Detailed information for compound 674684

Basic information

Technical information
  • TDR Targets ID: 674684
  • Name: 2-(3-chlorophenoxy)-N-(3,4-dimethoxyphenyl)pr opanamide
  • MW: 335.782 | Formula: C17H18ClNO4
  • H donors: 1 H acceptors: 1 LogP: 3.77 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)NC(=O)C(Oc1cccc(c1)Cl)C
  • InChi: 1S/C17H18ClNO4/c1-11(23-14-6-4-5-12(18)9-14)17(20)19-13-7-8-15(21-2)16(10-13)22-3/h4-11H,1-3H3,(H,19,20)
  • InChiKey: AHNYODZESNOMQR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(3-chlorophenoxy)-N-(3,4-dimethoxyphenyl)propionamide
  • STK208220
  • AN-652/12269509

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.008 0.2529 1
Echinococcus multilocularis survival motor neuron protein 1 0.0267 1 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.008 0.2529 0.2404
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0165 0.5
Echinococcus granulosus geminin 0.0192 0.6981 0.6931
Loa Loa (eye worm) hypothetical protein 0.003 0.0542 0.0542
Schistosoma mansoni hypothetical protein 0.0192 0.6981 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0165 0.5
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0564 0.0564
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0165 0.5
Toxoplasma gondii aldehyde dehydrogenase 0.0069 0.2084 1
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0165 0.5
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0564 0.0564
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.2084 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0069 0.2084 1
Echinococcus multilocularis geminin 0.0192 0.6981 0.6931
Schistosoma mansoni hypothetical protein 0.0055 0.1522 0.1991
Brugia malayi intermediate filament protein 0.0031 0.0564 0.0564
Entamoeba histolytica hypothetical protein 0.008 0.2529 1
Schistosoma mansoni survival motor neuron protein 0.0055 0.1522 0.1991
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0069 0.2084 0.1952
Echinococcus multilocularis musashi 0.0031 0.0564 0.0406
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0165 0.5
Schistosoma mansoni hypothetical protein 0.008 0.2529 0.3469
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.1522 0.1522
Entamoeba histolytica hypothetical protein 0.008 0.2529 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0165 0.5
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0165 0.5
Onchocerca volvulus 0.0055 0.1522 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0165 0.5
Echinococcus multilocularis lamin 0.0031 0.0564 0.0406
Schistosoma mansoni hypothetical protein 0.0192 0.6981 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.2084 1
Echinococcus granulosus intermediate filament protein 0.0031 0.0564 0.0406
Loa Loa (eye worm) hypothetical protein 0.0031 0.0564 0.0564
Brugia malayi hypothetical protein 0.008 0.2529 0.2529
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0564 0.0564
Echinococcus granulosus lamin 0.0031 0.0564 0.0406
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.2084 0.2816
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.2084 0.2816
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0069 0.2084 1
Schistosoma mansoni lamin 0.0031 0.0564 0.0586
Loa Loa (eye worm) hypothetical protein 0.0267 1 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0165 0.5
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.2084 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0165 0.0165
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0165 0.5
Schistosoma mansoni lamin 0.0031 0.0564 0.0586
Schistosoma mansoni transcription factor LCR-F1 0.008 0.2529 0.3469
Echinococcus granulosus survival motor neuron protein 1 0.0267 1 1
Schistosoma mansoni intermediate filament proteins 0.0031 0.0564 0.0586
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0069 0.2084 0.1952
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0165 0.0165
Echinococcus granulosus lamin dm0 0.0031 0.0564 0.0406
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.008 0.2529 0.2404
Entamoeba histolytica hypothetical protein 0.008 0.2529 1
Echinococcus multilocularis lamin dm0 0.0031 0.0564 0.0406

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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