Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | protein patched | 0.2728 | 0.3953 | 0.3953 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0217 | 0.0058 | 0.0058 |
Echinococcus granulosus | Protein patched homolog 1 | 0.2728 | 0.3953 | 0.3953 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.2728 | 0.3953 | 0.3953 |
Schistosoma mansoni | patched 1 | 0.2728 | 0.3953 | 0.3918 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.2728 | 0.3953 | 0.3918 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.6627 | 1 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0197 | 0.0027 | 0.0027 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0213 | 0.0052 | 0.0052 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.2728 | 0.3953 | 0.3953 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.6627 | 1 | 0.5 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.6627 | 1 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.6627 | 1 | 0.5 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.6627 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.6627 | 1 | 0.5 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.6627 | 1 | 1 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.6627 | 1 | 0.5 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.2728 | 0.3953 | 0.3953 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.2728 | 0.3953 | 0.3953 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0217 | 0.0058 | 0.0058 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0213 | 0.0052 | 0.0052 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.3109 | 0.4544 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.3109 | 0.4544 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.2728 | 0.3953 | 0.3953 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0288 | 0.0168 | 0.0111 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.3109 | 0.4544 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.6627 | 1 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0197 | 0.0027 | 0.0027 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.3109 | 0.4544 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.