • H donors: 1 H acceptors: 3 LogP: 4.99 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CN(S(=O)(=O)c1ccccc1)c1cccc(c1C)C)Nc1ccc(cc1C)C
  • InChi: 1S/C24H26N2O3S/c1-17-13-14-22(19(3)15-17)25-24(27)16-26(23-12-8-9-18(2)20(23)4)30(28,29)21-10-6-5-7-11-21/h5-15H,16H2,1-4H3,(H,25,27)
  • InChiKey: KGOOGYYQDBIION-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ZINC01143548

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis aldo-keto reductase, putative 0.0653 1 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0151 0.2234 0.2234
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0189 0.2829 0.2829
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0058 0.0797 0.0797
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0123 0.1805 0.1805
Echinococcus granulosus FTZ F1 alpha 0.0058 0.0797 0.0797
Brugia malayi NADH-dependent xylose reductase 0.0189 0.2829 0.2829
Trichomonas vaginalis aldo-keto reductase, putative 0.0189 0.2829 0.2829
Schistosoma mansoni hypothetical protein 0.0016 0.0158 0.0158
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0653 1 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0123 0.1805 0.1805
Onchocerca volvulus 0.0653 1 1
Echinococcus multilocularis muscleblind protein 1 0.0305 0.4627 0.4627
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0013 0.0104 0.0104
Brugia malayi nuclear hormone receptor family member odr-7 0.0027 0.0326 0.0326
Toxoplasma gondii aldose reductase, putative 0.0653 1 1
Loa Loa (eye worm) oxidoreductase 0.0653 1 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0653 1 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0706 0.0706
Trichomonas vaginalis aldo/keto reductase, putative 0.0653 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0706 0.0706
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0616 0.0616
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0616 0.0616
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0058 0.0797 0.0797
Trypanosoma brucei aldo/keto reductase, putative 0.0189 0.2829 0.2829
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0058 0.0797 0.0797
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0616 0.0616
Loa Loa (eye worm) hypothetical protein 0.0058 0.0797 0.0797
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0616 0.0616
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0452 0.0452
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0058 0.0797 0.0797
Trichomonas vaginalis aldo/keto reductase, putative 0.0653 1 1
Onchocerca volvulus 0.0027 0.0326 0.0326
Brugia malayi Muscleblind-like protein 0.0305 0.4627 0.4627
Trichomonas vaginalis aldo-keto reductase, putative 0.0189 0.2829 0.2829
Trichomonas vaginalis aldo-keto reductase, putative 0.0653 1 1
Plasmodium falciparum aldehyde reductase, putative 0.0189 0.2829 1
Toxoplasma gondii aldo-keto reductase 0.0189 0.2829 0.2753
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0376 0.0376
Trichomonas vaginalis dullard protein, putative 0.0013 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0027 0.0326 0.0326
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0058 0.0797 0.0797
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0158 0.0158
Loa Loa (eye worm) steroid hormone receptor 0.0058 0.0797 0.0797
Onchocerca volvulus 0.0653 1 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0653 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0616 0.0616
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0058 0.0797 0.0797
Mycobacterium ulcerans oxidoreductase 0.0653 1 1
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0533 0.0533
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.059 0.1782
Echinococcus granulosus nuclear receptor nhr 48 0.0027 0.0326 0.0326
Trichomonas vaginalis dullard protein, putative 0.0013 0.0104 0.0104
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0653 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0058 0.0797 0.0797
Brugia malayi nuclear receptor NHR-88 0.0058 0.0797 0.0797
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0123 0.1805 0.1805
Entamoeba histolytica alcohol dehydrogenase, putative 0.0189 0.2829 0.2829
Brugia malayi hypothetical protein 0.0027 0.0326 0.0326
Echinococcus granulosus aldo keto reductase 0.0653 1 1
Echinococcus multilocularis aldehyde reductase 0.0464 0.7076 0.7076
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.003 0.0376 0.0376
Schistosoma mansoni hypothetical protein 0.0016 0.0158 0.0158
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0013 0.0104 0.0104
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0013 0.0104 0.0104
Brugia malayi nuclear receptor RXR 0.003 0.0376 0.0376
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0616 0.0616
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0058 0.0797 0.0797
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0189 0.2829 0.2753
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0058 0.0797 0.0797
Trichomonas vaginalis aldo-keto reductase, putative 0.0653 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0326 0.0326
Loa Loa (eye worm) nuclear receptor NHR-67 0.0027 0.0326 0.0326
Echinococcus multilocularis thyroid hormone receptor alpha 0.0058 0.0797 0.0797
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0058 0.0797 0.0797
Echinococcus multilocularis voltage gated potassium channel subunit 0.0189 0.2829 0.2829
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0653 1 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.003 0.0376 0.0376
Echinococcus granulosus Nuclear hormone receptor HR96 0.0027 0.0326 0.0326
Schistosoma mansoni thyroid hormone receptor 0.0058 0.0797 0.0797
Loa Loa (eye worm) hypothetical protein 0.0058 0.0797 0.0797
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0158 0.0158
Echinococcus granulosus muscleblind protein 0.0305 0.4627 0.4627
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0533 0.0533
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.059 0.059
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.059 0.059
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.059 0.0491
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0189 0.2829 0.2829
Entamoeba histolytica aldose reductase, putative 0.0653 1 1
Schistosoma mansoni retinoic acid receptor RXR 0.0058 0.0797 0.0797
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0326 0.0326
Echinococcus granulosus ecdysone induced protein 78C 0.0058 0.0797 0.0797
Entamoeba histolytica alcohol dehydrogenase, putative 0.0189 0.2829 0.2829
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0013 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0058 0.0797 0.0797
Plasmodium vivax aldehyde reductase, putative 0.0189 0.2829 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0027 0.0326 0.0326
Brugia malayi Steroid receptor seven-up type 2 0.0058 0.0797 0.0797
Schistosoma mansoni coup transcription factor 0.0058 0.0797 0.0797
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0189 0.2829 0.2753
Echinococcus multilocularis ecdysone induced protein 78C 0.0058 0.0797 0.0797
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0653 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0058 0.0797 0.0797
Plasmodium falciparum aldo-keto reductase, putative 0.0189 0.2829 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0653 1 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0027 0.0326 0.0326
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0653 1 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0027 0.0326 0.0326
Loa Loa (eye worm) hypothetical protein 0.0058 0.0797 0.0797
Schistosoma mansoni aldo-keto reductase 0.0653 1 1
Trypanosoma cruzi aldo-keto reductase 0.0653 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0653 1 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0146 0.2169 0.2169
Echinococcus multilocularis aldo keto reductase 0.0653 1 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0058 0.0797 0.0797
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0123 0.1805 0.1805
Loa Loa (eye worm) DR-78 0.0027 0.0326 0.0326
Echinococcus granulosus aldo keto reductase 0.0653 1 1
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0158 0.0158
Schistosoma mansoni steroid hormone receptor ad4bp 0.0058 0.0797 0.0797
Loa Loa (eye worm) hypothetical protein 0.003 0.0376 0.0376
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0058 0.0797 0.0797
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0058 0.0797 0.0797
Schistosoma mansoni nuclear hormone receptor 0.0058 0.0797 0.0797
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0653 1 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0653 1 1
Loa Loa (eye worm) oxidoreductase 0.0653 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0058 0.0797 0.0797
Loa Loa (eye worm) hypothetical protein 0.0027 0.0326 0.0326
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0058 0.0797 0.0797
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0653 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0653 1 1
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0013 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0058 0.0797 0.0797
Schistosoma mansoni hypothetical protein 0.0013 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0058 0.0797 0.0797
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0653 1 1
Schistosoma mansoni thyroid hormone receptor 0.0058 0.0797 0.0797
Echinococcus granulosus aldo keto reductase 0.0653 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0058 0.0797 0.0797
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0013 0.0104 0.0104
Echinococcus multilocularis aldo keto reductase 0.0653 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0653 1 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0123 0.1805 0.1805
Trichomonas vaginalis aldo-keto reductase, putative 0.0189 0.2829 0.2829
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0013 0.0104 0.0104
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0653 1 1
Giardia lamblia Aldose reductase 0.0653 1 1
Entamoeba histolytica dual specificity protein phosphatase, putative 0.0603 0.9221 0.9221
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0123 0.1805 0.1805
Brugia malayi nuclear hormone receptor 0.0027 0.0326 0.0326
Brugia malayi ecdysone receptor 0.0027 0.0326 0.0326
Brugia malayi Nuclear hormone receptor E75 0.0027 0.0326 0.0326
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0058 0.0797 0.0797
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0058 0.0797 0.0797
Loa Loa (eye worm) nuclear hormone receptor 0.0027 0.0326 0.0326
Brugia malayi nuclear hormone receptor family member nhr-6 0.0027 0.0326 0.0326
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0653 1 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.003 0.0376 0.0376
Loa Loa (eye worm) hypothetical protein 0.0027 0.0326 0.0326
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0013 0.0104 0.0104
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0058 0.0797 0.0797
Loa Loa (eye worm) hypothetical protein 0.0653 1 1
Brugia malayi conserved hypotetical protein 0.0027 0.0326 0.0326
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0027 0.0326 0.0326
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.003 0.0376 0.0376
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0151 0.2234 0.2234
Loa Loa (eye worm) hypothetical protein 0.0013 0.0104 0.0104
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0653 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0706 0.0706
Echinococcus granulosus CTD small phosphatase protein like 0.0013 0.0104 0.0104
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0123 0.1805 0.1805
Echinococcus multilocularis FTZ F1 alpha 0.0058 0.0797 0.0797
Loa Loa (eye worm) hypothetical protein 0.0027 0.0326 0.0326
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0027 0.0326 0.0326
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0058 0.0797 0.0797
Schistosoma mansoni RAR-like nuclear receptor 0.0058 0.0797 0.0797
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.003 0.0376 0.0376
Mycobacterium leprae Conserved hypothetical protein 0.0464 0.7076 0.5922
Loa Loa (eye worm) hypothetical protein 0.0058 0.0797 0.0797
Trichomonas vaginalis aldo-keto reductase, putative 0.0653 1 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0027 0.0326 0.0326
Loa Loa (eye worm) hypothetical protein 0.0027 0.0326 0.0326
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0653 1 1
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0013 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0027 0.0326 0.0326
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0058 0.0797 0.0797
Giardia lamblia Aldose reductase 0.0653 1 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0058 0.0797 0.0797
Schistosoma mansoni potassium channel beta 0.0189 0.2829 0.2829
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0052 0.0706 0.0706
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0104 0.0104
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0376 0.0376
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0058 0.0797 0.0797
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0653 1 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.059 0.0491
Onchocerca volvulus Protein ultraspiracle homolog 0.0058 0.0797 0.0797
Loa Loa (eye worm) hypothetical protein 0.0058 0.0797 0.0797
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0376 0.0376
Trichomonas vaginalis aldo-keto reductase, putative 0.0653 1 1
Echinococcus granulosus voltage gated potassium channel subunit 0.0189 0.2829 0.2829
Loa Loa (eye worm) hypothetical protein 0.0013 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0027 0.0326 0.0326
Echinococcus granulosus aldehyde reductase 0.0464 0.7076 0.7076
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0058 0.0797 0.0797
Brugia malayi photoreceptor-specific nuclear receptor 0.0058 0.0797 0.0797
Trypanosoma brucei aldo-keto reductase, putative 0.0653 1 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0027 0.0326 0.0326
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0653 1 1
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0326 0.0326
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0653 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0058 0.0797 0.0797
Brugia malayi orphan nuclear receptor NR2E1 0.0027 0.0326 0.0326
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0058 0.0797 0.0797
Loa Loa (eye worm) oxidoreductase 0.0653 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0058 0.0797 0.0797
Onchocerca volvulus 0.0653 1 1
Schistosoma mansoni nuclear receptor nhr-48 0.0027 0.0326 0.0326
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0027 0.0326 0.0326
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0013 0.0104 0.0104
Brugia malayi nuclear receptor NHR-67 0.0027 0.0326 0.0326
Schistosoma mansoni pol-related 0.0653 1 1
Leishmania major aldo-keto reductase-like protein 0.0653 1 1
Loa Loa (eye worm) oxidoreductase 0.0653 1 1
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0189 0.2829 0.2829
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0653 1 1
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0189 0.2829 0.2829
Schistosoma mansoni hypothetical protein 0.0035 0.0452 0.0452
Loa Loa (eye worm) acetyltransferase 0.0151 0.2234 0.2234
Echinococcus multilocularis aldo keto reductase 0.0653 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0653 1 1
Schistosoma mansoni zinc finger protein 0.0027 0.0326 0.0326
Brugia malayi hypothetical protein 0.003 0.0376 0.0376
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0158 0.0158
Brugia malayi hypothetical protein 0.003 0.0376 0.0376
Loa Loa (eye worm) hypothetical protein 0.003 0.0376 0.0376
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0013 0.0104 0.0104
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0027 0.0326 0.0326
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0058 0.0797 0.0797
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0653 1 1
Onchocerca volvulus 0.0058 0.0797 0.0797
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0058 0.0797 0.0797
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0653 1 1
Echinococcus granulosus hypothetical protein 0.0653 1 1
Brugia malayi nuclear receptor RXR 0.0027 0.0326 0.0326
Echinococcus granulosus GPCR family 2 0.0016 0.0158 0.0158
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0058 0.0797 0.0797
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0027 0.0326 0.0326
Loa Loa (eye worm) hypothetical protein 0.0027 0.0326 0.0326
Loa Loa (eye worm) hypothetical protein 0.0027 0.0326 0.0326
Echinococcus granulosus thyroid hormone receptor alpha 0.0027 0.0326 0.0326
Onchocerca volvulus 0.0027 0.0326 0.0326
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0616 0.0616
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0058 0.0797 0.0797
Schistosoma mansoni nuclear receptor 0.0027 0.0326 0.0326
Trichomonas vaginalis aldo-keto reductase, putative 0.0653 1 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0616 0.0616
Trichomonas vaginalis aldo-keto reductase, putative 0.0653 1 1
Brugia malayi acetyltransferase, GNAT family protein 0.0151 0.2234 0.2234
Echinococcus multilocularis GPCR, family 2 0.0016 0.0158 0.0158
Brugia malayi hypothetical protein 0.0027 0.0326 0.0326
Entamoeba histolytica aldose reductase, putative 0.0653 1 1
Echinococcus multilocularis muscleblind protein 0.0305 0.4627 0.4627
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0058 0.0797 0.0797
Schistosoma mansoni aldo-keto reductase 0.0653 1 1
Loa Loa (eye worm) oxidoreductase 0.0653 1 1
Schistosoma mansoni hypothetical protein 0.0016 0.0158 0.0158
Schistosoma mansoni nuclear receptor 0.0027 0.0326 0.0326
Brugia malayi tailless protein 0.0027 0.0326 0.0326
Trypanosoma cruzi aldo/keto reductase, putative 0.0653 1 1
Onchocerca volvulus Bile acid receptor homolog 0.0058 0.0797 0.0797
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0058 0.0797 0.0797
Echinococcus multilocularis 0.0013 0.0104 0.0104
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.0603 0.9221 0.9221
Brugia malayi Nuclear hormone receptor E75 0.0027 0.0326 0.0326
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.003 0.0376 0.0376
Trypanosoma cruzi aldo/keto reductase, putative 0.0189 0.2829 0.2829
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0653 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0376 0.0376
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0653 1 1
Loa Loa (eye worm) hypothetical protein 0.0305 0.4627 0.4627
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0616 0.0616
Leishmania major hypothetical protein, conserved 0.0013 0.0104 0.0104
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0653 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0653 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0653 1 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0058 0.0797 0.0797
Onchocerca volvulus 0.0653 1 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0058 0.0797 0.0797
Echinococcus multilocularis aldo keto reductase 0.0653 1 1
Trichomonas vaginalis dullard protein, putative 0.0013 0.0104 0.0104
Brugia malayi steroid hormone receptor 0.0058 0.0797 0.0797
Trichomonas vaginalis aldo-keto reductase, putative 0.0653 1 1
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0013 0.0104 0.0104
Brugia malayi nuclear hormone receptor 0.0058 0.0797 0.0797
Trypanosoma brucei prostaglandin f synthase 0.0653 1 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0326 0.0326
Loa Loa (eye worm) hypothetical protein 0.0027 0.0326 0.0326
Entamoeba histolytica aldose reductase, putative 0.0653 1 1
Schistosoma mansoni hypothetical protein 0.0016 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0035 0.0452 0.0452
Onchocerca volvulus 0.0653 1 1
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0326 0.0326
Brugia malayi ecdysteroid receptor 0.0058 0.0797 0.0797
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0189 0.2829 0.2829
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0653 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0189 0.2829 0.2829
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0058 0.0797 0.0797
Loa Loa (eye worm) hypothetical protein 0.0027 0.0326 0.0326
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0058 0.0797 0.0797
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0027 0.0326 0.0326
Onchocerca volvulus 0.0189 0.2829 0.2829
Leishmania major prostaglandin f synthase, putative 0.0653 1 1
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0653 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0058 0.0797 0.0797
Brugia malayi nuclear receptor NHR-88 0.0027 0.0326 0.0326
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0653 1 1
Loa Loa (eye worm) hypothetical protein 0.0305 0.4627 0.4627
Loa Loa (eye worm) hypothetical protein 0.0027 0.0326 0.0326
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0058 0.0797 0.0797
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0533 0.1573
Onchocerca volvulus 0.0653 1 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.059 0.059
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0027 0.0326 0.0326
Loa Loa (eye worm) hypothetical protein 0.0016 0.0158 0.0158
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0058 0.0797 0.0797
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0653 1 1
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0189 0.2829 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0027 0.0326 0.0326

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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